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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
YTHDC1
Full Name:
YTH domain-containing protein 1
Alias:
KIAA1966; Putative splicing factor YT521; S521; YT521; YT521-B; YTDC1; YTH domain containing 1
Type:
RNA binding protein
Mass (Da):
84700
Number AA:
727
UniProt ID:
Q96MU7
International Prot ID:
IPI00144293
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
N
V
L
D
D
I
L
T
E
V
P
E
Q
D
D
Site 2
Y31
P
E
Q
D
D
E
L
Y
N
P
E
S
E
Q
D
Site 3
S35
D
E
L
Y
N
P
E
S
E
Q
D
K
N
E
K
Site 4
S45
D
K
N
E
K
K
G
S
K
R
K
S
D
R
M
Site 5
S49
K
K
G
S
K
R
K
S
D
R
M
E
S
T
D
Site 6
S54
R
K
S
D
R
M
E
S
T
D
T
K
R
Q
K
Site 7
T57
D
R
M
E
S
T
D
T
K
R
Q
K
P
S
V
Site 8
S71
V
H
S
R
Q
L
V
S
K
P
L
S
S
S
V
Site 9
S75
Q
L
V
S
K
P
L
S
S
S
V
S
N
N
K
Site 10
S76
L
V
S
K
P
L
S
S
S
V
S
N
N
K
R
Site 11
S77
V
S
K
P
L
S
S
S
V
S
N
N
K
R
I
Site 12
S79
K
P
L
S
S
S
V
S
N
N
K
R
I
V
S
Site 13
S86
S
N
N
K
R
I
V
S
T
K
G
K
S
A
T
Site 14
Y95
K
G
K
S
A
T
E
Y
K
N
E
E
Y
Q
R
Site 15
Y100
T
E
Y
K
N
E
E
Y
Q
R
S
E
R
N
K
Site 16
S103
K
N
E
E
Y
Q
R
S
E
R
N
K
R
L
D
Site 17
S118
A
D
R
K
I
R
L
S
S
S
A
S
R
E
P
Site 18
S119
D
R
K
I
R
L
S
S
S
A
S
R
E
P
Y
Site 19
S120
R
K
I
R
L
S
S
S
A
S
R
E
P
Y
K
Site 20
S122
I
R
L
S
S
S
A
S
R
E
P
Y
K
N
Q
Site 21
Y126
S
S
A
S
R
E
P
Y
K
N
Q
P
E
K
T
Site 22
T133
Y
K
N
Q
P
E
K
T
C
V
R
K
R
D
P
Site 23
S146
D
P
E
R
R
A
K
S
P
T
P
D
G
S
E
Site 24
T148
E
R
R
A
K
S
P
T
P
D
G
S
E
R
I
Site 25
S152
K
S
P
T
P
D
G
S
E
R
I
G
L
E
V
Site 26
S164
L
E
V
D
R
R
A
S
R
S
S
Q
S
S
K
Site 27
S166
V
D
R
R
A
S
R
S
S
Q
S
S
K
E
E
Site 28
S167
D
R
R
A
S
R
S
S
Q
S
S
K
E
E
V
Site 29
S170
A
S
R
S
S
Q
S
S
K
E
E
V
N
S
E
Site 30
S176
S
S
K
E
E
V
N
S
E
E
Y
G
S
D
H
Site 31
S181
V
N
S
E
E
Y
G
S
D
H
E
T
G
S
S
Site 32
T185
E
Y
G
S
D
H
E
T
G
S
S
G
S
S
D
Site 33
S187
G
S
D
H
E
T
G
S
S
G
S
S
D
E
Q
Site 34
S188
S
D
H
E
T
G
S
S
G
S
S
D
E
Q
G
Site 35
S191
E
T
G
S
S
G
S
S
D
E
Q
G
N
N
T
Site 36
Y250
E
E
E
E
E
E
E
Y
E
Q
D
E
R
D
Q
Site 37
Y264
Q
K
E
E
G
N
D
Y
D
T
R
S
E
A
S
Site 38
T266
E
E
G
N
D
Y
D
T
R
S
E
A
S
D
S
Site 39
S268
G
N
D
Y
D
T
R
S
E
A
S
D
S
G
S
Site 40
S271
Y
D
T
R
S
E
A
S
D
S
G
S
E
S
V
Site 41
S273
T
R
S
E
A
S
D
S
G
S
E
S
V
S
F
Site 42
S275
S
E
A
S
D
S
G
S
E
S
V
S
F
T
D
Site 43
S277
A
S
D
S
G
S
E
S
V
S
F
T
D
G
S
Site 44
S279
D
S
G
S
E
S
V
S
F
T
D
G
S
V
R
Site 45
T281
G
S
E
S
V
S
F
T
D
G
S
V
R
S
G
Site 46
S284
S
V
S
F
T
D
G
S
V
R
S
G
S
G
T
Site 47
S287
F
T
D
G
S
V
R
S
G
S
G
T
D
G
S
Site 48
S289
D
G
S
V
R
S
G
S
G
T
D
G
S
D
E
Site 49
T291
S
V
R
S
G
S
G
T
D
G
S
D
E
K
K
Site 50
S294
S
G
S
G
T
D
G
S
D
E
K
K
K
E
R
Site 51
S308
R
K
R
A
R
G
I
S
P
I
V
F
D
R
S
Site 52
S315
S
P
I
V
F
D
R
S
G
S
S
A
S
E
S
Site 53
S317
I
V
F
D
R
S
G
S
S
A
S
E
S
Y
A
Site 54
S318
V
F
D
R
S
G
S
S
A
S
E
S
Y
A
G
Site 55
S320
D
R
S
G
S
S
A
S
E
S
Y
A
G
S
E
Site 56
S322
S
G
S
S
A
S
E
S
Y
A
G
S
E
K
K
Site 57
S326
A
S
E
S
Y
A
G
S
E
K
K
H
E
K
L
Site 58
S334
E
K
K
H
E
K
L
S
S
S
V
R
A
V
R
Site 59
S335
K
K
H
E
K
L
S
S
S
V
R
A
V
R
K
Site 60
S336
K
H
E
K
L
S
S
S
V
R
A
V
R
K
D
Site 61
T345
R
A
V
R
K
D
Q
T
S
K
L
K
Y
V
L
Site 62
S346
A
V
R
K
D
Q
T
S
K
L
K
Y
V
L
Q
Site 63
Y350
D
Q
T
S
K
L
K
Y
V
L
Q
D
A
R
F
Site 64
S362
A
R
F
F
L
I
K
S
N
N
H
E
N
V
S
Site 65
S369
S
N
N
H
E
N
V
S
L
A
K
A
K
G
V
Site 66
S378
A
K
A
K
G
V
W
S
T
L
P
V
N
E
K
Site 67
S416
F
Q
G
F
A
R
L
S
S
E
S
H
H
G
G
Site 68
S417
Q
G
F
A
R
L
S
S
E
S
H
H
G
G
S
Site 69
S419
F
A
R
L
S
S
E
S
H
H
G
G
S
P
I
Site 70
S424
S
E
S
H
H
G
G
S
P
I
H
W
V
L
P
Site 71
S435
W
V
L
P
A
G
M
S
A
K
M
L
G
G
V
Site 72
T456
C
R
R
E
L
P
F
T
K
S
A
H
L
T
N
Site 73
S458
R
E
L
P
F
T
K
S
A
H
L
T
N
P
W
Site 74
Y501
P
D
E
S
I
D
L
Y
Q
V
I
H
K
M
R
Site 75
S515
R
H
K
R
R
M
H
S
Q
P
R
S
R
G
R
Site 76
S519
R
M
H
S
Q
P
R
S
R
G
R
P
S
R
R
Site 77
S524
P
R
S
R
G
R
P
S
R
R
E
P
V
R
D
Site 78
Y540
G
R
R
R
P
E
D
Y
D
I
H
N
S
R
K
Site 79
S545
E
D
Y
D
I
H
N
S
R
K
K
P
R
I
D
Site 80
Y553
R
K
K
P
R
I
D
Y
P
P
E
F
H
Q
R
Site 81
Y563
E
F
H
Q
R
P
G
Y
L
K
D
P
R
Y
Q
Site 82
Y569
G
Y
L
K
D
P
R
Y
Q
E
V
D
R
R
F
Site 83
S577
Q
E
V
D
R
R
F
S
G
V
R
R
D
V
F
Site 84
Y592
L
N
G
S
Y
N
D
Y
V
R
E
F
H
N
M
Site 85
Y611
P
W
Q
G
M
P
P
Y
P
G
M
E
Q
P
P
Site 86
Y622
E
Q
P
P
H
H
P
Y
Y
Q
H
H
A
P
P
Site 87
Y636
P
P
Q
A
H
P
P
Y
S
G
H
H
P
V
P
Site 88
S637
P
Q
A
H
P
P
Y
S
G
H
H
P
V
P
H
Site 89
Y648
P
V
P
H
E
A
R
Y
R
D
K
R
V
H
D
Site 90
Y656
R
D
K
R
V
H
D
Y
D
M
R
V
D
D
F
Site 91
T667
V
D
D
F
L
R
R
T
Q
A
V
V
S
G
R
Site 92
S672
R
R
T
Q
A
V
V
S
G
R
R
S
R
P
R
Site 93
S676
A
V
V
S
G
R
R
S
R
P
R
E
R
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation