KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LRRC7
Full Name:
Leucine-rich repeat-containing protein 7
Alias:
Densin-180; KIAA1365; LAP1; Leucine rich repeat containing 7; Leucine-rich repeat-containing 7; Protein LAP1
Type:
Adhesion protein
Mass (Da):
172581
Number AA:
1537
UniProt ID:
Q96NW7
International Prot ID:
IPI00384313
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
R
G
E
E
E
I
I
S
V
L
D
Y
S
H
C
Site 2
Y29
E
I
I
S
V
L
D
Y
S
H
C
S
L
Q
Q
Site 3
S33
V
L
D
Y
S
H
C
S
L
Q
Q
V
P
K
E
Site 4
T47
E
V
F
N
F
E
R
T
L
E
E
L
Y
L
D
Site 5
Y52
E
R
T
L
E
E
L
Y
L
D
A
N
Q
I
E
Site 6
S75
C
Q
A
L
R
K
L
S
I
P
D
N
D
L
S
Site 7
S82
S
I
P
D
N
D
L
S
N
L
P
T
T
I
A
Site 8
S100
N
L
K
E
L
D
I
S
K
N
G
V
Q
E
F
Site 9
S128
E
A
S
V
N
P
I
S
K
L
P
D
G
F
T
Site 10
T135
S
K
L
P
D
G
F
T
Q
L
L
N
L
T
Q
Site 11
T175
L
R
E
N
H
L
K
T
L
P
K
S
M
H
K
Site 12
S179
H
L
K
T
L
P
K
S
M
H
K
L
A
Q
L
Site 13
Y234
G
K
L
K
M
L
V
Y
L
D
M
S
K
N
R
Site 14
T244
M
S
K
N
R
I
E
T
V
D
M
D
I
S
G
Site 15
S250
E
T
V
D
M
D
I
S
G
C
E
A
L
E
D
Site 16
T289
K
V
D
D
N
Q
L
T
M
L
P
N
T
I
G
Site 17
S307
L
L
E
E
F
D
C
S
C
N
E
L
E
S
L
Site 18
S313
C
S
C
N
E
L
E
S
L
P
S
T
I
G
Y
Site 19
S316
N
E
L
E
S
L
P
S
T
I
G
Y
L
H
S
Site 20
T348
I
G
S
C
K
N
V
T
V
M
S
L
R
S
N
Site 21
S351
C
K
N
V
T
V
M
S
L
R
S
N
K
L
E
Site 22
S376
K
L
R
V
L
N
L
S
D
N
R
L
K
N
L
Site 23
S386
R
L
K
N
L
P
F
S
F
T
K
L
K
E
L
Site 24
S399
E
L
A
A
L
W
L
S
D
N
Q
S
K
A
L
Site 25
S403
L
W
L
S
D
N
Q
S
K
A
L
I
P
L
Q
Site 26
T411
K
A
L
I
P
L
Q
T
E
A
H
P
E
T
K
Site 27
T423
E
T
K
Q
R
V
L
T
N
Y
M
F
P
Q
Q
Site 28
Y425
K
Q
R
V
L
T
N
Y
M
F
P
Q
Q
P
R
Site 29
S439
R
G
D
E
D
F
Q
S
D
S
D
S
F
N
P
Site 30
S441
D
E
D
F
Q
S
D
S
D
S
F
N
P
T
L
Site 31
S443
D
F
Q
S
D
S
D
S
F
N
P
T
L
W
E
Site 32
T447
D
S
D
S
F
N
P
T
L
W
E
E
Q
R
Q
Site 33
T458
E
Q
R
Q
Q
R
M
T
V
A
F
E
F
E
D
Site 34
S480
A
G
K
V
K
D
L
S
C
Q
A
P
W
E
R
Site 35
T493
E
R
G
Q
R
G
I
T
L
Q
P
A
R
L
S
Site 36
S500
T
L
Q
P
A
R
L
S
G
D
C
C
T
P
W
Site 37
S539
S
G
L
Q
Q
E
R
S
M
C
T
P
L
P
V
Site 38
T542
Q
Q
E
R
S
M
C
T
P
L
P
V
A
A
Q
Site 39
T552
P
V
A
A
Q
S
T
T
L
P
S
L
S
G
R
Site 40
S555
A
Q
S
T
T
L
P
S
L
S
G
R
Q
V
E
Site 41
S557
S
T
T
L
P
S
L
S
G
R
Q
V
E
I
N
Site 42
Y568
V
E
I
N
L
K
R
Y
P
T
P
Y
P
E
D
Site 43
T570
I
N
L
K
R
Y
P
T
P
Y
P
E
D
L
K
Site 44
Y572
L
K
R
Y
P
T
P
Y
P
E
D
L
K
N
M
Site 45
S582
D
L
K
N
M
V
K
S
V
Q
N
L
V
G
K
Site 46
T608
P
T
A
N
T
E
Q
T
V
K
E
K
Y
E
H
Site 47
Y613
E
Q
T
V
K
E
K
Y
E
H
K
W
P
V
A
Site 48
T625
P
V
A
P
K
E
I
T
V
E
D
S
F
V
H
Site 49
S629
K
E
I
T
V
E
D
S
F
V
H
P
A
N
E
Site 50
S645
R
I
G
E
L
H
P
S
L
A
E
T
P
L
Y
Site 51
T649
L
H
P
S
L
A
E
T
P
L
Y
P
P
K
L
Site 52
S666
L
G
K
D
K
K
E
S
T
D
E
S
E
V
D
Site 53
S670
K
K
E
S
T
D
E
S
E
V
D
K
T
H
C
Site 54
T675
D
E
S
E
V
D
K
T
H
C
L
N
N
S
V
Site 55
S681
K
T
H
C
L
N
N
S
V
S
S
G
T
Y
S
Site 56
S683
H
C
L
N
N
S
V
S
S
G
T
Y
S
D
Y
Site 57
S684
C
L
N
N
S
V
S
S
G
T
Y
S
D
Y
S
Site 58
Y687
N
S
V
S
S
G
T
Y
S
D
Y
S
P
S
Q
Site 59
S688
S
V
S
S
G
T
Y
S
D
Y
S
P
S
Q
A
Site 60
Y690
S
S
G
T
Y
S
D
Y
S
P
S
Q
A
S
S
Site 61
S691
S
G
T
Y
S
D
Y
S
P
S
Q
A
S
S
G
Site 62
S693
T
Y
S
D
Y
S
P
S
Q
A
S
S
G
S
S
Site 63
S696
D
Y
S
P
S
Q
A
S
S
G
S
S
N
T
R
Site 64
S697
Y
S
P
S
Q
A
S
S
G
S
S
N
T
R
V
Site 65
S700
S
Q
A
S
S
G
S
S
N
T
R
V
K
V
G
Site 66
S708
N
T
R
V
K
V
G
S
L
Q
T
T
A
K
D
Site 67
T711
V
K
V
G
S
L
Q
T
T
A
K
D
A
V
H
Site 68
T712
K
V
G
S
L
Q
T
T
A
K
D
A
V
H
N
Site 69
S720
A
K
D
A
V
H
N
S
L
W
G
N
R
I
A
Site 70
S729
W
G
N
R
I
A
P
S
F
P
Q
P
L
D
S
Site 71
S736
S
F
P
Q
P
L
D
S
K
P
L
L
S
Q
R
Site 72
S741
L
D
S
K
P
L
L
S
Q
R
E
A
V
P
P
Site 73
S761
R
P
D
R
L
P
M
S
D
T
F
T
D
N
W
Site 74
T763
D
R
L
P
M
S
D
T
F
T
D
N
W
T
D
Site 75
T765
L
P
M
S
D
T
F
T
D
N
W
T
D
G
S
Site 76
Y774
N
W
T
D
G
S
H
Y
D
N
T
G
F
V
A
Site 77
T777
D
G
S
H
Y
D
N
T
G
F
V
A
E
E
T
Site 78
S791
T
T
A
E
N
A
N
S
N
P
L
L
S
S
K
Site 79
S796
A
N
S
N
P
L
L
S
S
K
S
R
S
T
S
Site 80
S797
N
S
N
P
L
L
S
S
K
S
R
S
T
S
S
Site 81
S799
N
P
L
L
S
S
K
S
R
S
T
S
S
H
G
Site 82
S801
L
L
S
S
K
S
R
S
T
S
S
H
G
R
R
Site 83
T802
L
S
S
K
S
R
S
T
S
S
H
G
R
R
P
Site 84
S803
S
S
K
S
R
S
T
S
S
H
G
R
R
P
L
Site 85
S804
S
K
S
R
S
T
S
S
H
G
R
R
P
L
I
Site 86
S826
V
P
L
E
L
E
Q
S
T
H
R
H
T
P
E
Site 87
T827
P
L
E
L
E
Q
S
T
H
R
H
T
P
E
T
Site 88
T831
E
Q
S
T
H
R
H
T
P
E
T
E
V
P
P
Site 89
T834
T
H
R
H
T
P
E
T
E
V
P
P
S
N
P
Site 90
T848
P
W
Q
N
W
T
R
T
P
S
P
F
E
D
R
Site 91
S850
Q
N
W
T
R
T
P
S
P
F
E
D
R
T
A
Site 92
T856
P
S
P
F
E
D
R
T
A
F
P
S
K
L
E
Site 93
S860
E
D
R
T
A
F
P
S
K
L
E
T
T
P
T
Site 94
T864
A
F
P
S
K
L
E
T
T
P
T
T
S
P
L
Site 95
T865
F
P
S
K
L
E
T
T
P
T
T
S
P
L
P
Site 96
T867
S
K
L
E
T
T
P
T
T
S
P
L
P
E
R
Site 97
T868
K
L
E
T
T
P
T
T
S
P
L
P
E
R
K
Site 98
S869
L
E
T
T
P
T
T
S
P
L
P
E
R
K
E
Site 99
S881
R
K
E
H
I
K
E
S
T
E
I
P
S
P
F
Site 100
T882
K
E
H
I
K
E
S
T
E
I
P
S
P
F
S
Site 101
S886
K
E
S
T
E
I
P
S
P
F
S
P
G
V
P
Site 102
S889
T
E
I
P
S
P
F
S
P
G
V
P
W
E
Y
Site 103
Y896
S
P
G
V
P
W
E
Y
H
D
S
N
P
N
R
Site 104
S899
V
P
W
E
Y
H
D
S
N
P
N
R
S
L
S
Site 105
S904
H
D
S
N
P
N
R
S
L
S
N
V
F
S
Q
Site 106
S906
S
N
P
N
R
S
L
S
N
V
F
S
Q
I
H
Site 107
S910
R
S
L
S
N
V
F
S
Q
I
H
C
R
P
E
Site 108
S918
Q
I
H
C
R
P
E
S
S
K
G
V
I
S
I
Site 109
S924
E
S
S
K
G
V
I
S
I
S
K
S
T
E
R
Site 110
S926
S
K
G
V
I
S
I
S
K
S
T
E
R
L
S
Site 111
S928
G
V
I
S
I
S
K
S
T
E
R
L
S
P
L
Site 112
T929
V
I
S
I
S
K
S
T
E
R
L
S
P
L
M
Site 113
S933
S
K
S
T
E
R
L
S
P
L
M
K
D
I
K
Site 114
S941
P
L
M
K
D
I
K
S
N
K
F
K
K
S
Q
Site 115
S947
K
S
N
K
F
K
K
S
Q
S
I
D
E
I
D
Site 116
S949
N
K
F
K
K
S
Q
S
I
D
E
I
D
I
G
Site 117
Y961
D
I
G
T
Y
K
V
Y
N
I
P
L
E
N
Y
Site 118
Y968
Y
N
I
P
L
E
N
Y
A
S
G
S
D
H
L
Site 119
S970
I
P
L
E
N
Y
A
S
G
S
D
H
L
G
S
Site 120
S972
L
E
N
Y
A
S
G
S
D
H
L
G
S
H
E
Site 121
S977
S
G
S
D
H
L
G
S
H
E
R
P
D
K
M
Site 122
S992
L
G
P
E
H
G
M
S
S
M
S
R
S
Q
S
Site 123
S993
G
P
E
H
G
M
S
S
M
S
R
S
Q
S
V
Site 124
S995
E
H
G
M
S
S
M
S
R
S
Q
S
V
P
M
Site 125
S997
G
M
S
S
M
S
R
S
Q
S
V
P
M
L
D
Site 126
S999
S
S
M
S
R
S
Q
S
V
P
M
L
D
D
E
Site 127
T1009
M
L
D
D
E
M
L
T
Y
G
S
S
K
G
P
Site 128
Y1010
L
D
D
E
M
L
T
Y
G
S
S
K
G
P
Q
Site 129
S1013
E
M
L
T
Y
G
S
S
K
G
P
Q
Q
Q
K
Site 130
Y1028
A
S
M
T
K
K
V
Y
Q
F
D
Q
S
F
N
Site 131
S1033
K
V
Y
Q
F
D
Q
S
F
N
P
Q
G
S
V
Site 132
S1039
Q
S
F
N
P
Q
G
S
V
E
V
K
A
E
K
Site 133
Y1058
P
F
Q
H
N
P
E
Y
V
Q
Q
A
S
K
N
Site 134
S1072
N
I
A
K
D
L
I
S
P
R
A
Y
R
G
Y
Site 135
Y1076
D
L
I
S
P
R
A
Y
R
G
Y
P
P
M
E
Site 136
Y1079
S
P
R
A
Y
R
G
Y
P
P
M
E
Q
M
F
Site 137
S1087
P
P
M
E
Q
M
F
S
F
S
Q
P
S
V
N
Site 138
S1089
M
E
Q
M
F
S
F
S
Q
P
S
V
N
E
D
Site 139
S1118
G
F
L
R
R
A
D
S
L
V
S
A
T
E
M
Site 140
S1121
R
R
A
D
S
L
V
S
A
T
E
M
A
M
F
Site 141
T1123
A
D
S
L
V
S
A
T
E
M
A
M
F
R
R
Site 142
T1140
E
P
H
E
L
P
P
T
D
R
Y
G
R
P
P
Site 143
Y1143
E
L
P
P
T
D
R
Y
G
R
P
P
Y
R
G
Site 144
Y1148
D
R
Y
G
R
P
P
Y
R
G
G
L
D
R
Q
Site 145
S1156
R
G
G
L
D
R
Q
S
S
V
T
V
T
E
S
Site 146
S1157
G
G
L
D
R
Q
S
S
V
T
V
T
E
S
Q
Site 147
T1159
L
D
R
Q
S
S
V
T
V
T
E
S
Q
F
L
Site 148
T1161
R
Q
S
S
V
T
V
T
E
S
Q
F
L
K
R
Site 149
S1163
S
S
V
T
V
T
E
S
Q
F
L
K
R
N
G
Site 150
Y1172
F
L
K
R
N
G
R
Y
E
D
E
H
P
S
Y
Site 151
Y1179
Y
E
D
E
H
P
S
Y
Q
E
V
K
A
Q
A
Site 152
S1188
E
V
K
A
Q
A
G
S
F
P
V
K
N
L
T
Site 153
T1195
S
F
P
V
K
N
L
T
Q
R
R
P
L
S
A
Site 154
S1201
L
T
Q
R
R
P
L
S
A
R
S
Y
S
T
E
Site 155
S1204
R
R
P
L
S
A
R
S
Y
S
T
E
S
Y
G
Site 156
Y1205
R
P
L
S
A
R
S
Y
S
T
E
S
Y
G
A
Site 157
S1206
P
L
S
A
R
S
Y
S
T
E
S
Y
G
A
S
Site 158
T1207
L
S
A
R
S
Y
S
T
E
S
Y
G
A
S
Q
Site 159
S1209
A
R
S
Y
S
T
E
S
Y
G
A
S
Q
T
R
Site 160
Y1210
R
S
Y
S
T
E
S
Y
G
A
S
Q
T
R
P
Site 161
S1213
S
T
E
S
Y
G
A
S
Q
T
R
P
V
S
A
Site 162
T1215
E
S
Y
G
A
S
Q
T
R
P
V
S
A
R
P
Site 163
S1219
A
S
Q
T
R
P
V
S
A
R
P
T
M
A
A
Site 164
T1223
R
P
V
S
A
R
P
T
M
A
A
L
L
E
K
Site 165
S1233
A
L
L
E
K
I
P
S
D
Y
N
L
G
N
Y
Site 166
Y1235
L
E
K
I
P
S
D
Y
N
L
G
N
Y
G
D
Site 167
Y1240
S
D
Y
N
L
G
N
Y
G
D
K
P
S
D
N
Site 168
S1245
G
N
Y
G
D
K
P
S
D
N
S
D
L
K
T
Site 169
T1252
S
D
N
S
D
L
K
T
R
P
T
P
V
K
G
Site 170
T1255
S
D
L
K
T
R
P
T
P
V
K
G
E
E
S
Site 171
T1293
N
A
A
Y
K
H
N
T
V
N
L
G
M
L
P
Site 172
T1314
M
H
A
G
R
S
M
T
L
N
L
Q
T
K
S
Site 173
T1319
S
M
T
L
N
L
Q
T
K
S
K
F
D
H
Q
Site 174
T1333
Q
E
L
P
L
Q
K
T
P
S
Q
Q
S
N
I
Site 175
S1335
L
P
L
Q
K
T
P
S
Q
Q
S
N
I
L
D
Site 176
S1349
D
N
G
Q
E
D
V
S
P
S
G
Q
W
N
P
Site 177
S1351
G
Q
E
D
V
S
P
S
G
Q
W
N
P
Y
P
Site 178
Y1357
P
S
G
Q
W
N
P
Y
P
L
G
R
R
D
V
Site 179
T1368
R
R
D
V
P
P
D
T
I
T
K
K
A
G
S
Site 180
T1370
D
V
P
P
D
T
I
T
K
K
A
G
S
H
I
Site 181
S1375
T
I
T
K
K
A
G
S
H
I
Q
T
L
M
G
Site 182
T1379
K
A
G
S
H
I
Q
T
L
M
G
S
Q
S
L
Site 183
S1383
H
I
Q
T
L
M
G
S
Q
S
L
Q
H
R
S
Site 184
S1385
Q
T
L
M
G
S
Q
S
L
Q
H
R
S
R
E
Site 185
S1390
S
Q
S
L
Q
H
R
S
R
E
Q
Q
P
Y
E
Site 186
Y1396
R
S
R
E
Q
Q
P
Y
E
G
N
I
N
K
V
Site 187
S1419
L
P
I
Q
I
P
S
S
Q
A
T
R
G
P
Q
Site 188
T1422
Q
I
P
S
S
Q
A
T
R
G
P
Q
P
G
R
Site 189
T1434
P
G
R
C
L
I
Q
T
K
G
Q
R
S
M
D
Site 190
S1439
I
Q
T
K
G
Q
R
S
M
D
G
Y
P
E
Q
Site 191
Y1443
G
Q
R
S
M
D
G
Y
P
E
Q
F
C
V
R
Site 192
S1460
K
N
P
G
L
G
F
S
I
S
G
G
I
S
G
Site 193
S1466
F
S
I
S
G
G
I
S
G
Q
G
N
P
F
K
Site 194
S1491
V
Q
P
D
G
P
A
S
N
L
L
Q
P
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation