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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP4
Full Name:
NACHT, LRR and PYD domains-containing protein 4
Alias:
Cancer/testis antigen 58;PAAD and NACHT-containing protein 2;PYRIN and NACHT-containing protein 2;PYRIN-containing APAF1-like protein 4;Ribonuclease inhibitor 2
Type:
Mass (Da):
113415
Number AA:
994
UniProt ID:
Q96MN2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
S
D
F
G
L
M
W
Y
L
E
E
L
K
K
E
Site 2
T45
E
L
K
Q
I
P
W
T
E
V
K
K
A
S
R
Site 3
Y63
A
N
L
L
I
K
H
Y
E
E
Q
Q
A
W
N
Site 4
T93
M
K
V
M
R
E
R
T
G
Y
T
K
T
Y
Q
Site 5
Y95
V
M
R
E
R
T
G
Y
T
K
T
Y
Q
A
H
Site 6
Y99
R
T
G
Y
T
K
T
Y
Q
A
H
A
K
Q
K
Site 7
S108
A
H
A
K
Q
K
F
S
R
L
W
S
S
K
S
Site 8
S112
Q
K
F
S
R
L
W
S
S
K
S
V
T
E
I
Site 9
S113
K
F
S
R
L
W
S
S
K
S
V
T
E
I
H
Site 10
S115
S
R
L
W
S
S
K
S
V
T
E
I
H
L
Y
Site 11
T117
L
W
S
S
K
S
V
T
E
I
H
L
Y
F
E
Site 12
Y122
S
V
T
E
I
H
L
Y
F
E
E
E
V
K
Q
Site 13
T150
E
A
G
K
Q
P
R
T
V
I
I
Q
G
P
Q
Site 14
Y187
D
R
F
L
Y
T
F
Y
F
C
C
R
E
L
R
Site 15
T199
E
L
R
E
L
P
P
T
S
L
A
D
L
I
S
Site 16
S200
L
R
E
L
P
P
T
S
L
A
D
L
I
S
R
Site 17
S206
T
S
L
A
D
L
I
S
R
E
W
P
D
P
A
Site 18
T217
P
D
P
A
A
P
I
T
E
I
V
S
Q
P
E
Site 19
S245
G
G
L
N
E
P
D
S
D
L
C
G
D
L
M
Site 20
T292
K
E
L
R
D
Q
V
T
I
S
E
I
Y
Q
P
Site 21
S294
L
R
D
Q
V
T
I
S
E
I
Y
Q
P
R
G
Site 22
Y297
Q
V
T
I
S
E
I
Y
Q
P
R
G
F
N
E
Site 23
Y310
N
E
S
D
R
L
V
Y
F
C
C
F
F
K
D
Site 24
T364
K
G
K
D
L
A
L
T
C
Q
S
T
T
S
V
Site 25
S367
D
L
A
L
T
C
Q
S
T
T
S
V
Y
S
S
Site 26
T389
P
E
G
A
E
G
P
T
P
Q
T
Q
H
Q
L
Site 27
Y441
G
T
K
I
L
L
K
Y
G
E
R
E
S
S
Y
Site 28
S446
L
K
Y
G
E
R
E
S
S
Y
V
F
L
H
V
Site 29
S447
K
Y
G
E
R
E
S
S
Y
V
F
L
H
V
C
Site 30
S468
A
L
F
Y
L
L
K
S
H
L
D
H
P
H
P
Site 31
S524
A
F
F
G
F
Q
L
S
Q
E
I
K
Q
Q
I
Site 32
S537
Q
I
H
Q
C
L
K
S
L
G
E
R
G
N
P
Site 33
S605
S
L
R
K
L
C
F
S
V
Q
N
V
F
K
K
Site 34
S617
F
K
K
E
D
E
H
S
S
T
S
D
Y
S
L
Site 35
S618
K
K
E
D
E
H
S
S
T
S
D
Y
S
L
I
Site 36
T619
K
E
D
E
H
S
S
T
S
D
Y
S
L
I
C
Site 37
S620
E
D
E
H
S
S
T
S
D
Y
S
L
I
C
W
Site 38
Y622
E
H
S
S
T
S
D
Y
S
L
I
C
W
H
H
Site 39
S648
R
E
L
Q
V
Q
D
S
T
L
S
E
S
T
F
Site 40
T649
E
L
Q
V
Q
D
S
T
L
S
E
S
T
F
V
Site 41
S651
Q
V
Q
D
S
T
L
S
E
S
T
F
V
T
W
Site 42
S666
C
N
Q
L
R
H
P
S
C
R
L
Q
K
L
G
Site 43
Y698
F
Y
Q
P
D
L
K
Y
L
S
F
T
L
T
K
Site 44
S700
Q
P
D
L
K
Y
L
S
F
T
L
T
K
L
S
Site 45
T702
D
L
K
Y
L
S
F
T
L
T
K
L
S
R
D
Site 46
T704
K
Y
L
S
F
T
L
T
K
L
S
R
D
D
I
Site 47
S707
S
F
T
L
T
K
L
S
R
D
D
I
R
S
L
Site 48
S713
L
S
R
D
D
I
R
S
L
C
D
A
L
N
Y
Site 49
Y720
S
L
C
D
A
L
N
Y
P
A
G
N
V
K
E
Site 50
T748
E
V
L
A
G
L
L
T
N
N
K
K
L
T
Y
Site 51
T754
L
T
N
N
K
K
L
T
Y
L
N
V
S
C
N
Site 52
Y755
T
N
N
K
K
L
T
Y
L
N
V
S
C
N
Q
Site 53
Y798
L
S
E
Q
C
C
E
Y
I
S
E
M
L
L
R
Site 54
S808
E
M
L
L
R
N
K
S
V
R
Y
L
D
L
S
Site 55
Y811
L
R
N
K
S
V
R
Y
L
D
L
S
A
N
V
Site 56
S815
S
V
R
Y
L
D
L
S
A
N
V
L
K
D
E
Site 57
T826
L
K
D
E
G
L
K
T
L
C
E
A
L
K
H
Site 58
S858
A
G
C
E
D
L
A
S
A
L
I
S
N
Q
N
Site 59
T889
Q
L
L
C
R
A
L
T
H
T
D
C
R
L
E
Site 60
T908
E
E
C
G
L
T
S
T
C
C
K
D
L
A
S
Site 61
T918
K
D
L
A
S
V
L
T
C
S
K
T
L
Q
Q
Site 62
T929
T
L
Q
Q
L
N
L
T
L
N
T
L
D
H
T
Site 63
T960
Q
V
L
G
L
R
K
T
D
F
D
E
E
T
Q
Site 64
T966
K
T
D
F
D
E
E
T
Q
A
L
L
T
A
E
Site 65
T981
E
E
R
N
P
N
L
T
I
T
D
D
C
D
T
Site 66
T988
T
I
T
D
D
C
D
T
I
T
R
V
E
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation