KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMG1
Full Name:
Serine/threonine-protein kinase SMG1
Alias:
Lambda/iota protein kinase C-interacting protein; Serine/threonine-protein kinase SMG1: Lambda/iota protein kinase C-interacting protein: 61E3.4: Serine/threonine-protein kinase SMG1: Lambda/iota protein kinase C-interacting protein: 61E3.4: Serine/threonine-protein kinase SMG1: Lambda/iota protein kinase C-interacting protein: 61E3.4: Serine/threonine-protein kinase SMG1: Lambda/iota protein kinase C-interacting protein: 61E3.4
Type:
Protein-serine kinase, Atypical group, PIKK family, SMG1 subfamily
Mass (Da):
410261
Number AA:
3657
UniProt ID:
Q96Q15
International Prot ID:
IPI00556369
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004428
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0000184
GO:0006139
GO:0006259
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase SMG1; Lambda/iota protein kinase C-interacting protein pan-specific antibody AB-NK233#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK233#Serine/threonine-protein kinase SMG1; Lambda/iota protein kinase C-interacting protein pan-specific antibody AB-NK233-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK233-1#Serine/threonine-protein kinase SMG1; Lambda/iota protein kinase C-interacting protein pan-specific antibody AB-NK233-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK233-2#Serine/threonine-protein kinase SMG1; Lambda/iota protein kinase C-interacting protein pan-specific antibody AB-NK233-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK233-3#Serine/threonine-protein kinase SMG1; Lambda/iota protein kinase C-interacting protein T3550 phosphosite-specific antibody AB-PK817#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK817#Serine/threonine-protein kinase SMG1 / Lambda/iota protein kinase C-interacting protein (S67-Q81, human) peptide - Powder PE-01ATH90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ATH90#Serine/threonine-protein kinase SMG1 / Lambda/iota protein kinase C-interacting protein (S67-Q81, human) peptide - Powder PE-01ATH90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ATH90#Serine/threonine-protein kinase SMG1 / Lambda/iota protein kinase C-interacting protein (Q3636-L3650, human) peptide - Powder PE-01ATI75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ATI75#Serine/threonine-protein kinase SMG1 / Lambda/iota protein kinase C-interacting protein (G3547-D3553, human) pT3550 phosphopeptide - Powder PE-04APQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APQ99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
R
R
A
P
G
S
R
L
S
S
G
G
T
Site 2
S11
R
A
P
G
S
R
L
S
S
G
G
T
N
Y
S
Site 3
S12
A
P
G
S
R
L
S
S
G
G
T
N
Y
S
R
Site 4
T15
S
R
L
S
S
G
G
T
N
Y
S
R
S
W
N
Site 5
Y17
L
S
S
G
G
T
N
Y
S
R
S
W
N
D
W
Site 6
T28
W
N
D
W
Q
P
R
T
D
S
A
S
A
D
P
Site 7
S30
D
W
Q
P
R
T
D
S
A
S
A
D
P
G
N
Site 8
S32
Q
P
R
T
D
S
A
S
A
D
P
G
N
L
K
Site 9
S41
D
P
G
N
L
K
Y
S
S
S
R
D
R
G
G
Site 10
S42
P
G
N
L
K
Y
S
S
S
R
D
R
G
G
S
Site 11
S43
G
N
L
K
Y
S
S
S
R
D
R
G
G
S
S
Site 12
S49
S
S
R
D
R
G
G
S
S
S
Y
G
L
Q
P
Site 13
S50
S
R
D
R
G
G
S
S
S
Y
G
L
Q
P
S
Site 14
S51
R
D
R
G
G
S
S
S
Y
G
L
Q
P
S
N
Site 15
S57
S
S
Y
G
L
Q
P
S
N
S
A
V
V
S
R
Site 16
S59
Y
G
L
Q
P
S
N
S
A
V
V
S
R
Q
R
Site 17
S63
P
S
N
S
A
V
V
S
R
Q
R
H
D
D
T
Site 18
T70
S
R
Q
R
H
D
D
T
R
V
H
A
D
I
Q
Site 19
Y84
Q
N
D
E
K
G
G
Y
S
V
N
G
G
S
G
Site 20
S85
N
D
E
K
G
G
Y
S
V
N
G
G
S
G
E
Site 21
S90
G
Y
S
V
N
G
G
S
G
E
N
T
Y
G
R
Site 22
T94
N
G
G
S
G
E
N
T
Y
G
R
K
S
L
G
Site 23
Y95
G
G
S
G
E
N
T
Y
G
R
K
S
L
G
Q
Site 24
S99
E
N
T
Y
G
R
K
S
L
G
Q
E
L
R
V
Site 25
T110
E
L
R
V
N
N
V
T
S
P
E
F
T
S
V
Site 26
S111
L
R
V
N
N
V
T
S
P
E
F
T
S
V
Q
Site 27
T115
N
V
T
S
P
E
F
T
S
V
Q
H
G
S
R
Site 28
S132
A
T
K
D
M
R
K
S
Q
E
R
S
M
S
Y
Site 29
S136
M
R
K
S
Q
E
R
S
M
S
Y
S
D
E
S
Site 30
S138
K
S
Q
E
R
S
M
S
Y
S
D
E
S
R
L
Site 31
S140
Q
E
R
S
M
S
Y
S
D
E
S
R
L
S
N
Site 32
S143
S
M
S
Y
S
D
E
S
R
L
S
N
L
L
R
Site 33
S146
Y
S
D
E
S
R
L
S
N
L
L
R
R
I
T
Site 34
T153
S
N
L
L
R
R
I
T
R
E
D
D
R
D
R
Site 35
T164
D
R
D
R
R
L
A
T
V
K
Q
L
K
E
F
Site 36
S234
K
I
F
K
W
I
F
S
K
F
S
S
S
A
K
Site 37
S238
W
I
F
S
K
F
S
S
S
A
K
D
E
V
K
Site 38
S239
I
F
S
K
F
S
S
S
A
K
D
E
V
K
L
Site 39
Y248
K
D
E
V
K
L
L
Y
L
C
A
T
Y
K
A
Site 40
T326
V
G
W
H
I
D
H
T
Q
K
P
S
L
T
Q
Site 41
S330
I
D
H
T
Q
K
P
S
L
T
Q
Q
V
S
G
Site 42
T332
H
T
Q
K
P
S
L
T
Q
Q
V
S
G
W
L
Site 43
S336
P
S
L
T
Q
Q
V
S
G
W
L
Q
S
L
E
Site 44
Y367
F
L
E
D
M
E
A
Y
A
E
D
L
S
H
V
Site 45
S372
E
A
Y
A
E
D
L
S
H
V
A
S
G
E
S
Site 46
S376
E
D
L
S
H
V
A
S
G
E
S
V
D
E
D
Site 47
S388
D
E
D
V
P
P
P
S
V
S
L
P
K
L
A
Site 48
S413
R
S
I
G
E
R
F
S
P
I
R
G
P
P
I
Site 49
T421
P
I
R
G
P
P
I
T
E
A
Y
V
T
D
V
Site 50
Y424
G
P
P
I
T
E
A
Y
V
T
D
V
L
Y
R
Site 51
Y531
S
K
L
L
F
L
R
Y
H
K
E
K
E
V
V
Site 52
T616
F
D
L
S
A
L
T
T
I
G
N
A
K
N
S
Site 53
Y665
Y
A
V
L
Y
T
L
Y
S
H
C
T
R
H
D
Site 54
S676
T
R
H
D
H
F
I
S
S
S
L
S
S
A
S
Site 55
S677
R
H
D
H
F
I
S
S
S
L
S
S
A
S
P
Site 56
S678
H
D
H
F
I
S
S
S
L
S
S
A
S
P
S
Site 57
S683
S
S
S
L
S
S
A
S
P
S
L
F
D
G
A
Site 58
Y744
L
M
R
K
S
E
T
Y
A
P
L
F
S
L
P
Site 59
S749
E
T
Y
A
P
L
F
S
L
P
S
F
H
K
F
Site 60
S783
C
S
S
L
H
A
L
S
S
S
L
P
D
D
L
Site 61
S785
S
L
H
A
L
S
S
S
L
P
D
D
L
L
Q
Site 62
S827
I
P
L
D
V
V
L
S
N
N
N
H
T
E
I
Site 63
S838
H
T
E
I
Q
E
I
S
L
A
L
R
S
H
M
Site 64
S843
E
I
S
L
A
L
R
S
H
M
S
K
A
P
S
Site 65
S846
L
A
L
R
S
H
M
S
K
A
P
S
N
T
F
Site 66
S850
S
H
M
S
K
A
P
S
N
T
F
H
P
Q
D
Site 67
T852
M
S
K
A
P
S
N
T
F
H
P
Q
D
F
S
Site 68
Y867
D
V
I
S
F
I
L
Y
G
N
S
H
R
T
G
Site 69
S870
S
F
I
L
Y
G
N
S
H
R
T
G
K
D
N
Site 70
Y884
N
W
L
E
R
L
F
Y
S
C
Q
R
L
D
K
Site 71
S895
R
L
D
K
R
D
Q
S
T
I
P
R
N
L
L
Site 72
T896
L
D
K
R
D
Q
S
T
I
P
R
N
L
L
K
Site 73
T904
I
P
R
N
L
L
K
T
D
A
V
L
W
Q
W
Site 74
T927
T
V
L
S
K
L
R
T
P
L
G
R
A
Q
D
Site 75
T935
P
L
G
R
A
Q
D
T
F
Q
T
I
E
G
I
Site 76
S958
L
N
P
D
Q
D
V
S
Q
W
T
T
A
D
N
Site 77
Y991
E
N
L
E
K
L
M
Y
N
A
Y
E
G
C
A
Site 78
Y994
E
K
L
M
Y
N
A
Y
E
G
C
A
N
A
L
Site 79
T1002
E
G
C
A
N
A
L
T
S
P
P
K
V
I
R
Site 80
S1003
G
C
A
N
A
L
T
S
P
P
K
V
I
R
T
Site 81
T1010
S
P
P
K
V
I
R
T
F
F
Y
T
N
R
Q
Site 82
Y1013
K
V
I
R
T
F
F
Y
T
N
R
Q
T
C
Q
Site 83
T1052
R
H
G
F
D
L
L
T
E
M
K
T
T
S
L
Site 84
T1056
D
L
L
T
E
M
K
T
T
S
L
S
Q
G
N
Site 85
S1058
L
T
E
M
K
T
T
S
L
S
Q
G
N
E
L
Site 86
S1060
E
M
K
T
T
S
L
S
Q
G
N
E
L
E
V
Site 87
S1105
K
N
L
L
W
I
N
S
V
A
Q
Q
A
E
G
Site 88
S1118
E
G
R
F
E
K
A
S
V
E
Y
Q
E
H
L
Site 89
T1144
S
F
D
K
S
V
L
T
L
A
N
A
G
R
N
Site 90
S1152
L
A
N
A
G
R
N
S
A
S
P
K
H
S
L
Site 91
S1154
N
A
G
R
N
S
A
S
P
K
H
S
L
N
G
Site 92
S1158
N
S
A
S
P
K
H
S
L
N
G
E
S
R
K
Site 93
T1166
L
N
G
E
S
R
K
T
V
L
S
K
P
T
D
Site 94
S1169
E
S
R
K
T
V
L
S
K
P
T
D
S
S
P
Site 95
S1174
V
L
S
K
P
T
D
S
S
P
E
V
I
N
Y
Site 96
S1175
L
S
K
P
T
D
S
S
P
E
V
I
N
Y
L
Site 97
Y1181
S
S
P
E
V
I
N
Y
L
G
N
K
A
C
E
Site 98
S1212
A
I
H
D
L
K
K
S
T
S
S
T
S
L
N
Site 99
T1213
I
H
D
L
K
K
S
T
S
S
T
S
L
N
L
Site 100
S1214
H
D
L
K
K
S
T
S
S
T
S
L
N
L
K
Site 101
T1216
L
K
K
S
T
S
S
T
S
L
N
L
K
A
D
Site 102
S1217
K
K
S
T
S
S
T
S
L
N
L
K
A
D
F
Site 103
Y1226
N
L
K
A
D
F
N
Y
I
K
S
L
S
S
F
Site 104
S1229
A
D
F
N
Y
I
K
S
L
S
S
F
E
S
G
Site 105
S1231
F
N
Y
I
K
S
L
S
S
F
E
S
G
K
F
Site 106
S1232
N
Y
I
K
S
L
S
S
F
E
S
G
K
F
V
Site 107
S1235
K
S
L
S
S
F
E
S
G
K
F
V
E
C
T
Site 108
T1242
S
G
K
F
V
E
C
T
E
Q
L
E
L
L
P
Site 109
S1260
I
N
L
L
A
G
G
S
K
E
K
I
D
M
K
Site 110
S1275
K
L
L
P
N
M
L
S
P
D
P
R
E
L
Q
Site 111
S1284
D
P
R
E
L
Q
K
S
I
E
V
Q
L
L
R
Site 112
Y1319
I
T
E
N
V
V
K
Y
L
K
Q
T
S
R
I
Site 113
T1359
C
S
S
A
L
E
N
T
V
S
N
R
L
S
T
Site 114
S1361
S
A
L
E
N
T
V
S
N
R
L
S
T
E
D
Site 115
S1365
N
T
V
S
N
R
L
S
T
E
D
C
L
I
P
Site 116
S1380
L
F
S
E
A
L
R
S
C
K
Q
H
D
V
R
Site 117
Y1398
Q
A
L
R
Y
T
M
Y
Q
N
Q
L
L
E
K
Site 118
T1410
L
E
K
I
K
E
Q
T
V
P
I
R
S
H
L
Site 119
S1435
A
R
K
R
G
N
V
S
L
A
T
R
L
L
A
Site 120
S1445
T
R
L
L
A
Q
C
S
E
V
Q
L
G
K
T
Site 121
Y1488
I
E
K
T
K
L
L
Y
T
A
G
Q
S
T
H
Site 122
T1489
E
K
T
K
L
L
Y
T
A
G
Q
S
T
H
A
Site 123
Y1543
S
G
Q
L
K
Q
V
Y
R
A
Q
H
Q
Q
N
Site 124
S1555
Q
Q
N
F
T
G
L
S
T
L
S
K
N
I
L
Site 125
S1569
L
T
L
I
E
L
P
S
V
N
T
M
E
E
E
Site 126
Y1577
V
N
T
M
E
E
E
Y
P
R
I
E
S
E
S
Site 127
S1582
E
E
Y
P
R
I
E
S
E
S
T
V
H
I
G
Site 128
S1584
Y
P
R
I
E
S
E
S
T
V
H
I
G
V
G
Site 129
T1585
P
R
I
E
S
E
S
T
V
H
I
G
V
G
E
Site 130
S1605
G
Q
L
Y
H
L
S
S
V
Q
A
P
E
V
A
Site 131
S1614
Q
A
P
E
V
A
K
S
W
A
A
L
A
S
W
Site 132
S1634
R
K
V
V
D
N
A
S
Q
G
E
G
V
R
L
Site 133
S1647
R
L
L
P
R
E
K
S
E
V
Q
N
L
L
P
Site 134
T1656
V
Q
N
L
L
P
D
T
I
T
E
E
E
K
E
Site 135
T1658
N
L
L
P
D
T
I
T
E
E
E
K
E
R
I
Site 136
Y1666
E
E
E
K
E
R
I
Y
G
I
L
G
Q
A
V
Site 137
T1685
G
I
Q
D
E
D
I
T
L
Q
I
T
E
S
E
Site 138
S1691
I
T
L
Q
I
T
E
S
E
D
N
E
E
D
D
Site 139
S1715
I
S
S
C
P
W
L
S
E
L
D
E
S
A
T
Site 140
S1720
W
L
S
E
L
D
E
S
A
T
E
G
V
I
K
Site 141
S1770
D
D
P
R
L
H
L
S
H
R
V
E
Q
S
T
Site 142
T1777
S
H
R
V
E
Q
S
T
D
D
M
I
V
M
A
Site 143
Y1802
H
A
G
E
L
R
Q
Y
L
E
H
G
L
E
T
Site 144
T1810
L
E
H
G
L
E
T
T
P
T
A
P
W
R
G
Site 145
T1812
H
G
L
E
T
T
P
T
A
P
W
R
G
I
I
Site 146
Y1832
R
L
N
H
P
E
V
Y
V
R
Q
S
I
C
N
Site 147
S1865
V
G
T
I
S
L
S
S
E
S
Q
A
S
G
N
Site 148
S1867
T
I
S
L
S
S
E
S
Q
A
S
G
N
K
F
Site 149
S1870
L
S
S
E
S
Q
A
S
G
N
K
F
S
T
A
Site 150
S1893
Q
G
E
E
L
L
V
S
E
C
E
G
G
S
P
Site 151
S1899
V
S
E
C
E
G
G
S
P
P
A
S
Q
D
S
Site 152
S1903
E
G
G
S
P
P
A
S
Q
D
S
N
K
D
E
Site 153
S1906
S
P
P
A
S
Q
D
S
N
K
D
E
P
K
S
Site 154
S1913
S
N
K
D
E
P
K
S
G
L
N
E
D
Q
A
Site 155
Y1926
Q
A
M
M
Q
D
C
Y
S
K
I
V
D
K
L
Site 156
S1934
S
K
I
V
D
K
L
S
S
A
N
P
T
M
V
Site 157
Y1972
V
L
L
Q
Q
H
M
Y
V
L
R
R
I
Q
Q
Site 158
T1992
K
R
V
Q
N
N
N
T
L
R
K
E
E
K
I
Site 159
T2024
L
E
H
V
R
S
I
T
A
A
P
A
E
T
P
Site 160
T2030
I
T
A
A
P
A
E
T
P
H
E
K
W
F
Q
Site 161
Y2040
E
K
W
F
Q
D
N
Y
G
D
A
I
E
N
A
Site 162
T2053
N
A
L
E
K
L
K
T
P
L
N
P
A
K
P
Site 163
S2062
L
N
P
A
K
P
G
S
S
W
I
P
F
K
E
Site 164
S2073
P
F
K
E
I
M
L
S
L
Q
Q
R
A
Q
K
Site 165
S2083
Q
R
A
Q
K
R
A
S
Y
I
L
R
L
E
E
Site 166
Y2084
R
A
Q
K
R
A
S
Y
I
L
R
L
E
E
I
Site 167
T2114
G
E
V
S
A
R
D
T
V
T
I
H
S
V
G
Site 168
T2125
H
S
V
G
G
T
I
T
I
L
P
T
K
T
K
Site 169
S2141
K
K
L
L
F
L
G
S
D
G
K
S
Y
P
Y
Site 170
S2145
F
L
G
S
D
G
K
S
Y
P
Y
L
F
K
G
Site 171
Y2146
L
G
S
D
G
K
S
Y
P
Y
L
F
K
G
L
Site 172
Y2148
S
D
G
K
S
Y
P
Y
L
F
K
G
L
E
D
Site 173
T2181
A
T
I
N
R
Q
E
T
P
R
F
H
A
R
H
Site 174
Y2189
P
R
F
H
A
R
H
Y
S
V
T
P
L
G
T
Site 175
S2190
R
F
H
A
R
H
Y
S
V
T
P
L
G
T
R
Site 176
T2192
H
A
R
H
Y
S
V
T
P
L
G
T
R
S
G
Site 177
Y2214
A
T
P
L
F
G
L
Y
K
R
W
Q
Q
R
E
Site 178
Y2233
A
Q
K
A
Q
D
S
Y
Q
T
P
Q
N
P
G
Site 179
T2235
K
A
Q
D
S
Y
Q
T
P
Q
N
P
G
I
V
Site 180
S2246
P
G
I
V
P
R
P
S
E
L
Y
Y
S
K
I
Site 181
Y2249
V
P
R
P
S
E
L
Y
Y
S
K
I
G
P
A
Site 182
Y2250
P
R
P
S
E
L
Y
Y
S
K
I
G
P
A
L
Site 183
S2251
R
P
S
E
L
Y
Y
S
K
I
G
P
A
L
K
Site 184
S2263
A
L
K
T
V
G
L
S
L
D
V
S
R
R
D
Site 185
S2267
V
G
L
S
L
D
V
S
R
R
D
W
P
L
H
Site 186
T2287
L
E
E
L
M
E
A
T
P
P
N
L
L
A
K
Site 187
S2298
L
L
A
K
E
L
W
S
S
C
T
T
P
D
E
Site 188
S2299
L
A
K
E
L
W
S
S
C
T
T
P
D
E
W
Site 189
T2317
T
Q
S
Y
A
R
S
T
A
V
M
S
M
V
G
Site 190
Y2351
G
E
V
V
H
I
D
Y
N
V
C
F
E
K
G
Site 191
S2360
V
C
F
E
K
G
K
S
L
R
V
P
E
K
V
Site 192
T2372
E
K
V
P
F
R
M
T
Q
N
I
E
T
A
L
Site 193
T2422
Y
D
P
L
V
D
W
T
A
G
G
E
A
G
F
Site 194
S2446
Q
Q
A
E
S
K
Q
S
K
R
E
M
E
R
E
Site 195
T2455
R
E
M
E
R
E
I
T
R
S
L
F
S
S
R
Site 196
S2457
M
E
R
E
I
T
R
S
L
F
S
S
R
V
A
Site 197
S2460
E
I
T
R
S
L
F
S
S
R
V
A
E
I
K
Site 198
Y2491
L
D
G
S
L
D
E
Y
L
S
L
Q
E
Q
L
Site 199
S2493
G
S
L
D
E
Y
L
S
L
Q
E
Q
L
T
D
Site 200
T2499
L
S
L
Q
E
Q
L
T
D
V
E
K
L
Q
G
Site 201
S2525
A
E
G
V
D
H
P
S
H
T
L
Q
H
R
Y
Site 202
T2527
G
V
D
H
P
S
H
T
L
Q
H
R
Y
S
E
Site 203
S2533
H
T
L
Q
H
R
Y
S
E
H
T
Q
L
Q
T
Site 204
T2536
Q
H
R
Y
S
E
H
T
Q
L
Q
T
Q
Q
R
Site 205
S2583
A
S
L
L
Q
E
I
S
T
Q
M
D
L
G
P
Site 206
T2584
S
L
L
Q
E
I
S
T
Q
M
D
L
G
P
P
Site 207
S2592
Q
M
D
L
G
P
P
S
Y
V
P
A
T
A
F
Site 208
S2610
A
G
Q
A
H
L
I
S
Q
C
E
Q
L
E
G
Site 209
S2628
A
L
L
Q
Q
R
R
S
V
L
R
G
C
L
E
Site 210
T2642
E
Q
L
H
H
Y
A
T
V
A
L
Q
Y
P
K
Site 211
T2672
E
E
L
I
C
N
T
T
V
E
R
C
Q
E
L
Site 212
Y2680
V
E
R
C
Q
E
L
Y
R
K
Y
E
M
Q
Y
Site 213
Y2683
C
Q
E
L
Y
R
K
Y
E
M
Q
Y
A
P
Q
Site 214
Y2709
T
E
M
T
L
Q
R
Y
A
A
D
I
N
S
R
Site 215
T2730
R
L
K
Q
E
A
V
T
V
P
V
C
E
D
Q
Site 216
S2757
H
E
N
G
E
E
G
S
L
S
L
A
S
V
I
Site 217
T2793
G
E
Q
L
V
D
L
T
S
R
D
G
A
W
F
Site 218
S2794
E
Q
L
V
D
L
T
S
R
D
G
A
W
F
L
Site 219
S2837
I
P
N
P
M
E
A
S
E
T
V
H
L
A
N
Site 220
T2839
N
P
M
E
A
S
E
T
V
H
L
A
N
G
V
Site 221
S2849
L
A
N
G
V
Y
T
S
L
Q
E
L
N
S
N
Site 222
S2855
T
S
L
Q
E
L
N
S
N
F
R
Q
I
I
F
Site 223
Y2874
R
C
L
M
K
G
E
Y
T
L
E
S
M
L
H
Site 224
T2875
C
L
M
K
G
E
Y
T
L
E
S
M
L
H
E
Site 225
S2878
K
G
E
Y
T
L
E
S
M
L
H
E
L
D
G
Site 226
T2891
D
G
L
I
E
Q
T
T
D
G
V
P
L
Q
T
Site 227
S2902
P
L
Q
T
L
V
E
S
L
Q
A
Y
L
R
N
Site 228
Y2922
E
E
E
T
H
A
H
Y
I
D
V
A
R
L
L
Site 229
S2943
L
I
Q
P
R
N
G
S
V
D
E
T
P
K
M
Site 230
T2947
R
N
G
S
V
D
E
T
P
K
M
S
A
G
Q
Site 231
S2998
D
I
I
R
E
A
R
S
T
Q
V
N
F
F
D
Site 232
T2999
I
I
R
E
A
R
S
T
Q
V
N
F
F
D
D
Site 233
S3036
F
R
L
C
G
T
F
S
K
T
L
S
G
S
S
Site 234
S3040
G
T
F
S
K
T
L
S
G
S
S
S
L
E
D
Site 235
S3044
K
T
L
S
G
S
S
S
L
E
D
Q
N
T
V
Site 236
T3050
S
S
L
E
D
Q
N
T
V
N
G
P
V
Q
I
Site 237
S3067
V
K
T
L
F
R
N
S
C
F
S
E
D
Q
M
Site 238
S3070
L
F
R
N
S
C
F
S
E
D
Q
M
A
K
P
Site 239
S3129
F
G
A
E
S
K
V
S
V
D
D
L
C
K
K
Site 240
T3164
V
L
A
S
S
Y
D
T
A
W
K
K
H
D
L
Site 241
T3177
D
L
V
R
R
L
E
T
S
I
S
S
C
K
T
Site 242
S3178
L
V
R
R
L
E
T
S
I
S
S
C
K
T
S
Site 243
S3180
R
R
L
E
T
S
I
S
S
C
K
T
S
L
Q
Site 244
S3181
R
L
E
T
S
I
S
S
C
K
T
S
L
Q
R
Site 245
T3184
T
S
I
S
S
C
K
T
S
L
Q
R
V
Q
L
Site 246
S3185
S
I
S
S
C
K
T
S
L
Q
R
V
Q
L
H
Site 247
S3212
I
N
R
P
Q
A
M
S
V
T
P
P
P
R
S
Site 248
T3214
R
P
Q
A
M
S
V
T
P
P
P
R
S
A
I
Site 249
S3219
S
V
T
P
P
P
R
S
A
I
L
T
S
M
K
Site 250
T3223
P
P
R
S
A
I
L
T
S
M
K
K
K
L
H
Site 251
S3224
P
R
S
A
I
L
T
S
M
K
K
K
L
H
T
Site 252
T3231
S
M
K
K
K
L
H
T
L
S
Q
I
E
T
S
Site 253
S3233
K
K
K
L
H
T
L
S
Q
I
E
T
S
I
A
Site 254
S3251
E
K
L
A
A
L
E
S
S
I
E
Q
R
L
K
Site 255
S3252
K
L
A
A
L
E
S
S
I
E
Q
R
L
K
W
Site 256
S3289
R
N
L
V
L
K
E
S
Q
R
A
S
Q
V
T
Site 257
S3293
L
K
E
S
Q
R
A
S
Q
V
T
F
L
C
S
Site 258
S3307
S
N
I
I
H
F
E
S
L
R
T
R
T
A
E
Site 259
T3312
F
E
S
L
R
T
R
T
A
E
A
L
N
L
D
Site 260
S3337
Q
Q
M
C
S
F
A
S
Q
F
N
S
S
V
S
Site 261
S3341
S
F
A
S
Q
F
N
S
S
V
S
E
L
E
L
Site 262
S3342
F
A
S
Q
F
N
S
S
V
S
E
L
E
L
R
Site 263
S3344
S
Q
F
N
S
S
V
S
E
L
E
L
R
L
L
Site 264
T3356
R
L
L
Q
R
V
D
T
G
L
E
H
P
I
G
Site 265
S3364
G
L
E
H
P
I
G
S
S
E
W
L
L
S
A
Site 266
S3370
G
S
S
E
W
L
L
S
A
H
K
Q
L
T
Q
Site 267
T3376
L
S
A
H
K
Q
L
T
Q
D
M
S
T
Q
R
Site 268
S3380
K
Q
L
T
Q
D
M
S
T
Q
R
A
I
Q
T
Site 269
T3381
Q
L
T
Q
D
M
S
T
Q
R
A
I
Q
T
E
Site 270
T3395
E
K
E
Q
Q
I
E
T
V
C
E
T
I
Q
N
Site 271
T3409
N
L
V
D
N
I
K
T
V
L
T
G
H
N
R
Site 272
Y3444
A
D
G
E
D
V
P
Y
E
N
S
V
R
Q
F
Site 273
S3447
E
D
V
P
Y
E
N
S
V
R
Q
F
L
G
E
Site 274
S3478
Q
A
M
G
Q
V
R
S
Q
E
H
V
E
M
L
Site 275
T3489
V
E
M
L
Q
E
I
T
P
T
L
K
E
L
K
Site 276
T3491
M
L
Q
E
I
T
P
T
L
K
E
L
K
T
Q
Site 277
T3497
P
T
L
K
E
L
K
T
Q
S
Q
S
I
Y
N
Site 278
S3499
L
K
E
L
K
T
Q
S
Q
S
I
Y
N
N
L
Site 279
Y3503
K
T
Q
S
Q
S
I
Y
N
N
L
V
S
F
A
Site 280
T3515
S
F
A
S
P
L
V
T
D
A
T
N
E
C
S
Site 281
T3518
S
P
L
V
T
D
A
T
N
E
C
S
S
P
T
Site 282
S3522
T
D
A
T
N
E
C
S
S
P
T
S
S
A
T
Site 283
S3523
D
A
T
N
E
C
S
S
P
T
S
S
A
T
Y
Site 284
S3526
N
E
C
S
S
P
T
S
S
A
T
Y
Q
P
S
Site 285
S3527
E
C
S
S
P
T
S
S
A
T
Y
Q
P
S
F
Site 286
T3529
S
S
P
T
S
S
A
T
Y
Q
P
S
F
A
A
Site 287
Y3530
S
P
T
S
S
A
T
Y
Q
P
S
F
A
A
A
Site 288
S3533
S
S
A
T
Y
Q
P
S
F
A
A
A
V
R
S
Site 289
S3540
S
F
A
A
A
V
R
S
N
T
G
Q
K
T
Q
Site 290
T3542
A
A
A
V
R
S
N
T
G
Q
K
T
Q
P
D
Site 291
T3546
R
S
N
T
G
Q
K
T
Q
P
D
V
M
S
Q
Site 292
S3552
K
T
Q
P
D
V
M
S
Q
N
A
R
K
L
I
Site 293
T3565
L
I
Q
K
N
L
A
T
S
A
D
T
P
P
S
Site 294
S3566
I
Q
K
N
L
A
T
S
A
D
T
P
P
S
T
Site 295
T3569
N
L
A
T
S
A
D
T
P
P
S
T
V
P
G
Site 296
S3572
T
S
A
D
T
P
P
S
T
V
P
G
T
G
K
Site 297
T3573
S
A
D
T
P
P
S
T
V
P
G
T
G
K
S
Site 298
T3577
P
P
S
T
V
P
G
T
G
K
S
V
A
C
S
Site 299
S3580
T
V
P
G
T
G
K
S
V
A
C
S
P
K
K
Site 300
S3584
T
G
K
S
V
A
C
S
P
K
K
A
V
R
D
Site 301
T3594
K
A
V
R
D
P
K
T
G
K
A
V
Q
E
R
Site 302
S3603
K
A
V
Q
E
R
N
S
Y
A
V
S
V
W
K
Site 303
Y3604
A
V
Q
E
R
N
S
Y
A
V
S
V
W
K
R
Site 304
S3607
E
R
N
S
Y
A
V
S
V
W
K
R
V
K
A
Site 305
S3628
V
D
P
N
R
R
M
S
V
A
E
Q
V
D
Y
Site 306
Y3635
S
V
A
E
Q
V
D
Y
V
I
K
E
A
T
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation