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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCYL1
Full Name:
N-terminal kinase-like protein
Alias:
Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase
Type:
Protein kinase, Ser/Thr (non-receptor), Other group, SCY1 family
Mass (Da):
89631
Number AA:
808
UniProt ID:
Q96KG9
International Prot ID:
IPI00102059
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
N-terminal kinase-like protein S754 phosphosite-specific antibody AB-PK809#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK809#N-terminal kinase-like protein (R751-E757, human) pS754 phosphopeptide - Powder PE-04APN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APN99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T39
H
R
G
R
K
K
A
T
G
S
P
V
S
I
F
Site 2
S41
G
R
K
K
A
T
G
S
P
V
S
I
F
V
Y
Site 3
T70
A
A
F
K
R
F
K
T
L
R
H
P
N
I
L
Site 4
Y162
W
K
L
G
G
L
D
Y
M
Y
S
A
Q
G
N
Site 5
Y164
L
G
G
L
D
Y
M
Y
S
A
Q
G
N
G
G
Site 6
S165
G
G
L
D
Y
M
Y
S
A
Q
G
N
G
G
G
Site 7
Y184
G
I
P
E
L
E
Q
Y
D
P
P
E
L
A
D
Site 8
S192
D
P
P
E
L
A
D
S
S
G
R
V
V
R
E
Site 9
S193
P
P
E
L
A
D
S
S
G
R
V
V
R
E
K
Site 10
T235
N
P
G
K
I
P
K
T
L
V
P
H
Y
C
E
Site 11
S269
R
A
P
G
G
F
M
S
N
R
F
V
E
T
N
Site 12
S298
Q
K
F
F
Q
E
L
S
K
S
L
D
A
F
P
Site 13
S300
F
F
Q
E
L
S
K
S
L
D
A
F
P
E
D
Site 14
S342
F
K
V
G
K
F
L
S
A
E
E
Y
Q
Q
K
Site 15
Y346
K
F
L
S
A
E
E
Y
Q
Q
K
I
I
P
V
Site 16
S359
P
V
V
V
K
M
F
S
S
T
D
R
A
M
R
Site 17
T361
V
V
K
M
F
S
S
T
D
R
A
M
R
I
R
Site 18
T384
I
Q
Y
L
D
E
P
T
V
N
T
Q
I
F
P
Site 19
Y458
C
L
G
K
I
G
S
Y
L
S
A
S
T
R
H
Site 20
S460
G
K
I
G
S
Y
L
S
A
S
T
R
H
R
V
Site 21
S462
I
G
S
Y
L
S
A
S
T
R
H
R
V
L
T
Site 22
T469
S
T
R
H
R
V
L
T
S
A
F
S
R
A
T
Site 23
S473
R
V
L
T
S
A
F
S
R
A
T
R
D
P
F
Site 24
T476
T
S
A
F
S
R
A
T
R
D
P
F
A
P
S
Site 25
S483
T
R
D
P
F
A
P
S
R
V
A
G
V
L
G
Site 26
S521
L
T
V
D
P
E
K
S
V
R
D
Q
A
F
K
Site 27
S532
Q
A
F
K
A
I
R
S
F
L
S
K
L
E
S
Site 28
S535
K
A
I
R
S
F
L
S
K
L
E
S
V
S
E
Site 29
S539
S
F
L
S
K
L
E
S
V
S
E
D
P
T
Q
Site 30
S541
L
S
K
L
E
S
V
S
E
D
P
T
Q
L
E
Site 31
T545
E
S
V
S
E
D
P
T
Q
L
E
E
V
E
K
Site 32
S558
E
K
D
V
H
A
A
S
S
P
G
M
G
G
A
Site 33
S559
K
D
V
H
A
A
S
S
P
G
M
G
G
A
A
Site 34
S568
G
M
G
G
A
A
A
S
W
A
G
W
A
V
T
Site 35
S582
T
G
V
S
S
L
T
S
K
L
I
R
S
H
P
Site 36
T591
L
I
R
S
H
P
T
T
A
P
T
E
T
N
I
Site 37
T594
S
H
P
T
T
A
P
T
E
T
N
I
P
Q
R
Site 38
T603
T
N
I
P
Q
R
P
T
P
E
G
V
P
A
P
Site 39
T618
A
P
T
P
V
P
A
T
P
T
T
S
G
H
W
Site 40
T634
T
Q
E
E
D
K
D
T
A
E
D
S
S
T
A
Site 41
S638
D
K
D
T
A
E
D
S
S
T
A
D
R
W
D
Site 42
S639
K
D
T
A
E
D
S
S
T
A
D
R
W
D
D
Site 43
T640
D
T
A
E
D
S
S
T
A
D
R
W
D
D
E
Site 44
S651
W
D
D
E
D
W
G
S
L
E
Q
E
A
E
S
Site 45
S667
L
A
Q
Q
D
D
W
S
T
G
G
Q
V
S
R
Site 46
S673
W
S
T
G
G
Q
V
S
R
A
S
Q
V
S
N
Site 47
S676
G
G
Q
V
S
R
A
S
Q
V
S
N
S
D
H
Site 48
S679
V
S
R
A
S
Q
V
S
N
S
D
H
K
S
S
Site 49
S681
R
A
S
Q
V
S
N
S
D
H
K
S
S
K
S
Site 50
S685
V
S
N
S
D
H
K
S
S
K
S
P
E
S
D
Site 51
S686
S
N
S
D
H
K
S
S
K
S
P
E
S
D
W
Site 52
S688
S
D
H
K
S
S
K
S
P
E
S
D
W
S
S
Site 53
S691
K
S
S
K
S
P
E
S
D
W
S
S
W
E
A
Site 54
S694
K
S
P
E
S
D
W
S
S
W
E
A
E
G
S
Site 55
S695
S
P
E
S
D
W
S
S
W
E
A
E
G
S
W
Site 56
S701
S
S
W
E
A
E
G
S
W
E
Q
G
W
Q
E
Site 57
S710
E
Q
G
W
Q
E
P
S
S
Q
E
P
P
P
D
Site 58
S711
Q
G
W
Q
E
P
S
S
Q
E
P
P
P
D
G
Site 59
T719
Q
E
P
P
P
D
G
T
R
L
A
S
E
Y
N
Site 60
S723
P
D
G
T
R
L
A
S
E
Y
N
W
G
G
P
Site 61
Y725
G
T
R
L
A
S
E
Y
N
W
G
G
P
E
S
Site 62
S732
Y
N
W
G
G
P
E
S
S
D
K
G
D
P
F
Site 63
S733
N
W
G
G
P
E
S
S
D
K
G
D
P
F
A
Site 64
T741
D
K
G
D
P
F
A
T
L
S
A
R
P
S
T
Site 65
S743
G
D
P
F
A
T
L
S
A
R
P
S
T
Q
P
Site 66
S747
A
T
L
S
A
R
P
S
T
Q
P
R
P
D
S
Site 67
T748
T
L
S
A
R
P
S
T
Q
P
R
P
D
S
W
Site 68
S754
S
T
Q
P
R
P
D
S
W
G
E
D
N
W
E
N-terminal kinase-like protein S754 phosphosite-specific antibody AB-PK809#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK809#N-terminal kinase-like protein (R751-E757, human) pS754 phosphopeptide - Powder PE-04APN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APN99
Site 69
T765
D
N
W
E
G
L
E
T
D
S
R
Q
V
K
A
Site 70
S767
W
E
G
L
E
T
D
S
R
Q
V
K
A
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation