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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPHOSPH1
Full Name:
Kinesin-like protein KIF20B
Alias:
Cancer/testis antigen 90; CT90; KIF20B; Kinesin family member 20B; Kinesin-related motor interacting with PIN1; KRMP1; Mitotic kinesin-like protein; M-phase phosphoprotein 1; MPP1; MPP-1; MPPH1
Type:
Motor protein
Mass (Da):
210683
Number AA:
1820
UniProt ID:
Q96Q89
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005874
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0050699
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0051301
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
Q
E
G
V
P
R
P
S
Y
V
F
S
A
D
P
Site 2
Y15
E
G
V
P
R
P
S
Y
V
F
S
A
D
P
I
Site 3
S18
P
R
P
S
Y
V
F
S
A
D
P
I
A
R
P
Site 4
S26
A
D
P
I
A
R
P
S
E
I
N
F
D
G
I
Site 5
S38
D
G
I
K
L
D
L
S
H
E
F
S
L
V
A
Site 6
S42
L
D
L
S
H
E
F
S
L
V
A
P
N
T
E
Site 7
T48
F
S
L
V
A
P
N
T
E
A
N
S
F
E
S
Site 8
S52
A
P
N
T
E
A
N
S
F
E
S
K
D
Y
L
Site 9
Y58
N
S
F
E
S
K
D
Y
L
Q
V
C
L
R
I
Site 10
T69
C
L
R
I
R
P
F
T
Q
S
E
K
E
L
E
Site 11
S71
R
I
R
P
F
T
Q
S
E
K
E
L
E
S
E
Site 12
T88
V
H
I
L
D
S
Q
T
V
V
L
K
E
P
Q
Site 13
S102
Q
C
I
L
G
R
L
S
E
K
S
S
G
Q
M
Site 14
S105
L
G
R
L
S
E
K
S
S
G
Q
M
A
Q
K
Site 15
S106
G
R
L
S
E
K
S
S
G
Q
M
A
Q
K
F
Site 16
S114
G
Q
M
A
Q
K
F
S
F
S
K
V
F
G
P
Site 17
S116
M
A
Q
K
F
S
F
S
K
V
F
G
P
A
T
Site 18
T123
S
K
V
F
G
P
A
T
T
Q
K
E
F
F
Q
Site 19
T124
K
V
F
G
P
A
T
T
Q
K
E
F
F
Q
G
Site 20
S145
K
D
L
L
K
G
Q
S
R
L
I
F
T
Y
G
Site 21
Y151
Q
S
R
L
I
F
T
Y
G
L
T
N
S
G
K
Site 22
T154
L
I
F
T
Y
G
L
T
N
S
G
K
T
Y
T
Site 23
Y160
L
T
N
S
G
K
T
Y
T
F
Q
G
T
E
E
Site 24
T161
T
N
S
G
K
T
Y
T
F
Q
G
T
E
E
N
Site 25
S182
T
L
N
V
L
F
D
S
L
Q
E
R
L
Y
T
Site 26
Y188
D
S
L
Q
E
R
L
Y
T
K
M
N
L
K
P
Site 27
T189
S
L
Q
E
R
L
Y
T
K
M
N
L
K
P
H
Site 28
S198
M
N
L
K
P
H
R
S
R
E
Y
L
R
L
S
Site 29
Y201
K
P
H
R
S
R
E
Y
L
R
L
S
S
E
Q
Site 30
S205
S
R
E
Y
L
R
L
S
S
E
Q
E
K
E
E
Site 31
S206
R
E
Y
L
R
L
S
S
E
Q
E
K
E
E
I
Site 32
S215
Q
E
K
E
E
I
A
S
K
S
A
L
L
R
Q
Site 33
S217
K
E
E
I
A
S
K
S
A
L
L
R
Q
I
K
Site 34
T227
L
R
Q
I
K
E
V
T
V
H
N
D
S
D
D
Site 35
S232
E
V
T
V
H
N
D
S
D
D
T
L
Y
G
S
Site 36
T235
V
H
N
D
S
D
D
T
L
Y
G
S
L
T
N
Site 37
Y237
N
D
S
D
D
T
L
Y
G
S
L
T
N
S
L
Site 38
S239
S
D
D
T
L
Y
G
S
L
T
N
S
L
N
I
Site 39
T241
D
T
L
Y
G
S
L
T
N
S
L
N
I
S
E
Site 40
S243
L
Y
G
S
L
T
N
S
L
N
I
S
E
F
E
Site 41
S247
L
T
N
S
L
N
I
S
E
F
E
E
S
I
K
Site 42
S252
N
I
S
E
F
E
E
S
I
K
D
Y
E
Q
A
Site 43
Y256
F
E
E
S
I
K
D
Y
E
Q
A
N
L
N
M
Site 44
S291
Y
D
L
F
V
P
V
S
S
K
F
Q
K
R
K
Site 45
S303
K
R
K
M
L
R
L
S
Q
D
V
K
G
Y
S
Site 46
Y309
L
S
Q
D
V
K
G
Y
S
F
I
K
D
L
Q
Site 47
S310
S
Q
D
V
K
G
Y
S
F
I
K
D
L
Q
W
Site 48
S321
D
L
Q
W
I
Q
V
S
D
S
K
E
A
Y
R
Site 49
S323
Q
W
I
Q
V
S
D
S
K
E
A
Y
R
L
L
Site 50
Y327
V
S
D
S
K
E
A
Y
R
L
L
K
L
G
I
Site 51
S338
K
L
G
I
K
H
Q
S
V
A
F
T
K
L
N
Site 52
T342
K
H
Q
S
V
A
F
T
K
L
N
N
A
S
S
Site 53
S348
F
T
K
L
N
N
A
S
S
R
S
H
S
I
F
Site 54
S349
T
K
L
N
N
A
S
S
R
S
H
S
I
F
T
Site 55
S351
L
N
N
A
S
S
R
S
H
S
I
F
T
V
K
Site 56
S353
N
A
S
S
R
S
H
S
I
F
T
V
K
I
L
Site 57
S365
K
I
L
Q
I
E
D
S
E
M
S
R
V
I
R
Site 58
S384
S
L
C
D
L
A
G
S
E
R
T
M
K
T
Q
Site 59
T390
G
S
E
R
T
M
K
T
Q
N
E
G
E
R
L
Site 60
T400
E
G
E
R
L
R
E
T
G
N
I
N
T
S
L
Site 61
S406
E
T
G
N
I
N
T
S
L
L
T
L
G
K
C
Site 62
T437
P
F
R
E
S
K
L
T
H
Y
F
Q
S
F
F
Site 63
Y439
R
E
S
K
L
T
H
Y
F
Q
S
F
F
N
G
Site 64
T484
Q
K
V
C
V
P
D
T
L
N
S
S
Q
E
K
Site 65
S487
C
V
P
D
T
L
N
S
S
Q
E
K
L
F
G
Site 66
S488
V
P
D
T
L
N
S
S
Q
E
K
L
F
G
P
Site 67
S498
K
L
F
G
P
V
K
S
S
Q
D
V
S
L
D
Site 68
S499
L
F
G
P
V
K
S
S
Q
D
V
S
L
D
S
Site 69
S503
V
K
S
S
Q
D
V
S
L
D
S
N
S
N
S
Site 70
S506
S
Q
D
V
S
L
D
S
N
S
N
S
K
I
L
Site 71
S508
D
V
S
L
D
S
N
S
N
S
K
I
L
N
V
Site 72
S510
S
L
D
S
N
S
N
S
K
I
L
N
V
K
R
Site 73
T519
I
L
N
V
K
R
A
T
I
S
W
E
N
S
L
Site 74
S521
N
V
K
R
A
T
I
S
W
E
N
S
L
E
D
Site 75
S525
A
T
I
S
W
E
N
S
L
E
D
L
M
E
D
Site 76
T560
L
D
E
D
L
D
K
T
L
E
E
N
K
A
F
Site 77
S569
E
E
N
K
A
F
I
S
H
E
E
K
R
K
L
Site 78
Y612
V
T
Q
E
F
T
Q
Y
W
A
Q
R
E
A
D
Site 79
T669
T
K
V
E
T
E
E
T
H
N
Y
V
G
F
E
Site 80
Y672
E
T
E
E
T
H
N
Y
V
G
F
E
D
I
I
Site 81
S681
G
F
E
D
I
I
D
S
L
Q
D
N
V
A
D
Site 82
T727
I
K
A
E
L
A
K
T
K
G
E
L
I
K
T
Site 83
T734
T
K
G
E
L
I
K
T
K
E
E
L
K
K
R
Site 84
S745
L
K
K
R
E
N
E
S
D
S
L
I
Q
E
L
Site 85
S747
K
R
E
N
E
S
D
S
L
I
Q
E
L
E
T
Site 86
S755
L
I
Q
E
L
E
T
S
N
K
K
I
I
T
Q
Site 87
T779
I
I
D
Q
K
E
D
T
I
N
E
F
Q
N
L
Site 88
T793
L
K
S
H
M
E
N
T
F
K
C
N
D
K
A
Site 89
S804
N
D
K
A
D
T
S
S
L
I
I
N
N
K
L
Site 90
S823
T
V
E
V
P
K
D
S
K
S
K
I
C
S
E
Site 91
S825
E
V
P
K
D
S
K
S
K
I
C
S
E
R
K
Site 92
S829
D
S
K
S
K
I
C
S
E
R
K
R
V
N
E
Site 93
S850
E
P
P
A
K
K
G
S
I
H
V
S
S
A
I
Site 94
S854
K
K
G
S
I
H
V
S
S
A
I
T
E
D
Q
Site 95
S920
V
H
F
Q
Q
E
L
S
L
S
E
K
K
N
L
Site 96
S922
F
Q
Q
E
L
S
L
S
E
K
K
N
L
T
L
Site 97
T928
L
S
E
K
K
N
L
T
L
S
K
E
V
Q
Q
Site 98
S930
E
K
K
N
L
T
L
S
K
E
V
Q
Q
I
Q
Site 99
S938
K
E
V
Q
Q
I
Q
S
N
Y
D
I
A
I
A
Site 100
Y940
V
Q
Q
I
Q
S
N
Y
D
I
A
I
A
E
L
Site 101
S952
A
E
L
H
V
Q
K
S
K
N
Q
E
Q
E
E
Site 102
S965
E
E
K
I
M
K
L
S
N
E
I
E
T
A
T
Site 103
S974
E
I
E
T
A
T
R
S
I
T
N
N
V
S
Q
Site 104
T976
E
T
A
T
R
S
I
T
N
N
V
S
Q
I
K
Site 105
S980
R
S
I
T
N
N
V
S
Q
I
K
L
M
H
T
Site 106
T987
S
Q
I
K
L
M
H
T
K
I
D
E
L
R
T
Site 107
T994
T
K
I
D
E
L
R
T
L
D
S
V
S
Q
I
Site 108
S997
D
E
L
R
T
L
D
S
V
S
Q
I
S
N
I
Site 109
S999
L
R
T
L
D
S
V
S
Q
I
S
N
I
D
L
Site 110
S1013
L
L
N
L
R
D
L
S
N
G
S
E
E
D
N
Site 111
S1016
L
R
D
L
S
N
G
S
E
E
D
N
L
P
N
Site 112
T1024
E
E
D
N
L
P
N
T
Q
L
D
L
L
G
N
Site 113
Y1033
L
D
L
L
G
N
D
Y
L
V
S
K
Q
V
K
Site 114
S1052
Q
E
P
N
R
E
N
S
F
H
S
S
I
E
A
Site 115
S1056
R
E
N
S
F
H
S
S
I
E
A
I
W
E
E
Site 116
S1075
V
K
A
S
S
K
K
S
H
Q
I
E
E
L
E
Site 117
Y1095
L
Q
A
E
V
K
G
Y
K
D
E
N
N
R
L
Site 118
T1134
E
L
Q
E
K
N
V
T
L
D
V
Q
I
Q
H
Site 119
S1150
V
E
G
K
R
A
L
S
E
L
T
Q
G
V
T
Site 120
S1180
Q
K
V
E
R
S
H
S
A
K
L
E
Q
D
I
Site 121
S1211
F
Q
E
H
L
Q
D
S
V
K
N
T
K
D
L
Site 122
T1252
L
K
E
E
E
E
E
T
N
R
Q
E
T
E
K
Site 123
T1257
E
E
T
N
R
Q
E
T
E
K
L
K
E
E
L
Site 124
S1265
E
K
L
K
E
E
L
S
A
S
S
A
R
T
Q
Site 125
S1267
L
K
E
E
L
S
A
S
S
A
R
T
Q
N
L
Site 126
S1268
K
E
E
L
S
A
S
S
A
R
T
Q
N
L
K
Site 127
T1271
L
S
A
S
S
A
R
T
Q
N
L
K
A
D
L
Site 128
Y1285
L
Q
R
K
E
E
D
Y
A
D
L
K
E
K
L
Site 129
T1293
A
D
L
K
E
K
L
T
D
A
K
K
Q
I
K
Site 130
S1307
K
Q
V
Q
K
E
V
S
V
M
R
D
E
D
K
Site 131
S1331
E
K
K
K
N
Q
C
S
Q
E
L
D
M
K
Q
Site 132
Y1360
V
E
E
A
I
Q
Q
Y
E
R
A
C
K
D
L
Site 133
T1380
I
I
E
D
M
R
M
T
L
E
E
Q
E
Q
T
Site 134
T1387
T
L
E
E
Q
E
Q
T
Q
V
E
Q
D
Q
V
Site 135
T1407
E
E
V
E
R
L
A
T
E
L
E
K
W
K
E
Site 136
T1421
E
K
C
N
D
L
E
T
K
N
N
Q
R
S
N
Site 137
S1427
E
T
K
N
N
Q
R
S
N
K
E
H
E
N
N
Site 138
S1451
L
Q
D
E
L
Q
E
S
E
Q
K
Y
N
A
D
Site 139
Y1455
L
Q
E
S
E
Q
K
Y
N
A
D
R
K
K
W
Site 140
T1471
E
E
K
M
M
L
I
T
Q
A
K
E
A
E
N
Site 141
Y1487
R
N
K
E
M
K
K
Y
A
E
D
R
E
R
F
Site 142
T1509
E
I
L
T
A
Q
L
T
E
K
D
S
D
L
Q
Site 143
S1513
A
Q
L
T
E
K
D
S
D
L
Q
K
W
R
E
Site 144
S1538
I
Q
L
K
A
L
I
S
S
N
V
Q
K
D
N
Site 145
S1555
E
Q
L
K
R
I
I
S
E
T
S
K
I
E
T
Site 146
T1557
L
K
R
I
I
S
E
T
S
K
I
E
T
Q
I
Site 147
T1562
S
E
T
S
K
I
E
T
Q
I
M
D
I
K
P
Site 148
S1573
D
I
K
P
K
R
I
S
S
A
D
P
D
K
L
Site 149
S1574
I
K
P
K
R
I
S
S
A
D
P
D
K
L
Q
Site 150
T1582
A
D
P
D
K
L
Q
T
E
P
L
S
T
S
F
Site 151
S1586
K
L
Q
T
E
P
L
S
T
S
F
E
I
S
R
Site 152
T1587
L
Q
T
E
P
L
S
T
S
F
E
I
S
R
N
Site 153
S1588
Q
T
E
P
L
S
T
S
F
E
I
S
R
N
K
Site 154
S1592
L
S
T
S
F
E
I
S
R
N
K
I
E
D
G
Site 155
S1600
R
N
K
I
E
D
G
S
V
V
L
D
S
C
E
Site 156
S1605
D
G
S
V
V
L
D
S
C
E
V
S
T
E
N
Site 157
S1609
V
L
D
S
C
E
V
S
T
E
N
D
Q
S
T
Site 158
S1615
V
S
T
E
N
D
Q
S
T
R
F
P
K
P
E
Site 159
T1616
S
T
E
N
D
Q
S
T
R
F
P
K
P
E
L
Site 160
T1628
P
E
L
E
I
Q
F
T
P
L
Q
P
N
K
M
Site 161
T1644
V
K
H
P
G
C
T
T
P
V
T
V
K
I
P
Site 162
T1647
P
G
C
T
T
P
V
T
V
K
I
P
K
A
R
Site 163
S1658
P
K
A
R
K
R
K
S
N
E
M
E
E
D
L
Site 164
T1675
C
E
N
K
K
N
A
T
P
R
T
N
L
K
F
Site 165
T1678
K
K
N
A
T
P
R
T
N
L
K
F
P
I
S
Site 166
S1685
T
N
L
K
F
P
I
S
D
D
R
N
S
S
V
Site 167
S1690
P
I
S
D
D
R
N
S
S
V
K
K
E
Q
K
Site 168
S1691
I
S
D
D
R
N
S
S
V
K
K
E
Q
K
V
Site 169
S1703
Q
K
V
A
I
R
P
S
S
K
K
T
Y
S
L
Site 170
S1704
K
V
A
I
R
P
S
S
K
K
T
Y
S
L
R
Site 171
T1707
I
R
P
S
S
K
K
T
Y
S
L
R
S
Q
A
Site 172
Y1708
R
P
S
S
K
K
T
Y
S
L
R
S
Q
A
S
Site 173
S1709
P
S
S
K
K
T
Y
S
L
R
S
Q
A
S
I
Site 174
S1712
K
K
T
Y
S
L
R
S
Q
A
S
I
I
G
V
Site 175
T1729
A
T
K
K
K
E
G
T
L
Q
K
F
G
D
F
Site 176
S1740
F
G
D
F
L
Q
H
S
P
S
I
L
Q
S
K
Site 177
S1742
D
F
L
Q
H
S
P
S
I
L
Q
S
K
A
K
Site 178
S1746
H
S
P
S
I
L
Q
S
K
A
K
K
I
I
E
Site 179
T1754
K
A
K
K
I
I
E
T
M
S
S
S
K
L
S
Site 180
S1756
K
K
I
I
E
T
M
S
S
S
K
L
S
N
V
Site 181
S1757
K
I
I
E
T
M
S
S
S
K
L
S
N
V
E
Site 182
S1761
T
M
S
S
S
K
L
S
N
V
E
A
S
K
E
Site 183
S1766
K
L
S
N
V
E
A
S
K
E
N
V
S
Q
P
Site 184
S1771
E
A
S
K
E
N
V
S
Q
P
K
R
A
K
R
Site 185
Y1781
K
R
A
K
R
K
L
Y
T
S
E
I
S
S
P
Site 186
T1782
R
A
K
R
K
L
Y
T
S
E
I
S
S
P
I
Site 187
S1783
A
K
R
K
L
Y
T
S
E
I
S
S
P
I
D
Site 188
S1787
L
Y
T
S
E
I
S
S
P
I
D
I
S
G
Q
Site 189
T1816
I
I
K
R
R
L
R
T
K
T
A
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation