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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AGAP3
Full Name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Alias:
AGAP-3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3; CEG3; CENG3; Centaurin gamma 3; Centaurin-gamma 3; CENTG3; CRAG; CRAM-associated GTPase; MR1-interacting protein; MRIP-1
Type:
GTPase-activating protein for G protein
Mass (Da):
95044
Number AA:
875
UniProt ID:
Q96P47
International Prot ID:
IPI00163185
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005083
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
F
Q
A
G
G
G
Q
S
P
Q
Q
Q
Q
Q
L
Site 2
S28
P
P
Q
Q
F
A
L
S
N
S
A
A
I
R
A
Site 3
S42
A
E
I
Q
R
F
E
S
V
H
P
N
I
Y
A
Site 4
S72
Q
I
R
E
H
V
I
S
I
E
D
S
F
V
N
Site 5
S76
H
V
I
S
I
E
D
S
F
V
N
S
Q
E
W
Site 6
S80
I
E
D
S
F
V
N
S
Q
E
W
T
L
S
R
Site 7
T84
F
V
N
S
Q
E
W
T
L
S
R
S
V
P
E
Site 8
S86
N
S
Q
E
W
T
L
S
R
S
V
P
E
L
K
Site 9
S88
Q
E
W
T
L
S
R
S
V
P
E
L
K
V
G
Site 10
S105
G
N
L
S
S
G
K
S
A
L
V
H
R
Y
L
Site 11
Y111
K
S
A
L
V
H
R
Y
L
T
G
T
Y
V
Q
Site 12
T113
A
L
V
H
R
Y
L
T
G
T
Y
V
Q
E
E
Site 13
T115
V
H
R
Y
L
T
G
T
Y
V
Q
E
E
S
P
Site 14
Y116
H
R
Y
L
T
G
T
Y
V
Q
E
E
S
P
E
Site 15
S121
G
T
Y
V
Q
E
E
S
P
E
G
G
R
F
K
Site 16
T174
E
D
E
I
S
F
Q
T
V
Y
N
Y
F
L
R
Site 17
S184
N
Y
F
L
R
L
C
S
F
R
N
A
S
E
V
Site 18
S213
N
P
R
V
I
D
D
S
R
A
R
K
L
S
T
Site 19
S219
D
S
R
A
R
K
L
S
T
D
L
K
R
C
T
Site 20
T220
S
R
A
R
K
L
S
T
D
L
K
R
C
T
Y
Site 21
T226
S
T
D
L
K
R
C
T
Y
Y
E
T
C
A
T
Site 22
Y227
T
D
L
K
R
C
T
Y
Y
E
T
C
A
T
Y
Site 23
Y228
D
L
K
R
C
T
Y
Y
E
T
C
A
T
Y
G
Site 24
T233
T
Y
Y
E
T
C
A
T
Y
G
L
N
V
E
R
Site 25
S265
L
A
I
G
P
C
K
S
L
P
N
S
P
S
H
Site 26
S269
P
C
K
S
L
P
N
S
P
S
H
S
A
V
S
Site 27
S271
K
S
L
P
N
S
P
S
H
S
A
V
S
A
A
Site 28
S273
L
P
N
S
P
S
H
S
A
V
S
A
A
S
I
Site 29
S297
N
G
G
G
S
A
F
S
D
Y
S
S
S
V
P
Site 30
Y299
G
G
S
A
F
S
D
Y
S
S
S
V
P
S
T
Site 31
S300
G
S
A
F
S
D
Y
S
S
S
V
P
S
T
P
Site 32
S301
S
A
F
S
D
Y
S
S
S
V
P
S
T
P
S
Site 33
S302
A
F
S
D
Y
S
S
S
V
P
S
T
P
S
I
Site 34
S305
D
Y
S
S
S
V
P
S
T
P
S
I
S
Q
R
Site 35
T306
Y
S
S
S
V
P
S
T
P
S
I
S
Q
R
E
Site 36
S308
S
S
V
P
S
T
P
S
I
S
Q
R
E
L
R
Site 37
S310
V
P
S
T
P
S
I
S
Q
R
E
L
R
I
E
Site 38
T318
Q
R
E
L
R
I
E
T
I
A
A
S
S
T
P
Site 39
S322
R
I
E
T
I
A
A
S
S
T
P
T
P
I
R
Site 40
S323
I
E
T
I
A
A
S
S
T
P
T
P
I
R
K
Site 41
T324
E
T
I
A
A
S
S
T
P
T
P
I
R
K
Q
Site 42
T326
I
A
A
S
S
T
P
T
P
I
R
K
Q
S
K
Site 43
S332
P
T
P
I
R
K
Q
S
K
R
R
S
N
I
F
Site 44
S336
R
K
Q
S
K
R
R
S
N
I
F
T
S
R
K
Site 45
T340
K
R
R
S
N
I
F
T
S
R
K
G
A
D
L
Site 46
S341
R
R
S
N
I
F
T
S
R
K
G
A
D
L
D
Site 47
S381
L
L
K
R
S
G
K
S
L
N
K
E
W
K
K
Site 48
Y390
N
K
E
W
K
K
K
Y
V
T
L
C
D
N
G
Site 49
T392
E
W
K
K
K
Y
V
T
L
C
D
N
G
L
L
Site 50
T400
L
C
D
N
G
L
L
T
Y
H
P
S
L
H
D
Site 51
Y408
Y
H
P
S
L
H
D
Y
M
Q
N
I
H
G
K
Site 52
T423
E
I
D
L
L
R
T
T
V
K
V
P
G
K
R
Site 53
T435
G
K
R
L
P
R
A
T
P
A
T
A
P
G
T
Site 54
T438
L
P
R
A
T
P
A
T
A
P
G
T
S
P
R
Site 55
T442
T
P
A
T
A
P
G
T
S
P
R
A
N
G
L
Site 56
S443
P
A
T
A
P
G
T
S
P
R
A
N
G
L
S
Site 57
S450
S
P
R
A
N
G
L
S
V
E
R
S
N
T
Q
Site 58
S454
N
G
L
S
V
E
R
S
N
T
Q
L
G
G
G
Site 59
T456
L
S
V
E
R
S
N
T
Q
L
G
G
G
T
G
Site 60
S467
G
G
T
G
A
P
H
S
A
S
S
A
S
L
H
Site 61
S469
T
G
A
P
H
S
A
S
S
A
S
L
H
S
E
Site 62
S470
G
A
P
H
S
A
S
S
A
S
L
H
S
E
R
Site 63
S472
P
H
S
A
S
S
A
S
L
H
S
E
R
P
L
Site 64
S475
A
S
S
A
S
L
H
S
E
R
P
L
S
S
S
Site 65
S480
L
H
S
E
R
P
L
S
S
S
A
W
A
G
P
Site 66
S482
S
E
R
P
L
S
S
S
A
W
A
G
P
R
P
Site 67
S496
P
E
G
L
H
Q
R
S
C
S
V
S
S
A
D
Site 68
S498
G
L
H
Q
R
S
C
S
V
S
S
A
D
Q
W
Site 69
S500
H
Q
R
S
C
S
V
S
S
A
D
Q
W
S
E
Site 70
S506
V
S
S
A
D
Q
W
S
E
A
T
T
S
L
P
Site 71
T510
D
Q
W
S
E
A
T
T
S
L
P
P
G
M
Q
Site 72
S511
Q
W
S
E
A
T
T
S
L
P
P
G
M
Q
H
Site 73
S521
P
G
M
Q
H
P
A
S
G
P
A
E
V
L
S
Site 74
S528
S
G
P
A
E
V
L
S
S
S
P
K
L
D
P
Site 75
S529
G
P
A
E
V
L
S
S
S
P
K
L
D
P
P
Site 76
S530
P
A
E
V
L
S
S
S
P
K
L
D
P
P
P
Site 77
S538
P
K
L
D
P
P
P
S
P
H
S
N
R
K
K
Site 78
S541
D
P
P
P
S
P
H
S
N
R
K
K
H
R
R
Site 79
S551
K
K
H
R
R
K
K
S
T
G
T
P
R
P
D
Site 80
T552
K
H
R
R
K
K
S
T
G
T
P
R
P
D
G
Site 81
T554
R
R
K
K
S
T
G
T
P
R
P
D
G
P
S
Site 82
S561
T
P
R
P
D
G
P
S
S
A
T
E
E
A
E
Site 83
S562
P
R
P
D
G
P
S
S
A
T
E
E
A
E
E
Site 84
S570
A
T
E
E
A
E
E
S
F
E
F
V
V
V
S
Site 85
S613
A
S
L
Q
G
C
R
S
A
K
D
K
T
R
L
Site 86
S639
V
R
T
V
R
G
N
S
F
C
I
D
C
D
A
Site 87
S676
R
H
L
G
A
H
L
S
R
V
R
S
L
D
L
Site 88
S680
A
H
L
S
R
V
R
S
L
D
L
D
D
W
P
Site 89
Y713
W
E
G
A
L
G
G
Y
S
K
P
G
P
D
A
Site 90
S714
E
G
A
L
G
G
Y
S
K
P
G
P
D
A
C
Site 91
Y733
E
R
W
I
R
A
K
Y
E
Q
K
L
F
L
A
Site 92
S773
V
M
L
L
A
H
G
S
K
E
E
V
N
E
T
Site 93
T780
S
K
E
E
V
N
E
T
Y
G
D
G
D
G
R
Site 94
T788
Y
G
D
G
D
G
R
T
A
L
H
L
S
S
A
Site 95
T821
S
R
D
A
R
G
L
T
P
L
A
Y
A
R
R
Site 96
Y825
R
G
L
T
P
L
A
Y
A
R
R
A
G
S
Q
Site 97
S831
A
Y
A
R
R
A
G
S
Q
E
C
A
D
I
L
Site 98
T853
E
G
C
G
L
A
P
T
P
N
R
E
P
A
N
Site 99
S865
P
A
N
G
T
N
P
S
A
E
L
H
R
S
P
Site 100
S871
P
S
A
E
L
H
R
S
P
S
L
L
_
_
_
Site 101
S873
A
E
L
H
R
S
P
S
L
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation