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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARK4
Full Name:
MAP/microtubule affinity-regulating kinase 4
Alias:
FLJ90097; KIAA1860; Kinase MARK4; MARKL1; MARKL1, EC 2.7.11.1; Nbla00650
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CAMK
group; CAMKL family; MARK subfamily
Mass (Da):
82520
Number AA:
752
UniProt ID:
Q96L34
International Prot ID:
IPI00064797
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0043005
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0043015
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0001578
GO:0007399
GO:0043068
Phosida
TranscriptoNet
STRING
Kinexus Products
MAP/microtubule affinity-regulating protein-serine kinase 4 pan-specific antibody AB-NK277-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK277-1#MAP/microtubule affinity-regulating protein-serine kinase 4 pan-specific antibody AB-NK277-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK277-2#MAP/microtubule affinity-regulating protein-serine kinase 4 (G22-C40, human) peptide - Powder PE-01BDV80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDV80#MAP/microtubule affinity-regulating protein-serine kinase 4 (S2-T20, human) peptide - Powder PE-01BDW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDW99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
R
T
V
L
A
P
Site 2
S15
A
P
G
N
D
R
N
S
D
T
H
G
T
L
G
Site 3
T17
G
N
D
R
N
S
D
T
H
G
T
L
G
S
G
Site 4
T20
R
N
S
D
T
H
G
T
L
G
S
G
R
S
S
Site 5
S23
D
T
H
G
T
L
G
S
G
R
S
S
D
K
G
Site 6
S26
G
T
L
G
S
G
R
S
S
D
K
G
P
S
W
Site 7
S27
T
L
G
S
G
R
S
S
D
K
G
P
S
W
S
Site 8
S32
R
S
S
D
K
G
P
S
W
S
S
R
S
L
G
Site 9
S34
S
D
K
G
P
S
W
S
S
R
S
L
G
A
R
Site 10
S35
D
K
G
P
S
W
S
S
R
S
L
G
A
R
C
Site 11
S37
G
P
S
W
S
S
R
S
L
G
A
R
C
R
N
Site 12
S45
L
G
A
R
C
R
N
S
I
A
S
C
P
E
E
Site 13
S48
R
C
R
N
S
I
A
S
C
P
E
E
Q
P
H
Site 14
T64
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
Site 15
T93
A
I
K
I
I
D
K
T
Q
L
N
P
S
S
L
Site 16
S99
K
T
Q
L
N
P
S
S
L
Q
K
L
F
R
E
Site 17
T130
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
Site 18
Y132
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
Site 19
Y137
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
Site 20
Y146
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
Site 21
S203
K
I
A
D
F
G
F
S
N
E
F
T
L
G
S
Site 22
T207
F
G
F
S
N
E
F
T
L
G
S
K
L
D
T
Site 23
S210
S
N
E
F
T
L
G
S
K
L
D
T
F
C
G
Site 24
T214
T
L
G
S
K
L
D
T
F
C
G
S
P
P
Y
Site 25
S218
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
Site 26
Y221
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
Site 27
Y232
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
I
Site 28
Y273
E
R
V
L
R
G
K
Y
R
V
P
F
Y
M
S
Site 29
Y278
G
K
Y
R
V
P
F
Y
M
S
T
D
C
E
S
Site 30
T281
R
V
P
F
Y
M
S
T
D
C
E
S
I
L
R
Site 31
T300
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
Site 32
Y322
E
G
E
E
L
K
P
Y
T
E
P
E
E
D
F
Site 33
T332
P
E
E
D
F
G
D
T
K
R
I
E
V
M
V
Site 34
Y343
E
V
M
V
G
M
G
Y
T
R
E
E
I
K
E
Site 35
S351
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
Site 36
S354
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
Site 37
Y357
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
Site 38
T363
K
Y
N
E
V
T
A
T
Y
L
L
L
G
R
K
Site 39
T371
Y
L
L
L
G
R
K
T
E
E
G
G
D
R
G
Site 40
S391
L
A
R
V
R
A
P
S
D
T
T
N
G
T
S
Site 41
T393
R
V
R
A
P
S
D
T
T
N
G
T
S
S
S
Site 42
T394
V
R
A
P
S
D
T
T
N
G
T
S
S
S
K
Site 43
T397
P
S
D
T
T
N
G
T
S
S
S
K
G
T
S
Site 44
S399
D
T
T
N
G
T
S
S
S
K
G
T
S
H
S
Site 45
S400
T
T
N
G
T
S
S
S
K
G
T
S
H
S
K
Site 46
T403
G
T
S
S
S
K
G
T
S
H
S
K
G
Q
R
Site 47
S404
T
S
S
S
K
G
T
S
H
S
K
G
Q
R
S
Site 48
S406
S
S
K
G
T
S
H
S
K
G
Q
R
S
S
S
Site 49
S411
S
H
S
K
G
Q
R
S
S
S
S
T
Y
H
R
Site 50
S412
H
S
K
G
Q
R
S
S
S
S
T
Y
H
R
Q
Site 51
S413
S
K
G
Q
R
S
S
S
S
T
Y
H
R
Q
R
Site 52
S414
K
G
Q
R
S
S
S
S
T
Y
H
R
Q
R
R
Site 53
T415
G
Q
R
S
S
S
S
T
Y
H
R
Q
R
R
H
Site 54
Y416
Q
R
S
S
S
S
T
Y
H
R
Q
R
R
H
S
Site 55
S423
Y
H
R
Q
R
R
H
S
D
F
C
G
P
S
P
Site 56
S429
H
S
D
F
C
G
P
S
P
A
P
L
H
P
K
Site 57
S438
A
P
L
H
P
K
R
S
P
T
S
T
G
E
A
Site 58
T440
L
H
P
K
R
S
P
T
S
T
G
E
A
E
L
Site 59
S441
H
P
K
R
S
P
T
S
T
G
E
A
E
L
K
Site 60
T442
P
K
R
S
P
T
S
T
G
E
A
E
L
K
E
Site 61
S458
R
L
P
G
R
K
A
S
C
S
T
A
G
S
G
Site 62
S460
P
G
R
K
A
S
C
S
T
A
G
S
G
S
R
Site 63
S464
A
S
C
S
T
A
G
S
G
S
R
G
L
P
P
Site 64
S466
C
S
T
A
G
S
G
S
R
G
L
P
P
S
S
Site 65
S472
G
S
R
G
L
P
P
S
S
P
M
V
S
S
A
Site 66
S473
S
R
G
L
P
P
S
S
P
M
V
S
S
A
H
Site 67
S477
P
P
S
S
P
M
V
S
S
A
H
N
P
N
K
Site 68
S478
P
S
S
P
M
V
S
S
A
H
N
P
N
K
A
Site 69
S494
I
P
E
R
R
K
D
S
T
S
T
P
N
N
L
Site 70
T495
P
E
R
R
K
D
S
T
S
T
P
N
N
L
P
Site 71
S496
E
R
R
K
D
S
T
S
T
P
N
N
L
P
P
Site 72
T497
R
R
K
D
S
T
S
T
P
N
N
L
P
P
S
Site 73
S504
T
P
N
N
L
P
P
S
M
M
T
R
R
N
T
Site 74
T511
S
M
M
T
R
R
N
T
Y
V
C
T
E
R
P
Site 75
Y512
M
M
T
R
R
N
T
Y
V
C
T
E
R
P
G
Site 76
T515
R
R
N
T
Y
V
C
T
E
R
P
G
A
E
R
Site 77
S524
R
P
G
A
E
R
P
S
L
L
P
N
G
K
E
Site 78
T536
G
K
E
N
S
S
G
T
P
R
V
P
P
A
S
Site 79
S543
T
P
R
V
P
P
A
S
P
S
S
H
S
L
A
Site 80
S545
R
V
P
P
A
S
P
S
S
H
S
L
A
P
P
Site 81
S546
V
P
P
A
S
P
S
S
H
S
L
A
P
P
S
Site 82
S548
P
A
S
P
S
S
H
S
L
A
P
P
S
G
E
Site 83
S553
S
H
S
L
A
P
P
S
G
E
R
S
R
L
A
Site 84
S557
A
P
P
S
G
E
R
S
R
L
A
R
G
S
T
Site 85
S563
R
S
R
L
A
R
G
S
T
I
R
S
T
F
H
Site 86
T564
S
R
L
A
R
G
S
T
I
R
S
T
F
H
G
Site 87
S567
A
R
G
S
T
I
R
S
T
F
H
G
G
Q
V
Site 88
T568
R
G
S
T
I
R
S
T
F
H
G
G
Q
V
R
Site 89
S594
V
Q
N
G
P
P
A
S
P
T
L
A
H
E
A
Site 90
T596
N
G
P
P
A
S
P
T
L
A
H
E
A
A
P
Site 91
T612
P
A
G
R
P
R
P
T
T
N
L
F
T
K
L
Site 92
T613
A
G
R
P
R
P
T
T
N
L
F
T
K
L
T
Site 93
T624
T
K
L
T
S
K
L
T
R
R
V
A
D
E
P
Site 94
T640
R
I
G
G
P
E
V
T
S
C
H
L
P
W
D
Site 95
S661
R
L
L
R
F
P
W
S
V
K
L
T
S
S
R
Site 96
T665
F
P
W
S
V
K
L
T
S
S
R
P
P
E
A
Site 97
S666
P
W
S
V
K
L
T
S
S
R
P
P
E
A
L
Site 98
S667
W
S
V
K
L
T
S
S
R
P
P
E
A
L
M
Site 99
S710
A
G
G
P
E
P
L
S
H
F
E
V
E
V
C
Site 100
S747
R
T
L
V
T
R
I
S
N
D
L
E
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation