KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HYLS1
Full Name:
Hydrolethalus syndrome protein 1
Alias:
FLJ32915; Hydrolethalus syndrome 1
Type:
Unknown function
Mass (Da):
34359
Number AA:
299
UniProt ID:
Q96M11
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
D
V
R
R
E
A
Q
S
I
Q
Y
D
P
Y
S
Site 2
Y48
R
E
A
Q
S
I
Q
Y
D
P
Y
S
K
A
S
Site 3
Y51
Q
S
I
Q
Y
D
P
Y
S
K
A
S
V
A
P
Site 4
S52
S
I
Q
Y
D
P
Y
S
K
A
S
V
A
P
G
Site 5
S55
Y
D
P
Y
S
K
A
S
V
A
P
G
K
R
P
Site 6
Y70
A
L
P
V
Q
L
Q
Y
P
H
V
E
S
N
V
Site 7
S75
L
Q
Y
P
H
V
E
S
N
V
P
S
E
T
V
Site 8
S79
H
V
E
S
N
V
P
S
E
T
V
S
E
A
S
Site 9
T81
E
S
N
V
P
S
E
T
V
S
E
A
S
Q
R
Site 10
S83
N
V
P
S
E
T
V
S
E
A
S
Q
R
L
R
Site 11
S86
S
E
T
V
S
E
A
S
Q
R
L
R
K
P
V
Site 12
T110
P
D
G
E
V
L
V
T
D
E
S
I
I
S
E
Site 13
S113
E
V
L
V
T
D
E
S
I
I
S
E
S
E
S
Site 14
S116
V
T
D
E
S
I
I
S
E
S
E
S
G
T
E
Site 15
S120
S
I
I
S
E
S
E
S
G
T
E
N
D
Q
D
Site 16
T122
I
S
E
S
E
S
G
T
E
N
D
Q
D
L
W
Site 17
S146
Q
F
Q
E
D
K
E
S
S
F
D
V
S
Q
K
Site 18
S147
F
Q
E
D
K
E
S
S
F
D
V
S
Q
K
F
Site 19
S151
K
E
S
S
F
D
V
S
Q
K
F
N
L
P
H
Site 20
Y160
K
F
N
L
P
H
E
Y
Q
G
I
S
Q
D
Q
Site 21
S164
P
H
E
Y
Q
G
I
S
Q
D
Q
L
I
C
S
Site 22
S171
S
Q
D
Q
L
I
C
S
L
Q
R
E
G
M
G
Site 23
S179
L
Q
R
E
G
M
G
S
P
A
Y
E
Q
D
L
Site 24
Y182
E
G
M
G
S
P
A
Y
E
Q
D
L
I
V
A
Site 25
S204
L
P
K
L
D
Q
L
S
R
N
R
G
K
T
D
Site 26
T210
L
S
R
N
R
G
K
T
D
R
V
A
R
Y
F
Site 27
Y216
K
T
D
R
V
A
R
Y
F
E
Y
K
R
D
W
Site 28
Y219
R
V
A
R
Y
F
E
Y
K
R
D
W
D
S
I
Site 29
S225
E
Y
K
R
D
W
D
S
I
R
L
P
G
E
D
Site 30
S253
L
C
R
A
E
P
Q
S
K
P
Q
H
I
Y
V
Site 31
Y259
Q
S
K
P
Q
H
I
Y
V
P
N
N
Y
L
V
Site 32
Y264
H
I
Y
V
P
N
N
Y
L
V
P
T
E
K
K
Site 33
S273
V
P
T
E
K
K
R
S
A
L
R
W
G
V
R
Site 34
S297
R
K
L
P
F
P
L
S
P
S
_
_
_
_
_
Site 35
S299
L
P
F
P
L
S
P
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation