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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTCHD1
Full Name:
Patched domain-containing protein 1
Alias:
Type:
Mass (Da):
101341
Number AA:
888
UniProt ID:
Q96NR3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
I
L
L
G
A
S
F
S
R
Y
Q
V
E
E
S
Site 2
Y46
L
G
A
S
F
S
R
Y
Q
V
E
E
S
V
E
Site 3
S51
S
R
Y
Q
V
E
E
S
V
E
H
L
L
A
P
Site 4
S61
H
L
L
A
P
Q
H
S
L
A
K
I
E
R
N
Site 5
S72
I
E
R
N
L
V
N
S
L
F
P
V
N
R
S
Site 6
S79
S
L
F
P
V
N
R
S
K
H
R
L
Y
S
D
Site 7
Y84
N
R
S
K
H
R
L
Y
S
D
L
Q
T
P
G
Site 8
S85
R
S
K
H
R
L
Y
S
D
L
Q
T
P
G
R
Site 9
T89
R
L
Y
S
D
L
Q
T
P
G
R
Y
G
R
V
Site 10
T166
E
L
K
N
A
R
A
T
N
R
T
N
F
A
I
Site 11
T169
N
A
R
A
T
N
R
T
N
F
A
I
T
Y
P
Site 12
Y175
R
T
N
F
A
I
T
Y
P
I
T
H
L
K
D
Site 13
Y187
L
K
D
G
R
A
V
Y
N
G
H
Q
L
G
G
Site 14
S199
L
G
G
V
T
V
H
S
K
D
R
V
K
S
A
Site 15
S205
H
S
K
D
R
V
K
S
A
E
A
I
Q
L
T
Site 16
T212
S
A
E
A
I
Q
L
T
Y
Y
L
Q
S
I
N
Site 17
Y213
A
E
A
I
Q
L
T
Y
Y
L
Q
S
I
N
S
Site 18
S220
Y
Y
L
Q
S
I
N
S
L
N
D
M
V
A
E
Site 19
S232
V
A
E
R
W
E
S
S
F
C
D
T
V
R
L
Site 20
T236
W
E
S
S
F
C
D
T
V
R
L
F
Q
K
S
Site 21
S243
T
V
R
L
F
Q
K
S
N
S
K
V
K
M
Y
Site 22
S245
R
L
F
Q
K
S
N
S
K
V
K
M
Y
P
Y
Site 23
Y250
S
N
S
K
V
K
M
Y
P
Y
T
S
S
S
L
Site 24
Y252
S
K
V
K
M
Y
P
Y
T
S
S
S
L
R
E
Site 25
T253
K
V
K
M
Y
P
Y
T
S
S
S
L
R
E
D
Site 26
S255
K
M
Y
P
Y
T
S
S
S
L
R
E
D
F
Q
Site 27
S256
M
Y
P
Y
T
S
S
S
L
R
E
D
F
Q
K
Site 28
T264
L
R
E
D
F
Q
K
T
S
R
V
S
E
R
Y
Site 29
S268
F
Q
K
T
S
R
V
S
E
R
Y
L
V
T
S
Site 30
S295
S
M
Q
D
C
V
R
S
K
P
W
L
G
L
L
Site 31
S349
Y
G
T
F
E
M
L
S
S
W
R
K
T
R
E
Site 32
S350
G
T
F
E
M
L
S
S
W
R
K
T
R
E
D
Site 33
T354
M
L
S
S
W
R
K
T
R
E
D
Q
H
V
K
Site 34
Y368
K
E
R
T
A
A
V
Y
A
D
S
M
L
S
F
Site 35
T428
Y
G
S
S
L
V
F
T
G
Y
I
E
N
N
Y
Site 36
Y430
S
S
L
V
F
T
G
Y
I
E
N
N
Y
Q
H
Site 37
Y435
T
G
Y
I
E
N
N
Y
Q
H
S
I
F
C
R
Site 38
T462
A
W
Y
R
F
L
L
T
A
R
F
S
E
D
T
Site 39
S466
F
L
L
T
A
R
F
S
E
D
T
A
E
G
E
Site 40
T469
T
A
R
F
S
E
D
T
A
E
G
E
E
A
N
Site 41
T477
A
E
G
E
E
A
N
T
Y
E
S
H
L
L
V
Site 42
Y478
E
G
E
E
A
N
T
Y
E
S
H
L
L
V
C
Site 43
S523
L
M
G
Y
L
Q
V
S
E
G
S
D
L
S
N
Site 44
Y548
Y
T
T
A
Q
Q
K
Y
F
S
N
Y
S
P
V
Site 45
S550
T
A
Q
Q
K
Y
F
S
N
Y
S
P
V
I
G
Site 46
Y552
Q
Q
K
Y
F
S
N
Y
S
P
V
I
G
F
Y
Site 47
Y566
Y
I
Y
E
S
I
E
Y
W
N
T
S
V
Q
E
Site 48
T569
E
S
I
E
Y
W
N
T
S
V
Q
E
D
V
L
Site 49
S586
T
K
G
F
V
R
I
S
W
F
E
S
Y
L
N
Site 50
Y591
R
I
S
W
F
E
S
Y
L
N
Y
L
R
K
L
Site 51
Y594
W
F
E
S
Y
L
N
Y
L
R
K
L
N
V
S
Site 52
S601
Y
L
R
K
L
N
V
S
T
G
L
P
K
K
N
Site 53
S616
F
T
D
M
L
R
N
S
F
L
K
A
P
Q
F
Site 54
T656
L
V
A
K
T
M
E
T
N
R
E
E
L
Y
D
Site 55
Y662
E
T
N
R
E
E
L
Y
D
L
L
E
T
L
R
Site 56
T667
E
L
Y
D
L
L
E
T
L
R
R
L
S
V
T
Site 57
S672
L
E
T
L
R
R
L
S
V
T
S
K
V
K
F
Site 58
Y688
V
F
N
P
S
F
V
Y
M
D
R
Y
A
S
S
Site 59
Y692
S
F
V
Y
M
D
R
Y
A
S
S
L
G
A
P
Site 60
S694
V
Y
M
D
R
Y
A
S
S
L
G
A
P
L
H
Site 61
S695
Y
M
D
R
Y
A
S
S
L
G
A
P
L
H
N
Site 62
S852
I
L
T
F
L
P
P
S
K
K
K
R
K
E
K
Site 63
T879
E
M
V
D
I
D
S
T
R
V
V
D
Q
I
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation