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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TReP-132
Full Name:
Transcriptional-regulating factor 1
Alias:
BCAR2; DJ139D8.5; DJ139D8.5.1; HSA277276; RAPA; Transcriptional regulating factor 1; TREF1; Zinc finger transcription factor TReP-132; Zinc finger transcription regulating protein TReP-132, variant 1
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
132256
Number AA:
1200
UniProt ID:
Q96PN7
International Prot ID:
IPI00044583
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008301
GO:0016455
GO:0030374
PhosphoSite+
KinaseNET
Biological Process:
GO:0006707
GO:0042592
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
D
Q
Q
L
Y
K
T
N
H
V
A
H
G
S
Site 2
Y21
H
G
S
E
N
L
F
Y
Q
Q
P
P
L
G
V
Site 3
Y36
H
S
G
L
N
H
N
Y
G
N
A
V
T
G
G
Site 4
S51
G
M
D
A
P
Q
A
S
P
I
S
P
H
F
P
Site 5
S54
A
P
Q
A
S
P
I
S
P
H
F
P
Q
D
T
Site 6
T61
S
P
H
F
P
Q
D
T
R
D
G
L
G
L
P
Site 7
S71
G
L
G
L
P
V
G
S
K
N
L
G
Q
M
D
Site 8
T79
K
N
L
G
Q
M
D
T
S
R
Q
G
G
W
G
Site 9
S80
N
L
G
Q
M
D
T
S
R
Q
G
G
W
G
S
Site 10
S87
S
R
Q
G
G
W
G
S
H
A
G
P
G
N
H
Site 11
Y120
Q
A
E
P
T
D
G
Y
Q
Y
T
Y
S
Q
A
Site 12
Y122
E
P
T
D
G
Y
Q
Y
T
Y
S
Q
A
S
E
Site 13
T123
P
T
D
G
Y
Q
Y
T
Y
S
Q
A
S
E
I
Site 14
Y124
T
D
G
Y
Q
Y
T
Y
S
Q
A
S
E
I
R
Site 15
S125
D
G
Y
Q
Y
T
Y
S
Q
A
S
E
I
R
T
Site 16
T132
S
Q
A
S
E
I
R
T
Q
K
L
T
S
G
V
Site 17
T136
E
I
R
T
Q
K
L
T
S
G
V
L
H
K
L
Site 18
T147
L
H
K
L
D
S
F
T
Q
V
F
A
N
Q
N
Site 19
S186
S
A
L
R
Q
L
L
S
Q
K
P
M
E
P
P
Site 20
Y233
H
P
T
Q
G
H
L
Y
Y
D
Y
Q
Q
P
L
Site 21
Y234
P
T
Q
G
H
L
Y
Y
D
Y
Q
Q
P
L
A
Site 22
Y236
Q
G
H
L
Y
Y
D
Y
Q
Q
P
L
A
Q
V
Site 23
S284
Q
A
G
Q
Q
R
I
S
M
Q
E
I
Q
T
Q
Site 24
S298
Q
P
Q
Q
I
R
P
S
Q
P
Q
P
P
P
Q
Site 25
Y326
G
S
M
Q
I
P
Q
Y
Y
Q
P
Q
P
M
M
Site 26
Y351
M
H
L
Q
P
P
S
Y
H
R
D
P
H
Q
Y
Site 27
Y358
Y
H
R
D
P
H
Q
Y
T
P
E
Q
A
H
T
Site 28
T359
H
R
D
P
H
Q
Y
T
P
E
Q
A
H
T
V
Site 29
T365
Y
T
P
E
Q
A
H
T
V
Q
L
I
P
L
G
Site 30
S375
L
I
P
L
G
S
M
S
Q
Y
Y
Y
Q
E
P
Site 31
Y377
P
L
G
S
M
S
Q
Y
Y
Y
Q
E
P
Q
Q
Site 32
Y378
L
G
S
M
S
Q
Y
Y
Y
Q
E
P
Q
Q
P
Site 33
Y379
G
S
M
S
Q
Y
Y
Y
Q
E
P
Q
Q
P
Y
Site 34
Y386
Y
Q
E
P
Q
Q
P
Y
S
H
P
L
Y
Q
Q
Site 35
S387
Q
E
P
Q
Q
P
Y
S
H
P
L
Y
Q
Q
S
Site 36
Y391
Q
P
Y
S
H
P
L
Y
Q
Q
S
H
L
S
Q
Site 37
S394
S
H
P
L
Y
Q
Q
S
H
L
S
Q
H
Q
Q
Site 38
S397
L
Y
Q
Q
S
H
L
S
Q
H
Q
Q
R
E
D
Site 39
S405
Q
H
Q
Q
R
E
D
S
Q
L
K
T
Y
S
S
Site 40
T409
R
E
D
S
Q
L
K
T
Y
S
S
D
R
Q
A
Site 41
Y410
E
D
S
Q
L
K
T
Y
S
S
D
R
Q
A
Q
Site 42
S411
D
S
Q
L
K
T
Y
S
S
D
R
Q
A
Q
A
Site 43
S412
S
Q
L
K
T
Y
S
S
D
R
Q
A
Q
A
M
Site 44
T431
G
D
L
G
P
P
D
T
G
M
G
D
P
A
S
Site 45
S438
T
G
M
G
D
P
A
S
S
D
L
T
R
V
S
Site 46
T442
D
P
A
S
S
D
L
T
R
V
S
S
T
L
P
Site 47
S445
S
S
D
L
T
R
V
S
S
T
L
P
H
R
P
Site 48
S446
S
D
L
T
R
V
S
S
T
L
P
H
R
P
L
Site 49
T447
D
L
T
R
V
S
S
T
L
P
H
R
P
L
L
Site 50
S455
L
P
H
R
P
L
L
S
P
S
G
I
H
L
N
Site 51
S457
H
R
P
L
L
S
P
S
G
I
H
L
N
N
M
Site 52
S472
G
P
Q
H
Q
Q
L
S
P
S
A
M
W
P
Q
Site 53
S491
D
G
R
A
Q
P
G
S
P
E
S
S
G
Q
P
Site 54
S495
Q
P
G
S
P
E
S
S
G
Q
P
K
G
A
F
Site 55
S515
A
K
N
K
L
T
C
S
I
C
L
K
E
F
K
Site 56
S533
A
L
N
G
H
M
R
S
H
G
G
M
R
A
S
Site 57
S540
S
H
G
G
M
R
A
S
P
N
L
K
Q
E
E
Site 58
S578
Q
L
P
P
E
A
E
S
L
T
P
M
V
M
P
Site 59
T580
P
P
E
A
E
S
L
T
P
M
V
M
P
V
S
Site 60
S598
K
L
L
P
P
K
P
S
S
Q
G
F
T
N
S
Site 61
S599
L
L
P
P
K
P
S
S
Q
G
F
T
N
S
T
Site 62
T603
K
P
S
S
Q
G
F
T
N
S
T
V
A
A
P
Site 63
S605
S
S
Q
G
F
T
N
S
T
V
A
A
P
S
A
Site 64
T606
S
Q
G
F
T
N
S
T
V
A
A
P
S
A
R
Site 65
S611
N
S
T
V
A
A
P
S
A
R
D
K
P
A
S
Site 66
S618
S
A
R
D
K
P
A
S
S
M
S
D
D
E
M
Site 67
S619
A
R
D
K
P
A
S
S
M
S
D
D
E
M
P
Site 68
S621
D
K
P
A
S
S
M
S
D
D
E
M
P
V
L
Site 69
S637
I
P
R
K
H
Q
P
S
V
P
K
A
E
E
P
Site 70
T647
K
A
E
E
P
L
K
T
V
Q
E
K
K
K
F
Site 71
S668
L
F
I
P
P
P
P
S
Y
N
P
N
P
A
A
Site 72
Y669
F
I
P
P
P
P
S
Y
N
P
N
P
A
A
S
Site 73
S676
Y
N
P
N
P
A
A
S
Y
S
G
A
T
L
Y
Site 74
Y683
S
Y
S
G
A
T
L
Y
Q
S
Q
L
R
S
P
Site 75
S685
S
G
A
T
L
Y
Q
S
Q
L
R
S
P
R
V
Site 76
S689
L
Y
Q
S
Q
L
R
S
P
R
V
L
G
D
H
Site 77
T702
D
H
L
L
L
D
P
T
H
E
L
P
P
Y
T
Site 78
Y708
P
T
H
E
L
P
P
Y
T
P
P
P
M
L
S
Site 79
T709
T
H
E
L
P
P
Y
T
P
P
P
M
L
S
P
Site 80
S715
Y
T
P
P
P
M
L
S
P
V
R
Q
G
S
G
Site 81
S725
R
Q
G
S
G
L
F
S
N
V
L
I
S
G
H
Site 82
S730
L
F
S
N
V
L
I
S
G
H
G
P
G
A
H
Site 83
T743
A
H
P
Q
L
P
L
T
P
L
T
P
T
P
R
Site 84
T746
Q
L
P
L
T
P
L
T
P
T
P
R
V
L
L
Site 85
T748
P
L
T
P
L
T
P
T
P
R
V
L
L
C
R
Site 86
S756
P
R
V
L
L
C
R
S
N
S
I
D
G
S
N
Site 87
S762
R
S
N
S
I
D
G
S
N
V
T
V
T
P
G
Site 88
T765
S
I
D
G
S
N
V
T
V
T
P
G
P
G
E
Site 89
T767
D
G
S
N
V
T
V
T
P
G
P
G
E
Q
T
Site 90
T774
T
P
G
P
G
E
Q
T
V
D
V
E
P
R
I
Site 91
T843
S
A
L
P
G
G
G
T
N
S
E
F
A
L
H
Site 92
S845
L
P
G
G
G
T
N
S
E
F
A
L
H
S
L
Site 93
Y882
K
C
H
P
L
A
N
Y
H
Y
A
G
S
D
K
Site 94
T891
Y
A
G
S
D
K
W
T
S
L
E
R
K
L
F
Site 95
S892
A
G
S
D
K
W
T
S
L
E
R
K
L
F
N
Site 96
S906
N
K
A
L
A
T
Y
S
K
D
F
I
F
V
Q
Site 97
T920
Q
K
M
V
K
S
K
T
V
A
Q
C
V
E
Y
Site 98
T954
E
I
I
D
D
C
V
T
S
E
E
E
E
E
L
Site 99
S955
I
I
D
D
C
V
T
S
E
E
E
E
E
L
E
Site 100
S975
D
P
E
E
D
R
K
S
T
K
E
E
E
S
E
Site 101
T976
P
E
E
D
R
K
S
T
K
E
E
E
S
E
V
Site 102
S981
K
S
T
K
E
E
E
S
E
V
P
K
S
P
E
Site 103
S986
E
E
S
E
V
P
K
S
P
E
P
P
P
V
P
Site 104
S1012
A
L
G
Q
P
S
G
S
F
I
C
E
M
P
N
Site 105
S1025
P
N
C
G
A
V
F
S
S
R
Q
A
L
N
G
Site 106
T1040
H
A
R
I
H
G
G
T
N
Q
V
T
K
A
R
Site 107
T1044
H
G
G
T
N
Q
V
T
K
A
R
G
A
I
P
Site 108
S1052
K
A
R
G
A
I
P
S
G
K
Q
K
P
G
G
Site 109
T1060
G
K
Q
K
P
G
G
T
Q
S
G
Y
C
S
V
Site 110
S1062
Q
K
P
G
G
T
Q
S
G
Y
C
S
V
K
S
Site 111
Y1064
P
G
G
T
Q
S
G
Y
C
S
V
K
S
S
P
Site 112
S1066
G
T
Q
S
G
Y
C
S
V
K
S
S
P
S
H
Site 113
S1069
S
G
Y
C
S
V
K
S
S
P
S
H
S
T
T
Site 114
S1070
G
Y
C
S
V
K
S
S
P
S
H
S
T
T
S
Site 115
S1072
C
S
V
K
S
S
P
S
H
S
T
T
S
G
E
Site 116
S1074
V
K
S
S
P
S
H
S
T
T
S
G
E
T
D
Site 117
T1076
S
S
P
S
H
S
T
T
S
G
E
T
D
P
T
Site 118
T1083
T
S
G
E
T
D
P
T
T
I
F
P
C
K
E
Site 119
T1084
S
G
E
T
D
P
T
T
I
F
P
C
K
E
C
Site 120
T1107
S
R
N
A
H
M
K
T
H
R
Q
Q
E
E
Q
Site 121
T1136
A
A
T
I
E
R
T
T
G
P
V
G
A
P
G
Site 122
T1182
E
E
A
E
V
V
D
T
D
L
L
L
D
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation