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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALS2CR12
Full Name:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein
Alias:
Type:
Mass (Da):
52439
Number AA:
445
UniProt ID:
Q96Q35
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
G
P
R
K
L
I
K
T
P
Q
L
P
R
K
N
Site 2
S33
P
Q
L
P
R
K
N
S
T
G
S
S
K
L
T
Site 3
S37
R
K
N
S
T
G
S
S
K
L
T
P
L
V
P
Site 4
T40
S
T
G
S
S
K
L
T
P
L
V
P
A
P
K
Site 5
Y51
P
A
P
K
N
H
N
Y
L
Q
P
T
K
P
V
Site 6
S60
Q
P
T
K
P
V
V
S
P
K
M
K
I
H
S
Site 7
S67
S
P
K
M
K
I
H
S
A
R
Q
E
E
T
N
Site 8
S76
R
Q
E
E
T
N
K
S
F
Y
E
V
I
N
V
Site 9
Y78
E
E
T
N
K
S
F
Y
E
V
I
N
V
S
P
Site 10
Y87
V
I
N
V
S
P
G
Y
Q
L
V
R
N
R
E
Site 11
S113
D
R
K
K
R
W
E
S
E
I
P
D
K
G
R
Site 12
S122
I
P
D
K
G
R
F
S
R
T
N
I
I
S
D
Site 13
T124
D
K
G
R
F
S
R
T
N
I
I
S
D
L
E
Site 14
S128
F
S
R
T
N
I
I
S
D
L
E
E
Q
I
S
Site 15
S135
S
D
L
E
E
Q
I
S
E
L
T
A
I
I
E
Site 16
S150
Q
M
N
R
D
H
Q
S
A
Q
K
L
L
S
S
Site 17
S186
E
A
H
E
A
E
L
S
E
L
E
N
N
Y
K
Site 18
Y192
L
S
E
L
E
N
N
Y
K
A
A
L
K
A
E
Site 19
Y216
E
M
G
K
E
Y
K
Y
L
K
N
M
F
R
T
Site 20
Y224
L
K
N
M
F
R
T
Y
Q
D
S
I
Y
D
E
Site 21
Y229
R
T
Y
Q
D
S
I
Y
D
E
M
E
E
K
W
Site 22
S282
K
K
I
N
E
S
C
S
A
V
F
E
N
F
I
Site 23
S301
E
L
L
K
Q
H
Q
S
D
T
L
Q
L
E
E
Site 24
T303
L
K
Q
H
Q
S
D
T
L
Q
L
E
E
L
R
Site 25
T312
Q
L
E
E
L
R
K
T
K
E
V
P
W
R
R
Site 26
Y358
E
S
L
N
T
N
L
Y
Y
T
Q
L
E
L
Q
Site 27
Y359
S
L
N
T
N
L
Y
Y
T
Q
L
E
L
Q
K
Site 28
S419
E
E
I
C
E
G
C
S
G
R
L
A
S
I
T
Site 29
S424
G
C
S
G
R
L
A
S
I
T
V
S
K
D
D
Site 30
T426
S
G
R
L
A
S
I
T
V
S
K
D
D
S
D
Site 31
S428
R
L
A
S
I
T
V
S
K
D
D
S
D
T
V
Site 32
S432
I
T
V
S
K
D
D
S
D
T
V
Q
D
G
S
Site 33
T434
V
S
K
D
D
S
D
T
V
Q
D
G
S
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation