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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARAP1
Full Name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alias:
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1; Centaurin-delta 2; Centaurin-delta-2
Type:
GTPase-activating protein for G protein
Mass (Da):
162192
Number AA:
1450
UniProt ID:
Q96P48
International Prot ID:
IPI00479190
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005100
GO:0005547
PhosphoSite+
KinaseNET
Biological Process:
GO:0030037
GO:0051497
GO:0043089
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
R
A
L
H
L
E
Q
Y
T
G
L
F
E
Q
H
Site 2
S42
A
T
E
C
Q
G
L
S
D
T
R
L
M
D
M
Site 3
T69
A
G
L
L
R
A
H
T
S
P
A
P
A
P
R
Site 4
S70
G
L
L
R
A
H
T
S
P
A
P
A
P
R
P
Site 5
T78
P
A
P
A
P
R
P
T
P
R
P
V
P
M
K
Site 6
S91
M
K
R
H
I
F
R
S
P
P
V
P
A
T
P
Site 7
T97
R
S
P
P
V
P
A
T
P
P
E
P
L
P
T
Site 8
T104
T
P
P
E
P
L
P
T
T
T
E
D
E
G
L
Site 9
T105
P
P
E
P
L
P
T
T
T
E
D
E
G
L
P
Site 10
S122
P
P
I
P
P
R
R
S
C
L
P
P
T
C
F
Site 11
T127
R
R
S
C
L
P
P
T
C
F
T
T
P
S
T
Site 12
T131
L
P
P
T
C
F
T
T
P
S
T
A
A
P
D
Site 13
S154
K
R
H
L
A
E
L
S
V
P
P
V
P
P
R
Site 14
T162
V
P
P
V
P
P
R
T
G
P
P
R
L
L
V
Site 15
S170
G
P
P
R
L
L
V
S
L
P
T
K
E
E
E
Site 16
S178
L
P
T
K
E
E
E
S
L
L
P
S
L
S
S
Site 17
S182
E
E
E
S
L
L
P
S
L
S
S
P
P
Q
P
Site 18
S184
E
S
L
L
P
S
L
S
S
P
P
Q
P
Q
S
Site 19
S185
S
L
L
P
S
L
S
S
P
P
Q
P
Q
S
E
Site 20
S191
S
S
P
P
Q
P
Q
S
E
E
P
L
S
T
L
Site 21
S196
P
Q
S
E
E
P
L
S
T
L
P
Q
G
P
P
Site 22
T197
Q
S
E
E
P
L
S
T
L
P
Q
G
P
P
Q
Site 23
S207
Q
G
P
P
Q
P
P
S
P
P
P
C
P
P
E
Site 24
S229
L
F
P
E
F
D
D
S
D
Y
D
E
V
P
E
Site 25
Y231
P
E
F
D
D
S
D
Y
D
E
V
P
E
E
G
Site 26
T247
G
A
P
A
R
V
M
T
K
K
E
E
P
P
P
Site 27
S255
K
K
E
E
P
P
P
S
R
V
P
R
A
V
R
Site 28
S265
P
R
A
V
R
V
A
S
L
L
S
E
G
E
E
Site 29
Y288
E
E
E
D
D
H
A
Y
E
G
V
P
N
G
G
Site 30
T298
V
P
N
G
G
W
H
T
S
S
L
S
L
S
L
Site 31
S299
P
N
G
G
W
H
T
S
S
L
S
L
S
L
P
Site 32
S300
N
G
G
W
H
T
S
S
L
S
L
S
L
P
S
Site 33
S302
G
W
H
T
S
S
L
S
L
S
L
P
S
T
I
Site 34
T323
D
G
P
P
G
G
S
T
P
V
T
P
V
I
K
Site 35
Y345
P
P
Q
G
S
Y
I
Y
Q
K
R
W
V
R
L
Site 36
T354
K
R
W
V
R
L
D
T
D
H
L
R
Y
F
D
Site 37
S362
D
H
L
R
Y
F
D
S
N
K
D
A
Y
S
K
Site 38
Y367
F
D
S
N
K
D
A
Y
S
K
R
F
I
S
V
Site 39
S368
D
S
N
K
D
A
Y
S
K
R
F
I
S
V
A
Site 40
T396
E
V
I
T
N
N
R
T
F
A
F
R
A
E
S
Site 41
S403
T
F
A
F
R
A
E
S
D
V
E
R
K
E
W
Site 42
S428
Q
R
A
R
A
R
L
S
S
A
Y
L
L
G
V
Site 43
Y431
R
A
R
L
S
S
A
Y
L
L
G
V
P
G
S
Site 44
S438
Y
L
L
G
V
P
G
S
E
Q
P
D
R
A
G
Site 45
S446
E
Q
P
D
R
A
G
S
L
E
L
R
G
F
K
Site 46
Y457
R
G
F
K
N
K
L
Y
V
A
V
V
G
D
K
Site 47
Y468
V
G
D
K
V
Q
L
Y
K
N
L
E
E
Y
H
Site 48
Y474
L
Y
K
N
L
E
E
Y
H
L
G
I
G
I
T
Site 49
S497
V
K
E
V
D
R
R
S
F
D
L
T
T
P
Y
Site 50
T501
D
R
R
S
F
D
L
T
T
P
Y
R
I
F
S
Site 51
T502
R
R
S
F
D
L
T
T
P
Y
R
I
F
S
F
Site 52
Y504
S
F
D
L
T
T
P
Y
R
I
F
S
F
S
A
Site 53
S508
T
T
P
Y
R
I
F
S
F
S
A
D
S
E
L
Site 54
S510
P
Y
R
I
F
S
F
S
A
D
S
E
L
E
K
Site 55
S513
I
F
S
F
S
A
D
S
E
L
E
K
E
Q
W
Site 56
S533
G
A
I
A
E
A
L
S
T
S
E
V
A
E
R
Site 57
S585
R
G
L
G
A
G
V
S
K
V
R
S
L
K
M
Site 58
S589
A
G
V
S
K
V
R
S
L
K
M
D
R
K
V
Site 59
S624
W
A
A
N
V
P
P
S
E
A
L
Q
P
S
S
Site 60
S630
P
S
E
A
L
Q
P
S
S
S
P
S
T
R
R
Site 61
S631
S
E
A
L
Q
P
S
S
S
P
S
T
R
R
C
Site 62
S632
E
A
L
Q
P
S
S
S
P
S
T
R
R
C
H
Site 63
S634
L
Q
P
S
S
S
P
S
T
R
R
C
H
L
E
Site 64
T635
Q
P
S
S
S
P
S
T
R
R
C
H
L
E
A
Site 65
Y644
R
C
H
L
E
A
K
Y
R
E
G
K
Y
R
R
Site 66
Y649
A
K
Y
R
E
G
K
Y
R
R
Y
H
P
L
F
Site 67
Y652
R
E
G
K
Y
R
R
Y
H
P
L
F
G
N
Q
Site 68
T699
S
G
D
P
E
A
P
T
P
L
A
L
A
E
Q
Site 69
T722
F
L
R
N
N
R
T
T
E
V
P
R
L
D
S
Site 70
S729
T
E
V
P
R
L
D
S
M
K
P
L
E
K
H
Site 71
Y737
M
K
P
L
E
K
H
Y
S
V
V
L
P
T
V
Site 72
S738
K
P
L
E
K
H
Y
S
V
V
L
P
T
V
S
Site 73
T743
H
Y
S
V
V
L
P
T
V
S
H
S
G
F
L
Site 74
Y751
V
S
H
S
G
F
L
Y
K
T
A
S
A
G
K
Site 75
S755
G
F
L
Y
K
T
A
S
A
G
K
L
L
Q
D
Site 76
S770
R
R
A
R
E
E
F
S
R
R
W
C
V
L
G
Site 77
S782
V
L
G
D
G
V
L
S
Y
F
E
N
E
R
A
Site 78
Y783
L
G
D
G
V
L
S
Y
F
E
N
E
R
A
V
Site 79
T791
F
E
N
E
R
A
V
T
P
N
G
E
I
R
A
Site 80
T811
L
A
V
P
P
P
D
T
H
G
F
E
H
T
F
Site 81
T817
D
T
H
G
F
E
H
T
F
E
V
Y
T
E
G
Site 82
Y828
Y
T
E
G
E
R
L
Y
L
F
G
L
E
S
A
Site 83
Y870
E
R
L
G
R
L
P
Y
K
A
G
L
S
L
Q
Site 84
S875
L
P
Y
K
A
G
L
S
L
Q
R
A
Q
E
G
Site 85
S885
R
A
Q
E
G
W
F
S
L
S
G
S
E
L
R
Site 86
S887
Q
E
G
W
F
S
L
S
G
S
E
L
R
A
V
Site 87
S913
L
R
K
L
Q
E
L
S
I
Q
G
D
S
E
N
Site 88
T931
V
L
V
E
R
R
R
T
L
Y
I
Q
G
E
R
Site 89
Y933
V
E
R
R
R
T
L
Y
I
Q
G
E
R
R
L
Site 90
T959
A
A
A
S
M
G
D
T
L
S
E
Q
Q
L
G
Site 91
S961
A
S
M
G
D
T
L
S
E
Q
Q
L
G
D
S
Site 92
S968
S
E
Q
Q
L
G
D
S
D
I
P
V
I
V
Y
Site 93
Y975
S
D
I
P
V
I
V
Y
R
C
V
D
Y
I
T
Site 94
Y992
G
L
T
S
E
G
I
Y
R
K
C
G
Q
T
S
Site 95
T1001
K
C
G
Q
T
S
K
T
Q
R
L
L
E
S
L
Site 96
S1007
K
T
Q
R
L
L
E
S
L
R
Q
D
A
R
S
Site 97
S1014
S
L
R
Q
D
A
R
S
V
H
L
K
E
G
E
Site 98
S1028
E
Q
H
V
D
D
V
S
S
A
L
K
R
F
L
Site 99
T1050
F
T
R
A
Q
R
L
T
W
L
E
A
S
E
I
Site 100
S1065
E
D
E
E
E
K
V
S
R
Y
R
E
L
L
V
Site 101
Y1122
F
Q
T
D
G
Q
D
Y
K
A
G
R
V
V
E
Site 102
S1140
N
H
Y
V
V
V
F
S
V
D
E
E
E
L
R
Site 103
T1177
H
A
G
D
F
I
C
T
V
Y
L
E
E
K
K
Site 104
Y1179
G
D
F
I
C
T
V
Y
L
E
E
K
K
A
E
Site 105
S1196
Q
H
I
K
V
P
A
S
M
T
A
E
E
L
T
Site 106
Y1219
V
G
I
R
E
K
D
Y
W
T
C
F
E
V
N
Site 107
S1252
L
H
G
L
G
T
D
S
H
L
V
V
K
K
H
Site 108
S1288
M
K
F
R
E
D
R
S
L
L
G
L
G
L
P
Site 109
Y1303
S
G
G
F
H
D
R
Y
F
I
L
N
S
S
C
Site 110
S1308
D
R
Y
F
I
L
N
S
S
C
L
R
L
Y
K
Site 111
S1309
R
Y
F
I
L
N
S
S
C
L
R
L
Y
K
E
Site 112
Y1314
N
S
S
C
L
R
L
Y
K
E
V
R
S
Q
R
Site 113
S1319
R
L
Y
K
E
V
R
S
Q
R
P
W
S
G
A
Site 114
S1324
V
R
S
Q
R
P
W
S
G
A
P
E
T
S
H
Site 115
S1330
W
S
G
A
P
E
T
S
H
R
P
E
K
E
W
Site 116
S1341
E
K
E
W
P
I
K
S
L
K
V
Y
L
G
V
Site 117
Y1345
P
I
K
S
L
K
V
Y
L
G
V
K
K
K
L
Site 118
T1356
K
K
K
L
R
P
P
T
C
W
G
F
T
V
V
Site 119
S1403
H
D
G
L
V
W
P
S
E
P
S
R
V
S
R
Site 120
S1409
P
S
E
P
S
R
V
S
R
A
V
P
E
V
R
Site 121
S1419
V
P
E
V
R
L
G
S
V
S
L
I
P
L
R
Site 122
S1428
S
L
I
P
L
R
G
S
E
N
E
M
R
R
S
Site 123
S1435
S
E
N
E
M
R
R
S
V
A
A
F
T
A
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation