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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC25
Full Name:
Tetratricopeptide repeat protein 25
Alias:
Type:
Mass (Da):
76655
Number AA:
672
UniProt ID:
Q96NG3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
D
P
E
G
E
T
L
R
S
T
F
P
S
Site 2
S11
P
E
G
E
T
L
R
S
T
F
P
S
Y
M
A
Site 3
T12
E
G
E
T
L
R
S
T
F
P
S
Y
M
A
E
Site 4
S15
T
L
R
S
T
F
P
S
Y
M
A
E
G
E
R
Site 5
Y16
L
R
S
T
F
P
S
Y
M
A
E
G
E
R
L
Site 6
Y24
M
A
E
G
E
R
L
Y
L
C
G
E
F
S
K
Site 7
S35
E
F
S
K
A
A
Q
S
F
S
N
A
L
Y
L
Site 8
S37
S
K
A
A
Q
S
F
S
N
A
L
Y
L
Q
D
Site 9
Y41
Q
S
F
S
N
A
L
Y
L
Q
D
G
D
K
N
Site 10
S66
K
M
G
D
L
E
R
S
L
K
D
A
E
A
S
Site 11
S73
S
L
K
D
A
E
A
S
L
Q
S
D
P
A
F
Site 12
Y92
L
Q
K
A
E
T
L
Y
T
M
G
D
F
E
F
Site 13
T93
Q
K
A
E
T
L
Y
T
M
G
D
F
E
F
A
Site 14
Y104
F
E
F
A
L
V
F
Y
H
R
G
Y
K
L
R
Site 15
Y108
L
V
F
Y
H
R
G
Y
K
L
R
P
D
R
E
Site 16
S130
A
Q
E
A
I
N
N
S
V
G
S
P
S
S
I
Site 17
S133
A
I
N
N
S
V
G
S
P
S
S
I
K
L
E
Site 18
S136
N
S
V
G
S
P
S
S
I
K
L
E
N
K
G
Site 19
S146
L
E
N
K
G
D
L
S
F
L
S
K
Q
A
E
Site 20
S180
G
E
P
K
W
K
A
S
L
K
S
E
K
T
V
Site 21
S183
K
W
K
A
S
L
K
S
E
K
T
V
R
Q
L
Site 22
T186
A
S
L
K
S
E
K
T
V
R
Q
L
L
G
E
Site 23
Y195
R
Q
L
L
G
E
L
Y
V
D
K
E
Y
L
E
Site 24
Y200
E
L
Y
V
D
K
E
Y
L
E
K
L
L
L
D
Site 25
T227
T
V
E
D
L
I
M
T
G
I
N
Y
L
D
T
Site 26
Y246
W
R
Q
Q
K
P
I
Y
A
R
E
R
D
R
K
Site 27
S268
R
D
H
K
R
R
P
S
Q
T
A
H
Y
I
L
Site 28
T270
H
K
R
R
P
S
Q
T
A
H
Y
I
L
K
S
Site 29
Y273
R
P
S
Q
T
A
H
Y
I
L
K
S
L
E
D
Site 30
S289
D
M
L
L
T
S
G
S
A
E
G
S
L
Q
K
Site 31
S293
T
S
G
S
A
E
G
S
L
Q
K
A
E
K
V
Site 32
Y323
D
E
L
V
G
N
L
Y
S
C
I
G
N
A
Q
Site 33
S342
Q
M
E
A
A
L
Q
S
H
R
K
D
L
E
I
Site 34
Y353
D
L
E
I
A
K
E
Y
D
L
P
D
A
K
S
Site 35
S360
Y
D
L
P
D
A
K
S
R
A
L
D
N
I
G
Site 36
T382
K
F
Q
Q
A
I
D
T
W
E
E
K
I
P
L
Site 37
T392
E
K
I
P
L
A
K
T
T
L
E
K
T
W
L
Site 38
Y407
F
H
E
I
G
R
C
Y
L
E
L
D
Q
A
W
Site 39
Y419
Q
A
W
Q
A
Q
N
Y
G
E
K
S
Q
Q
C
Site 40
S423
A
Q
N
Y
G
E
K
S
Q
Q
C
A
E
E
E
Site 41
S455
V
K
L
R
D
F
E
S
A
V
N
N
F
E
K
Site 42
S481
E
A
Q
Q
A
I
I
S
A
L
D
D
A
N
K
Site 43
T497
I
I
R
E
L
R
K
T
N
Y
V
E
N
L
K
Site 44
Y499
R
E
L
R
K
T
N
Y
V
E
N
L
K
E
K
Site 45
S507
V
E
N
L
K
E
K
S
E
G
E
A
S
L
Y
Site 46
S512
E
K
S
E
G
E
A
S
L
Y
E
D
R
I
I
Site 47
Y514
S
E
G
E
A
S
L
Y
E
D
R
I
I
T
R
Site 48
T520
L
Y
E
D
R
I
I
T
R
E
K
D
M
R
R
Site 49
S542
V
V
K
Q
W
D
H
S
E
D
E
K
E
T
D
Site 50
S561
A
F
G
E
A
L
Q
S
P
A
S
G
K
Q
S
Site 51
S564
E
A
L
Q
S
P
A
S
G
K
Q
S
V
E
A
Site 52
S568
S
P
A
S
G
K
Q
S
V
E
A
G
K
A
R
Site 53
S586
G
A
V
A
K
G
L
S
G
E
L
G
T
R
S
Site 54
S593
S
G
E
L
G
T
R
S
G
E
T
G
R
K
L
Site 55
T596
L
G
T
R
S
G
E
T
G
R
K
L
L
E
A
Site 56
S608
L
E
A
G
R
R
E
S
R
E
I
Y
R
R
P
Site 57
Y612
R
R
E
S
R
E
I
Y
R
R
P
S
G
E
L
Site 58
S616
R
E
I
Y
R
R
P
S
G
E
L
E
Q
R
L
Site 59
S624
G
E
L
E
Q
R
L
S
G
E
F
S
R
Q
E
Site 60
S628
Q
R
L
S
G
E
F
S
R
Q
E
P
E
E
L
Site 61
S639
P
E
E
L
K
K
L
S
E
V
G
R
R
E
P
Site 62
T652
E
P
E
E
L
G
K
T
Q
F
G
E
I
G
E
Site 63
T660
Q
F
G
E
I
G
E
T
K
K
T
G
N
E
M
Site 64
T663
E
I
G
E
T
K
K
T
G
N
E
M
E
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation