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Updated November 2019
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Protein Info
Short Name:
NSD1
Full Name:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
Alias:
Androgen receptor-associated coregulator 267; ARA267; FLJ22263; H3-K36-HMTase; H4-K20-HMTase; Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; KMT3B; NR-binding SET domain containing protein; Nuclear receptor binding SET domain containing protein 1; Nuclear receptor binding SET domain protein 1; SOTOS; Sotos syndrome; STO
Type:
EC 2.1.1.43; Methyltransferase; Nuclear receptor co-regulator; Amino Acid Metabolism - lysine degradation; Transcription, coactivator/corepressor
Mass (Da):
296652
Number AA:
2696
UniProt ID:
Q96L73
International Prot ID:
IPI00102107
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0003712
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006139
GO:0006325
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
R
N
C
L
L
P
F
S
N
P
V
N
L
D
A
Site 2
S30
D
A
P
E
D
K
D
S
P
F
G
N
G
Q
S
Site 3
S37
S
P
F
G
N
G
Q
S
N
F
S
E
P
L
N
Site 4
S40
G
N
G
Q
S
N
F
S
E
P
L
N
G
C
T
Site 5
T47
S
E
P
L
N
G
C
T
M
Q
L
S
T
V
S
Site 6
S51
N
G
C
T
M
Q
L
S
T
V
S
G
T
S
Q
Site 7
T52
G
C
T
M
Q
L
S
T
V
S
G
T
S
Q
N
Site 8
S54
T
M
Q
L
S
T
V
S
G
T
S
Q
N
A
Y
Site 9
Y61
S
G
T
S
Q
N
A
Y
G
Q
D
S
P
S
C
Site 10
S65
Q
N
A
Y
G
Q
D
S
P
S
C
Y
I
P
L
Site 11
S67
A
Y
G
Q
D
S
P
S
C
Y
I
P
L
R
R
Site 12
Y69
G
Q
D
S
P
S
C
Y
I
P
L
R
R
L
Q
Site 13
S80
R
R
L
Q
D
L
A
S
M
I
N
V
E
Y
L
Site 14
Y86
A
S
M
I
N
V
E
Y
L
N
G
S
A
D
G
Site 15
S90
N
V
E
Y
L
N
G
S
A
D
G
S
E
S
F
Site 16
S94
L
N
G
S
A
D
G
S
E
S
F
Q
D
P
E
Site 17
S96
G
S
A
D
G
S
E
S
F
Q
D
P
E
K
S
Site 18
S103
S
F
Q
D
P
E
K
S
D
S
R
A
Q
T
P
Site 19
S105
Q
D
P
E
K
S
D
S
R
A
Q
T
P
I
V
Site 20
T109
K
S
D
S
R
A
Q
T
P
I
V
C
T
S
L
Site 21
S131
L
A
M
K
Q
E
P
S
C
N
N
S
P
E
L
Site 22
S135
Q
E
P
S
C
N
N
S
P
E
L
Q
V
K
V
Site 23
T145
L
Q
V
K
V
T
K
T
I
K
N
G
F
L
H
Site 24
S166
V
D
D
A
D
V
D
S
E
M
D
P
E
Q
P
Site 25
T175
M
D
P
E
Q
P
V
T
E
D
E
S
I
E
E
Site 26
S179
Q
P
V
T
E
D
E
S
I
E
E
I
F
E
E
Site 27
Y195
Q
T
N
A
T
C
N
Y
E
T
K
S
E
N
G
Site 28
S199
T
C
N
Y
E
T
K
S
E
N
G
V
K
V
A
Site 29
S209
G
V
K
V
A
M
G
S
E
Q
D
S
T
P
E
Site 30
S213
A
M
G
S
E
Q
D
S
T
P
E
S
R
H
G
Site 31
T214
M
G
S
E
Q
D
S
T
P
E
S
R
H
G
A
Site 32
S217
E
Q
D
S
T
P
E
S
R
H
G
A
V
K
S
Site 33
S224
S
R
H
G
A
V
K
S
P
F
L
P
L
A
P
Site 34
S247
Q
R
N
E
V
D
G
S
N
E
K
A
A
L
L
Site 35
T263
A
P
F
S
L
G
D
T
N
I
T
I
E
E
Q
Site 36
S273
T
I
E
E
Q
L
N
S
I
N
L
S
F
Q
D
Site 37
S277
Q
L
N
S
I
N
L
S
F
Q
D
D
P
D
S
Site 38
S284
S
F
Q
D
D
P
D
S
S
T
S
T
L
G
N
Site 39
T288
D
P
D
S
S
T
S
T
L
G
N
M
L
E
L
Site 40
T298
N
M
L
E
L
P
G
T
S
S
S
S
T
S
Q
Site 41
S300
L
E
L
P
G
T
S
S
S
S
T
S
Q
E
L
Site 42
S301
E
L
P
G
T
S
S
S
S
T
S
Q
E
L
P
Site 43
S302
L
P
G
T
S
S
S
S
T
S
Q
E
L
P
F
Site 44
T303
P
G
T
S
S
S
S
T
S
Q
E
L
P
F
C
Site 45
S304
G
T
S
S
S
S
T
S
Q
E
L
P
F
C
Q
Site 46
S316
F
C
Q
P
K
K
K
S
T
P
L
K
Y
E
V
Site 47
T317
C
Q
P
K
K
K
S
T
P
L
K
Y
E
V
G
Site 48
Y321
K
K
S
T
P
L
K
Y
E
V
G
D
L
I
W
Site 49
S343
W
W
P
C
R
I
C
S
D
P
L
I
N
T
H
Site 50
S351
D
P
L
I
N
T
H
S
K
M
K
V
S
N
R
Site 51
S356
T
H
S
K
M
K
V
S
N
R
R
P
Y
R
Q
Site 52
Y361
K
V
S
N
R
R
P
Y
R
Q
Y
Y
V
E
A
Site 53
Y364
N
R
R
P
Y
R
Q
Y
Y
V
E
A
F
G
D
Site 54
Y365
R
R
P
Y
R
Q
Y
Y
V
E
A
F
G
D
P
Site 55
S373
V
E
A
F
G
D
P
S
E
R
A
W
V
A
G
Site 56
Y431
S
V
G
L
A
E
Q
Y
D
V
P
K
G
S
K
Site 57
S437
Q
Y
D
V
P
K
G
S
K
N
R
K
C
I
P
Site 58
S446
N
R
K
C
I
P
G
S
I
K
L
D
S
E
E
Site 59
S451
P
G
S
I
K
L
D
S
E
E
D
M
P
F
E
Site 60
S466
D
C
T
N
D
P
E
S
E
H
D
L
L
L
N
Site 61
S483
L
K
S
L
A
F
D
S
E
H
S
A
D
E
K
Site 62
S486
L
A
F
D
S
E
H
S
A
D
E
K
E
K
P
Site 63
S497
K
E
K
P
C
A
K
S
R
A
R
K
S
S
D
Site 64
S502
A
K
S
R
A
R
K
S
S
D
N
P
K
R
T
Site 65
S503
K
S
R
A
R
K
S
S
D
N
P
K
R
T
S
Site 66
T509
S
S
D
N
P
K
R
T
S
V
K
K
G
H
I
Site 67
S510
S
D
N
P
K
R
T
S
V
K
K
G
H
I
Q
Site 68
S539
N
L
G
L
N
F
I
S
G
D
I
S
D
T
Q
Site 69
S543
N
F
I
S
G
D
I
S
D
T
Q
A
S
N
E
Site 70
T545
I
S
G
D
I
S
D
T
Q
A
S
N
E
L
S
Site 71
S552
T
Q
A
S
N
E
L
S
R
I
A
N
S
L
T
Site 72
S557
E
L
S
R
I
A
N
S
L
T
G
S
N
T
A
Site 73
T559
S
R
I
A
N
S
L
T
G
S
N
T
A
P
G
Site 74
S561
I
A
N
S
L
T
G
S
N
T
A
P
G
S
F
Site 75
T563
N
S
L
T
G
S
N
T
A
P
G
S
F
L
F
Site 76
S567
G
S
N
T
A
P
G
S
F
L
F
S
S
C
G
Site 77
S571
A
P
G
S
F
L
F
S
S
C
G
K
N
T
A
Site 78
S572
P
G
S
F
L
F
S
S
C
G
K
N
T
A
K
Site 79
S585
A
K
K
E
F
E
T
S
N
G
D
S
L
L
G
Site 80
S589
F
E
T
S
N
G
D
S
L
L
G
L
P
E
G
Site 81
S600
L
P
E
G
A
L
I
S
K
C
S
R
E
K
N
Site 82
S612
E
K
N
K
P
Q
R
S
L
V
C
G
S
K
V
Site 83
S633
A
G
D
E
E
K
R
S
D
S
I
S
I
C
T
Site 84
S635
D
E
E
K
R
S
D
S
I
S
I
C
T
T
S
Site 85
S637
E
K
R
S
D
S
I
S
I
C
T
T
S
D
D
Site 86
T641
D
S
I
S
I
C
T
T
S
D
D
G
S
S
D
Site 87
S642
S
I
S
I
C
T
T
S
D
D
G
S
S
D
L
Site 88
S646
C
T
T
S
D
D
G
S
S
D
L
D
P
I
E
Site 89
S647
T
T
S
D
D
G
S
S
D
L
D
P
I
E
H
Site 90
S655
D
L
D
P
I
E
H
S
S
E
S
D
N
S
V
Site 91
S656
L
D
P
I
E
H
S
S
E
S
D
N
S
V
L
Site 92
S658
P
I
E
H
S
S
E
S
D
N
S
V
L
E
I
Site 93
S661
H
S
S
E
S
D
N
S
V
L
E
I
P
D
A
Site 94
T672
I
P
D
A
F
D
R
T
E
N
M
L
S
M
Q
Site 95
S677
D
R
T
E
N
M
L
S
M
Q
K
N
E
K
I
Site 96
Y686
Q
K
N
E
K
I
K
Y
S
R
F
A
A
T
N
Site 97
S705
A
K
Q
K
P
L
I
S
N
S
H
T
D
H
L
Site 98
S707
Q
K
P
L
I
S
N
S
H
T
D
H
L
M
G
Site 99
T709
P
L
I
S
N
S
H
T
D
H
L
M
G
C
T
Site 100
S718
H
L
M
G
C
T
K
S
A
E
P
G
T
E
T
Site 101
S726
A
E
P
G
T
E
T
S
Q
V
N
L
S
D
L
Site 102
S731
E
T
S
Q
V
N
L
S
D
L
K
A
S
T
L
Site 103
T737
L
S
D
L
K
A
S
T
L
V
H
K
P
Q
S
Site 104
S744
T
L
V
H
K
P
Q
S
D
F
T
N
D
A
L
Site 105
S752
D
F
T
N
D
A
L
S
P
K
F
N
L
S
S
Site 106
S758
L
S
P
K
F
N
L
S
S
S
I
S
S
E
N
Site 107
S759
S
P
K
F
N
L
S
S
S
I
S
S
E
N
S
Site 108
S760
P
K
F
N
L
S
S
S
I
S
S
E
N
S
L
Site 109
S762
F
N
L
S
S
S
I
S
S
E
N
S
L
I
K
Site 110
S763
N
L
S
S
S
I
S
S
E
N
S
L
I
K
G
Site 111
S766
S
S
I
S
S
E
N
S
L
I
K
G
G
A
A
Site 112
S780
A
N
Q
A
L
L
H
S
K
S
K
Q
P
K
F
Site 113
S782
Q
A
L
L
H
S
K
S
K
Q
P
K
F
R
S
Site 114
S789
S
K
Q
P
K
F
R
S
I
K
C
K
H
K
E
Site 115
S811
P
V
I
N
E
E
C
S
L
K
C
C
S
S
D
Site 116
S817
C
S
L
K
C
C
S
S
D
T
K
G
S
P
L
Site 117
T819
L
K
C
C
S
S
D
T
K
G
S
P
L
A
S
Site 118
S822
C
S
S
D
T
K
G
S
P
L
A
S
I
S
K
Site 119
S826
T
K
G
S
P
L
A
S
I
S
K
S
G
K
V
Site 120
S828
G
S
P
L
A
S
I
S
K
S
G
K
V
D
G
Site 121
S830
P
L
A
S
I
S
K
S
G
K
V
D
G
L
K
Site 122
S849
M
H
E
K
T
R
D
S
S
D
I
E
T
A
V
Site 123
S850
H
E
K
T
R
D
S
S
D
I
E
T
A
V
V
Site 124
T854
R
D
S
S
D
I
E
T
A
V
V
K
H
V
L
Site 125
S868
L
S
E
L
K
E
L
S
Y
R
S
L
G
E
D
Site 126
Y869
S
E
L
K
E
L
S
Y
R
S
L
G
E
D
V
Site 127
S871
L
K
E
L
S
Y
R
S
L
G
E
D
V
S
D
Site 128
S877
R
S
L
G
E
D
V
S
D
S
G
T
S
K
P
Site 129
S879
L
G
E
D
V
S
D
S
G
T
S
K
P
S
K
Site 130
T881
E
D
V
S
D
S
G
T
S
K
P
S
K
P
L
Site 131
S882
D
V
S
D
S
G
T
S
K
P
S
K
P
L
L
Site 132
S885
D
S
G
T
S
K
P
S
K
P
L
L
F
S
S
Site 133
S891
P
S
K
P
L
L
F
S
S
A
S
S
Q
N
H
Site 134
S892
S
K
P
L
L
F
S
S
A
S
S
Q
N
H
I
Site 135
S895
L
L
F
S
S
A
S
S
Q
N
H
I
P
I
E
Site 136
Y905
H
I
P
I
E
P
D
Y
K
F
S
T
L
L
M
Site 137
T909
E
P
D
Y
K
F
S
T
L
L
M
M
L
K
D
Site 138
T922
K
D
M
H
D
S
K
T
K
E
Q
R
L
M
T
Site 139
T929
T
K
E
Q
R
L
M
T
A
Q
N
L
V
S
Y
Site 140
S935
M
T
A
Q
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Site 292
S2523
S
G
K
A
A
A
P
S
E
D
P
W
Q
A
V
Site 293
S2532
D
P
W
Q
A
V
K
S
L
T
Q
A
R
L
L
Site 294
T2534
W
Q
A
V
K
S
L
T
Q
A
R
L
L
S
Q
Site 295
S2540
L
T
Q
A
R
L
L
S
Q
P
P
A
K
A
F
Site 296
Y2549
P
P
A
K
A
F
L
Y
E
P
T
T
Q
A
S
Site 297
T2553
A
F
L
Y
E
P
T
T
Q
A
S
G
R
A
S
Site 298
S2556
Y
E
P
T
T
Q
A
S
G
R
A
S
A
G
A
Site 299
S2560
T
Q
A
S
G
R
A
S
A
G
A
E
Q
T
P
Site 300
T2566
A
S
A
G
A
E
Q
T
P
G
P
L
S
Q
S
Site 301
S2571
E
Q
T
P
G
P
L
S
Q
S
P
G
L
V
K
Site 302
S2573
T
P
G
P
L
S
Q
S
P
G
L
V
K
Q
A
Site 303
S2599
L
A
A
K
S
G
Q
S
F
R
S
L
G
K
A
Site 304
S2602
K
S
G
Q
S
F
R
S
L
G
K
A
P
A
S
Site 305
S2609
S
L
G
K
A
P
A
S
L
P
T
E
E
K
K
Site 306
T2619
T
E
E
K
K
L
V
T
T
E
Q
S
P
W
A
Site 307
S2623
K
L
V
T
T
E
Q
S
P
W
A
L
G
K
A
Site 308
S2631
P
W
A
L
G
K
A
S
S
R
A
G
L
W
P
Site 309
S2648
A
G
Q
T
L
A
Q
S
C
W
S
A
G
S
T
Site 310
T2655
S
C
W
S
A
G
S
T
Q
T
L
A
Q
T
C
Site 311
T2661
S
T
Q
T
L
A
Q
T
C
W
S
L
G
R
G
Site 312
S2664
T
L
A
Q
T
C
W
S
L
G
R
G
Q
D
P
Site 313
S2686
P
A
L
N
Q
A
P
S
S
H
K
C
A
E
S
Site 314
S2687
A
L
N
Q
A
P
S
S
H
K
C
A
E
S
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation