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Updated November 2019
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Protein Info
Short Name:
EP400
Full Name:
E1A-binding protein p400
Alias:
CAG repeat protein 32; CAGH32; DKFZP434I225; Domino; E1A binding protein p400; E1A-binding protein p400: p400 kDa SWI2/SNF2-related protein: Domino homolog: CAG repeat protein 32: Trinucleotide repeat-containing gene 12 protein: E1A-binding protein p400: p400 kDa SWI2/SNF2-related protein: Domino homolog: CAG repeat protein 32: Trinucleotide repeat-containing gene 12 protein: Putative uncharacterized protein EP400: Putative uncharacterized protein EP400: E1A-binding protein p400: p400 kDa SWI2/SNF2-related protein: Domino homolog: CAG repeat protein 32: Trinucleotide repeat-containing gene 12 protein: E1A-binding protein p400: p400 kDa SWI2/SNF2-related protein: Domino homolog: CAG repeat protein 32: Trinucleotide repeat-containing gene 12 protein; KIAA1498; KIAA1818; P400; P400 SWI2/SNF2-related protein; TNRC12; Trinucleotide repeat-containing gene 12 protein
Type:
EC 3.6.1.-; Helicase; Apoptosis
Mass (Da):
343617
Number AA:
3160
UniProt ID:
Q96L91
International Prot ID:
IPI00167535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035267
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
GO:0043968
GO:0043967
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
R
S
R
A
C
P
G
S
E
G
E
E
Q
P
A
Site 2
S37
A
H
P
N
P
P
P
S
P
A
A
P
F
A
P
Site 3
S45
P
A
A
P
F
A
P
S
A
S
P
S
A
P
Q
Site 4
S47
A
P
F
A
P
S
A
S
P
S
A
P
Q
S
P
Site 5
S49
F
A
P
S
A
S
P
S
A
P
Q
S
P
S
Y
Site 6
S53
A
S
P
S
A
P
Q
S
P
S
Y
Q
I
Q
Q
Site 7
S55
P
S
A
P
Q
S
P
S
Y
Q
I
Q
Q
L
M
Site 8
Y56
S
A
P
Q
S
P
S
Y
Q
I
Q
Q
L
M
N
Site 9
S65
I
Q
Q
L
M
N
R
S
P
A
T
G
Q
N
V
Site 10
S98
L
A
P
L
P
L
P
S
P
T
S
P
G
F
Q
Site 11
T100
P
L
P
L
P
S
P
T
S
P
G
F
Q
F
S
Site 12
S101
L
P
L
P
S
P
T
S
P
G
F
Q
F
S
A
Site 13
S107
T
S
P
G
F
Q
F
S
A
Q
P
R
R
F
E
Site 14
S117
P
R
R
F
E
H
G
S
P
S
Y
I
Q
V
T
Site 15
S119
R
F
E
H
G
S
P
S
Y
I
Q
V
T
S
P
Site 16
Y120
F
E
H
G
S
P
S
Y
I
Q
V
T
S
P
L
Site 17
T124
S
P
S
Y
I
Q
V
T
S
P
L
S
Q
Q
V
Site 18
S125
P
S
Y
I
Q
V
T
S
P
L
S
Q
Q
V
Q
Site 19
S128
I
Q
V
T
S
P
L
S
Q
Q
V
Q
T
Q
S
Site 20
T133
P
L
S
Q
Q
V
Q
T
Q
S
P
T
Q
P
S
Site 21
S135
S
Q
Q
V
Q
T
Q
S
P
T
Q
P
S
P
G
Site 22
T137
Q
V
Q
T
Q
S
P
T
Q
P
S
P
G
P
G
Site 23
S140
T
Q
S
P
T
Q
P
S
P
G
P
G
Q
A
L
Site 24
S181
S
V
L
V
R
Q
I
S
L
S
P
S
S
G
G
Site 25
S183
L
V
R
Q
I
S
L
S
P
S
S
G
G
H
F
Site 26
S185
R
Q
I
S
L
S
P
S
S
G
G
H
F
V
F
Site 27
S186
Q
I
S
L
S
P
S
S
G
G
H
F
V
F
Q
Site 28
S196
H
F
V
F
Q
D
G
S
G
L
T
Q
I
A
Q
Site 29
T214
V
Q
L
Q
H
P
G
T
P
I
T
V
R
E
R
Site 30
T217
Q
H
P
G
T
P
I
T
V
R
E
R
R
P
S
Site 31
S224
T
V
R
E
R
R
P
S
Q
P
H
T
Q
S
G
Site 32
T228
R
R
P
S
Q
P
H
T
Q
S
G
G
T
I
H
Site 33
S241
I
H
H
L
G
P
Q
S
P
A
A
A
G
G
A
Site 34
T261
A
S
P
S
H
I
T
T
A
N
L
P
P
Q
I
Site 35
T297
R
P
L
G
F
E
R
T
P
G
V
L
L
P
G
Site 36
T314
G
A
A
G
F
G
M
T
S
P
P
P
P
T
S
Site 37
S315
A
A
G
F
G
M
T
S
P
P
P
P
T
S
P
Site 38
T320
M
T
S
P
P
P
P
T
S
P
S
R
T
A
V
Site 39
S321
T
S
P
P
P
P
T
S
P
S
R
T
A
V
P
Site 40
S323
P
P
P
P
T
S
P
S
R
T
A
V
P
P
G
Site 41
T325
P
P
T
S
P
S
R
T
A
V
P
P
G
L
S
Site 42
T342
P
L
T
S
V
G
N
T
G
M
K
K
V
P
K
Site 43
S358
L
E
E
I
P
P
A
S
P
E
M
A
Q
M
R
Site 44
Y371
M
R
K
Q
C
L
D
Y
H
Y
Q
E
M
Q
A
Site 45
Y373
K
Q
C
L
D
Y
H
Y
Q
E
M
Q
A
L
K
Site 46
Y386
L
K
E
V
F
K
E
Y
L
I
E
L
F
F
L
Site 47
Y417
H
Y
A
P
L
Q
A
Y
L
R
Q
N
D
L
D
Site 48
S439
E
E
E
E
E
E
K
S
E
V
I
N
D
E
V
Site 49
T458
G
K
D
G
Q
T
G
T
P
V
A
I
A
T
Q
Site 50
S471
T
Q
L
P
P
K
V
S
A
A
F
S
S
Q
Q
Site 51
S475
P
K
V
S
A
A
F
S
S
Q
Q
Q
P
F
Q
Site 52
S476
K
V
S
A
A
F
S
S
Q
Q
Q
P
F
Q
Q
Site 53
T499
G
A
G
S
T
V
E
T
D
L
F
K
R
Q
Q
Site 54
S517
S
T
G
M
A
E
Q
S
K
R
P
R
L
E
V
Site 55
T556
A
Q
G
G
M
P
P
T
P
Q
A
A
Q
L
A
Site 56
S568
Q
L
A
G
Q
R
Q
S
Q
Q
Q
Y
D
P
S
Site 57
Y572
Q
R
Q
S
Q
Q
Q
Y
D
P
S
T
G
P
P
Site 58
S575
S
Q
Q
Q
Y
D
P
S
T
G
P
P
V
Q
N
Site 59
T576
Q
Q
Q
Y
D
P
S
T
G
P
P
V
Q
N
A
Site 60
S585
P
P
V
Q
N
A
A
S
L
H
T
P
L
P
Q
Site 61
T588
Q
N
A
A
S
L
H
T
P
L
P
Q
L
P
G
Site 62
T632
Q
L
Q
I
P
V
K
T
Q
Q
P
N
V
P
I
Site 63
S645
P
I
P
A
P
P
S
S
Q
L
P
I
P
P
S
Site 64
S652
S
Q
L
P
I
P
P
S
Q
P
A
Q
L
A
L
Site 65
T663
Q
L
A
L
H
V
P
T
P
G
K
V
Q
V
Q
Site 66
S672
G
K
V
Q
V
Q
A
S
Q
L
S
S
L
P
Q
Site 67
S683
S
L
P
Q
M
V
A
S
T
R
L
P
V
D
P
Site 68
T700
P
C
P
R
P
L
P
T
S
S
T
S
S
L
A
Site 69
S701
C
P
R
P
L
P
T
S
S
T
S
S
L
A
P
Site 70
S702
P
R
P
L
P
T
S
S
T
S
S
L
A
P
V
Site 71
T703
R
P
L
P
T
S
S
T
S
S
L
A
P
V
S
Site 72
S705
L
P
T
S
S
T
S
S
L
A
P
V
S
G
S
Site 73
S710
T
S
S
L
A
P
V
S
G
S
G
P
G
P
S
Site 74
S712
S
L
A
P
V
S
G
S
G
P
G
P
S
P
A
Site 75
S717
S
G
S
G
P
G
P
S
P
A
R
S
S
P
V
Site 76
S721
P
G
P
S
P
A
R
S
S
P
V
N
R
P
S
Site 77
S722
G
P
S
P
A
R
S
S
P
V
N
R
P
S
S
Site 78
S728
S
S
P
V
N
R
P
S
S
A
T
N
K
A
L
Site 79
S729
S
P
V
N
R
P
S
S
A
T
N
K
A
L
S
Site 80
T731
V
N
R
P
S
S
A
T
N
K
A
L
S
P
V
Site 81
S736
S
A
T
N
K
A
L
S
P
V
T
S
R
T
P
Site 82
S748
R
T
P
G
V
V
A
S
A
P
T
K
P
Q
S
Site 83
S755
S
A
P
T
K
P
Q
S
P
A
Q
N
A
T
S
Site 84
S762
S
P
A
Q
N
A
T
S
S
Q
D
S
S
Q
D
Site 85
S763
P
A
Q
N
A
T
S
S
Q
D
S
S
Q
D
T
Site 86
S766
N
A
T
S
S
Q
D
S
S
Q
D
T
L
T
E
Site 87
S767
A
T
S
S
Q
D
S
S
Q
D
T
L
T
E
Q
Site 88
T770
S
Q
D
S
S
Q
D
T
L
T
E
Q
I
T
L
Site 89
T772
D
S
S
Q
D
T
L
T
E
Q
I
T
L
E
N
Site 90
T776
D
T
L
T
E
Q
I
T
L
E
N
Q
V
H
Q
Site 91
S795
L
R
K
A
G
L
W
S
Q
R
R
L
P
K
L
Site 92
S810
Q
E
A
P
R
P
K
S
H
W
D
Y
L
L
E
Site 93
Y814
R
P
K
S
H
W
D
Y
L
L
E
E
M
Q
W
Site 94
T843
A
A
K
K
L
V
R
T
V
V
R
H
H
E
E
Site 95
S864
R
G
K
K
E
E
Q
S
R
L
R
R
I
A
A
Site 96
S872
R
L
R
R
I
A
A
S
T
A
R
E
I
E
C
Site 97
S910
A
L
N
L
Q
K
V
S
R
R
G
K
E
L
R
Site 98
S927
G
F
D
A
L
Q
E
S
S
L
D
S
G
M
S
Site 99
S928
F
D
A
L
Q
E
S
S
L
D
S
G
M
S
G
Site 100
S931
L
Q
E
S
S
L
D
S
G
M
S
G
R
K
R
Site 101
S934
S
S
L
D
S
G
M
S
G
R
K
R
K
A
S
Site 102
S941
S
G
R
K
R
K
A
S
I
S
L
T
D
D
E
Site 103
S943
R
K
R
K
A
S
I
S
L
T
D
D
E
V
D
Site 104
T945
R
K
A
S
I
S
L
T
D
D
E
V
D
D
E
Site 105
T955
E
V
D
D
E
E
E
T
I
E
E
E
E
A
N
Site 106
T970
E
G
V
V
D
H
Q
T
E
L
S
N
L
A
K
Site 107
S973
V
D
H
Q
T
E
L
S
N
L
A
K
E
A
E
Site 108
S998
E
G
A
F
L
P
S
S
Q
W
P
R
P
K
P
Site 109
T1010
P
K
P
D
G
E
D
T
S
G
E
E
D
A
D
Site 110
S1011
K
P
D
G
E
D
T
S
G
E
E
D
A
D
D
Site 111
S1025
D
C
P
G
D
R
E
S
R
K
D
L
V
L
I
Site 112
T1076
P
K
G
S
A
R
V
T
T
S
V
K
F
N
A
Site 113
T1077
K
G
S
A
R
V
T
T
S
V
K
F
N
A
P
Site 114
S1078
G
S
A
R
V
T
T
S
V
K
F
N
A
P
S
Site 115
Y1094
L
Y
G
A
L
R
D
Y
Q
K
I
G
L
D
W
Site 116
S1170
C
P
G
L
K
I
L
S
Y
I
G
S
H
R
E
Site 117
Y1171
P
G
L
K
I
L
S
Y
I
G
S
H
R
E
L
Site 118
S1174
K
I
L
S
Y
I
G
S
H
R
E
L
K
A
K
Site 119
T1206
T
Q
F
F
R
G
L
T
A
F
T
R
V
R
W
Site 120
T1237
R
H
W
E
A
V
F
T
L
Q
S
Q
Q
R
L
Site 121
S1270
H
F
L
V
P
G
I
S
R
P
Y
L
S
S
P
Site 122
Y1273
V
P
G
I
S
R
P
Y
L
S
S
P
L
R
A
Site 123
S1275
G
I
S
R
P
Y
L
S
S
P
L
R
A
P
S
Site 124
S1276
I
S
R
P
Y
L
S
S
P
L
R
A
P
S
E
Site 125
S1282
S
S
P
L
R
A
P
S
E
E
S
Q
D
Y
Y
Site 126
Y1288
P
S
E
E
S
Q
D
Y
Y
H
K
V
V
I
R
Site 127
Y1289
S
E
E
S
Q
D
Y
Y
H
K
V
V
I
R
L
Site 128
T1308
Q
P
F
I
L
R
R
T
K
R
D
V
E
K
Q
Site 129
T1317
R
D
V
E
K
Q
L
T
K
K
Y
E
H
V
L
Site 130
Y1320
E
K
Q
L
T
K
K
Y
E
H
V
L
K
C
R
Site 131
S1329
H
V
L
K
C
R
L
S
N
R
Q
K
A
L
Y
Site 132
Y1336
S
N
R
Q
K
A
L
Y
E
D
V
I
L
Q
P
Site 133
S1351
G
T
Q
E
A
L
K
S
G
H
F
V
N
V
L
Site 134
S1359
G
H
F
V
N
V
L
S
I
L
V
R
L
Q
R
Site 135
S1381
V
E
P
R
H
P
G
S
S
Y
V
A
G
P
L
Site 136
S1382
E
P
R
H
P
G
S
S
Y
V
A
G
P
L
E
Site 137
Y1383
P
R
H
P
G
S
S
Y
V
A
G
P
L
E
Y
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S
A
S
Q
Q
A
S
P
Site 290
S3068
I
Q
Q
V
A
S
A
S
Q
Q
A
S
P
Q
T
Site 291
S3072
A
S
A
S
Q
Q
A
S
P
Q
T
V
A
L
T
Site 292
T3075
S
Q
Q
A
S
P
Q
T
V
A
L
T
Q
A
T
Site 293
T3120
T
A
S
A
P
L
Q
T
P
G
A
P
N
P
A
Site 294
S3132
N
P
A
Q
V
P
A
S
S
D
S
P
S
Q
Q
Site 295
S3133
P
A
Q
V
P
A
S
S
D
S
P
S
Q
Q
P
Site 296
S3135
Q
V
P
A
S
S
D
S
P
S
Q
Q
P
K
L
Site 297
S3137
P
A
S
S
D
S
P
S
Q
Q
P
K
L
Q
M
Site 298
T3153
V
P
A
V
R
L
K
T
P
T
K
P
P
C
Q
Site 299
T3155
A
V
R
L
K
T
P
T
K
P
P
C
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation