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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AGAP4
Full Name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
Alias:
Centaurin-gamma-like family member 1
Type:
Mass (Da):
73070
Number AA:
663
UniProt ID:
Q96P64
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
L
T
C
R
V
H
P
S
V
S
L
E
F
D
Q
Site 2
S23
E
F
D
Q
Q
Q
G
S
V
C
P
S
E
S
E
Site 3
S27
Q
Q
G
S
V
C
P
S
E
S
E
I
Y
E
A
Site 4
S29
G
S
V
C
P
S
E
S
E
I
Y
E
A
G
A
Site 5
Y32
C
P
S
E
S
E
I
Y
E
A
G
A
G
D
R
Site 6
S81
E
A
L
E
F
N
P
S
A
N
P
E
A
S
T
Site 7
S94
S
T
I
F
Q
R
N
S
Q
T
D
V
V
E
I
Site 8
S104
D
V
V
E
I
R
R
S
N
C
T
N
H
V
S
Site 9
T107
E
I
R
R
S
N
C
T
N
H
V
S
T
V
R
Site 10
T112
N
C
T
N
H
V
S
T
V
R
F
S
Q
Q
Y
Site 11
S116
H
V
S
T
V
R
F
S
Q
Q
Y
S
L
C
S
Site 12
T124
Q
Q
Y
S
L
C
S
T
I
F
L
D
D
S
T
Site 13
T153
L
E
I
P
H
H
I
T
Q
R
D
A
D
R
S
Site 14
S160
T
Q
R
D
A
D
R
S
L
S
I
P
D
E
Q
Site 15
S162
R
D
A
D
R
S
L
S
I
P
D
E
Q
L
H
Site 16
S170
I
P
D
E
Q
L
H
S
F
A
V
S
T
V
H
Site 17
S187
K
K
R
N
G
G
G
S
L
N
N
Y
S
S
S
Site 18
Y191
G
G
G
S
L
N
N
Y
S
S
S
I
P
S
T
Site 19
S192
G
G
S
L
N
N
Y
S
S
S
I
P
S
T
P
Site 20
S193
G
S
L
N
N
Y
S
S
S
I
P
S
T
P
S
Site 21
S194
S
L
N
N
Y
S
S
S
I
P
S
T
P
S
T
Site 22
S197
N
Y
S
S
S
I
P
S
T
P
S
T
S
Q
E
Site 23
T198
Y
S
S
S
I
P
S
T
P
S
T
S
Q
E
D
Site 24
S200
S
S
I
P
S
T
P
S
T
S
Q
E
D
P
Q
Site 25
T201
S
I
P
S
T
P
S
T
S
Q
E
D
P
Q
F
Site 26
S202
I
P
S
T
P
S
T
S
Q
E
D
P
Q
F
S
Site 27
S209
S
Q
E
D
P
Q
F
S
V
P
P
T
A
N
T
Site 28
T213
P
Q
F
S
V
P
P
T
A
N
T
P
T
P
V
Site 29
T216
S
V
P
P
T
A
N
T
P
T
P
V
C
K
R
Site 30
T218
P
P
T
A
N
T
P
T
P
V
C
K
R
S
M
Site 31
S228
C
K
R
S
M
R
W
S
N
L
F
T
S
E
K
Site 32
T232
M
R
W
S
N
L
F
T
S
E
K
G
S
D
P
Site 33
S233
R
W
S
N
L
F
T
S
E
K
G
S
D
P
D
Site 34
S237
L
F
T
S
E
K
G
S
D
P
D
K
E
R
K
Site 35
T252
A
P
E
N
H
A
D
T
I
G
S
G
R
A
I
Site 36
S255
N
H
A
D
T
I
G
S
G
R
A
I
P
I
K
Site 37
T276
R
S
G
K
W
L
K
T
W
K
K
K
Y
V
T
Site 38
Y281
L
K
T
W
K
K
K
Y
V
T
L
C
S
N
G
Site 39
T283
T
W
K
K
K
Y
V
T
L
C
S
N
G
V
L
Site 40
Y292
C
S
N
G
V
L
T
Y
Y
S
S
L
G
D
Y
Site 41
Y293
S
N
G
V
L
T
Y
Y
S
S
L
G
D
Y
M
Site 42
S295
G
V
L
T
Y
Y
S
S
L
G
D
Y
M
K
N
Site 43
Y299
Y
Y
S
S
L
G
D
Y
M
K
N
I
H
K
K
Site 44
S323
K
V
P
G
K
W
P
S
L
A
T
S
A
C
T
Site 45
S327
K
W
P
S
L
A
T
S
A
C
T
P
I
S
S
Site 46
T330
S
L
A
T
S
A
C
T
P
I
S
S
S
K
S
Site 47
S333
T
S
A
C
T
P
I
S
S
S
K
S
N
G
L
Site 48
S334
S
A
C
T
P
I
S
S
S
K
S
N
G
L
S
Site 49
S335
A
C
T
P
I
S
S
S
K
S
N
G
L
S
K
Site 50
S337
T
P
I
S
S
S
K
S
N
G
L
S
K
D
M
Site 51
S341
S
S
K
S
N
G
L
S
K
D
M
D
T
G
L
Site 52
T346
G
L
S
K
D
M
D
T
G
L
G
D
S
I
C
Site 53
S357
D
S
I
C
F
S
P
S
I
S
S
T
T
S
P
Site 54
T361
F
S
P
S
I
S
S
T
T
S
P
K
L
N
P
Site 55
S363
P
S
I
S
S
T
T
S
P
K
L
N
P
P
P
Site 56
S371
P
K
L
N
P
P
P
S
P
H
A
N
K
K
K
Site 57
Y405
W
H
F
E
A
T
T
Y
E
E
R
D
A
W
V
Site 58
S417
A
W
V
Q
A
I
Q
S
Q
I
L
A
S
L
Q
Site 59
S422
I
Q
S
Q
I
L
A
S
L
Q
S
C
E
S
S
Site 60
S425
Q
I
L
A
S
L
Q
S
C
E
S
S
K
S
K
Site 61
S428
A
S
L
Q
S
C
E
S
S
K
S
K
S
Q
L
Site 62
S429
S
L
Q
S
C
E
S
S
K
S
K
S
Q
L
T
Site 63
S431
Q
S
C
E
S
S
K
S
K
S
Q
L
T
S
Q
Site 64
S433
C
E
S
S
K
S
K
S
Q
L
T
S
Q
S
K
Site 65
S437
K
S
K
S
Q
L
T
S
Q
S
K
A
M
A
L
Site 66
S439
K
S
Q
L
T
S
Q
S
K
A
M
A
L
Q
S
Site 67
S485
E
C
S
G
I
H
R
S
L
G
T
R
L
S
R
Site 68
S491
R
S
L
G
T
R
L
S
R
V
R
S
L
E
L
Site 69
S495
T
R
L
S
R
V
R
S
L
E
L
D
D
W
P
Site 70
S511
E
L
R
K
V
M
S
S
I
G
N
D
L
A
N
Site 71
S519
I
G
N
D
L
A
N
S
I
W
E
G
S
S
Q
Site 72
T529
E
G
S
S
Q
G
Q
T
K
P
S
E
K
S
T
Site 73
S535
Q
T
K
P
S
E
K
S
T
R
E
E
K
E
R
Site 74
T536
T
K
P
S
E
K
S
T
R
E
E
K
E
R
W
Site 75
S546
E
K
E
R
W
I
R
S
K
Y
E
E
K
L
F
Site 76
Y548
E
R
W
I
R
S
K
Y
E
E
K
L
F
L
A
Site 77
T572
G
Q
Q
L
L
R
A
T
A
D
E
D
L
Q
T
Site 78
T595
S
R
E
E
V
N
E
T
C
G
E
G
D
G
C
Site 79
T639
A
H
G
N
T
A
L
T
Y
A
R
Q
A
S
S
Site 80
Y640
H
G
N
T
A
L
T
Y
A
R
Q
A
S
S
Q
Site 81
S645
L
T
Y
A
R
Q
A
S
S
Q
E
C
I
N
V
Site 82
S646
T
Y
A
R
Q
A
S
S
Q
E
C
I
N
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation