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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHG4B
Full Name:
Pleckstrin homology domain-containing family G member 4B
Alias:
Type:
Mass (Da):
139667
Number AA:
1271
UniProt ID:
Q96PX9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
N
P
M
P
L
G
S
S
E
E
A
L
G
D
Site 2
S24
L
G
D
L
A
C
S
S
L
T
G
A
S
R
D
Site 3
T34
G
A
S
R
D
L
G
T
G
A
V
A
S
G
T
Site 4
S39
L
G
T
G
A
V
A
S
G
T
Q
E
E
T
S
Site 5
T41
T
G
A
V
A
S
G
T
Q
E
E
T
S
G
P
Site 6
S46
S
G
T
Q
E
E
T
S
G
P
R
G
D
P
Q
Site 7
T55
P
R
G
D
P
Q
Q
T
P
S
L
E
K
E
R
Site 8
S57
G
D
P
Q
Q
T
P
S
L
E
K
E
R
H
T
Site 9
T64
S
L
E
K
E
R
H
T
P
S
R
T
G
P
G
Site 10
S66
E
K
E
R
H
T
P
S
R
T
G
P
G
A
A
Site 11
T76
G
P
G
A
A
G
R
T
L
P
R
R
S
R
S
Site 12
S81
G
R
T
L
P
R
R
S
R
S
W
E
R
A
P
Site 13
S83
T
L
P
R
R
S
R
S
W
E
R
A
P
R
S
Site 14
S90
S
W
E
R
A
P
R
S
S
R
G
A
Q
A
A
Site 15
S91
W
E
R
A
P
R
S
S
R
G
A
Q
A
A
A
Site 16
S102
Q
A
A
A
C
H
T
S
H
H
S
A
G
S
R
Site 17
S105
A
C
H
T
S
H
H
S
A
G
S
R
P
G
G
Site 18
S108
T
S
H
H
S
A
G
S
R
P
G
G
H
L
G
Site 19
S142
E
E
D
V
L
A
S
S
A
C
V
S
T
D
G
Site 20
S158
S
L
H
C
H
N
P
S
G
P
S
D
V
P
A
Site 21
S184
P
G
T
G
D
F
P
S
Q
V
P
K
Q
V
L
Site 22
S194
P
K
Q
V
L
D
V
S
Q
E
L
L
Q
S
G
Site 23
T204
L
L
Q
S
G
V
V
T
L
P
G
T
R
D
R
Site 24
T208
G
V
V
T
L
P
G
T
R
D
R
H
G
R
A
Site 25
S223
V
V
Q
V
R
T
R
S
L
L
W
T
R
E
H
Site 26
T227
R
T
R
S
L
L
W
T
R
E
H
S
S
C
A
Site 27
S231
L
L
W
T
R
E
H
S
S
C
A
E
L
T
R
Site 28
S232
L
W
T
R
E
H
S
S
C
A
E
L
T
R
L
Site 29
Y242
E
L
T
R
L
L
L
Y
F
H
S
I
P
R
K
Site 30
S245
R
L
L
L
Y
F
H
S
I
P
R
K
E
V
R
Site 31
S276
P
A
V
S
Q
A
L
S
G
L
Q
N
N
T
S
Site 32
S283
S
G
L
Q
N
N
T
S
P
I
I
H
S
I
L
Site 33
S297
L
L
L
V
D
K
E
S
A
F
R
P
D
K
D
Site 34
S334
L
T
A
D
L
D
G
S
F
P
Y
S
H
G
D
Site 35
Y337
D
L
D
G
S
F
P
Y
S
H
G
D
W
I
C
Site 36
S369
F
L
Q
N
S
F
C
S
L
N
T
H
R
T
P
Site 37
T375
C
S
L
N
T
H
R
T
P
R
T
A
Q
E
V
Site 38
T411
S
L
R
L
E
G
G
T
V
L
A
R
L
R
R
Site 39
T423
L
R
R
E
E
L
G
T
E
D
S
R
D
T
L
Site 40
S426
E
E
L
G
T
E
D
S
R
D
T
L
E
A
A
Site 41
T429
G
T
E
D
S
R
D
T
L
E
A
A
T
S
L
Site 42
S435
D
T
L
E
A
A
T
S
L
Y
D
R
V
D
E
Site 43
Y437
L
E
A
A
T
S
L
Y
D
R
V
D
E
E
V
Site 44
S451
V
H
R
L
V
L
T
S
N
N
R
L
Q
Q
L
Site 45
S466
E
H
L
R
E
L
A
S
L
L
E
G
N
D
Q
Site 46
S475
L
E
G
N
D
Q
Q
S
C
Q
K
G
L
Q
L
Site 47
S502
Q
D
F
R
R
G
L
S
A
V
V
S
Q
A
E
Site 48
S506
R
G
L
S
A
V
V
S
Q
A
E
C
R
E
G
Site 49
T519
E
G
E
L
A
R
W
T
R
S
S
E
L
C
E
Site 50
S522
L
A
R
W
T
R
S
S
E
L
C
E
T
V
S
Site 51
T527
R
S
S
E
L
C
E
T
V
S
S
W
M
G
P
Site 52
S529
S
E
L
C
E
T
V
S
S
W
M
G
P
L
D
Site 53
S530
E
L
C
E
T
V
S
S
W
M
G
P
L
D
P
Site 54
S543
D
P
E
A
C
P
S
S
P
V
A
E
C
L
R
Site 55
S551
P
V
A
E
C
L
R
S
C
H
Q
E
A
T
S
Site 56
S583
A
L
G
K
P
W
A
S
Q
Q
D
L
W
L
Q
Site 57
Y591
Q
Q
D
L
W
L
Q
Y
P
Q
T
R
L
R
L
Site 58
S603
L
R
L
E
E
A
L
S
E
A
A
P
D
P
S
Site 59
S610
S
E
A
A
P
D
P
S
L
P
P
L
A
Q
S
Site 60
S617
S
L
P
P
L
A
Q
S
P
P
K
H
E
R
A
Site 61
S636
R
R
H
Q
K
P
P
S
F
P
S
T
D
S
G
Site 62
S639
Q
K
P
P
S
F
P
S
T
D
S
G
G
G
A
Site 63
T640
K
P
P
S
F
P
S
T
D
S
G
G
G
A
W
Site 64
S642
P
S
F
P
S
T
D
S
G
G
G
A
W
E
P
Site 65
S654
W
E
P
A
Q
P
L
S
G
L
P
G
R
A
L
Site 66
S700
T
T
A
H
L
E
D
S
S
A
C
S
S
E
P
Site 67
S701
T
A
H
L
E
D
S
S
A
C
S
S
E
P
T
Site 68
S704
L
E
D
S
S
A
C
S
S
E
P
T
Q
T
L
Site 69
S705
E
D
S
S
A
C
S
S
E
P
T
Q
T
L
A
Site 70
T708
S
A
C
S
S
E
P
T
Q
T
L
A
S
R
P
Site 71
T710
C
S
S
E
P
T
Q
T
L
A
S
R
P
R
K
Site 72
S713
E
P
T
Q
T
L
A
S
R
P
R
K
H
P
Q
Site 73
T727
Q
K
K
M
I
K
K
T
Q
S
F
E
I
P
Q
Site 74
S729
K
M
I
K
K
T
Q
S
F
E
I
P
Q
P
D
Site 75
S737
F
E
I
P
Q
P
D
S
G
P
R
D
S
C
Q
Site 76
S742
P
D
S
G
P
R
D
S
C
Q
P
D
H
T
S
Site 77
T748
D
S
C
Q
P
D
H
T
S
V
F
S
K
G
L
Site 78
S749
S
C
Q
P
D
H
T
S
V
F
S
K
G
L
E
Site 79
T758
F
S
K
G
L
E
V
T
S
T
V
A
T
E
K
Site 80
T760
K
G
L
E
V
T
S
T
V
A
T
E
K
K
L
Site 81
T763
E
V
T
S
T
V
A
T
E
K
K
L
P
L
W
Site 82
S775
P
L
W
Q
H
A
R
S
P
P
V
T
Q
S
R
Site 83
T779
H
A
R
S
P
P
V
T
Q
S
R
S
L
S
S
Site 84
S781
R
S
P
P
V
T
Q
S
R
S
L
S
S
P
S
Site 85
S783
P
P
V
T
Q
S
R
S
L
S
S
P
S
G
L
Site 86
S785
V
T
Q
S
R
S
L
S
S
P
S
G
L
H
P
Site 87
S786
T
Q
S
R
S
L
S
S
P
S
G
L
H
P
A
Site 88
S803
D
G
R
Q
Q
V
G
S
S
R
L
R
H
I
M
Site 89
S804
G
R
Q
Q
V
G
S
S
R
L
R
H
I
M
A
Site 90
Y831
L
G
Y
V
I
D
N
Y
F
P
E
M
E
R
M
Site 91
S883
C
P
L
A
V
G
R
S
F
L
R
H
E
E
Q
Site 92
Y894
H
E
E
Q
F
G
M
Y
V
I
Y
S
K
N
K
Site 93
Y897
Q
F
G
M
Y
V
I
Y
S
K
N
K
P
Q
S
Site 94
S904
Y
S
K
N
K
P
Q
S
D
A
L
L
S
S
H
Site 95
S909
P
Q
S
D
A
L
L
S
S
H
G
N
A
F
F
Site 96
Y932
D
K
M
D
L
A
S
Y
L
L
R
P
V
Q
R
Site 97
S955
Q
D
L
L
K
E
A
S
C
G
L
A
Q
G
Q
Site 98
T1034
D
L
I
L
F
S
K
T
Q
K
V
E
G
S
H
Site 99
S1040
K
T
Q
K
V
E
G
S
H
D
V
Y
L
Y
K
Site 100
Y1044
V
E
G
S
H
D
V
Y
L
Y
K
Q
S
F
K
Site 101
Y1046
G
S
H
D
V
Y
L
Y
K
Q
S
F
K
T
A
Site 102
S1049
D
V
Y
L
Y
K
Q
S
F
K
T
A
E
I
G
Site 103
T1058
K
T
A
E
I
G
M
T
E
N
V
G
D
S
G
Site 104
S1078
W
F
R
R
R
Q
K
S
Q
D
T
Y
I
L
Q
Site 105
Y1082
R
Q
K
S
Q
D
T
Y
I
L
Q
A
S
S
A
Site 106
S1088
T
Y
I
L
Q
A
S
S
A
E
V
K
S
A
W
Site 107
S1110
L
W
R
Q
A
L
K
S
R
E
L
R
I
Q
E
Site 108
T1137
D
V
K
P
R
D
R
T
P
D
C
A
V
I
S
Site 109
S1154
A
P
K
C
A
V
M
S
D
R
V
P
D
S
I
Site 110
S1160
M
S
D
R
V
P
D
S
I
V
K
G
T
E
S
Site 111
S1167
S
I
V
K
G
T
E
S
Q
M
R
G
S
T
A
Site 112
S1172
T
E
S
Q
M
R
G
S
T
A
V
S
S
S
D
Site 113
T1173
E
S
Q
M
R
G
S
T
A
V
S
S
S
D
H
Site 114
S1176
M
R
G
S
T
A
V
S
S
S
D
H
A
A
P
Site 115
S1178
G
S
T
A
V
S
S
S
D
H
A
A
P
F
K
Site 116
S1189
A
P
F
K
R
P
H
S
T
I
S
D
S
S
T
Site 117
T1190
P
F
K
R
P
H
S
T
I
S
D
S
S
T
S
Site 118
S1192
K
R
P
H
S
T
I
S
D
S
S
T
S
S
S
Site 119
S1194
P
H
S
T
I
S
D
S
S
T
S
S
S
S
S
Site 120
S1195
H
S
T
I
S
D
S
S
T
S
S
S
S
S
Q
Site 121
T1196
S
T
I
S
D
S
S
T
S
S
S
S
S
Q
S
Site 122
S1197
T
I
S
D
S
S
T
S
S
S
S
S
Q
S
S
Site 123
S1198
I
S
D
S
S
T
S
S
S
S
S
Q
S
S
S
Site 124
S1199
S
D
S
S
T
S
S
S
S
S
Q
S
S
S
I
Site 125
S1200
D
S
S
T
S
S
S
S
S
Q
S
S
S
I
L
Site 126
S1201
S
S
T
S
S
S
S
S
Q
S
S
S
I
L
G
Site 127
S1203
T
S
S
S
S
S
Q
S
S
S
I
L
G
S
L
Site 128
S1204
S
S
S
S
S
Q
S
S
S
I
L
G
S
L
G
Site 129
S1205
S
S
S
S
Q
S
S
S
I
L
G
S
L
G
L
Site 130
S1225
P
A
H
P
G
L
W
S
P
A
H
S
P
W
S
Site 131
S1229
G
L
W
S
P
A
H
S
P
W
S
S
D
I
R
Site 132
S1232
S
P
A
H
S
P
W
S
S
D
I
R
A
C
V
Site 133
S1233
P
A
H
S
P
W
S
S
D
I
R
A
C
V
E
Site 134
S1266
G
A
P
A
V
L
L
S
R
T
R
Q
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation