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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLJ32786
Full Name:
Leucine-rich repeat and guanylate kinase domain-containing protein
Alias:
EC 2.7.4.8; Leucine-rich repeats and guanylate kinase domain containing
Type:
Kinase (non-protein); EC 2.7.4.8
Mass (Da):
93618
Number AA:
825
UniProt ID:
Q96M69
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016301
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
S
E
R
A
L
L
R
T
R
A
A
S
L
L
R
Site 2
S15
L
L
R
T
R
A
A
S
L
L
R
G
L
G
R
Site 3
S23
L
L
R
G
L
G
R
S
R
T
G
A
R
S
L
Site 4
T25
R
G
L
G
R
S
R
T
G
A
R
S
L
Q
F
Site 5
S29
R
S
R
T
G
A
R
S
L
Q
F
R
A
E
K
Site 6
T50
S
F
P
M
G
Q
K
T
K
G
S
S
N
I
A
Site 7
S53
M
G
Q
K
T
K
G
S
S
N
I
A
S
S
Y
Site 8
S54
G
Q
K
T
K
G
S
S
N
I
A
S
S
Y
L
Site 9
S58
K
G
S
S
N
I
A
S
S
Y
L
L
Q
Q
L
Site 10
Y60
S
S
N
I
A
S
S
Y
L
L
Q
Q
L
M
H
Site 11
S74
H
R
Y
Q
E
L
D
S
D
G
D
E
D
Q
G
Site 12
S87
Q
G
E
G
E
A
G
S
E
E
S
S
E
S
E
Site 13
S91
E
A
G
S
E
E
S
S
E
S
E
M
L
N
L
Site 14
S93
G
S
E
E
S
S
E
S
E
M
L
N
L
E
E
Site 15
S123
H
H
L
G
R
S
G
S
G
T
E
Q
V
Y
L
Site 16
T125
L
G
R
S
G
S
G
T
E
Q
V
Y
L
N
L
Site 17
Y129
G
S
G
T
E
Q
V
Y
L
N
L
T
L
S
G
Site 18
S157
H
L
Q
K
L
D
L
S
A
N
K
I
E
D
L
Site 19
S179
Y
L
L
E
L
N
A
S
Q
N
N
L
T
T
F
Site 20
T185
A
S
Q
N
N
L
T
T
F
F
N
F
K
P
P
Site 21
S201
N
L
K
K
A
D
F
S
H
N
Q
I
S
E
I
Site 22
S206
D
F
S
H
N
Q
I
S
E
I
C
D
L
S
A
Site 23
S288
A
L
Q
N
L
D
L
S
H
N
Q
I
S
S
L
Site 24
S294
L
S
H
N
Q
I
S
S
L
Q
G
L
E
N
H
Site 25
Y376
K
V
S
A
V
N
K
Y
D
P
P
P
E
V
V
Site 26
S405
Q
P
Q
R
I
F
D
S
T
L
P
S
L
D
A
Site 27
T406
P
Q
R
I
F
D
S
T
L
P
S
L
D
A
P
Site 28
T449
F
R
Y
G
A
C
H
T
T
R
P
P
Y
F
G
Site 29
Y454
C
H
T
T
R
P
P
Y
F
G
E
G
D
R
V
Site 30
Y463
G
E
G
D
R
V
D
Y
H
F
I
S
Q
D
V
Site 31
Y486
K
F
I
L
T
F
S
Y
G
N
H
K
Y
G
L
Site 32
Y491
F
S
Y
G
N
H
K
Y
G
L
N
R
D
T
V
Site 33
T497
K
Y
G
L
N
R
D
T
V
E
G
I
A
R
D
Site 34
S519
M
E
I
E
G
V
R
S
L
K
Y
S
Y
F
E
Site 35
Y522
E
G
V
R
S
L
K
Y
S
Y
F
E
P
R
Y
Site 36
S523
G
V
R
S
L
K
Y
S
Y
F
E
P
R
Y
I
Site 37
Y524
V
R
S
L
K
Y
S
Y
F
E
P
R
Y
I
L
Site 38
Y529
Y
S
Y
F
E
P
R
Y
I
L
V
V
P
M
N
Site 39
Y540
V
P
M
N
K
E
K
Y
E
G
Y
L
R
R
K
Site 40
Y543
N
K
E
K
Y
E
G
Y
L
R
R
K
G
L
F
Site 41
S551
L
R
R
K
G
L
F
S
R
A
E
I
E
F
A
Site 42
Y565
A
V
S
R
V
D
L
Y
I
K
I
N
Q
N
F
Site 43
Y575
I
N
Q
N
F
P
G
Y
F
D
E
V
I
N
A
Site 44
Y589
A
D
D
L
D
V
A
Y
Q
K
L
S
Q
L
I
Site 45
S593
D
V
A
Y
Q
K
L
S
Q
L
I
R
E
Y
L
Site 46
Y599
L
S
Q
L
I
R
E
Y
L
G
L
T
E
E
P
Site 47
T603
I
R
E
Y
L
G
L
T
E
E
P
A
K
S
L
Site 48
S609
L
T
E
E
P
A
K
S
L
A
T
T
A
D
V
Site 49
T613
P
A
K
S
L
A
T
T
A
D
V
K
T
S
H
Site 50
T618
A
T
T
A
D
V
K
T
S
H
L
K
P
E
A
Site 51
T628
L
K
P
E
A
H
P
T
K
Y
I
S
S
N
M
Site 52
Y630
P
E
A
H
P
T
K
Y
I
S
S
N
M
G
D
Site 53
Y646
L
H
S
T
D
R
N
Y
L
I
K
F
W
A
K
Site 54
S655
I
K
F
W
A
K
L
S
A
K
K
T
P
A
E
Site 55
T659
A
K
L
S
A
K
K
T
P
A
E
R
D
S
I
Site 56
S665
K
T
P
A
E
R
D
S
I
H
R
Q
H
E
A
Site 57
T686
G
R
I
R
P
D
H
T
L
L
F
Q
R
G
P
Site 58
T699
G
P
V
P
A
P
L
T
S
G
L
H
Y
Y
T
Site 59
Y704
P
L
T
S
G
L
H
Y
Y
T
T
L
E
E
L
Site 60
Y705
L
T
S
G
L
H
Y
Y
T
T
L
E
E
L
W
Site 61
T707
S
G
L
H
Y
Y
T
T
L
E
E
L
W
K
S
Site 62
Y721
S
F
D
L
C
E
D
Y
F
K
P
P
F
G
P
Site 63
Y729
F
K
P
P
F
G
P
Y
P
E
K
S
G
K
D
Site 64
S733
F
G
P
Y
P
E
K
S
G
K
D
S
L
V
S
Site 65
S737
P
E
K
S
G
K
D
S
L
V
S
M
K
C
S
Site 66
S740
S
G
K
D
S
L
V
S
M
K
C
S
L
F
R
Site 67
S763
P
F
Q
P
P
E
G
S
I
S
S
H
L
G
S
Site 68
S765
Q
P
P
E
G
S
I
S
S
H
L
G
S
G
A
Site 69
S766
P
P
E
G
S
I
S
S
H
L
G
S
G
A
S
Site 70
S770
S
I
S
S
H
L
G
S
G
A
S
D
S
E
T
Site 71
S773
S
H
L
G
S
G
A
S
D
S
E
T
E
E
T
Site 72
S775
L
G
S
G
A
S
D
S
E
T
E
E
T
R
K
Site 73
T777
S
G
A
S
D
S
E
T
E
E
T
R
K
A
L
Site 74
T780
S
D
S
E
T
E
E
T
R
K
A
L
P
I
Q
Site 75
S788
R
K
A
L
P
I
Q
S
F
S
H
E
K
E
S
Site 76
S790
A
L
P
I
Q
S
F
S
H
E
K
E
S
H
Q
Site 77
S802
S
H
Q
H
R
Q
H
S
V
P
V
I
S
R
P
Site 78
S807
Q
H
S
V
P
V
I
S
R
P
G
S
N
V
K
Site 79
S811
P
V
I
S
R
P
G
S
N
V
K
P
T
L
P
Site 80
T816
P
G
S
N
V
K
P
T
L
P
P
I
P
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation