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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC14
Full Name:
Tetratricopeptide repeat protein 14
Alias:
FLJ00166; KIAA1980; tetratricopeptide repeat 14; tetratricopeptide repeat domain 14; TPR repeat 14
Type:
Unknown function
Mass (Da):
88319
Number AA:
770
UniProt ID:
Q96N46
International Prot ID:
IPI00550503
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
R
D
L
L
R
Q
S
L
N
C
H
G
S
S
Site 2
S15
Q
S
L
N
C
H
G
S
S
L
L
S
L
L
R
Site 3
S19
C
H
G
S
S
L
L
S
L
L
R
S
E
Q
Q
Site 4
S23
S
L
L
S
L
L
R
S
E
Q
Q
D
N
P
H
Site 5
S33
Q
D
N
P
H
F
R
S
L
L
G
S
A
A
E
Site 6
S37
H
F
R
S
L
L
G
S
A
A
E
P
A
R
G
Site 7
S82
L
F
A
L
S
W
K
S
D
A
P
A
T
S
E
Site 8
S88
K
S
D
A
P
A
T
S
E
I
N
E
D
S
E
Site 9
S94
T
S
E
I
N
E
D
S
E
D
H
Y
A
I
M
Site 10
Y98
N
E
D
S
E
D
H
Y
A
I
M
P
P
L
E
Site 11
S112
E
Q
F
M
E
I
P
S
M
D
R
R
E
L
F
Site 12
S150
M
V
L
I
C
L
G
S
G
I
M
R
D
I
A
Site 13
S172
C
P
L
R
D
V
P
S
H
S
N
H
G
D
P
Site 14
S174
L
R
D
V
P
S
H
S
N
H
G
D
P
L
S
Site 15
S181
S
N
H
G
D
P
L
S
Y
Y
Q
T
G
D
I
Site 16
Y183
H
G
D
P
L
S
Y
Y
Q
T
G
D
I
I
R
Site 17
T185
D
P
L
S
Y
Y
Q
T
G
D
I
I
R
A
G
Site 18
Y199
G
I
K
D
I
D
R
Y
H
E
K
L
A
V
S
Site 19
S206
Y
H
E
K
L
A
V
S
L
Y
S
S
S
L
P
Site 20
Y208
E
K
L
A
V
S
L
Y
S
S
S
L
P
P
H
Site 21
S225
G
I
K
L
G
V
I
S
S
E
E
L
P
L
Y
Site 22
Y232
S
S
E
E
L
P
L
Y
Y
R
R
S
V
E
L
Site 23
Y233
S
E
E
L
P
L
Y
Y
R
R
S
V
E
L
N
Site 24
S236
L
P
L
Y
Y
R
R
S
V
E
L
N
S
N
S
Site 25
S241
R
R
S
V
E
L
N
S
N
S
L
E
S
Y
E
Site 26
S243
S
V
E
L
N
S
N
S
L
E
S
Y
E
N
V
Site 27
Y247
N
S
N
S
L
E
S
Y
E
N
V
M
Q
S
S
Site 28
S275
E
K
L
G
I
D
E
S
N
P
P
S
L
M
R
Site 29
S279
I
D
E
S
N
P
P
S
L
M
R
G
L
Q
S
Site 30
S286
S
L
M
R
G
L
Q
S
K
N
F
S
E
D
D
Site 31
S290
G
L
Q
S
K
N
F
S
E
D
D
F
A
S
A
Site 32
S296
F
S
E
D
D
F
A
S
A
L
R
K
K
Q
S
Site 33
S303
S
A
L
R
K
K
Q
S
A
S
W
A
L
K
C
Site 34
T373
L
A
L
E
N
C
P
T
H
R
N
A
R
K
Y
Site 35
Y380
T
H
R
N
A
R
K
Y
L
C
Q
T
L
V
E
Site 36
T384
A
R
K
Y
L
C
Q
T
L
V
E
R
G
G
Q
Site 37
Y405
F
L
N
A
E
S
Y
Y
K
K
A
L
A
L
D
Site 38
T414
K
A
L
A
L
D
E
T
F
K
D
A
E
D
A
Site 39
Y428
A
L
Q
K
L
H
K
Y
M
Q
K
S
L
E
L
Site 40
S432
L
H
K
Y
M
Q
K
S
L
E
L
R
E
K
Q
Site 41
T448
E
K
E
E
K
Q
K
T
K
K
I
E
T
S
A
Site 42
T453
Q
K
T
K
K
I
E
T
S
A
E
K
L
R
K
Site 43
S454
K
T
K
K
I
E
T
S
A
E
K
L
R
K
L
Site 44
S475
L
K
K
K
R
R
K
S
T
S
S
S
S
V
S
Site 45
T476
K
K
K
R
R
K
S
T
S
S
S
S
V
S
S
Site 46
S477
K
K
R
R
K
S
T
S
S
S
S
V
S
S
A
Site 47
S478
K
R
R
K
S
T
S
S
S
S
V
S
S
A
D
Site 48
S479
R
R
K
S
T
S
S
S
S
V
S
S
A
D
E
Site 49
S480
R
K
S
T
S
S
S
S
V
S
S
A
D
E
S
Site 50
S482
S
T
S
S
S
S
V
S
S
A
D
E
S
V
S
Site 51
S483
T
S
S
S
S
V
S
S
A
D
E
S
V
S
S
Site 52
S487
S
V
S
S
A
D
E
S
V
S
S
S
S
S
S
Site 53
S489
S
S
A
D
E
S
V
S
S
S
S
S
S
S
S
Site 54
S490
S
A
D
E
S
V
S
S
S
S
S
S
S
S
S
Site 55
S491
A
D
E
S
V
S
S
S
S
S
S
S
S
S
G
Site 56
S492
D
E
S
V
S
S
S
S
S
S
S
S
S
G
H
Site 57
S493
E
S
V
S
S
S
S
S
S
S
S
S
G
H
K
Site 58
S494
S
V
S
S
S
S
S
S
S
S
S
G
H
K
R
Site 59
S495
V
S
S
S
S
S
S
S
S
S
G
H
K
R
H
Site 60
S496
S
S
S
S
S
S
S
S
S
G
H
K
R
H
K
Site 61
S497
S
S
S
S
S
S
S
S
G
H
K
R
H
K
K
Site 62
S510
K
K
H
K
R
N
R
S
E
S
S
R
S
S
R
Site 63
S512
H
K
R
N
R
S
E
S
S
R
S
S
R
R
H
Site 64
S513
K
R
N
R
S
E
S
S
R
S
S
R
R
H
S
Site 65
S515
N
R
S
E
S
S
R
S
S
R
R
H
S
S
R
Site 66
S516
R
S
E
S
S
R
S
S
R
R
H
S
S
R
A
Site 67
S520
S
R
S
S
R
R
H
S
S
R
A
S
S
N
Q
Site 68
S521
R
S
S
R
R
H
S
S
R
A
S
S
N
Q
I
Site 69
S524
R
R
H
S
S
R
A
S
S
N
Q
I
D
Q
N
Site 70
S525
R
H
S
S
R
A
S
S
N
Q
I
D
Q
N
R
Site 71
Y537
Q
N
R
K
D
E
C
Y
P
V
P
A
N
T
S
Site 72
S546
V
P
A
N
T
S
A
S
F
L
N
H
K
Q
E
Site 73
Y566
G
K
Q
D
R
L
Q
Y
E
K
T
Q
I
K
E
Site 74
T569
D
R
L
Q
Y
E
K
T
Q
I
K
E
K
D
R
Site 75
S580
E
K
D
R
C
P
L
S
S
S
S
L
E
I
P
Site 76
S581
K
D
R
C
P
L
S
S
S
S
L
E
I
P
D
Site 77
S582
D
R
C
P
L
S
S
S
S
L
E
I
P
D
D
Site 78
S583
R
C
P
L
S
S
S
S
L
E
I
P
D
D
F
Site 79
S594
P
D
D
F
G
G
R
S
E
D
P
R
D
F
Y
Site 80
Y601
S
E
D
P
R
D
F
Y
N
S
Y
K
T
Q
A
Site 81
S603
D
P
R
D
F
Y
N
S
Y
K
T
Q
A
G
S
Site 82
Y604
P
R
D
F
Y
N
S
Y
K
T
Q
A
G
S
S
Site 83
T606
D
F
Y
N
S
Y
K
T
Q
A
G
S
S
K
T
Site 84
S611
Y
K
T
Q
A
G
S
S
K
T
E
K
P
Y
K
Site 85
T613
T
Q
A
G
S
S
K
T
E
K
P
Y
K
S
E
Site 86
S619
K
T
E
K
P
Y
K
S
E
R
H
F
S
S
R
Site 87
S624
Y
K
S
E
R
H
F
S
S
R
R
N
S
S
D
Site 88
S625
K
S
E
R
H
F
S
S
R
R
N
S
S
D
S
Site 89
S629
H
F
S
S
R
R
N
S
S
D
S
F
C
R
N
Site 90
S630
F
S
S
R
R
N
S
S
D
S
F
C
R
N
S
Site 91
S632
S
R
R
N
S
S
D
S
F
C
R
N
S
E
D
Site 92
S637
S
D
S
F
C
R
N
S
E
D
K
I
Y
G
Y
Site 93
Y642
R
N
S
E
D
K
I
Y
G
Y
R
R
F
E
K
Site 94
Y644
S
E
D
K
I
Y
G
Y
R
R
F
E
K
D
I
Site 95
Y658
I
E
G
R
K
E
H
Y
R
R
W
E
P
G
S
Site 96
S665
Y
R
R
W
E
P
G
S
V
R
H
S
T
S
P
Site 97
S669
E
P
G
S
V
R
H
S
T
S
P
A
S
S
E
Site 98
T670
P
G
S
V
R
H
S
T
S
P
A
S
S
E
Y
Site 99
S671
G
S
V
R
H
S
T
S
P
A
S
S
E
Y
S
Site 100
S674
R
H
S
T
S
P
A
S
S
E
Y
S
W
K
S
Site 101
S675
H
S
T
S
P
A
S
S
E
Y
S
W
K
S
V
Site 102
Y677
T
S
P
A
S
S
E
Y
S
W
K
S
V
E
K
Site 103
S678
S
P
A
S
S
E
Y
S
W
K
S
V
E
K
Y
Site 104
S681
S
S
E
Y
S
W
K
S
V
E
K
Y
K
K
Y
Site 105
Y685
S
W
K
S
V
E
K
Y
K
K
Y
A
H
S
G
Site 106
Y688
S
V
E
K
Y
K
K
Y
A
H
S
G
S
R
D
Site 107
S691
K
Y
K
K
Y
A
H
S
G
S
R
D
F
S
R
Site 108
S693
K
K
Y
A
H
S
G
S
R
D
F
S
R
H
E
Site 109
S697
H
S
G
S
R
D
F
S
R
H
E
Q
R
Y
R
Site 110
Y703
F
S
R
H
E
Q
R
Y
R
L
N
T
N
Q
G
Site 111
T707
E
Q
R
Y
R
L
N
T
N
Q
G
E
Y
E
R
Site 112
Y712
L
N
T
N
Q
G
E
Y
E
R
E
D
N
Y
G
Site 113
Y718
E
Y
E
R
E
D
N
Y
G
E
D
I
K
T
E
Site 114
T724
N
Y
G
E
D
I
K
T
E
V
P
E
E
D
A
Site 115
S733
V
P
E
E
D
A
L
S
S
K
E
H
S
E
S
Site 116
S734
P
E
E
D
A
L
S
S
K
E
H
S
E
S
S
Site 117
S738
A
L
S
S
K
E
H
S
E
S
S
V
K
K
N
Site 118
S740
S
S
K
E
H
S
E
S
S
V
K
K
N
L
P
Site 119
S741
S
K
E
H
S
E
S
S
V
K
K
N
L
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation