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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FGD4
Full Name:
FYVE, RhoGEF and PH domain-containing protein 4
Alias:
Actin filament-binding protein frabin; Actin-filament binding protein frabin; CMT4H; FGD1 family, member 4; FGD1-related F-actin-binding protein; FRABIN; FRABP; FYVE, RhoGEF and PH domain containing 4; FYVE, RhoGEF and PH domain containing protein 4; ZFYVE6; Zinc finger FYVE domain-containing protein 6
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
86608
Number AA:
766
UniProt ID:
Q96M96
International Prot ID:
IPI00065435
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001726
GO:0005622
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005083
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0000902
GO:0006996
GO:0007010
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
E
I
K
P
A
S
A
S
C
V
S
K
E
Site 2
S10
E
I
K
P
A
S
A
S
C
V
S
K
E
K
P
Site 3
S13
P
A
S
A
S
C
V
S
K
E
K
P
S
K
V
Site 4
S18
C
V
S
K
E
K
P
S
K
V
S
D
L
I
S
Site 5
S21
K
E
K
P
S
K
V
S
D
L
I
S
R
F
E
Site 6
S25
S
K
V
S
D
L
I
S
R
F
E
G
G
S
S
Site 7
S31
I
S
R
F
E
G
G
S
S
L
S
N
Y
S
D
Site 8
S32
S
R
F
E
G
G
S
S
L
S
N
Y
S
D
L
Site 9
S34
F
E
G
G
S
S
L
S
N
Y
S
D
L
K
K
Site 10
Y36
G
G
S
S
L
S
N
Y
S
D
L
K
K
E
S
Site 11
S37
G
S
S
L
S
N
Y
S
D
L
K
K
E
S
A
Site 12
T52
V
N
L
N
A
P
R
T
P
G
R
H
G
L
T
Site 13
T59
T
P
G
R
H
G
L
T
T
T
P
Q
Q
K
L
Site 14
T60
P
G
R
H
G
L
T
T
T
P
Q
Q
K
L
L
Site 15
T61
G
R
H
G
L
T
T
T
P
Q
Q
K
L
L
S
Site 16
S68
T
P
Q
Q
K
L
L
S
Q
H
L
P
Q
R
Q
Site 17
T79
P
Q
R
Q
G
N
D
T
D
K
T
Q
G
A
Q
Site 18
T82
Q
G
N
D
T
D
K
T
Q
G
A
Q
T
C
V
Site 19
T109
C
E
E
E
K
A
A
T
L
S
S
D
T
S
I
Site 20
S111
E
E
K
A
A
T
L
S
S
D
T
S
I
Q
A
Site 21
S112
E
K
A
A
T
L
S
S
D
T
S
I
Q
A
S
Site 22
S115
A
T
L
S
S
D
T
S
I
Q
A
S
E
P
L
Site 23
S119
S
D
T
S
I
Q
A
S
E
P
L
L
D
T
H
Site 24
T125
A
S
E
P
L
L
D
T
H
I
V
N
G
E
R
Site 25
T135
V
N
G
E
R
D
E
T
A
T
A
P
A
S
P
Site 26
T137
G
E
R
D
E
T
A
T
A
P
A
S
P
T
T
Site 27
S141
E
T
A
T
A
P
A
S
P
T
T
D
S
C
D
Site 28
S146
P
A
S
P
T
T
D
S
C
D
G
N
A
S
D
Site 29
S152
D
S
C
D
G
N
A
S
D
S
S
Y
R
T
P
Site 30
S154
C
D
G
N
A
S
D
S
S
Y
R
T
P
G
I
Site 31
S155
D
G
N
A
S
D
S
S
Y
R
T
P
G
I
G
Site 32
Y156
G
N
A
S
D
S
S
Y
R
T
P
G
I
G
P
Site 33
T158
A
S
D
S
S
Y
R
T
P
G
I
G
P
V
L
Site 34
S186
Q
E
R
E
N
G
E
S
P
L
E
L
E
Q
L
Site 35
T202
Q
H
H
E
M
K
E
T
N
E
Q
K
L
H
K
Site 36
T217
I
A
N
E
L
L
L
T
E
R
A
Y
V
N
R
Site 37
S244
L
E
E
A
N
R
G
S
F
P
A
E
M
V
N
Site 38
S258
N
K
I
F
S
N
I
S
S
I
N
A
F
H
S
Site 39
S259
K
I
F
S
N
I
S
S
I
N
A
F
H
S
K
Site 40
T282
R
M
Q
E
W
E
T
T
P
R
I
G
D
I
L
Site 41
Y302
F
L
K
M
Y
G
E
Y
V
K
G
F
D
N
A
Site 42
T317
M
E
L
V
K
N
M
T
E
R
I
P
Q
F
K
Site 43
S325
E
R
I
P
Q
F
K
S
V
V
E
E
I
Q
K
Site 44
T340
Q
K
I
C
G
S
L
T
L
Q
H
H
M
L
E
Site 45
Y355
P
V
Q
R
I
P
R
Y
E
M
L
L
K
D
Y
Site 46
Y362
Y
E
M
L
L
K
D
Y
L
R
K
L
P
P
D
Site 47
S370
L
R
K
L
P
P
D
S
L
D
W
N
D
A
K
Site 48
S379
D
W
N
D
A
K
K
S
L
E
I
I
S
T
A
Site 49
S384
K
K
S
L
E
I
I
S
T
A
A
S
H
S
N
Site 50
T385
K
S
L
E
I
I
S
T
A
A
S
H
S
N
S
Site 51
S388
E
I
I
S
T
A
A
S
H
S
N
S
A
I
R
Site 52
S390
I
S
T
A
A
S
H
S
N
S
A
I
R
K
M
Site 53
S392
T
A
A
S
H
S
N
S
A
I
R
K
M
E
N
Site 54
Y407
L
K
K
L
L
E
I
Y
E
M
L
G
E
E
E
Site 55
S420
E
E
D
I
V
N
P
S
N
E
L
I
K
E
G
Site 56
T437
L
K
L
A
A
R
N
T
S
A
Q
E
R
Y
L
Site 57
S438
K
L
A
A
R
N
T
S
A
Q
E
R
Y
L
F
Site 58
Y443
N
T
S
A
Q
E
R
Y
L
F
L
F
N
N
M
Site 59
Y453
L
F
N
N
M
L
L
Y
C
V
P
K
F
S
L
Site 60
S463
P
K
F
S
L
V
G
S
K
F
T
V
R
T
R
Site 61
Y486
V
E
T
Q
N
E
E
Y
P
H
T
F
Q
V
S
Site 62
T489
Q
N
E
E
Y
P
H
T
F
Q
V
S
G
K
E
Site 63
S504
R
T
L
E
L
Q
A
S
S
A
Q
D
K
E
E
Site 64
T529
A
F
H
Q
R
H
E
T
F
R
N
A
I
A
K
Site 65
S542
A
K
D
N
D
I
H
S
E
V
S
T
A
E
L
Site 66
Y596
V
C
W
K
C
S
D
Y
K
A
Q
L
E
Y
D
Site 67
Y602
D
Y
K
A
Q
L
E
Y
D
G
G
K
L
S
K
Site 68
Y615
S
K
V
C
K
D
C
Y
Q
I
I
S
G
F
T
Site 69
S624
I
I
S
G
F
T
D
S
E
E
K
K
R
K
G
Site 70
S637
K
G
I
L
E
I
E
S
A
E
V
S
G
N
S
Site 71
S648
S
G
N
S
V
V
C
S
F
L
Q
Y
M
E
K
Site 72
Y652
V
V
C
S
F
L
Q
Y
M
E
K
S
K
P
W
Site 73
Y675
K
Q
D
P
L
V
L
Y
M
Y
G
A
P
Q
D
Site 74
Y677
D
P
L
V
L
Y
M
Y
G
A
P
Q
D
V
R
Site 75
S702
V
V
D
E
M
P
R
S
A
D
L
P
H
S
F
Site 76
S708
R
S
A
D
L
P
H
S
F
K
L
T
Q
S
K
Site 77
T712
L
P
H
S
F
K
L
T
Q
S
K
S
V
H
S
Site 78
S714
H
S
F
K
L
T
Q
S
K
S
V
H
S
F
A
Site 79
S716
F
K
L
T
Q
S
K
S
V
H
S
F
A
A
D
Site 80
S719
T
Q
S
K
S
V
H
S
F
A
A
D
S
E
E
Site 81
T743
L
L
A
V
T
G
E
T
P
G
G
P
N
E
H
Site 82
T753
G
P
N
E
H
P
A
T
L
D
D
H
P
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation