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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UHRF2
Full Name:
E3 ubiquitin-protein ligase UHRF2
Alias:
MGC33463; NIRF; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear zinc finger protein Np97; RING finger protein 107; RNF107; Ubiquitin-like PHD and RING finger domain-containing 2; Ubiquitin-like with PHD and ring finger domains 2; Ubiquitin-like, containing PHD and RING finger domains 2; Ubiquitin-like-containing PHD and RING finger domains 2; URF2
Type:
Cell cycle regulation; Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
89990
Number AA:
UniProt ID:
Q96PU4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0030154
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
Q
V
R
T
I
D
G
S
K
T
C
T
I
E
D
Site 2
T13
R
T
I
D
G
S
K
T
C
T
I
E
D
V
S
Site 3
T15
I
D
G
S
K
T
C
T
I
E
D
V
S
R
K
Site 4
T24
E
D
V
S
R
K
A
T
I
E
E
L
R
E
R
Site 5
Y47
P
E
C
Q
R
L
F
Y
R
G
K
Q
L
E
N
Site 6
T57
K
Q
L
E
N
G
Y
T
L
F
D
Y
D
V
G
Site 7
Y61
N
G
Y
T
L
F
D
Y
D
V
G
L
N
D
I
Site 8
S93
Q
I
E
A
K
P
C
S
N
S
P
P
K
V
K
Site 9
S95
E
A
K
P
C
S
N
S
P
P
K
V
K
K
A
Site 10
S108
K
A
P
R
V
G
P
S
N
Q
P
S
T
S
A
Site 11
S112
V
G
P
S
N
Q
P
S
T
S
A
R
A
R
L
Site 12
S114
P
S
N
Q
P
S
T
S
A
R
A
R
L
I
D
Site 13
S150
W
F
E
A
H
I
H
S
V
T
R
A
S
D
G
Site 14
S155
I
H
S
V
T
R
A
S
D
G
Q
S
R
G
K
Site 15
S159
T
R
A
S
D
G
Q
S
R
G
K
T
P
L
K
Site 16
T163
D
G
Q
S
R
G
K
T
P
L
K
N
G
S
S
Site 17
S169
K
T
P
L
K
N
G
S
S
C
K
R
T
N
G
Site 18
S170
T
P
L
K
N
G
S
S
C
K
R
T
N
G
N
Site 19
T174
N
G
S
S
C
K
R
T
N
G
N
I
K
H
K
Site 20
S182
N
G
N
I
K
H
K
S
K
E
N
T
N
K
L
Site 21
S191
E
N
T
N
K
L
D
S
V
P
S
T
S
N
S
Site 22
S194
N
K
L
D
S
V
P
S
T
S
N
S
D
C
V
Site 23
T195
K
L
D
S
V
P
S
T
S
N
S
D
C
V
A
Site 24
S196
L
D
S
V
P
S
T
S
N
S
D
C
V
A
A
Site 25
S198
S
V
P
S
T
S
N
S
D
C
V
A
A
D
E
Site 26
Y209
A
A
D
E
D
V
I
Y
H
I
Q
Y
D
E
Y
Site 27
Y213
D
V
I
Y
H
I
Q
Y
D
E
Y
P
E
S
G
Site 28
Y216
Y
H
I
Q
Y
D
E
Y
P
E
S
G
T
L
E
Site 29
S219
Q
Y
D
E
Y
P
E
S
G
T
L
E
M
N
V
Site 30
T235
D
L
R
P
R
A
R
T
I
L
K
W
N
E
L
Site 31
Y252
G
D
V
V
M
V
N
Y
N
V
E
S
P
G
Q
Site 32
T273
A
E
I
T
T
L
K
T
I
S
R
T
K
K
E
Site 33
S317
R
P
G
A
H
P
L
S
F
A
D
G
K
F
L
Site 34
Y386
D
K
V
P
E
E
E
Y
W
Y
C
P
S
C
K
Site 35
Y388
V
P
E
E
E
Y
W
Y
C
P
S
C
K
T
D
Site 36
S396
C
P
S
C
K
T
D
S
S
E
V
V
K
A
G
Site 37
S397
P
S
C
K
T
D
S
S
E
V
V
K
A
G
E
Site 38
S417
K
K
K
A
K
M
P
S
A
S
T
E
S
R
R
Site 39
S419
K
A
K
M
P
S
A
S
T
E
S
R
R
D
W
Site 40
S422
M
P
S
A
S
T
E
S
R
R
D
W
G
R
G
Site 41
T440
V
G
R
T
R
E
C
T
I
V
P
S
N
H
Y
Site 42
T458
P
G
I
P
V
G
S
T
W
R
F
R
V
Q
V
Site 43
S482
V
G
G
I
H
G
R
S
N
D
G
A
Y
S
L
Site 44
Y487
G
R
S
N
D
G
A
Y
S
L
V
L
A
G
G
Site 45
T506
V
D
R
G
D
E
F
T
Y
T
G
S
G
G
K
Site 46
Y507
D
R
G
D
E
F
T
Y
T
G
S
G
G
K
N
Site 47
T508
R
G
D
E
F
T
Y
T
G
S
G
G
K
N
L
Site 48
S510
D
E
F
T
Y
T
G
S
G
G
K
N
L
A
G
Site 49
S525
N
K
R
I
G
A
P
S
A
D
Q
T
L
T
N
Site 50
T529
G
A
P
S
A
D
Q
T
L
T
N
M
N
R
A
Site 51
S567
K
P
V
R
V
I
R
S
F
K
G
R
K
I
S
Site 52
S574
S
F
K
G
R
K
I
S
K
Y
A
P
E
E
G
Site 53
Y576
K
G
R
K
I
S
K
Y
A
P
E
E
G
N
R
Site 54
Y584
A
P
E
E
G
N
R
Y
D
G
I
Y
K
V
V
Site 55
Y588
G
N
R
Y
D
G
I
Y
K
V
V
K
Y
W
P
Site 56
Y593
G
I
Y
K
V
V
K
Y
W
P
E
I
S
S
S
Site 57
Y608
H
G
F
L
V
W
R
Y
L
L
R
R
D
D
V
Site 58
S622
V
E
P
A
P
W
T
S
E
G
I
E
R
S
R
Site 59
S628
T
S
E
G
I
E
R
S
R
R
L
C
L
R
L
Site 60
Y637
R
L
C
L
R
L
Q
Y
P
A
G
Y
P
S
D
Site 61
Y641
R
L
Q
Y
P
A
G
Y
P
S
D
K
E
G
K
Site 62
S643
Q
Y
P
A
G
Y
P
S
D
K
E
G
K
K
P
Site 63
S654
G
K
K
P
K
G
Q
S
K
K
Q
P
S
G
T
Site 64
T661
S
K
K
Q
P
S
G
T
T
K
R
P
I
S
D
Site 65
T662
K
K
Q
P
S
G
T
T
K
R
P
I
S
D
D
Site 66
S667
G
T
T
K
R
P
I
S
D
D
D
C
P
S
A
Site 67
S673
I
S
D
D
D
C
P
S
A
S
K
V
Y
K
A
Site 68
S675
D
D
D
C
P
S
A
S
K
V
Y
K
A
S
D
Site 69
S681
A
S
K
V
Y
K
A
S
D
S
A
E
A
I
E
Site 70
S683
K
V
Y
K
A
S
D
S
A
E
A
I
E
A
F
Site 71
T693
A
I
E
A
F
Q
L
T
P
Q
Q
Q
H
L
I
Site 72
Y779
R
H
D
L
G
Q
N
Y
I
M
I
P
N
E
I
Site 73
Y798
L
D
L
F
F
P
G
Y
S
K
G
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation