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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NT5C1B
Full Name:
Cytosolic 5'-nucleotidase 1B
Alias:
5' nucleotidase, cytosolic IB; 5NT1B; AIRP; CN-IB
Type:
Hydrolase; EC 3.1.3.5; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide
Mass (Da):
68804
Number AA:
610
UniProt ID:
Q96P26
International Prot ID:
IPI00410373
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008253
GO:0000287
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0009117
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Q
T
S
L
K
Q
K
Site 2
T4
_
_
_
_
M
S
Q
T
S
L
K
Q
K
K
N
Site 3
S17
K
N
E
P
G
M
R
S
S
K
E
S
L
E
A
Site 4
S18
N
E
P
G
M
R
S
S
K
E
S
L
E
A
E
Site 5
S21
G
M
R
S
S
K
E
S
L
E
A
E
K
R
K
Site 6
S30
E
A
E
K
R
K
E
S
D
K
T
G
V
R
L
Site 7
T33
K
R
K
E
S
D
K
T
G
V
R
L
S
N
Q
Site 8
S38
D
K
T
G
V
R
L
S
N
Q
M
R
R
A
V
Site 9
Y83
P
C
H
T
I
R
I
Y
I
H
M
C
L
L
W
Site 10
S102
Q
I
T
M
M
R
G
S
Q
E
S
S
L
R
K
Site 11
S105
M
M
R
G
S
Q
E
S
S
L
R
K
T
D
S
Site 12
S106
M
R
G
S
Q
E
S
S
L
R
K
T
D
S
R
Site 13
T110
Q
E
S
S
L
R
K
T
D
S
R
G
Y
L
V
Site 14
S112
S
S
L
R
K
T
D
S
R
G
Y
L
V
R
S
Site 15
Y115
R
K
T
D
S
R
G
Y
L
V
R
S
Q
W
S
Site 16
S119
S
R
G
Y
L
V
R
S
Q
W
S
R
I
S
R
Site 17
S125
R
S
Q
W
S
R
I
S
R
S
P
S
T
K
A
Site 18
S127
Q
W
S
R
I
S
R
S
P
S
T
K
A
P
S
Site 19
S129
S
R
I
S
R
S
P
S
T
K
A
P
S
I
D
Site 20
T130
R
I
S
R
S
P
S
T
K
A
P
S
I
D
E
Site 21
S134
S
P
S
T
K
A
P
S
I
D
E
P
R
S
R
Site 22
S140
P
S
I
D
E
P
R
S
R
N
T
S
A
K
L
Site 23
T143
D
E
P
R
S
R
N
T
S
A
K
L
P
S
S
Site 24
S144
E
P
R
S
R
N
T
S
A
K
L
P
S
S
S
Site 25
S149
N
T
S
A
K
L
P
S
S
S
T
S
S
R
T
Site 26
S150
T
S
A
K
L
P
S
S
S
T
S
S
R
T
P
Site 27
S151
S
A
K
L
P
S
S
S
T
S
S
R
T
P
S
Site 28
T152
A
K
L
P
S
S
S
T
S
S
R
T
P
S
T
Site 29
S153
K
L
P
S
S
S
T
S
S
R
T
P
S
T
S
Site 30
S154
L
P
S
S
S
T
S
S
R
T
P
S
T
S
P
Site 31
T156
S
S
S
T
S
S
R
T
P
S
T
S
P
S
L
Site 32
S158
S
T
S
S
R
T
P
S
T
S
P
S
L
H
D
Site 33
T159
T
S
S
R
T
P
S
T
S
P
S
L
H
D
S
Site 34
S160
S
S
R
T
P
S
T
S
P
S
L
H
D
S
S
Site 35
S162
R
T
P
S
T
S
P
S
L
H
D
S
S
P
P
Site 36
S166
T
S
P
S
L
H
D
S
S
P
P
P
L
S
G
Site 37
S167
S
P
S
L
H
D
S
S
P
P
P
L
S
G
Q
Site 38
S172
D
S
S
P
P
P
L
S
G
Q
P
S
L
Q
P
Site 39
S176
P
P
L
S
G
Q
P
S
L
Q
P
P
A
S
P
Site 40
S182
P
S
L
Q
P
P
A
S
P
Q
L
P
R
S
L
Site 41
S188
A
S
P
Q
L
P
R
S
L
D
S
R
P
P
T
Site 42
S191
Q
L
P
R
S
L
D
S
R
P
P
T
P
P
E
Site 43
T195
S
L
D
S
R
P
P
T
P
P
E
P
D
P
G
Site 44
S203
P
P
E
P
D
P
G
S
R
R
S
T
K
M
Q
Site 45
S206
P
D
P
G
S
R
R
S
T
K
M
Q
E
N
P
Site 46
T207
D
P
G
S
R
R
S
T
K
M
Q
E
N
P
E
Site 47
T227
I
V
R
E
I
R
Q
T
R
D
S
Q
P
L
E
Site 48
S230
E
I
R
Q
T
R
D
S
Q
P
L
E
Y
S
R
Site 49
Y235
R
D
S
Q
P
L
E
Y
S
R
T
S
P
T
E
Site 50
S236
D
S
Q
P
L
E
Y
S
R
T
S
P
T
E
W
Site 51
T238
Q
P
L
E
Y
S
R
T
S
P
T
E
W
K
S
Site 52
S239
P
L
E
Y
S
R
T
S
P
T
E
W
K
S
S
Site 53
T241
E
Y
S
R
T
S
P
T
E
W
K
S
S
S
Q
Site 54
S246
S
P
T
E
W
K
S
S
S
Q
R
R
G
I
Y
Site 55
S247
P
T
E
W
K
S
S
S
Q
R
R
G
I
Y
P
Site 56
Y253
S
S
Q
R
R
G
I
Y
P
A
S
T
Q
L
D
Site 57
S256
R
R
G
I
Y
P
A
S
T
Q
L
D
R
N
S
Site 58
T257
R
G
I
Y
P
A
S
T
Q
L
D
R
N
S
L
Site 59
S263
S
T
Q
L
D
R
N
S
L
S
E
Q
Q
Q
Q
Site 60
S265
Q
L
D
R
N
S
L
S
E
Q
Q
Q
Q
Q
R
Site 61
Y278
Q
R
E
D
E
D
D
Y
E
A
A
Y
W
A
S
Site 62
Y282
E
D
D
Y
E
A
A
Y
W
A
S
M
R
S
F
Site 63
S288
A
Y
W
A
S
M
R
S
F
Y
E
K
N
P
S
Site 64
Y290
W
A
S
M
R
S
F
Y
E
K
N
P
S
C
S
Site 65
S295
S
F
Y
E
K
N
P
S
C
S
R
P
W
P
P
Site 66
S297
Y
E
K
N
P
S
C
S
R
P
W
P
P
K
P
Site 67
Y327
M
V
D
G
R
K
I
Y
E
Q
E
G
L
E
K
Site 68
Y335
E
Q
E
G
L
E
K
Y
M
E
Y
Q
L
T
N
Site 69
T341
K
Y
M
E
Y
Q
L
T
N
E
N
V
I
L
T
Site 70
T348
T
N
E
N
V
I
L
T
P
G
P
A
F
R
F
Site 71
Y361
R
F
V
K
A
L
Q
Y
V
N
A
R
L
R
D
Site 72
Y370
N
A
R
L
R
D
L
Y
P
D
E
Q
D
L
F
Site 73
Y418
G
G
K
D
P
I
G
Y
L
K
A
Y
L
T
N
Site 74
Y427
K
A
Y
L
T
N
L
Y
I
A
A
D
S
E
K
Site 75
S432
N
L
Y
I
A
A
D
S
E
K
V
Q
E
A
I
Site 76
Y457
D
G
A
K
D
M
A
Y
C
D
T
Q
L
R
V
Site 77
S474
D
G
D
A
V
L
F
S
D
E
S
E
H
F
T
Site 78
S477
A
V
L
F
S
D
E
S
E
H
F
T
K
E
H
Site 79
T481
S
D
E
S
E
H
F
T
K
E
H
G
L
D
K
Site 80
Y492
G
L
D
K
F
F
Q
Y
D
T
L
C
E
S
K
Site 81
T494
D
K
F
F
Q
Y
D
T
L
C
E
S
K
P
L
Site 82
Y521
G
R
L
Q
K
K
F
Y
A
K
N
E
R
L
L
Site 83
T537
P
I
R
T
Y
L
V
T
A
R
S
A
A
S
S
Site 84
S540
T
Y
L
V
T
A
R
S
A
A
S
S
G
A
R
Site 85
S544
T
A
R
S
A
A
S
S
G
A
R
V
L
K
T
Site 86
T551
S
G
A
R
V
L
K
T
L
R
R
W
G
L
E
Site 87
S598
E
G
A
Q
R
L
G
S
I
A
A
Y
G
F
N
Site 88
Y602
R
L
G
S
I
A
A
Y
G
F
N
K
K
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation