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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRICKLE1
Full Name:
Prickle-like protein 1
Alias:
FLJ31937; PRIC1; Prickle 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; RILP
Type:
Uncharacterized protein
Mass (Da):
94300
Number AA:
831
UniProt ID:
Q96MT3
International Prot ID:
IPI00043363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
E
M
E
P
K
M
S
K
L
A
F
G
C
Q
Site 2
S20
A
F
G
C
Q
R
S
S
T
S
D
D
D
S
G
Site 3
T21
F
G
C
Q
R
S
S
T
S
D
D
D
S
G
C
Site 4
S22
G
C
Q
R
S
S
T
S
D
D
D
S
G
C
A
Site 5
S26
S
S
T
S
D
D
D
S
G
C
A
L
E
E
Y
Site 6
Y48
R
P
E
Q
I
Q
L
Y
F
A
C
L
P
E
E
Site 7
Y59
L
P
E
E
K
V
P
Y
V
N
S
P
G
E
K
Site 8
S62
E
K
V
P
Y
V
N
S
P
G
E
K
H
R
I
Site 9
Y74
H
R
I
K
Q
L
L
Y
Q
L
P
P
H
D
N
Site 10
Y85
P
H
D
N
E
V
R
Y
C
Q
S
L
S
E
E
Site 11
S88
N
E
V
R
Y
C
Q
S
L
S
E
E
E
K
K
Site 12
S90
V
R
Y
C
Q
S
L
S
E
E
E
K
K
E
L
Site 13
S101
K
K
E
L
Q
V
F
S
A
Q
R
K
K
E
A
Site 14
T113
K
E
A
L
G
R
G
T
I
K
L
L
S
R
A
Site 15
Y230
T
V
L
G
G
Q
R
Y
I
M
K
D
G
R
P
Site 16
Y250
F
E
S
L
Y
A
E
Y
C
E
T
C
G
E
H
Site 17
Y301
L
P
K
Q
G
Q
I
Y
C
S
K
T
C
S
L
Site 18
S303
K
Q
G
Q
I
Y
C
S
K
T
C
S
L
G
E
Site 19
T305
G
Q
I
Y
C
S
K
T
C
S
L
G
E
D
V
Site 20
S307
I
Y
C
S
K
T
C
S
L
G
E
D
V
H
A
Site 21
S315
L
G
E
D
V
H
A
S
D
S
S
D
S
A
F
Site 22
S317
E
D
V
H
A
S
D
S
S
D
S
A
F
Q
S
Site 23
S318
D
V
H
A
S
D
S
S
D
S
A
F
Q
S
A
Site 24
S320
H
A
S
D
S
S
D
S
A
F
Q
S
A
R
S
Site 25
S324
S
S
D
S
A
F
Q
S
A
R
S
R
D
S
R
Site 26
S327
S
A
F
Q
S
A
R
S
R
D
S
R
R
S
V
Site 27
S330
Q
S
A
R
S
R
D
S
R
R
S
V
R
M
G
Site 28
S333
R
S
R
D
S
R
R
S
V
R
M
G
K
S
S
Site 29
S339
R
S
V
R
M
G
K
S
S
R
S
A
D
Q
C
Site 30
S340
S
V
R
M
G
K
S
S
R
S
A
D
Q
C
R
Site 31
S349
S
A
D
Q
C
R
Q
S
L
L
L
S
P
A
L
Site 32
T370
L
S
G
N
A
D
D
T
L
S
R
K
L
D
D
Site 33
S372
G
N
A
D
D
T
L
S
R
K
L
D
D
L
S
Site 34
S379
S
R
K
L
D
D
L
S
L
S
R
Q
G
T
S
Site 35
S381
K
L
D
D
L
S
L
S
R
Q
G
T
S
F
A
Site 36
T385
L
S
L
S
R
Q
G
T
S
F
A
S
E
E
F
Site 37
S386
S
L
S
R
Q
G
T
S
F
A
S
E
E
F
W
Site 38
S389
R
Q
G
T
S
F
A
S
E
E
F
W
K
G
R
Site 39
T401
K
G
R
V
E
Q
E
T
P
E
D
P
E
E
W
Site 40
Y414
E
W
A
D
H
E
D
Y
M
T
Q
L
L
L
K
Site 41
T416
A
D
H
E
D
Y
M
T
Q
L
L
L
K
F
G
Site 42
S426
L
L
K
F
G
D
K
S
L
F
Q
P
Q
P
N
Site 43
S445
R
A
S
E
H
W
I
S
D
N
M
V
K
S
K
Site 44
S451
I
S
D
N
M
V
K
S
K
T
E
L
K
Q
N
Site 45
S461
E
L
K
Q
N
N
Q
S
L
A
S
K
K
Y
Q
Site 46
Y467
Q
S
L
A
S
K
K
Y
Q
S
D
M
Y
W
A
Site 47
Y472
K
K
Y
Q
S
D
M
Y
W
A
Q
S
Q
D
G
Site 48
S476
S
D
M
Y
W
A
Q
S
Q
D
G
L
G
D
S
Site 49
S483
S
Q
D
G
L
G
D
S
A
Y
G
S
H
P
G
Site 50
Y485
D
G
L
G
D
S
A
Y
G
S
H
P
G
P
A
Site 51
S487
L
G
D
S
A
Y
G
S
H
P
G
P
A
S
S
Site 52
S493
G
S
H
P
G
P
A
S
S
R
R
L
Q
E
L
Site 53
S494
S
H
P
G
P
A
S
S
R
R
L
Q
E
L
E
Site 54
Y509
L
D
H
G
A
S
G
Y
N
H
D
E
T
Q
W
Site 55
Y517
N
H
D
E
T
Q
W
Y
E
D
S
L
E
C
L
Site 56
S520
E
T
Q
W
Y
E
D
S
L
E
C
L
S
D
L
Site 57
S525
E
D
S
L
E
C
L
S
D
L
K
P
E
Q
S
Site 58
S532
S
D
L
K
P
E
Q
S
V
R
D
S
M
D
S
Site 59
S536
P
E
Q
S
V
R
D
S
M
D
S
L
A
L
S
Site 60
S539
S
V
R
D
S
M
D
S
L
A
L
S
N
I
T
Site 61
S559
G
E
N
K
P
R
P
S
L
Y
S
L
Q
N
F
Site 62
S562
K
P
R
P
S
L
Y
S
L
Q
N
F
E
E
M
Site 63
T571
Q
N
F
E
E
M
E
T
E
D
C
E
K
M
S
Site 64
T582
E
K
M
S
N
M
G
T
L
N
S
S
M
L
H
Site 65
S585
S
N
M
G
T
L
N
S
S
M
L
H
R
S
A
Site 66
S586
N
M
G
T
L
N
S
S
M
L
H
R
S
A
E
Site 67
S591
N
S
S
M
L
H
R
S
A
E
S
L
K
S
L
Site 68
S594
M
L
H
R
S
A
E
S
L
K
S
L
S
S
E
Site 69
S597
R
S
A
E
S
L
K
S
L
S
S
E
L
C
P
Site 70
S599
A
E
S
L
K
S
L
S
S
E
L
C
P
E
K
Site 71
S600
E
S
L
K
S
L
S
S
E
L
C
P
E
K
I
Site 72
S622
H
L
P
V
L
R
R
S
K
S
Q
S
R
P
Q
Site 73
S624
P
V
L
R
R
S
K
S
Q
S
R
P
Q
Q
V
Site 74
S626
L
R
R
S
K
S
Q
S
R
P
Q
Q
V
K
F
Site 75
S634
R
P
Q
Q
V
K
F
S
D
D
V
I
D
N
G
Site 76
S653
E
I
R
Q
P
P
M
S
E
R
T
R
R
R
V
Site 77
T656
Q
P
P
M
S
E
R
T
R
R
R
V
Y
N
F
Site 78
Y661
E
R
T
R
R
R
V
Y
N
F
E
E
R
G
S
Site 79
S668
Y
N
F
E
E
R
G
S
R
S
H
H
H
R
R
Site 80
S670
F
E
E
R
G
S
R
S
H
H
H
R
R
R
R
Site 81
S678
H
H
H
R
R
R
R
S
R
K
S
R
S
D
N
Site 82
S681
R
R
R
R
S
R
K
S
R
S
D
N
A
L
N
Site 83
S683
R
R
S
R
K
S
R
S
D
N
A
L
N
L
V
Site 84
T691
D
N
A
L
N
L
V
T
E
R
K
Y
S
P
K
Site 85
Y695
N
L
V
T
E
R
K
Y
S
P
K
D
R
L
R
Site 86
S696
L
V
T
E
R
K
Y
S
P
K
D
R
L
R
L
Site 87
Y704
P
K
D
R
L
R
L
Y
T
P
D
N
Y
E
K
Site 88
T705
K
D
R
L
R
L
Y
T
P
D
N
Y
E
K
F
Site 89
Y709
R
L
Y
T
P
D
N
Y
E
K
F
I
Q
N
K
Site 90
S717
E
K
F
I
Q
N
K
S
A
R
E
I
Q
A
Y
Site 91
Y724
S
A
R
E
I
Q
A
Y
I
Q
N
A
D
L
Y
Site 92
Y731
Y
I
Q
N
A
D
L
Y
G
Q
Y
A
H
A
T
Site 93
Y741
Y
A
H
A
T
S
D
Y
G
L
Q
N
P
G
M
Site 94
Y755
M
N
R
F
L
G
L
Y
G
E
D
D
D
S
W
Site 95
S761
L
Y
G
E
D
D
D
S
W
C
S
S
S
S
S
Site 96
S764
E
D
D
D
S
W
C
S
S
S
S
S
S
S
D
Site 97
S765
D
D
D
S
W
C
S
S
S
S
S
S
S
D
S
Site 98
S766
D
D
S
W
C
S
S
S
S
S
S
S
D
S
E
Site 99
S767
D
S
W
C
S
S
S
S
S
S
S
D
S
E
E
Site 100
S768
S
W
C
S
S
S
S
S
S
S
D
S
E
E
E
Site 101
S769
W
C
S
S
S
S
S
S
S
D
S
E
E
E
G
Site 102
S770
C
S
S
S
S
S
S
S
D
S
E
E
E
G
Y
Site 103
S772
S
S
S
S
S
S
D
S
E
E
E
G
Y
F
L
Site 104
Y777
S
D
S
E
E
E
G
Y
F
L
G
Q
P
I
P
Site 105
Y793
P
R
P
Q
R
F
A
Y
Y
T
D
D
L
S
S
Site 106
Y794
R
P
Q
R
F
A
Y
Y
T
D
D
L
S
S
P
Site 107
T795
P
Q
R
F
A
Y
Y
T
D
D
L
S
S
P
P
Site 108
S799
A
Y
Y
T
D
D
L
S
S
P
P
S
A
L
P
Site 109
S800
Y
Y
T
D
D
L
S
S
P
P
S
A
L
P
T
Site 110
S803
D
D
L
S
S
P
P
S
A
L
P
T
P
Q
F
Site 111
T807
S
P
P
S
A
L
P
T
P
Q
F
G
Q
R
T
Site 112
T815
P
Q
F
G
Q
R
T
T
K
S
K
K
K
K
G
Site 113
S817
F
G
Q
R
T
T
K
S
K
K
K
K
G
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation