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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SORCS2
Full Name:
VPS10 domain-containing receptor SorCS2
Alias:
Type:
Mass (Da):
128152
Number AA:
1159
UniProt ID:
Q96PQ0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
H
R
G
P
S
R
A
S
K
G
P
G
Site 2
S10
H
R
G
P
S
R
A
S
K
G
P
G
P
T
A
Site 3
T16
A
S
K
G
P
G
P
T
A
R
A
P
S
P
G
Site 4
S21
G
P
T
A
R
A
P
S
P
G
A
P
P
P
P
Site 5
S30
G
A
P
P
P
P
R
S
P
R
S
R
P
L
L
Site 6
S33
P
P
P
R
S
P
R
S
R
P
L
L
L
L
L
Site 7
S52
A
C
G
A
A
G
R
S
P
E
P
G
R
L
G
Site 8
T65
L
G
P
H
A
Q
L
T
R
V
P
R
S
P
P
Site 9
S70
Q
L
T
R
V
P
R
S
P
P
A
G
R
A
E
Site 10
T89
E
D
R
Q
A
R
G
T
E
P
G
A
P
G
P
Site 11
S97
E
P
G
A
P
G
P
S
P
G
P
A
P
G
P
Site 12
Y114
D
G
A
P
A
A
G
Y
R
R
W
E
R
A
A
Site 13
T146
F
V
L
K
G
D
A
T
H
N
Q
A
M
V
H
Site 14
T155
N
Q
A
M
V
H
W
T
G
E
N
S
S
V
I
Site 15
S180
M
G
K
V
L
E
S
S
L
W
R
S
S
D
F
Site 16
S184
L
E
S
S
L
W
R
S
S
D
F
G
T
S
Y
Site 17
S185
E
S
S
L
W
R
S
S
D
F
G
T
S
Y
T
Site 18
T189
W
R
S
S
D
F
G
T
S
Y
T
K
L
T
L
Site 19
S190
R
S
S
D
F
G
T
S
Y
T
K
L
T
L
Q
Site 20
Y191
S
S
D
F
G
T
S
Y
T
K
L
T
L
Q
P
Site 21
T195
G
T
S
Y
T
K
L
T
L
Q
P
G
V
T
T
Site 22
Y208
T
T
V
I
D
N
F
Y
I
C
P
T
N
K
R
Site 23
S221
K
R
K
V
I
L
V
S
S
S
L
S
D
R
D
Site 24
S223
K
V
I
L
V
S
S
S
L
S
D
R
D
Q
S
Site 25
S225
I
L
V
S
S
S
L
S
D
R
D
Q
S
L
F
Site 26
S230
S
L
S
D
R
D
Q
S
L
F
L
S
A
D
E
Site 27
S234
R
D
Q
S
L
F
L
S
A
D
E
G
A
T
F
Site 28
T240
L
S
A
D
E
G
A
T
F
Q
K
Q
P
I
P
Site 29
Y266
E
E
D
K
V
L
A
Y
T
K
E
S
K
L
Y
Site 30
T267
E
D
K
V
L
A
Y
T
K
E
S
K
L
Y
V
Site 31
Y273
Y
T
K
E
S
K
L
Y
V
S
S
D
L
G
K
Site 32
S276
E
S
K
L
Y
V
S
S
D
L
G
K
K
W
T
Site 33
T283
S
D
L
G
K
K
W
T
L
L
Q
E
R
V
T
Site 34
T290
T
L
L
Q
E
R
V
T
K
D
H
V
F
W
S
Site 35
S297
T
K
D
H
V
F
W
S
V
S
G
V
D
A
D
Site 36
S299
D
H
V
F
W
S
V
S
G
V
D
A
D
P
D
Site 37
Y321
D
L
G
G
D
F
R
Y
V
T
C
A
I
H
N
Site 38
S346
A
G
P
I
D
H
G
S
L
T
V
Q
D
D
Y
Site 39
T348
P
I
D
H
G
S
L
T
V
Q
D
D
Y
I
F
Site 40
Y353
S
L
T
V
Q
D
D
Y
I
F
F
K
A
T
S
Site 41
T364
K
A
T
S
A
N
Q
T
K
Y
Y
V
S
Y
R
Site 42
Y366
T
S
A
N
Q
T
K
Y
Y
V
S
Y
R
R
N
Site 43
Y367
S
A
N
Q
T
K
Y
Y
V
S
Y
R
R
N
E
Site 44
Y370
Q
T
K
Y
Y
V
S
Y
R
R
N
E
F
V
L
Site 45
Y383
V
L
M
K
L
P
K
Y
A
L
P
K
D
L
Q
Site 46
S393
P
K
D
L
Q
I
I
S
T
D
E
S
Q
V
F
Site 47
T394
K
D
L
Q
I
I
S
T
D
E
S
Q
V
F
V
Site 48
Y412
E
W
Y
Q
M
D
T
Y
N
L
Y
Q
S
D
P
Site 49
Y415
Q
M
D
T
Y
N
L
Y
Q
S
D
P
R
G
V
Site 50
S417
D
T
Y
N
L
Y
Q
S
D
P
R
G
V
R
Y
Site 51
S433
L
V
L
Q
D
V
R
S
S
R
Q
A
E
E
S
Site 52
S434
V
L
Q
D
V
R
S
S
R
Q
A
E
E
S
V
Site 53
S440
S
S
R
Q
A
E
E
S
V
L
I
D
I
L
E
Site 54
Y471
K
V
M
T
L
I
T
Y
N
K
G
R
D
W
D
Site 55
Y479
N
K
G
R
D
W
D
Y
L
R
P
P
S
M
D
Site 56
Y512
L
R
W
A
D
N
P
Y
V
S
G
T
V
H
T
Site 57
S535
M
G
A
G
N
L
G
S
Q
L
V
E
Y
K
E
Site 58
Y540
L
G
S
Q
L
V
E
Y
K
E
E
M
Y
I
T
Site 59
Y566
E
E
E
H
H
I
L
Y
L
D
H
G
G
V
I
Site 60
S632
F
G
H
I
S
F
R
S
D
W
E
L
V
K
V
Site 61
S644
V
K
V
D
F
R
P
S
F
S
R
Q
C
G
E
Site 62
S646
V
D
F
R
P
S
F
S
R
Q
C
G
E
E
D
Site 63
Y654
R
Q
C
G
E
E
D
Y
S
S
W
E
L
S
N
Site 64
S655
Q
C
G
E
E
D
Y
S
S
W
E
L
S
N
L
Site 65
S656
C
G
E
E
D
Y
S
S
W
E
L
S
N
L
Q
Site 66
S660
D
Y
S
S
W
E
L
S
N
L
Q
G
D
R
C
Site 67
S674
C
I
M
G
Q
Q
R
S
F
R
K
R
K
S
T
Site 68
S680
R
S
F
R
K
R
K
S
T
S
W
C
I
K
G
Site 69
T681
S
F
R
K
R
K
S
T
S
W
C
I
K
G
R
Site 70
S682
F
R
K
R
K
S
T
S
W
C
I
K
G
R
S
Site 71
S689
S
W
C
I
K
G
R
S
F
T
S
A
L
T
S
Site 72
T691
C
I
K
G
R
S
F
T
S
A
L
T
S
R
V
Site 73
S692
I
K
G
R
S
F
T
S
A
L
T
S
R
V
C
Site 74
T695
R
S
F
T
S
A
L
T
S
R
V
C
E
C
R
Site 75
S696
S
F
T
S
A
L
T
S
R
V
C
E
C
R
D
Site 76
Y710
D
S
D
F
L
C
D
Y
G
F
E
R
S
P
S
Site 77
S715
C
D
Y
G
F
E
R
S
P
S
S
E
S
S
T
Site 78
S717
Y
G
F
E
R
S
P
S
S
E
S
S
T
N
K
Site 79
S718
G
F
E
R
S
P
S
S
E
S
S
T
N
K
C
Site 80
S720
E
R
S
P
S
S
E
S
S
T
N
K
C
S
A
Site 81
S721
R
S
P
S
S
E
S
S
T
N
K
C
S
A
N
Site 82
T722
S
P
S
S
E
S
S
T
N
K
C
S
A
N
F
Site 83
S735
N
F
W
F
N
P
L
S
P
P
D
D
C
A
L
Site 84
T745
D
D
C
A
L
G
Q
T
Y
T
S
S
L
G
Y
Site 85
Y746
D
C
A
L
G
Q
T
Y
T
S
S
L
G
Y
R
Site 86
S749
L
G
Q
T
Y
T
S
S
L
G
Y
R
K
V
V
Site 87
Y752
T
Y
T
S
S
L
G
Y
R
K
V
V
S
N
V
Site 88
S769
G
G
V
D
M
Q
Q
S
Q
V
Q
L
Q
C
P
Site 89
S786
P
P
R
G
L
Q
V
S
I
Q
G
E
A
V
A
Site 90
Y816
G
D
V
L
T
T
K
Y
Q
V
D
L
G
D
G
Site 91
T832
K
A
M
Y
V
N
L
T
L
T
G
E
P
I
R
Site 92
T834
M
Y
V
N
L
T
L
T
G
E
P
I
R
H
R
Site 93
Y842
G
E
P
I
R
H
R
Y
E
S
P
G
I
Y
R
Site 94
S844
P
I
R
H
R
Y
E
S
P
G
I
Y
R
V
S
Site 95
Y848
R
Y
E
S
P
G
I
Y
R
V
S
V
R
A
E
Site 96
S851
S
P
G
I
Y
R
V
S
V
R
A
E
N
T
A
Site 97
S919
H
S
L
Q
P
L
L
S
L
D
N
S
V
T
T
Site 98
S923
P
L
L
S
L
D
N
S
V
T
T
R
F
S
D
Site 99
T925
L
S
L
D
N
S
V
T
T
R
F
S
D
T
G
Site 100
S929
N
S
V
T
T
R
F
S
D
T
G
D
V
R
V
Site 101
T937
D
T
G
D
V
R
V
T
V
Q
A
A
C
G
N
Site 102
S945
V
Q
A
A
C
G
N
S
V
L
Q
D
S
R
V
Site 103
Y973
F
S
K
E
L
D
A
Y
N
P
N
T
P
E
W
Site 104
T977
L
D
A
Y
N
P
N
T
P
E
W
R
E
D
V
Site 105
S997
R
L
L
S
K
E
T
S
V
P
Q
E
L
L
V
Site 106
T1027
L
L
P
P
P
R
P
T
R
K
R
S
L
S
S
Site 107
S1031
P
R
P
T
R
K
R
S
L
S
S
D
K
R
L
Site 108
S1033
P
T
R
K
R
S
L
S
S
D
K
R
L
A
A
Site 109
S1034
T
R
K
R
S
L
S
S
D
K
R
L
A
A
I
Site 110
T1069
V
A
L
R
D
T
G
T
G
A
E
Q
L
G
G
Site 111
Y1100
A
A
G
A
F
I
L
Y
K
F
K
R
K
R
P
Site 112
Y1112
K
R
P
G
R
T
V
Y
A
Q
M
H
N
E
K
Site 113
T1124
N
E
K
E
Q
E
M
T
S
P
V
S
H
S
E
Site 114
S1125
E
K
E
Q
E
M
T
S
P
V
S
H
S
E
D
Site 115
S1128
Q
E
M
T
S
P
V
S
H
S
E
D
V
Q
G
Site 116
S1147
N
H
S
G
V
V
L
S
I
N
S
R
E
M
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation