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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GBP4
Full Name:
Guanylate-binding protein 4
Alias:
GTP-binding protein 4;Guanine nucleotide-binding protein 4
Type:
Mass (Da):
73165
Number AA:
640
UniProt ID:
Q96PP9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
T
L
H
A
A
V
P
T
P
G
Y
P
E
S
E
Site 2
Y15
A
A
V
P
T
P
G
Y
P
E
S
E
S
I
M
Site 3
S18
P
T
P
G
Y
P
E
S
E
S
I
M
M
A
P
Site 4
T37
E
N
Q
E
E
Q
L
T
V
N
S
K
A
L
E
Site 5
S67
G
L
Y
R
T
G
K
S
Y
L
M
N
R
L
A
Site 6
Y68
L
Y
R
T
G
K
S
Y
L
M
N
R
L
A
G
Site 7
S84
R
N
G
F
P
L
G
S
T
V
Q
S
E
T
K
Site 8
T85
N
G
F
P
L
G
S
T
V
Q
S
E
T
K
G
Site 9
S88
P
L
G
S
T
V
Q
S
E
T
K
G
I
W
M
Site 10
S122
G
L
G
D
V
E
K
S
N
P
K
N
D
S
W
Site 11
S128
K
S
N
P
K
N
D
S
W
I
F
A
L
A
V
Site 12
S145
S
S
S
F
V
Y
N
S
V
S
T
I
N
H
Q
Site 13
Y159
Q
A
L
E
Q
L
H
Y
V
T
E
L
A
E
L
Site 14
S171
A
E
L
I
R
A
K
S
C
P
R
P
D
E
A
Site 15
S181
R
P
D
E
A
E
D
S
S
E
F
A
S
F
F
Site 16
S182
P
D
E
A
E
D
S
S
E
F
A
S
F
F
P
Site 17
S186
E
D
S
S
E
F
A
S
F
F
P
D
F
I
W
Site 18
T210
K
L
D
G
N
P
I
T
E
D
E
Y
L
E
N
Site 19
Y214
N
P
I
T
E
D
E
Y
L
E
N
A
L
K
L
Site 20
Y260
R
P
T
N
D
K
Q
Y
L
N
H
M
D
E
V
Site 21
T289
N
F
C
S
Y
I
F
T
H
A
K
T
K
T
L
Site 22
T295
F
T
H
A
K
T
K
T
L
R
E
G
I
I
V
Site 23
T303
L
R
E
G
I
I
V
T
G
K
R
L
G
T
L
Site 24
Y349
V
Q
R
A
A
D
H
Y
S
Q
Q
M
A
Q
Q
Site 25
S350
Q
R
A
A
D
H
Y
S
Q
Q
M
A
Q
Q
L
Site 26
T361
A
Q
Q
L
R
L
P
T
D
T
L
Q
E
L
L
Site 27
T363
Q
L
R
L
P
T
D
T
L
Q
E
L
L
D
V
Site 28
T401
F
Q
K
K
L
V
D
T
I
E
K
K
K
G
D
Site 29
S429
Q
A
E
L
K
R
L
S
E
H
L
T
E
S
I
Site 30
T433
K
R
L
S
E
H
L
T
E
S
I
L
R
G
I
Site 31
Y450
V
P
G
G
H
N
L
Y
L
E
E
K
K
Q
V
Site 32
Y461
K
K
Q
V
E
W
D
Y
K
L
V
P
R
K
G
Site 33
S492
V
E
E
S
I
L
Q
S
D
K
A
L
T
A
G
Site 34
Y541
Q
E
R
S
F
Q
E
Y
M
A
Q
M
E
K
K
Site 35
S615
L
K
I
L
D
M
A
S
N
I
M
I
V
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation