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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAEL
Full Name:
Protein maelstrom homolog
Alias:
Type:
Mass (Da):
49219
Number AA:
434
UniProt ID:
Q96JY0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
R
K
A
S
R
N
A
Y
Y
F
F
V
Q
E
K
Site 2
Y12
K
A
S
R
N
A
Y
Y
F
F
V
Q
E
K
I
Site 3
S41
D
A
I
P
Y
C
S
S
D
W
A
L
L
R
E
Site 4
Y54
R
E
E
E
K
E
K
Y
A
E
M
A
R
E
W
Site 5
S72
Q
G
K
D
P
G
P
S
E
K
Q
K
P
V
F
Site 6
T80
E
K
Q
K
P
V
F
T
P
L
R
R
P
G
M
Site 7
S95
L
V
P
K
Q
N
V
S
P
P
D
M
S
A
L
Site 8
S100
N
V
S
P
P
D
M
S
A
L
S
L
K
G
D
Site 9
S103
P
P
D
M
S
A
L
S
L
K
G
D
Q
A
L
Site 10
S175
R
F
H
C
Q
A
A
S
D
S
S
H
K
I
P
Site 11
S177
H
C
Q
A
A
S
D
S
S
H
K
I
P
I
S
Site 12
S184
S
S
H
K
I
P
I
S
N
F
E
R
G
H
N
Site 13
T194
E
R
G
H
N
Q
A
T
V
L
Q
N
L
Y
R
Site 14
Y200
A
T
V
L
Q
N
L
Y
R
F
I
H
P
N
P
Site 15
Y214
P
G
N
W
P
P
I
Y
C
K
S
D
D
R
T
Site 16
S234
L
K
H
M
A
K
A
S
E
I
R
Q
D
L
Q
Site 17
Y253
E
D
L
V
V
G
I
Y
Q
Q
K
F
L
K
E
Site 18
T264
F
L
K
E
P
S
K
T
W
I
R
S
L
L
D
Site 19
Y277
L
D
V
A
M
W
D
Y
S
S
N
T
R
C
K
Site 20
Y328
A
H
V
P
L
Q
D
Y
E
A
S
N
S
V
T
Site 21
S333
Q
D
Y
E
A
S
N
S
V
T
P
K
M
V
V
Site 22
T335
Y
E
A
S
N
S
V
T
P
K
M
V
V
L
D
Site 23
S353
Y
Q
K
L
R
V
G
S
S
G
F
S
H
F
N
Site 24
S354
Q
K
L
R
V
G
S
S
G
F
S
H
F
N
S
Site 25
S357
R
V
G
S
S
G
F
S
H
F
N
S
S
N
E
Site 26
S361
S
G
F
S
H
F
N
S
S
N
E
E
Q
R
S
Site 27
S362
G
F
S
H
F
N
S
S
N
E
E
Q
R
S
N
Site 28
S368
S
S
N
E
E
Q
R
S
N
T
P
I
G
D
Y
Site 29
T370
N
E
E
Q
R
S
N
T
P
I
G
D
Y
P
S
Site 30
Y375
S
N
T
P
I
G
D
Y
P
S
R
A
K
I
S
Site 31
S377
T
P
I
G
D
Y
P
S
R
A
K
I
S
G
Q
Site 32
S382
Y
P
S
R
A
K
I
S
G
Q
N
S
S
V
R
Site 33
S386
A
K
I
S
G
Q
N
S
S
V
R
G
R
G
I
Site 34
S387
K
I
S
G
Q
N
S
S
V
R
G
R
G
I
T
Site 35
T394
S
V
R
G
R
G
I
T
R
L
L
E
S
I
S
Site 36
S399
G
I
T
R
L
L
E
S
I
S
N
S
S
S
N
Site 37
S401
T
R
L
L
E
S
I
S
N
S
S
S
N
I
H
Site 38
S403
L
L
E
S
I
S
N
S
S
S
N
I
H
K
F
Site 39
S405
E
S
I
S
N
S
S
S
N
I
H
K
F
S
N
Site 40
S411
S
S
N
I
H
K
F
S
N
C
D
T
S
L
S
Site 41
T415
H
K
F
S
N
C
D
T
S
L
S
P
Y
M
S
Site 42
S416
K
F
S
N
C
D
T
S
L
S
P
Y
M
S
Q
Site 43
S418
S
N
C
D
T
S
L
S
P
Y
M
S
Q
K
D
Site 44
Y420
C
D
T
S
L
S
P
Y
M
S
Q
K
D
G
Y
Site 45
S422
T
S
L
S
P
Y
M
S
Q
K
D
G
Y
K
S
Site 46
Y427
Y
M
S
Q
K
D
G
Y
K
S
F
S
S
L
S
Site 47
S429
S
Q
K
D
G
Y
K
S
F
S
S
L
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation