KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ROBO3
Full Name:
Roundabout homolog 3
Alias:
Roundabout-like protein 3
Type:
Membrane, Integral membrane protein
Mass (Da):
148209
Number AA:
1386
UniProt ID:
Q96MS0
International Prot ID:
IPI00418275
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0007411
GO:0006935
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
Q
M
N
L
F
A
D
S
L
A
G
D
I
S
N
Site 2
Y98
P
R
P
N
I
E
W
Y
K
N
G
A
R
V
A
Site 3
Y234
L
K
S
D
A
G
M
Y
V
C
V
A
S
N
M
Site 4
T300
K
E
D
G
E
L
P
T
G
R
Y
E
I
R
S
Site 5
Y324
S
A
E
D
E
G
T
Y
T
C
V
A
E
N
S
Site 6
T550
G
V
S
P
D
P
P
T
E
P
S
S
P
P
G
Site 7
S560
S
S
P
P
G
A
P
S
Q
P
V
V
T
E
I
Site 8
T565
A
P
S
Q
P
V
V
T
E
I
T
K
N
S
I
Site 9
S638
A
V
G
A
W
G
L
S
E
P
S
P
V
S
E
Site 10
S641
A
W
G
L
S
E
P
S
P
V
S
E
P
V
R
Site 11
Y913
L
G
L
C
A
A
L
Y
W
R
R
K
Q
R
K
Site 12
S923
R
K
Q
R
K
E
L
S
H
Y
T
A
S
F
A
Site 13
Y925
Q
R
K
E
L
S
H
Y
T
A
S
F
A
Y
T
Site 14
S940
P
A
V
S
F
P
H
S
E
G
L
S
G
A
S
Site 15
S944
F
P
H
S
E
G
L
S
G
A
S
S
R
P
P
Site 16
S947
S
E
G
L
S
G
A
S
S
R
P
P
M
G
L
Site 17
S948
E
G
L
S
G
A
S
S
R
P
P
M
G
L
G
Site 18
Y959
M
G
L
G
P
A
P
Y
S
W
L
A
D
S
W
Site 19
S960
G
L
G
P
A
P
Y
S
W
L
A
D
S
W
P
Site 20
S965
P
Y
S
W
L
A
D
S
W
P
H
P
S
R
S
Site 21
S970
A
D
S
W
P
H
P
S
R
S
P
S
A
Q
E
Site 22
S972
S
W
P
H
P
S
R
S
P
S
A
Q
E
P
R
Site 23
S974
P
H
P
S
R
S
P
S
A
Q
E
P
R
G
S
Site 24
S981
S
A
Q
E
P
R
G
S
C
C
P
S
N
P
D
Site 25
S985
P
R
G
S
C
C
P
S
N
P
D
P
D
D
R
Site 26
Y993
N
P
D
P
D
D
R
Y
Y
N
E
A
G
I
S
Site 27
Y994
P
D
P
D
D
R
Y
Y
N
E
A
G
I
S
L
Site 28
S1000
Y
Y
N
E
A
G
I
S
L
Y
L
A
Q
T
A
Site 29
Y1002
N
E
A
G
I
S
L
Y
L
A
Q
T
A
R
G
Site 30
T1010
L
A
Q
T
A
R
G
T
A
A
P
G
E
G
P
Site 31
Y1019
A
P
G
E
G
P
V
Y
S
T
I
D
P
A
G
Site 32
S1020
P
G
E
G
P
V
Y
S
T
I
D
P
A
G
E
Site 33
T1021
G
E
G
P
V
Y
S
T
I
D
P
A
G
E
E
Site 34
T1031
P
A
G
E
E
L
Q
T
F
H
G
G
F
P
Q
Site 35
S1041
G
G
F
P
Q
H
P
S
G
D
L
G
P
W
S
Site 36
S1048
S
G
D
L
G
P
W
S
Q
Y
A
P
P
E
W
Site 37
Y1050
D
L
G
P
W
S
Q
Y
A
P
P
E
W
S
Q
Site 38
S1056
Q
Y
A
P
P
E
W
S
Q
G
D
S
G
A
K
Site 39
S1060
P
E
W
S
Q
G
D
S
G
A
K
G
G
K
V
Site 40
S1078
G
K
P
V
Q
M
P
S
L
N
W
P
E
A
L
Site 41
S1091
A
L
P
P
P
P
P
S
C
E
L
S
C
L
E
Site 42
S1095
P
P
P
S
C
E
L
S
C
L
E
G
P
E
E
Site 43
S1107
P
E
E
E
L
E
G
S
S
E
P
E
E
W
C
Site 44
S1121
C
P
P
M
P
E
R
S
H
L
T
E
P
S
S
Site 45
T1124
M
P
E
R
S
H
L
T
E
P
S
S
S
G
G
Site 46
S1127
R
S
H
L
T
E
P
S
S
S
G
G
C
L
V
Site 47
S1128
S
H
L
T
E
P
S
S
S
G
G
C
L
V
T
Site 48
S1129
H
L
T
E
P
S
S
S
G
G
C
L
V
T
P
Site 49
T1135
S
S
G
G
C
L
V
T
P
S
R
R
E
T
P
Site 50
S1137
G
G
C
L
V
T
P
S
R
R
E
T
P
S
P
Site 51
T1141
V
T
P
S
R
R
E
T
P
S
P
T
P
S
Y
Site 52
S1143
P
S
R
R
E
T
P
S
P
T
P
S
Y
G
Q
Site 53
T1145
R
R
E
T
P
S
P
T
P
S
Y
G
Q
Q
S
Site 54
S1147
E
T
P
S
P
T
P
S
Y
G
Q
Q
S
T
A
Site 55
Y1148
T
P
S
P
T
P
S
Y
G
Q
Q
S
T
A
T
Site 56
S1152
T
P
S
Y
G
Q
Q
S
T
A
T
L
T
P
S
Site 57
T1155
Y
G
Q
Q
S
T
A
T
L
T
P
S
P
P
D
Site 58
T1157
Q
Q
S
T
A
T
L
T
P
S
P
P
D
P
P
Site 59
S1159
S
T
A
T
L
T
P
S
P
P
D
P
P
Q
P
Site 60
T1168
P
D
P
P
Q
P
P
T
D
M
P
H
L
H
Q
Site 61
S1185
R
R
V
P
L
G
P
S
S
P
L
S
V
S
Q
Site 62
S1186
R
V
P
L
G
P
S
S
P
L
S
V
S
Q
P
Site 63
S1191
P
S
S
P
L
S
V
S
Q
P
M
L
G
I
R
Site 64
S1212
L
G
A
G
P
A
A
S
P
H
L
S
P
S
P
Site 65
S1216
P
A
A
S
P
H
L
S
P
S
P
A
P
S
T
Site 66
S1218
A
S
P
H
L
S
P
S
P
A
P
S
T
A
S
Site 67
S1222
L
S
P
S
P
A
P
S
T
A
S
S
A
P
G
Site 68
T1223
S
P
S
P
A
P
S
T
A
S
S
A
P
G
R
Site 69
S1225
S
P
A
P
S
T
A
S
S
A
P
G
R
T
W
Site 70
S1226
P
A
P
S
T
A
S
S
A
P
G
R
T
W
Q
Site 71
T1239
W
Q
G
N
G
E
M
T
P
P
L
Q
G
P
R
Site 72
Y1258
K
K
P
K
A
L
P
Y
R
R
E
N
S
P
G
Site 73
S1263
L
P
Y
R
R
E
N
S
P
G
D
L
P
P
P
Site 74
S1280
P
P
P
E
E
E
A
S
W
A
L
E
L
R
A
Site 75
S1290
L
E
L
R
A
A
G
S
M
S
S
L
E
R
E
Site 76
S1293
R
A
A
G
S
M
S
S
L
E
R
E
R
S
G
Site 77
S1299
S
S
L
E
R
E
R
S
G
E
R
K
A
V
Q
Site 78
Y1326
D
E
E
A
W
L
P
Y
S
R
P
S
F
L
S
Site 79
S1327
E
E
A
W
L
P
Y
S
R
P
S
F
L
S
R
Site 80
S1330
W
L
P
Y
S
R
P
S
F
L
S
R
G
Q
G
Site 81
S1333
Y
S
R
P
S
F
L
S
R
G
Q
G
T
S
T
Site 82
T1338
F
L
S
R
G
Q
G
T
S
T
C
S
T
A
G
Site 83
S1339
L
S
R
G
Q
G
T
S
T
C
S
T
A
G
S
Site 84
T1340
S
R
G
Q
G
T
S
T
C
S
T
A
G
S
N
Site 85
S1342
G
Q
G
T
S
T
C
S
T
A
G
S
N
S
S
Site 86
T1343
Q
G
T
S
T
C
S
T
A
G
S
N
S
S
R
Site 87
S1346
S
T
C
S
T
A
G
S
N
S
S
R
G
S
S
Site 88
S1348
C
S
T
A
G
S
N
S
S
R
G
S
S
S
S
Site 89
S1349
S
T
A
G
S
N
S
S
R
G
S
S
S
S
R
Site 90
S1352
G
S
N
S
S
R
G
S
S
S
S
R
G
S
R
Site 91
S1353
S
N
S
S
R
G
S
S
S
S
R
G
S
R
G
Site 92
S1354
N
S
S
R
G
S
S
S
S
R
G
S
R
G
P
Site 93
S1355
S
S
R
G
S
S
S
S
R
G
S
R
G
P
G
Site 94
S1358
G
S
S
S
S
R
G
S
R
G
P
G
R
S
R
Site 95
S1364
G
S
R
G
P
G
R
S
R
S
R
S
Q
S
R
Site 96
S1366
R
G
P
G
R
S
R
S
R
S
Q
S
R
S
Q
Site 97
S1368
P
G
R
S
R
S
R
S
Q
S
R
S
Q
S
Q
Site 98
S1370
R
S
R
S
R
S
Q
S
R
S
Q
S
Q
R
P
Site 99
S1372
R
S
R
S
Q
S
R
S
Q
S
Q
R
P
G
Q
Site 100
S1374
R
S
Q
S
R
S
Q
S
Q
R
P
G
Q
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation