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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP47
Full Name:
Ubiquitin carboxyl-terminal hydrolase 47
Alias:
Ubiquitin specific peptidase 47; Ubiquitin thioesterase 47; UBP47
Type:
Ubiquitin conjugating system; Actin binding protein; EC 3.1.2.15; Protease
Mass (Da):
157268
Number AA:
1375
UniProt ID:
Q96K76
International Prot ID:
IPI00607554
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T51
L
C
I
I
Q
D
T
T
N
S
K
T
V
N
E
Site 2
T55
Q
D
T
T
N
S
K
T
V
N
E
R
I
T
L
Site 3
T61
K
T
V
N
E
R
I
T
L
N
L
P
A
S
T
Site 4
T68
T
L
N
L
P
A
S
T
P
V
R
K
L
F
E
Site 5
T107
D
M
A
P
L
D
H
T
S
D
K
S
L
L
D
Site 6
S108
M
A
P
L
D
H
T
S
D
K
S
L
L
D
A
Site 7
S111
L
D
H
T
S
D
K
S
L
L
D
A
N
F
E
Site 8
T128
K
K
N
F
L
H
L
T
D
K
D
G
E
Q
P
Site 9
S142
P
Q
I
L
L
E
D
S
S
A
G
E
D
S
V
Site 10
S143
Q
I
L
L
E
D
S
S
A
G
E
D
S
V
H
Site 11
S148
D
S
S
A
G
E
D
S
V
H
D
R
F
I
G
Site 12
S162
G
P
L
P
R
E
G
S
V
G
S
T
S
D
Y
Site 13
S165
P
R
E
G
S
V
G
S
T
S
D
Y
V
S
Q
Site 14
T166
R
E
G
S
V
G
S
T
S
D
Y
V
S
Q
S
Site 15
S167
E
G
S
V
G
S
T
S
D
Y
V
S
Q
S
Y
Site 16
Y169
S
V
G
S
T
S
D
Y
V
S
Q
S
Y
S
Y
Site 17
S171
G
S
T
S
D
Y
V
S
Q
S
Y
S
Y
S
S
Site 18
S173
T
S
D
Y
V
S
Q
S
Y
S
Y
S
S
I
L
Site 19
Y174
S
D
Y
V
S
Q
S
Y
S
Y
S
S
I
L
N
Site 20
S175
D
Y
V
S
Q
S
Y
S
Y
S
S
I
L
N
K
Site 21
Y176
Y
V
S
Q
S
Y
S
Y
S
S
I
L
N
K
S
Site 22
S177
V
S
Q
S
Y
S
Y
S
S
I
L
N
K
S
E
Site 23
S178
S
Q
S
Y
S
Y
S
S
I
L
N
K
S
E
T
Site 24
S183
Y
S
S
I
L
N
K
S
E
T
G
Y
V
G
L
Site 25
T185
S
I
L
N
K
S
E
T
G
Y
V
G
L
V
N
Site 26
Y187
L
N
K
S
E
T
G
Y
V
G
L
V
N
Q
A
Site 27
Y217
P
E
F
R
N
A
L
Y
K
W
E
F
E
E
S
Site 28
S224
Y
K
W
E
F
E
E
S
E
E
D
P
V
T
S
Site 29
T230
E
S
E
E
D
P
V
T
S
I
P
Y
Q
L
Q
Site 30
S231
S
E
E
D
P
V
T
S
I
P
Y
Q
L
Q
R
Site 31
T254
K
K
R
A
I
E
T
T
D
V
T
R
S
F
G
Site 32
T257
A
I
E
T
T
D
V
T
R
S
F
G
W
D
S
Site 33
S259
E
T
T
D
V
T
R
S
F
G
W
D
S
S
E
Site 34
Y301
A
D
L
I
N
E
L
Y
Q
G
K
L
K
D
Y
Site 35
Y308
Y
Q
G
K
L
K
D
Y
V
R
C
L
E
C
G
Site 36
T323
Y
E
G
W
R
I
D
T
Y
L
D
I
P
L
V
Site 37
S337
V
I
R
P
Y
G
S
S
Q
A
F
A
S
V
E
Site 38
S342
G
S
S
Q
A
F
A
S
V
E
E
A
L
H
A
Site 39
Y362
I
L
D
G
P
N
Q
Y
F
C
E
R
C
K
K
Site 40
Y397
L
K
R
F
D
F
D
Y
T
T
M
H
R
I
K
Site 41
T410
I
K
L
N
D
R
M
T
F
P
E
E
L
D
M
Site 42
S418
F
P
E
E
L
D
M
S
T
F
I
D
V
E
D
Site 43
T419
P
E
E
L
D
M
S
T
F
I
D
V
E
D
E
Site 44
S428
I
D
V
E
D
E
K
S
P
Q
T
E
S
C
T
Site 45
T431
E
D
E
K
S
P
Q
T
E
S
C
T
D
S
G
Site 46
S433
E
K
S
P
Q
T
E
S
C
T
D
S
G
A
E
Site 47
S437
Q
T
E
S
C
T
D
S
G
A
E
N
E
G
S
Site 48
S444
S
G
A
E
N
E
G
S
C
H
S
D
Q
M
S
Site 49
S447
E
N
E
G
S
C
H
S
D
Q
M
S
N
D
F
Site 50
S451
S
C
H
S
D
Q
M
S
N
D
F
S
N
D
D
Site 51
S455
D
Q
M
S
N
D
F
S
N
D
D
G
V
D
E
Site 52
S470
G
I
C
L
E
T
N
S
G
T
E
K
I
S
K
Site 53
S478
G
T
E
K
I
S
K
S
G
L
E
K
N
S
L
Site 54
S484
K
S
G
L
E
K
N
S
L
I
Y
E
L
F
S
Site 55
Y487
L
E
K
N
S
L
I
Y
E
L
F
S
V
M
A
Site 56
S498
S
V
M
A
H
S
G
S
A
A
G
G
H
Y
Y
Site 57
Y504
G
S
A
A
G
G
H
Y
Y
A
C
I
K
S
F
Site 58
Y505
S
A
A
G
G
H
Y
Y
A
C
I
K
S
F
S
Site 59
Y517
S
F
S
D
E
Q
W
Y
S
F
D
D
Q
H
V
Site 60
T528
D
Q
H
V
S
R
I
T
Q
E
D
I
K
K
T
Site 61
T535
T
Q
E
D
I
K
K
T
H
G
G
S
S
G
S
Site 62
S539
I
K
K
T
H
G
G
S
S
G
S
R
G
Y
Y
Site 63
S540
K
K
T
H
G
G
S
S
G
S
R
G
Y
Y
S
Site 64
S542
T
H
G
G
S
S
G
S
R
G
Y
Y
S
S
A
Site 65
Y545
G
S
S
G
S
R
G
Y
Y
S
S
A
F
A
S
Site 66
Y546
S
S
G
S
R
G
Y
Y
S
S
A
F
A
S
S
Site 67
S547
S
G
S
R
G
Y
Y
S
S
A
F
A
S
S
T
Site 68
S548
G
S
R
G
Y
Y
S
S
A
F
A
S
S
T
N
Site 69
S552
Y
Y
S
S
A
F
A
S
S
T
N
A
Y
M
L
Site 70
Y557
F
A
S
S
T
N
A
Y
M
L
I
Y
R
L
K
Site 71
Y561
T
N
A
Y
M
L
I
Y
R
L
K
D
P
A
R
Site 72
Y578
K
F
L
E
V
G
E
Y
P
E
H
I
K
N
L
Site 73
T606
Q
R
E
I
E
R
N
T
C
K
I
K
L
F
C
Site 74
T633
L
E
V
H
K
D
K
T
L
K
E
A
V
E
M
Site 75
Y661
D
C
C
R
L
V
K
Y
D
E
F
H
D
Y
L
Site 76
Y667
K
Y
D
E
F
H
D
Y
L
E
R
S
Y
E
G
Site 77
S671
F
H
D
Y
L
E
R
S
Y
E
G
E
E
D
T
Site 78
Y672
H
D
Y
L
E
R
S
Y
E
G
E
E
D
T
P
Site 79
T678
S
Y
E
G
E
E
D
T
P
M
G
L
L
L
G
Site 80
S708
K
P
D
Q
V
F
Q
S
Y
K
P
G
E
V
M
Site 81
Y737
A
P
I
T
V
R
A
Y
L
N
Q
T
V
T
E
Site 82
T741
V
R
A
Y
L
N
Q
T
V
T
E
F
K
Q
L
Site 83
T743
A
Y
L
N
Q
T
V
T
E
F
K
Q
L
I
S
Site 84
Y768
R
I
V
L
E
R
C
Y
N
D
L
R
L
L
S
Site 85
S775
Y
N
D
L
R
L
L
S
V
S
S
K
T
L
K
Site 86
S777
D
L
R
L
L
S
V
S
S
K
T
L
K
A
E
Site 87
S778
L
R
L
L
S
V
S
S
K
T
L
K
A
E
G
Site 88
S789
K
A
E
G
F
F
R
S
N
K
V
F
V
E
S
Site 89
Y802
E
S
S
E
T
L
D
Y
Q
M
A
F
A
D
S
Site 90
S832
F
V
L
L
P
E
Q
S
P
V
S
Y
S
K
R
Site 91
S835
L
P
E
Q
S
P
V
S
Y
S
K
R
T
A
Y
Site 92
Y836
P
E
Q
S
P
V
S
Y
S
K
R
T
A
Y
Q
Site 93
S837
E
Q
S
P
V
S
Y
S
K
R
T
A
Y
Q
K
Site 94
Y842
S
Y
S
K
R
T
A
Y
Q
K
A
G
G
D
S
Site 95
S865
R
V
K
G
P
V
G
S
L
K
S
V
E
A
I
Site 96
S876
V
E
A
I
L
E
E
S
T
E
K
L
K
S
L
Site 97
T877
E
A
I
L
E
E
S
T
E
K
L
K
S
L
S
Site 98
S882
E
S
T
E
K
L
K
S
L
S
L
Q
Q
Q
Q
Site 99
S884
T
E
K
L
K
S
L
S
L
Q
Q
Q
Q
D
G
Site 100
S896
Q
D
G
D
N
G
D
S
S
K
S
T
E
T
S
Site 101
S897
S
D
F
E
N
I
E
S
P
L
N
E
R
D
S
Site 102
S899
D
N
G
D
S
S
K
S
T
E
T
S
D
F
E
Site 103
T900
N
G
D
S
S
K
S
T
E
T
S
D
F
E
N
Site 104
S903
S
S
K
S
T
E
T
S
D
F
E
N
I
E
S
Site 105
S910
S
D
F
E
N
I
E
S
P
L
N
E
R
D
S
Site 106
S917
S
P
L
N
E
R
D
S
S
A
S
V
D
N
R
Site 107
S918
P
L
N
E
R
D
S
S
A
S
V
D
N
R
E
Site 108
S920
N
E
R
D
S
S
A
S
V
D
N
R
E
L
E
Site 109
T932
E
L
E
Q
H
I
Q
T
S
D
P
E
N
F
Q
Site 110
S933
L
E
Q
H
I
Q
T
S
D
P
E
N
F
Q
S
Site 111
S940
S
D
P
E
N
F
Q
S
E
E
R
S
D
S
D
Site 112
S944
N
F
Q
S
E
E
R
S
D
S
D
V
N
N
D
Site 113
S946
Q
S
E
E
R
S
D
S
D
V
N
N
D
R
S
Site 114
S953
S
D
V
N
N
D
R
S
T
S
S
V
D
S
D
Site 115
T954
D
V
N
N
D
R
S
T
S
S
V
D
S
D
I
Site 116
S955
V
N
N
D
R
S
T
S
S
V
D
S
D
I
L
Site 117
S956
N
N
D
R
S
T
S
S
V
D
S
D
I
L
S
Site 118
S959
R
S
T
S
S
V
D
S
D
I
L
S
S
S
H
Site 119
S963
S
V
D
S
D
I
L
S
S
S
H
S
S
D
T
Site 120
S964
V
D
S
D
I
L
S
S
S
H
S
S
D
T
L
Site 121
S965
D
S
D
I
L
S
S
S
H
S
S
D
T
L
C
Site 122
S967
D
I
L
S
S
S
H
S
S
D
T
L
C
N
A
Site 123
S968
I
L
S
S
S
H
S
S
D
T
L
C
N
A
D
Site 124
T970
S
S
S
H
S
S
D
T
L
C
N
A
D
N
A
Site 125
S987
P
L
A
N
G
L
D
S
H
S
I
T
S
S
R
Site 126
S989
A
N
G
L
D
S
H
S
I
T
S
S
R
R
T
Site 127
T991
G
L
D
S
H
S
I
T
S
S
R
R
T
K
A
Site 128
S992
L
D
S
H
S
I
T
S
S
R
R
T
K
A
N
Site 129
S993
D
S
H
S
I
T
S
S
R
R
T
K
A
N
E
Site 130
T996
S
I
T
S
S
R
R
T
K
A
N
E
G
K
K
Site 131
T1008
G
K
K
E
T
W
D
T
A
E
E
D
S
G
T
Site 132
S1013
W
D
T
A
E
E
D
S
G
T
D
S
E
Y
D
Site 133
T1015
T
A
E
E
D
S
G
T
D
S
E
Y
D
E
S
Site 134
S1017
E
E
D
S
G
T
D
S
E
Y
D
E
S
G
K
Site 135
Y1019
D
S
G
T
D
S
E
Y
D
E
S
G
K
S
R
Site 136
S1022
T
D
S
E
Y
D
E
S
G
K
S
R
G
E
M
Site 137
S1025
E
Y
D
E
S
G
K
S
R
G
E
M
Q
Y
M
Site 138
Y1031
K
S
R
G
E
M
Q
Y
M
Y
F
K
A
E
P
Site 139
Y1033
R
G
E
M
Q
Y
M
Y
F
K
A
E
P
Y
A
Site 140
Y1039
M
Y
F
K
A
E
P
Y
A
A
D
E
G
S
G
Site 141
S1045
P
Y
A
A
D
E
G
S
G
E
G
H
K
W
L
Site 142
T1061
V
H
V
D
K
R
I
T
L
A
A
F
K
Q
H
Site 143
Y1086
H
F
K
V
F
R
V
Y
A
S
N
Q
E
F
E
Site 144
S1088
K
V
F
R
V
Y
A
S
N
Q
E
F
E
S
V
Site 145
S1094
A
S
N
Q
E
F
E
S
V
R
L
N
E
T
L
Site 146
T1100
E
S
V
R
L
N
E
T
L
S
S
F
S
D
D
Site 147
S1102
V
R
L
N
E
T
L
S
S
F
S
D
D
N
K
Site 148
S1103
R
L
N
E
T
L
S
S
F
S
D
D
N
K
I
Site 149
Y1123
R
A
L
K
K
G
E
Y
R
V
K
V
Y
Q
L
Site 150
T1151
A
V
F
A
K
G
M
T
V
R
Q
S
K
E
E
Site 151
S1155
K
G
M
T
V
R
Q
S
K
E
E
L
I
P
Q
Site 152
S1172
E
Q
C
G
L
E
L
S
I
D
R
F
R
L
R
Site 153
T1182
R
F
R
L
R
K
K
T
W
K
N
P
G
T
V
Site 154
T1188
K
T
W
K
N
P
G
T
V
F
L
D
Y
H
I
Site 155
Y1193
P
G
T
V
F
L
D
Y
H
I
Y
E
E
D
I
Site 156
Y1196
V
F
L
D
Y
H
I
Y
E
E
D
I
N
I
S
Site 157
S1204
E
E
D
I
N
I
S
S
N
W
E
V
F
L
E
Site 158
S1221
D
G
V
E
K
M
K
S
M
S
Q
L
A
V
L
Site 159
S1223
V
E
K
M
K
S
M
S
Q
L
A
V
L
S
R
Site 160
S1229
M
S
Q
L
A
V
L
S
R
R
W
K
P
S
E
Site 161
S1235
L
S
R
R
W
K
P
S
E
M
K
L
D
P
F
Site 162
S1251
E
V
V
L
E
S
S
S
V
D
E
L
R
E
K
Site 163
S1260
D
E
L
R
E
K
L
S
E
I
S
G
I
P
L
Site 164
T1278
E
F
A
K
G
R
G
T
F
P
C
D
I
S
V
Site 165
T1321
V
I
F
Y
R
D
K
T
E
E
L
M
E
L
T
Site 166
S1340
N
E
L
M
K
K
E
S
S
R
L
Q
K
T
G
Site 167
S1341
E
L
M
K
K
E
S
S
R
L
Q
K
T
G
H
Site 168
T1346
E
S
S
R
L
Q
K
T
G
H
R
V
T
Y
S
Site 169
T1351
Q
K
T
G
H
R
V
T
Y
S
P
R
K
E
K
Site 170
Y1352
K
T
G
H
R
V
T
Y
S
P
R
K
E
K
A
Site 171
S1353
T
G
H
R
V
T
Y
S
P
R
K
E
K
A
L
Site 172
Y1363
K
E
K
A
L
K
I
Y
L
D
G
A
P
N
K
Site 173
T1373
G
A
P
N
K
D
L
T
Q
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation