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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKRD27
Full Name:
Ankyrin repeat domain-containing protein 27
Alias:
Ankyrin repeat domain 27 (VPS9 domain); ANR27; DKFZp434L0718; FLJ00040; VARP; Vps9 domain and ankyrin-repeat-containing protein; VPS9 domain-containing protein
Type:
Guanine nucleotide exchange factor, Rab
Mass (Da):
116984
Number AA:
1050
UniProt ID:
Q96NW4
International Prot ID:
IPI00102377
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005769
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0045022
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
D
L
L
K
N
P
F
Y
L
A
L
Q
K
C
R
Site 2
S26
K
C
R
P
D
L
C
S
K
V
A
Q
I
H
G
Site 3
S44
V
P
C
K
G
S
L
S
S
S
I
Q
S
T
C
Site 4
S45
P
C
K
G
S
L
S
S
S
I
Q
S
T
C
Q
Site 5
S46
C
K
G
S
L
S
S
S
I
Q
S
T
C
Q
F
Site 6
S49
S
L
S
S
S
I
Q
S
T
C
Q
F
E
S
Y
Site 7
T50
L
S
S
S
I
Q
S
T
C
Q
F
E
S
Y
I
Site 8
T67
P
V
E
E
H
F
Q
T
L
N
G
K
D
V
F
Site 9
Y101
I
L
F
E
E
T
F
Y
N
E
K
E
E
S
F
Site 10
S107
F
Y
N
E
K
E
E
S
F
S
I
L
C
I
A
Site 11
S109
N
E
K
E
E
S
F
S
I
L
C
I
A
H
P
Site 12
S122
H
P
L
E
K
R
E
S
S
E
E
P
L
A
P
Site 13
S123
P
L
E
K
R
E
S
S
E
E
P
L
A
P
S
Site 14
S130
S
E
E
P
L
A
P
S
D
P
F
S
L
K
T
Site 15
S134
L
A
P
S
D
P
F
S
L
K
T
I
E
D
V
Site 16
T137
S
D
P
F
S
L
K
T
I
E
D
V
R
E
F
Site 17
S149
R
E
F
L
G
R
H
S
E
R
F
D
R
N
I
Site 18
S158
R
F
D
R
N
I
A
S
F
H
R
T
F
R
E
Site 19
T162
N
I
A
S
F
H
R
T
F
R
E
C
E
R
K
Site 20
S170
F
R
E
C
E
R
K
S
L
R
H
H
I
D
S
Site 21
S177
S
L
R
H
H
I
D
S
A
N
A
L
Y
T
K
Site 22
S193
L
Q
Q
L
L
R
D
S
H
L
K
M
L
A
K
Site 23
Y215
M
K
Q
A
V
E
I
Y
V
H
H
E
I
Y
N
Site 24
S245
A
F
N
K
I
T
R
S
L
Q
D
L
Q
Q
K
Site 25
S261
I
G
V
K
P
E
F
S
F
N
I
P
R
A
K
Site 26
S279
A
Q
L
N
K
C
T
S
P
Q
Q
K
L
V
C
Site 27
T295
R
K
V
V
Q
L
I
T
Q
S
P
S
Q
R
V
Site 28
S299
Q
L
I
T
Q
S
P
S
Q
R
V
N
L
E
T
Site 29
T306
S
Q
R
V
N
L
E
T
M
C
A
D
D
L
L
Site 30
S341
Y
I
K
N
F
R
F
S
S
L
A
K
D
E
L
Site 31
S342
I
K
N
F
R
F
S
S
L
A
K
D
E
L
G
Site 32
Y361
S
F
E
A
A
I
E
Y
I
R
Q
G
S
L
S
Site 33
S366
I
E
Y
I
R
Q
G
S
L
S
A
K
P
P
E
Site 34
S368
Y
I
R
Q
G
S
L
S
A
K
P
P
E
S
E
Site 35
S374
L
S
A
K
P
P
E
S
E
G
F
G
D
R
L
Site 36
S391
K
Q
R
M
S
L
L
S
Q
M
T
S
S
P
T
Site 37
S396
L
L
S
Q
M
T
S
S
P
T
D
C
L
F
K
Site 38
T398
S
Q
M
T
S
S
P
T
D
C
L
F
K
H
I
Site 39
S418
K
E
V
E
R
L
L
S
Q
E
D
H
D
K
D
Site 40
S445
D
D
C
E
K
L
V
S
G
R
L
N
D
P
S
Site 41
S452
S
G
R
L
N
D
P
S
V
V
T
P
F
S
R
Site 42
T455
L
N
D
P
S
V
V
T
P
F
S
R
D
D
R
Site 43
S458
P
S
V
V
T
P
F
S
R
D
D
R
G
H
T
Site 44
T465
S
R
D
D
R
G
H
T
P
L
H
V
A
A
V
Site 45
Y494
A
M
V
N
A
T
D
Y
H
G
A
T
P
L
H
Site 46
T498
A
T
D
Y
H
G
A
T
P
L
H
L
A
C
Q
Site 47
T531
V
Q
D
N
N
G
N
T
P
L
H
L
A
C
T
Site 48
Y550
D
C
V
K
A
L
V
Y
Y
D
V
E
S
C
R
Site 49
T567
I
G
N
E
K
G
D
T
P
L
H
I
A
A
R
Site 50
S590
T
L
L
Q
N
G
A
S
T
E
I
Q
N
R
L
Site 51
T600
I
Q
N
R
L
K
E
T
P
L
K
C
A
L
N
Site 52
S620
V
M
E
A
Y
H
L
S
F
E
R
R
Q
K
S
Site 53
S627
S
F
E
R
R
Q
K
S
S
E
A
P
V
Q
S
Site 54
S628
F
E
R
R
Q
K
S
S
E
A
P
V
Q
S
P
Site 55
S634
S
S
E
A
P
V
Q
S
P
Q
R
S
V
D
S
Site 56
S638
P
V
Q
S
P
Q
R
S
V
D
S
I
S
Q
E
Site 57
S641
S
P
Q
R
S
V
D
S
I
S
Q
E
S
S
T
Site 58
S643
Q
R
S
V
D
S
I
S
Q
E
S
S
T
S
S
Site 59
S646
V
D
S
I
S
Q
E
S
S
T
S
S
F
S
S
Site 60
S647
D
S
I
S
Q
E
S
S
T
S
S
F
S
S
M
Site 61
T648
S
I
S
Q
E
S
S
T
S
S
F
S
S
M
S
Site 62
S649
I
S
Q
E
S
S
T
S
S
F
S
S
M
S
A
Site 63
S650
S
Q
E
S
S
T
S
S
F
S
S
M
S
A
S
Site 64
S652
E
S
S
T
S
S
F
S
S
M
S
A
S
S
R
Site 65
S653
S
S
T
S
S
F
S
S
M
S
A
S
S
R
Q
Site 66
S655
T
S
S
F
S
S
M
S
A
S
S
R
Q
E
E
Site 67
S657
S
F
S
S
M
S
A
S
S
R
Q
E
E
T
K
Site 68
Y667
Q
E
E
T
K
K
D
Y
R
E
V
E
K
L
L
Site 69
Y687
G
D
L
E
M
V
R
Y
L
L
E
W
T
E
E
Site 70
T702
D
L
E
D
A
E
D
T
V
S
A
A
D
P
E
Site 71
S704
E
D
A
E
D
T
V
S
A
A
D
P
E
F
C
Site 72
T740
S
G
L
G
V
N
V
T
S
Q
D
G
S
S
P
Site 73
S741
G
L
G
V
N
V
T
S
Q
D
G
S
S
P
L
Site 74
S745
N
V
T
S
Q
D
G
S
S
P
L
H
V
A
A
Site 75
S799
V
V
K
C
L
L
D
S
N
A
K
P
N
K
K
Site 76
S809
K
P
N
K
K
D
L
S
G
N
T
P
L
I
Y
Site 77
T812
K
K
D
L
S
G
N
T
P
L
I
Y
A
C
S
Site 78
Y816
S
G
N
T
P
L
I
Y
A
C
S
G
G
H
H
Site 79
S835
L
L
L
Q
H
G
A
S
I
N
A
S
N
N
K
Site 80
S839
H
G
A
S
I
N
A
S
N
N
K
G
N
T
A
Site 81
S868
L
L
L
L
H
G
A
S
V
Q
V
L
N
K
R
Site 82
T878
V
L
N
K
R
Q
R
T
A
V
D
C
A
E
Q
Site 83
T909
S
L
D
D
V
A
E
T
D
R
K
E
Y
V
T
Site 84
Y914
A
E
T
D
R
K
E
Y
V
T
V
K
I
R
K
Site 85
T916
T
D
R
K
E
Y
V
T
V
K
I
R
K
K
W
Site 86
S925
K
I
R
K
K
W
N
S
K
L
Y
D
L
P
D
Site 87
Y928
K
K
W
N
S
K
L
Y
D
L
P
D
E
P
F
Site 88
Y940
E
P
F
T
R
Q
F
Y
F
V
H
S
A
G
Q
Site 89
T952
A
G
Q
F
K
G
K
T
S
R
E
I
M
A
R
Site 90
S962
E
I
M
A
R
D
R
S
V
P
N
L
T
E
G
Site 91
S970
V
P
N
L
T
E
G
S
L
H
E
P
G
R
Q
Site 92
S978
L
H
E
P
G
R
Q
S
V
T
L
R
Q
N
N
Site 93
S1000
H
A
A
E
K
G
N
S
D
W
P
E
R
P
G
Site 94
T1009
W
P
E
R
P
G
L
T
Q
T
G
P
G
H
R
Site 95
T1023
R
R
M
L
R
R
H
T
V
E
D
A
V
V
S
Site 96
S1030
T
V
E
D
A
V
V
S
Q
G
P
E
A
A
G
Site 97
S1040
P
E
A
A
G
P
L
S
T
P
Q
E
V
S
A
Site 98
T1041
E
A
A
G
P
L
S
T
P
Q
E
V
S
A
S
Site 99
S1046
L
S
T
P
Q
E
V
S
A
S
R
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation