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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL15
Full Name:
Kelch-like protein 15
Alias:
Kelch-like 15; KIAA1677; KLH15
Type:
Unknown function
Mass (Da):
69775
Number AA:
604
UniProt ID:
Q96M94
International Prot ID:
IPI00307535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
D
V
E
G
F
C
S
S
I
H
D
T
S
V
Site 2
S11
D
V
E
G
F
C
S
S
I
H
D
T
S
V
S
Site 3
T15
F
C
S
S
I
H
D
T
S
V
S
A
G
F
R
Site 4
S16
C
S
S
I
H
D
T
S
V
S
A
G
F
R
A
Site 5
Y55
L
L
A
T
Q
S
D
Y
F
R
I
M
F
T
A
Site 6
S167
D
N
F
V
P
L
M
S
R
P
D
F
L
S
Y
Site 7
S173
M
S
R
P
D
F
L
S
Y
L
S
F
E
K
L
Site 8
Y174
S
R
P
D
F
L
S
Y
L
S
F
E
K
L
M
Site 9
S176
P
D
F
L
S
Y
L
S
F
E
K
L
M
S
Y
Site 10
S182
L
S
F
E
K
L
M
S
Y
L
D
N
D
H
L
Site 11
Y183
S
F
E
K
L
M
S
Y
L
D
N
D
H
L
S
Site 12
S190
Y
L
D
N
D
H
L
S
R
F
P
E
I
E
L
Site 13
Y198
R
F
P
E
I
E
L
Y
E
A
V
Q
S
W
L
Site 14
S203
E
L
Y
E
A
V
Q
S
W
L
R
H
D
R
R
Site 15
T215
D
R
R
R
W
R
H
T
D
T
I
I
Q
N
I
Site 16
T217
R
R
W
R
H
T
D
T
I
I
Q
N
I
R
F
Site 17
T238
S
V
F
E
K
V
K
T
S
E
F
Y
R
Y
S
Site 18
Y244
K
T
S
E
F
Y
R
Y
S
R
Q
L
R
Y
E
Site 19
S245
T
S
E
F
Y
R
Y
S
R
Q
L
R
Y
E
V
Site 20
Y258
E
V
D
Q
A
L
N
Y
F
Q
N
V
H
Q
Q
Site 21
S272
Q
P
L
L
D
M
K
S
S
R
I
R
S
A
K
Site 22
S273
P
L
L
D
M
K
S
S
R
I
R
S
A
K
P
Site 23
S277
M
K
S
S
R
I
R
S
A
K
P
Q
T
T
V
Site 24
T282
I
R
S
A
K
P
Q
T
T
V
F
R
G
M
I
Site 25
T283
R
S
A
K
P
Q
T
T
V
F
R
G
M
I
G
Site 26
S346
P
D
G
E
F
H
A
S
S
K
V
F
R
Y
D
Site 27
Y352
A
S
S
K
V
F
R
Y
D
P
R
Q
N
S
W
Site 28
S366
W
L
Q
M
A
D
M
S
V
P
R
S
E
F
A
Site 29
T392
A
G
R
T
R
D
E
T
F
Y
S
T
E
R
Y
Site 30
Y394
R
T
R
D
E
T
F
Y
S
T
E
R
Y
D
I
Site 31
S395
T
R
D
E
T
F
Y
S
T
E
R
Y
D
I
T
Site 32
T396
R
D
E
T
F
Y
S
T
E
R
Y
D
I
T
N
Site 33
Y399
T
F
Y
S
T
E
R
Y
D
I
T
N
D
K
W
Site 34
Y412
K
W
E
F
V
D
P
Y
P
V
N
K
Y
G
H
Site 35
Y417
D
P
Y
P
V
N
K
Y
G
H
E
G
T
V
L
Site 36
S436
F
I
T
G
G
I
T
S
S
S
T
S
K
Q
V
Site 37
S437
I
T
G
G
I
T
S
S
S
T
S
K
Q
V
C
Site 38
S438
T
G
G
I
T
S
S
S
T
S
K
Q
V
C
V
Site 39
S440
G
I
T
S
S
S
T
S
K
Q
V
C
V
F
D
Site 40
T453
F
D
P
S
K
E
G
T
I
E
Q
R
T
R
R
Site 41
T465
T
R
R
T
Q
V
V
T
N
C
W
E
N
K
S
Site 42
Y476
E
N
K
S
K
M
N
Y
A
R
C
F
H
K
M
Site 43
S506
I
L
R
A
S
F
E
S
Q
G
C
P
S
T
E
Site 44
T512
E
S
Q
G
C
P
S
T
E
V
Y
N
P
E
T
Site 45
Y515
G
C
P
S
T
E
V
Y
N
P
E
T
D
Q
W
Site 46
T523
N
P
E
T
D
Q
W
T
I
L
A
S
M
P
I
Site 47
S527
D
Q
W
T
I
L
A
S
M
P
I
G
R
S
G
Site 48
T538
G
R
S
G
H
G
V
T
V
L
D
K
Q
I
M
Site 49
T562
H
Y
S
D
S
I
L
T
F
D
P
D
E
N
K
Site 50
Y575
N
K
W
K
E
D
E
Y
P
R
M
P
C
K
L
Site 51
Y595
C
N
L
H
F
P
D
Y
V
L
D
E
V
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation