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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM74
Full Name:
Transmembrane protein 74
Alias:
Type:
Mass (Da):
33338
Number AA:
305
UniProt ID:
Q96NL1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
C
D
A
R
D
W
S
S
R
G
L
P
G
D
Site 2
T49
C
Q
K
Q
C
A
S
T
P
R
A
T
E
M
E
Site 3
T53
C
A
S
T
P
R
A
T
E
M
E
G
S
K
L
Site 4
S58
R
A
T
E
M
E
G
S
K
L
S
S
S
P
A
Site 5
S61
E
M
E
G
S
K
L
S
S
S
P
A
S
P
S
Site 6
S62
M
E
G
S
K
L
S
S
S
P
A
S
P
S
S
Site 7
S63
E
G
S
K
L
S
S
S
P
A
S
P
S
S
S
Site 8
S66
K
L
S
S
S
P
A
S
P
S
S
S
L
Q
N
Site 9
S68
S
S
S
P
A
S
P
S
S
S
L
Q
N
S
T
Site 10
S69
S
S
P
A
S
P
S
S
S
L
Q
N
S
T
L
Site 11
S70
S
P
A
S
P
S
S
S
L
Q
N
S
T
L
Q
Site 12
S74
P
S
S
S
L
Q
N
S
T
L
Q
P
D
A
F
Site 13
T75
S
S
S
L
Q
N
S
T
L
Q
P
D
A
F
P
Site 14
S88
F
P
P
G
L
L
H
S
G
N
N
Q
I
T
A
Site 15
S110
C
S
Q
E
L
E
T
S
F
T
Y
V
D
K
N
Site 16
T112
Q
E
L
E
T
S
F
T
Y
V
D
K
N
I
N
Site 17
Y113
E
L
E
T
S
F
T
Y
V
D
K
N
I
N
L
Site 18
S126
N
L
E
Q
R
N
R
S
S
P
S
A
K
G
H
Site 19
S127
L
E
Q
R
N
R
S
S
P
S
A
K
G
H
N
Site 20
S154
W
S
Q
E
A
A
I
S
L
I
S
E
E
E
D
Site 21
T163
I
S
E
E
E
D
D
T
S
S
E
A
T
S
S
Site 22
S164
S
E
E
E
D
D
T
S
S
E
A
T
S
S
G
Site 23
S165
E
E
E
D
D
T
S
S
E
A
T
S
S
G
K
Site 24
T168
D
D
T
S
S
E
A
T
S
S
G
K
S
I
D
Site 25
S169
D
T
S
S
E
A
T
S
S
G
K
S
I
D
Y
Site 26
S170
T
S
S
E
A
T
S
S
G
K
S
I
D
Y
G
Site 27
S173
E
A
T
S
S
G
K
S
I
D
Y
G
F
I
S
Site 28
T208
E
V
T
V
D
P
N
T
V
A
A
R
E
M
E
Site 29
S221
M
E
R
L
E
K
E
S
A
R
L
G
A
H
L
Site 30
Y260
S
M
W
K
G
E
L
Y
R
R
N
R
F
A
S
Site 31
S267
Y
R
R
N
R
F
A
S
S
K
E
S
A
K
L
Site 32
S268
R
R
N
R
F
A
S
S
K
E
S
A
K
L
Y
Site 33
S271
R
F
A
S
S
K
E
S
A
K
L
Y
G
S
F
Site 34
Y275
S
K
E
S
A
K
L
Y
G
S
F
N
F
R
M
Site 35
S277
E
S
A
K
L
Y
G
S
F
N
F
R
M
K
T
Site 36
T284
S
F
N
F
R
M
K
T
S
T
N
E
N
T
L
Site 37
T286
N
F
R
M
K
T
S
T
N
E
N
T
L
E
L
Site 38
T290
K
T
S
T
N
E
N
T
L
E
L
S
L
V
E
Site 39
S294
N
E
N
T
L
E
L
S
L
V
E
E
D
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation