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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALS2CR4
Full Name:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein
Alias:
AL2S4; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4
Type:
Membrane protein, integral
Mass (Da):
48244
Number AA:
432
UniProt ID:
Q96Q45
International Prot ID:
IPI00044683
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
R
A
L
P
P
V
P
S
Q
D
D
I
P
L
S
Site 2
S56
S
Q
D
D
I
P
L
S
R
P
K
K
K
K
P
Site 3
T68
K
K
P
R
T
K
N
T
P
A
S
A
S
L
E
Site 4
S71
R
T
K
N
T
P
A
S
A
S
L
E
G
L
A
Site 5
S73
K
N
T
P
A
S
A
S
L
E
G
L
A
Q
T
Site 6
T80
S
L
E
G
L
A
Q
T
A
G
R
R
P
S
E
Site 7
S86
Q
T
A
G
R
R
P
S
E
G
N
E
P
S
T
Site 8
S92
P
S
E
G
N
E
P
S
T
K
E
L
K
E
H
Site 9
T93
S
E
G
N
E
P
S
T
K
E
L
K
E
H
P
Site 10
T111
V
Q
R
R
Q
K
K
T
R
L
P
L
E
L
E
Site 11
S120
L
P
L
E
L
E
T
S
S
T
Q
K
K
S
S
Site 12
S121
P
L
E
L
E
T
S
S
T
Q
K
K
S
S
S
Site 13
T122
L
E
L
E
T
S
S
T
Q
K
K
S
S
S
S
Site 14
S126
T
S
S
T
Q
K
K
S
S
S
S
S
L
L
R
Site 15
S127
S
S
T
Q
K
K
S
S
S
S
S
L
L
R
N
Site 16
S128
S
T
Q
K
K
S
S
S
S
S
L
L
R
N
E
Site 17
S130
Q
K
K
S
S
S
S
S
L
L
R
N
E
N
G
Site 18
T155
I
Q
K
P
R
R
K
T
K
K
T
Q
P
A
E
Site 19
T158
P
R
R
K
T
K
K
T
Q
P
A
E
L
Q
Y
Site 20
T178
V
E
D
E
D
I
I
T
D
E
Q
T
T
V
E
Site 21
S208
G
K
V
F
V
E
K
S
R
R
F
Q
A
A
D
Site 22
S217
R
F
Q
A
A
D
R
S
E
L
I
K
T
T
E
Site 23
T222
D
R
S
E
L
I
K
T
T
E
N
I
D
V
S
Site 24
S229
T
T
E
N
I
D
V
S
M
D
V
K
P
S
W
Site 25
T244
T
T
R
D
V
A
L
T
V
H
R
A
F
R
M
Site 26
T291
N
L
L
Q
Q
Y
K
T
L
A
Y
P
F
Q
S
Site 27
Y294
Q
Q
Y
K
T
L
A
Y
P
F
Q
S
L
L
Y
Site 28
S349
T
A
L
I
L
S
L
S
Q
Q
M
T
S
D
R
Site 29
T353
L
S
L
S
Q
Q
M
T
S
D
R
I
H
L
Y
Site 30
S354
S
L
S
Q
Q
M
T
S
D
R
I
H
L
Y
T
Site 31
Y360
T
S
D
R
I
H
L
Y
T
P
S
S
V
N
G
Site 32
T361
S
D
R
I
H
L
Y
T
P
S
S
V
N
G
S
Site 33
S363
R
I
H
L
Y
T
P
S
S
V
N
G
S
L
W
Site 34
S364
I
H
L
Y
T
P
S
S
V
N
G
S
L
W
E
Site 35
S368
T
P
S
S
V
N
G
S
L
W
E
A
G
I
E
Site 36
S409
Y
R
P
G
M
D
L
S
E
E
L
M
F
S
S
Site 37
S415
L
S
E
E
L
M
F
S
S
E
V
E
E
Y
P
Site 38
S416
S
E
E
L
M
F
S
S
E
V
E
E
Y
P
D
Site 39
Y421
F
S
S
E
V
E
E
Y
P
D
K
E
K
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation