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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOX2
Full Name:
TOX high mobility group box family member 2
Alias:
Granulosa cell HMG box protein 1
Type:
Mass (Da):
51604
Number AA:
488
UniProt ID:
Q96NM4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
P
Q
K
F
D
G
D
S
A
Y
V
G
M
S
D
Site 2
Y49
K
F
D
G
D
S
A
Y
V
G
M
S
D
G
N
Site 3
S61
D
G
N
P
E
L
L
S
T
S
Q
T
Y
N
G
Site 4
T62
G
N
P
E
L
L
S
T
S
Q
T
Y
N
G
Q
Site 5
S63
N
P
E
L
L
S
T
S
Q
T
Y
N
G
Q
S
Site 6
T65
E
L
L
S
T
S
Q
T
Y
N
G
Q
S
E
N
Site 7
Y76
Q
S
E
N
N
E
D
Y
E
I
P
P
I
T
P
Site 8
T82
D
Y
E
I
P
P
I
T
P
P
N
L
P
E
P
Site 9
Y101
L
G
D
H
E
A
S
Y
H
S
L
C
H
G
L
Site 10
S103
D
H
E
A
S
Y
H
S
L
C
H
G
L
T
P
Site 11
Y117
P
N
G
L
L
P
A
Y
S
Y
Q
A
M
D
L
Site 12
S118
N
G
L
L
P
A
Y
S
Y
Q
A
M
D
L
P
Site 13
S137
S
N
M
L
A
Q
D
S
H
L
L
S
G
Q
L
Site 14
S141
A
Q
D
S
H
L
L
S
G
Q
L
P
T
I
Q
Site 15
S153
T
I
Q
E
M
V
H
S
E
V
A
A
Y
D
S
Site 16
Y158
V
H
S
E
V
A
A
Y
D
S
G
R
P
G
P
Site 17
S160
S
E
V
A
A
Y
D
S
G
R
P
G
P
L
L
Site 18
S175
G
R
P
A
M
L
A
S
H
M
S
A
L
S
Q
Site 19
S181
A
S
H
M
S
A
L
S
Q
S
Q
L
I
S
Q
Site 20
S183
H
M
S
A
L
S
Q
S
Q
L
I
S
Q
M
G
Site 21
S187
L
S
Q
S
Q
L
I
S
Q
M
G
I
R
S
S
Site 22
S193
I
S
Q
M
G
I
R
S
S
I
A
H
S
S
P
Site 23
S194
S
Q
M
G
I
R
S
S
I
A
H
S
S
P
S
Site 24
S198
I
R
S
S
I
A
H
S
S
P
S
P
P
G
S
Site 25
S199
R
S
S
I
A
H
S
S
P
S
P
P
G
S
K
Site 26
S201
S
I
A
H
S
S
P
S
P
P
G
S
K
S
A
Site 27
S205
S
S
P
S
P
P
G
S
K
S
A
T
P
S
P
Site 28
S207
P
S
P
P
G
S
K
S
A
T
P
S
P
S
S
Site 29
T209
P
P
G
S
K
S
A
T
P
S
P
S
S
S
T
Site 30
S211
G
S
K
S
A
T
P
S
P
S
S
S
T
Q
E
Site 31
S214
S
A
T
P
S
P
S
S
S
T
Q
E
E
E
S
Site 32
S215
A
T
P
S
P
S
S
S
T
Q
E
E
E
S
E
Site 33
S221
S
S
T
Q
E
E
E
S
E
V
H
F
K
I
S
Site 34
S228
S
E
V
H
F
K
I
S
G
E
K
R
P
S
A
Site 35
S234
I
S
G
E
K
R
P
S
A
D
P
G
K
K
A
Site 36
S260
N
E
P
Q
K
P
V
S
A
Y
A
L
F
F
R
Site 37
T269
Y
A
L
F
F
R
D
T
Q
A
A
I
K
G
Q
Site 38
T281
K
G
Q
N
P
S
A
T
F
G
D
V
S
K
I
Site 39
S291
D
V
S
K
I
V
A
S
M
W
D
S
L
G
E
Site 40
S295
I
V
A
S
M
W
D
S
L
G
E
E
Q
K
Q
Site 41
S303
L
G
E
E
Q
K
Q
S
S
P
D
Q
G
E
T
Site 42
S304
G
E
E
Q
K
Q
S
S
P
D
Q
G
E
T
K
Site 43
S312
P
D
Q
G
E
T
K
S
T
Q
A
N
P
P
A
Site 44
T313
D
Q
G
E
T
K
S
T
Q
A
N
P
P
A
K
Site 45
Y329
L
P
P
K
Q
P
M
Y
A
M
P
G
L
A
S
Site 46
S348
S
D
L
Q
A
F
R
S
G
A
S
P
A
S
L
Site 47
S351
Q
A
F
R
S
G
A
S
P
A
S
L
A
R
T
Site 48
S354
R
S
G
A
S
P
A
S
L
A
R
T
L
G
S
Site 49
S369
K
S
L
L
P
G
L
S
A
S
P
P
P
P
P
Site 50
S377
A
S
P
P
P
P
P
S
F
P
L
S
P
T
L
Site 51
S381
P
P
P
S
F
P
L
S
P
T
L
H
Q
Q
L
Site 52
T383
P
S
F
P
L
S
P
T
L
H
Q
Q
L
S
L
Site 53
S389
P
T
L
H
Q
Q
L
S
L
P
P
H
A
Q
G
Site 54
S406
L
S
P
P
V
S
M
S
P
A
P
Q
P
P
V
Site 55
T416
P
Q
P
P
V
L
P
T
P
M
A
L
Q
V
Q
Site 56
S427
L
Q
V
Q
L
A
M
S
P
S
P
P
G
P
Q
Site 57
S429
V
Q
L
A
M
S
P
S
P
P
G
P
Q
D
F
Site 58
S440
P
Q
D
F
P
H
I
S
E
F
P
S
S
S
G
Site 59
S444
P
H
I
S
E
F
P
S
S
S
G
S
C
S
P
Site 60
S445
H
I
S
E
F
P
S
S
S
G
S
C
S
P
G
Site 61
S446
I
S
E
F
P
S
S
S
G
S
C
S
P
G
P
Site 62
S448
E
F
P
S
S
S
G
S
C
S
P
G
P
S
N
Site 63
S450
P
S
S
S
G
S
C
S
P
G
P
S
N
P
T
Site 64
S454
G
S
C
S
P
G
P
S
N
P
T
S
S
G
D
Site 65
S458
P
G
P
S
N
P
T
S
S
G
D
W
D
S
S
Site 66
S459
G
P
S
N
P
T
S
S
G
D
W
D
S
S
Y
Site 67
S464
T
S
S
G
D
W
D
S
S
Y
P
S
G
E
C
Site 68
S465
S
S
G
D
W
D
S
S
Y
P
S
G
E
C
G
Site 69
Y466
S
G
D
W
D
S
S
Y
P
S
G
E
C
G
I
Site 70
S468
D
W
D
S
S
Y
P
S
G
E
C
G
I
S
T
Site 71
S474
P
S
G
E
C
G
I
S
T
C
S
L
L
P
R
Site 72
T475
S
G
E
C
G
I
S
T
C
S
L
L
P
R
D
Site 73
S477
E
C
G
I
S
T
C
S
L
L
P
R
D
K
S
Site 74
S484
S
L
L
P
R
D
K
S
L
Y
L
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation