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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF157
Full Name:
RING finger protein 157
Alias:
Type:
Mass (Da):
73561
Number AA:
679
UniProt ID:
Q96PX1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
V
E
E
V
D
I
P
S
N
S
V
Y
R
Y
P
Site 2
S21
E
V
D
I
P
S
N
S
V
Y
R
Y
P
P
K
Site 3
Y23
D
I
P
S
N
S
V
Y
R
Y
P
P
K
S
G
Site 4
Y25
P
S
N
S
V
Y
R
Y
P
P
K
S
G
S
Y
Site 5
S29
V
Y
R
Y
P
P
K
S
G
S
Y
F
A
S
H
Site 6
S31
R
Y
P
P
K
S
G
S
Y
F
A
S
H
F
I
Site 7
Y32
Y
P
P
K
S
G
S
Y
F
A
S
H
F
I
M
Site 8
S35
K
S
G
S
Y
F
A
S
H
F
I
M
G
G
E
Site 9
S46
M
G
G
E
K
F
D
S
T
H
P
E
G
Y
L
Site 10
T47
G
G
E
K
F
D
S
T
H
P
E
G
Y
L
F
Site 11
Y52
D
S
T
H
P
E
G
Y
L
F
G
E
N
S
D
Site 12
S58
G
Y
L
F
G
E
N
S
D
L
N
F
L
G
N
Site 13
Y72
N
R
P
V
V
F
P
Y
A
A
P
P
P
Q
E
Site 14
T83
P
P
Q
E
P
V
K
T
L
R
S
L
V
N
I
Site 15
S86
E
P
V
K
T
L
R
S
L
V
N
I
R
K
D
Site 16
S106
K
C
A
E
E
V
K
S
P
G
E
E
A
S
K
Site 17
S112
K
S
P
G
E
E
A
S
K
A
K
V
H
Y
N
Site 18
Y118
A
S
K
A
K
V
H
Y
N
V
E
F
T
F
D
Site 19
Y136
R
V
A
I
T
I
Y
Y
Q
A
T
E
E
F
Q
Site 20
S155
S
Y
I
P
K
D
N
S
L
Q
S
E
T
V
Q
Site 21
Y163
L
Q
S
E
T
V
Q
Y
K
R
G
V
C
Q
Q
Site 22
T177
Q
F
C
L
P
S
H
T
V
D
P
S
E
W
A
Site 23
S181
P
S
H
T
V
D
P
S
E
W
A
E
E
E
L
Site 24
Y211
V
V
D
E
G
D
E
Y
F
G
H
C
H
V
L
Site 25
T221
H
C
H
V
L
L
G
T
F
E
K
H
T
D
G
Site 26
T229
F
E
K
H
T
D
G
T
F
C
V
K
P
L
K
Site 27
Y252
S
Y
L
L
Q
E
I
Y
G
I
E
N
K
Y
N
Site 28
Y258
I
Y
G
I
E
N
K
Y
N
T
Q
D
S
K
V
Site 29
S263
N
K
Y
N
T
Q
D
S
K
V
A
E
D
E
V
Site 30
S271
K
V
A
E
D
E
V
S
D
N
S
A
E
C
V
Site 31
S274
E
D
E
V
S
D
N
S
A
E
C
V
V
C
L
Site 32
S336
R
K
K
L
G
P
L
S
P
T
S
F
N
P
I
Site 33
S345
T
S
F
N
P
I
I
S
S
Q
T
S
D
S
E
Site 34
S346
S
F
N
P
I
I
S
S
Q
T
S
D
S
E
E
Site 35
S349
P
I
I
S
S
Q
T
S
D
S
E
E
H
P
S
Site 36
S351
I
S
S
Q
T
S
D
S
E
E
H
P
S
S
E
Site 37
S356
S
D
S
E
E
H
P
S
S
E
N
I
P
P
G
Site 38
S357
D
S
E
E
H
P
S
S
E
N
I
P
P
G
Y
Site 39
Y364
S
E
N
I
P
P
G
Y
E
V
V
S
L
L
E
Site 40
T378
E
A
L
N
G
P
L
T
P
S
P
A
V
P
P
Site 41
S380
L
N
G
P
L
T
P
S
P
A
V
P
P
L
H
Site 42
S400
H
L
S
G
M
L
P
S
Y
G
S
D
G
H
L
Site 43
Y401
L
S
G
M
L
P
S
Y
G
S
D
G
H
L
P
Site 44
S403
G
M
L
P
S
Y
G
S
D
G
H
L
P
P
V
Site 45
T412
G
H
L
P
P
V
R
T
I
S
P
L
D
R
L
Site 46
S414
L
P
P
V
R
T
I
S
P
L
D
R
L
S
D
Site 47
S420
I
S
P
L
D
R
L
S
D
S
S
S
Q
G
L
Site 48
S422
P
L
D
R
L
S
D
S
S
S
Q
G
L
K
L
Site 49
S423
L
D
R
L
S
D
S
S
S
Q
G
L
K
L
K
Site 50
S424
D
R
L
S
D
S
S
S
Q
G
L
K
L
K
K
Site 51
S432
Q
G
L
K
L
K
K
S
L
S
K
S
T
S
Q
Site 52
S434
L
K
L
K
K
S
L
S
K
S
T
S
Q
N
S
Site 53
S436
L
K
K
S
L
S
K
S
T
S
Q
N
S
S
V
Site 54
S438
K
S
L
S
K
S
T
S
Q
N
S
S
V
L
H
Site 55
S442
K
S
T
S
Q
N
S
S
V
L
H
E
E
E
D
Site 56
S452
H
E
E
E
D
E
H
S
C
S
E
S
E
T
Q
Site 57
S454
E
E
D
E
H
S
C
S
E
S
E
T
Q
L
S
Site 58
S456
D
E
H
S
C
S
E
S
E
T
Q
L
S
Q
R
Site 59
T458
H
S
C
S
E
S
E
T
Q
L
S
Q
R
P
S
Site 60
S461
S
E
S
E
T
Q
L
S
Q
R
P
S
V
Q
H
Site 61
S465
T
Q
L
S
Q
R
P
S
V
Q
H
L
G
E
E
Site 62
T476
L
G
E
E
C
G
V
T
P
E
S
E
N
L
T
Site 63
S479
E
C
G
V
T
P
E
S
E
N
L
T
L
S
S
Site 64
T483
T
P
E
S
E
N
L
T
L
S
S
S
G
A
I
Site 65
S485
E
S
E
N
L
T
L
S
S
S
G
A
I
D
Q
Site 66
S487
E
N
L
T
L
S
S
S
G
A
I
D
Q
S
S
Site 67
S493
S
S
G
A
I
D
Q
S
S
C
T
G
T
P
L
Site 68
S494
S
G
A
I
D
Q
S
S
C
T
G
T
P
L
S
Site 69
T496
A
I
D
Q
S
S
C
T
G
T
P
L
S
S
T
Site 70
T498
D
Q
S
S
C
T
G
T
P
L
S
S
T
I
S
Site 71
S501
S
C
T
G
T
P
L
S
S
T
I
S
S
P
E
Site 72
S502
C
T
G
T
P
L
S
S
T
I
S
S
P
E
G
Site 73
T503
T
G
T
P
L
S
S
T
I
S
S
P
E
G
P
Site 74
S505
T
P
L
S
S
T
I
S
S
P
E
G
P
A
S
Site 75
S506
P
L
S
S
T
I
S
S
P
E
G
P
A
S
S
Site 76
S512
S
S
P
E
G
P
A
S
S
S
L
A
Q
S
V
Site 77
S513
S
P
E
G
P
A
S
S
S
L
A
Q
S
V
M
Site 78
S514
P
E
G
P
A
S
S
S
L
A
Q
S
V
M
S
Site 79
S524
Q
S
V
M
S
M
A
S
S
Q
I
S
T
D
T
Site 80
S528
S
M
A
S
S
Q
I
S
T
D
T
V
S
S
M
Site 81
T529
M
A
S
S
Q
I
S
T
D
T
V
S
S
M
S
Site 82
T531
S
S
Q
I
S
T
D
T
V
S
S
M
S
G
S
Site 83
S533
Q
I
S
T
D
T
V
S
S
M
S
G
S
Y
I
Site 84
S536
T
D
T
V
S
S
M
S
G
S
Y
I
A
P
G
Site 85
S538
T
V
S
S
M
S
G
S
Y
I
A
P
G
T
E
Site 86
Y539
V
S
S
M
S
G
S
Y
I
A
P
G
T
E
E
Site 87
T544
G
S
Y
I
A
P
G
T
E
E
E
G
E
A
L
Site 88
S552
E
E
E
G
E
A
L
S
S
P
Q
P
A
S
R
Site 89
S553
E
E
G
E
A
L
S
S
P
Q
P
A
S
R
A
Site 90
S558
L
S
S
P
Q
P
A
S
R
A
P
S
E
E
G
Site 91
S562
Q
P
A
S
R
A
P
S
E
E
G
E
G
L
P
Site 92
S572
G
E
G
L
P
A
E
S
P
D
S
N
F
A
G
Site 93
S575
L
P
A
E
S
P
D
S
N
F
A
G
L
P
A
Site 94
S599
V
I
E
E
E
D
G
S
P
T
Q
E
G
Q
R
Site 95
T607
P
T
Q
E
G
Q
R
T
C
A
F
L
G
M
E
Site 96
S625
N
N
D
F
D
I
A
S
V
K
A
L
D
N
K
Site 97
S660
N
A
Q
R
R
R
L
S
S
S
S
L
E
D
S
Site 98
S661
A
Q
R
R
R
L
S
S
S
S
L
E
D
S
E
Site 99
S662
Q
R
R
R
L
S
S
S
S
L
E
D
S
E
T
Site 100
S663
R
R
R
L
S
S
S
S
L
E
D
S
E
T
R
Site 101
S667
S
S
S
S
L
E
D
S
E
T
R
P
C
V
W
Site 102
T669
S
S
L
E
D
S
E
T
R
P
C
V
W
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation