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Updated November 2019
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Protein Info
Short Name:
DLC1
Full Name:
Rho GTPase-activating protein 7
Alias:
ARHGAP7; Deleted in liver cancer 1; DLC-1; HP; P122-RhoGAP; RHG07; Rho-GTPase-activating protein 7; Rho-type GTPase-activating protein 7;Deleted in liver cancer 1 protein;Dlc-1;HP protein;StAR-related lipid transfer protein 12;StARD12;START domain-containing protein 12; StARD12; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; START domain-containing protein 12
Type:
GTPase-activating protein for G protein
Mass (Da):
170592
Number AA:
1528
UniProt ID:
Q96QB1
International Prot ID:
IPI00374033
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005901
GO:0005737
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0042169
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006919
GO:0048041
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
V
A
I
R
K
R
S
W
E
E
H
V
T
H
Site 2
S39
H
H
G
L
V
A
D
S
L
Q
A
S
M
E
K
Site 3
S43
V
A
D
S
L
Q
A
S
M
E
K
D
A
T
L
Site 4
T49
A
S
M
E
K
D
A
T
L
N
V
D
R
K
E
Site 5
S60
D
R
K
E
K
C
V
S
L
P
D
C
C
H
G
Site 6
S68
L
P
D
C
C
H
G
S
E
L
R
D
F
P
G
Site 7
S82
G
R
P
M
G
H
L
S
K
D
V
D
E
N
D
Site 8
S90
K
D
V
D
E
N
D
S
H
E
G
E
D
Q
F
Site 9
S99
E
G
E
D
Q
F
L
S
L
E
A
S
T
E
T
Site 10
S156
K
A
L
P
I
I
Q
S
N
Q
V
S
S
N
S
Site 11
S160
I
I
Q
S
N
Q
V
S
S
N
S
W
G
I
A
Site 12
S161
I
Q
S
N
Q
V
S
S
N
S
W
G
I
A
G
Site 13
S163
S
N
Q
V
S
S
N
S
W
G
I
A
G
E
T
Site 14
T184
E
S
G
E
R
K
V
T
D
S
I
S
K
S
L
Site 15
S186
G
E
R
K
V
T
D
S
I
S
K
S
L
E
L
Site 16
S188
R
K
V
T
D
S
I
S
K
S
L
E
L
C
N
Site 17
S190
V
T
D
S
I
S
K
S
L
E
L
C
N
E
I
Site 18
S198
L
E
L
C
N
E
I
S
L
S
E
I
K
D
A
Site 19
S200
L
C
N
E
I
S
L
S
E
I
K
D
A
P
K
Site 20
S248
P
K
D
E
N
E
R
S
T
C
N
V
V
Q
D
Site 21
T249
K
D
E
N
E
R
S
T
C
N
V
V
Q
D
E
Site 22
T260
V
Q
D
E
F
L
D
T
P
C
T
N
R
G
L
Site 23
T263
E
F
L
D
T
P
C
T
N
R
G
L
P
L
L
Site 24
S283
S
C
L
L
Q
P
P
S
C
P
N
G
M
S
A
Site 25
S297
A
E
N
G
L
E
K
S
G
F
S
Q
H
Q
N
Site 26
S306
F
S
Q
H
Q
N
K
S
P
P
K
V
K
A
E
Site 27
T327
Q
L
K
E
T
L
A
T
Q
E
P
T
D
N
Q
Site 28
S354
R
D
R
A
R
L
D
S
M
V
L
L
I
M
K
Site 29
S374
Q
D
I
E
N
A
L
S
T
S
S
S
P
S
G
Site 30
S376
I
E
N
A
L
S
T
S
S
S
P
S
G
T
P
Site 31
S378
N
A
L
S
T
S
S
S
P
S
G
T
P
T
N
Site 32
S380
L
S
T
S
S
S
P
S
G
T
P
T
N
L
R
Site 33
T382
T
S
S
S
P
S
G
T
P
T
N
L
R
R
H
Site 34
T384
S
S
P
S
G
T
P
T
N
L
R
R
H
V
P
Site 35
S395
R
H
V
P
D
L
E
S
G
S
E
S
G
A
D
Site 36
S397
V
P
D
L
E
S
G
S
E
S
G
A
D
T
I
Site 37
S399
D
L
E
S
G
S
E
S
G
A
D
T
I
S
V
Site 38
T403
G
S
E
S
G
A
D
T
I
S
V
N
Q
T
R
Site 39
S405
E
S
G
A
D
T
I
S
V
N
Q
T
R
V
N
Site 40
T409
D
T
I
S
V
N
Q
T
R
V
N
L
S
S
D
Site 41
S414
N
Q
T
R
V
N
L
S
S
D
T
E
S
T
D
Site 42
S415
Q
T
R
V
N
L
S
S
D
T
E
S
T
D
L
Site 43
T417
R
V
N
L
S
S
D
T
E
S
T
D
L
P
S
Site 44
S419
N
L
S
S
D
T
E
S
T
D
L
P
S
S
T
Site 45
T420
L
S
S
D
T
E
S
T
D
L
P
S
S
T
P
Site 46
S424
T
E
S
T
D
L
P
S
S
T
P
V
A
N
S
Site 47
S425
E
S
T
D
L
P
S
S
T
P
V
A
N
S
G
Site 48
T426
S
T
D
L
P
S
S
T
P
V
A
N
S
G
T
Site 49
S431
S
S
T
P
V
A
N
S
G
T
K
P
K
T
T
Site 50
T437
N
S
G
T
K
P
K
T
T
A
I
Q
G
I
S
Site 51
T463
A
C
D
W
L
R
A
T
G
F
P
Q
Y
A
Q
Site 52
Y468
R
A
T
G
F
P
Q
Y
A
Q
L
Y
E
D
F
Site 53
S517
A
V
M
K
L
E
I
S
P
H
R
K
R
S
D
Site 54
S523
I
S
P
H
R
K
R
S
D
D
S
D
E
D
E
Site 55
S526
H
R
K
R
S
D
D
S
D
E
D
E
P
C
A
Site 56
T539
C
A
I
S
G
K
W
T
F
Q
R
D
S
K
R
Site 57
S544
K
W
T
F
Q
R
D
S
K
R
W
S
R
L
E
Site 58
S548
Q
R
D
S
K
R
W
S
R
L
E
E
F
D
V
Site 59
S557
L
E
E
F
D
V
F
S
P
K
Q
D
L
V
P
Site 60
S566
K
Q
D
L
V
P
G
S
P
D
D
S
H
P
K
Site 61
S570
V
P
G
S
P
D
D
S
H
P
K
D
G
P
S
Site 62
S577
S
H
P
K
D
G
P
S
P
G
G
T
L
M
D
Site 63
T581
D
G
P
S
P
G
G
T
L
M
D
L
S
E
R
Site 64
S586
G
G
T
L
M
D
L
S
E
R
Q
E
V
S
S
Site 65
S592
L
S
E
R
Q
E
V
S
S
V
R
S
L
S
S
Site 66
S593
S
E
R
Q
E
V
S
S
V
R
S
L
S
S
T
Site 67
S596
Q
E
V
S
S
V
R
S
L
S
S
T
G
S
L
Site 68
S598
V
S
S
V
R
S
L
S
S
T
G
S
L
P
S
Site 69
S599
S
S
V
R
S
L
S
S
T
G
S
L
P
S
H
Site 70
T600
S
V
R
S
L
S
S
T
G
S
L
P
S
H
A
Site 71
S602
R
S
L
S
S
T
G
S
L
P
S
H
A
P
P
Site 72
S605
S
S
T
G
S
L
P
S
H
A
P
P
S
E
D
Site 73
S610
L
P
S
H
A
P
P
S
E
D
A
A
T
P
R
Site 74
T615
P
P
S
E
D
A
A
T
P
R
T
N
S
V
I
Site 75
T618
E
D
A
A
T
P
R
T
N
S
V
I
S
V
C
Site 76
S623
P
R
T
N
S
V
I
S
V
C
S
S
S
N
L
Site 77
S628
V
I
S
V
C
S
S
S
N
L
A
G
N
D
D
Site 78
S636
N
L
A
G
N
D
D
S
F
G
S
L
P
S
P
Site 79
S639
G
N
D
D
S
F
G
S
L
P
S
P
K
E
L
Site 80
S642
D
S
F
G
S
L
P
S
P
K
E
L
S
S
F
Site 81
S647
L
P
S
P
K
E
L
S
S
F
S
F
S
M
K
Site 82
S648
P
S
P
K
E
L
S
S
F
S
F
S
M
K
G
Site 83
S650
P
K
E
L
S
S
F
S
F
S
M
K
G
H
E
Site 84
S652
E
L
S
S
F
S
F
S
M
K
G
H
E
K
T
Site 85
T659
S
M
K
G
H
E
K
T
A
K
S
K
T
R
S
Site 86
S662
G
H
E
K
T
A
K
S
K
T
R
S
L
L
K
Site 87
S666
T
A
K
S
K
T
R
S
L
L
K
R
M
E
S
Site 88
S673
S
L
L
K
R
M
E
S
L
K
L
K
S
S
H
Site 89
S678
M
E
S
L
K
L
K
S
S
H
H
S
K
H
K
Site 90
S679
E
S
L
K
L
K
S
S
H
H
S
K
H
K
A
Site 91
S682
K
L
K
S
S
H
H
S
K
H
K
A
P
S
K
Site 92
S733
V
P
M
V
R
K
R
S
V
S
N
S
T
Q
T
Site 93
S735
M
V
R
K
R
S
V
S
N
S
T
Q
T
S
S
Site 94
S737
R
K
R
S
V
S
N
S
T
Q
T
S
S
S
S
Site 95
T738
K
R
S
V
S
N
S
T
Q
T
S
S
S
S
S
Site 96
T740
S
V
S
N
S
T
Q
T
S
S
S
S
S
Q
S
Site 97
S741
V
S
N
S
T
Q
T
S
S
S
S
S
Q
S
E
Site 98
S742
S
N
S
T
Q
T
S
S
S
S
S
Q
S
E
T
Site 99
S743
N
S
T
Q
T
S
S
S
S
S
Q
S
E
T
S
Site 100
S744
S
T
Q
T
S
S
S
S
S
Q
S
E
T
S
S
Site 101
S745
T
Q
T
S
S
S
S
S
Q
S
E
T
S
S
A
Site 102
S747
T
S
S
S
S
S
Q
S
E
T
S
S
A
V
S
Site 103
T749
S
S
S
S
Q
S
E
T
S
S
A
V
S
T
P
Site 104
S750
S
S
S
Q
S
E
T
S
S
A
V
S
T
P
S
Site 105
S751
S
S
Q
S
E
T
S
S
A
V
S
T
P
S
P
Site 106
S754
S
E
T
S
S
A
V
S
T
P
S
P
V
T
R
Site 107
T755
E
T
S
S
A
V
S
T
P
S
P
V
T
R
T
Site 108
S757
S
S
A
V
S
T
P
S
P
V
T
R
T
R
S
Site 109
T760
V
S
T
P
S
P
V
T
R
T
R
S
L
S
A
Site 110
T762
T
P
S
P
V
T
R
T
R
S
L
S
A
C
N
Site 111
S764
S
P
V
T
R
T
R
S
L
S
A
C
N
K
R
Site 112
S766
V
T
R
T
R
S
L
S
A
C
N
K
R
V
G
Site 113
Y775
C
N
K
R
V
G
M
Y
L
E
G
F
D
P
F
Site 114
S800
Q
N
F
K
N
R
E
S
Y
P
E
D
T
V
F
Site 115
Y801
N
F
K
N
R
E
S
Y
P
E
D
T
V
F
Y
Site 116
T805
R
E
S
Y
P
E
D
T
V
F
Y
I
P
E
D
Site 117
T817
P
E
D
H
K
P
G
T
F
P
K
A
L
T
N
Site 118
T823
G
T
F
P
K
A
L
T
N
G
S
F
S
P
S
Site 119
S826
P
K
A
L
T
N
G
S
F
S
P
S
G
N
N
Site 120
S828
A
L
T
N
G
S
F
S
P
S
G
N
N
G
S
Site 121
S830
T
N
G
S
F
S
P
S
G
N
N
G
S
V
N
Site 122
S835
S
P
S
G
N
N
G
S
V
N
W
R
T
G
S
Site 123
T840
N
G
S
V
N
W
R
T
G
S
F
H
G
P
G
Site 124
S842
S
V
N
W
R
T
G
S
F
H
G
P
G
H
I
Site 125
S850
F
H
G
P
G
H
I
S
L
R
R
E
N
S
S
Site 126
S856
I
S
L
R
R
E
N
S
S
D
S
P
K
E
L
Site 127
S857
S
L
R
R
E
N
S
S
D
S
P
K
E
L
K
Site 128
S859
R
R
E
N
S
S
D
S
P
K
E
L
K
R
R
Site 129
S868
K
E
L
K
R
R
N
S
S
S
S
M
S
S
R
Site 130
S869
E
L
K
R
R
N
S
S
S
S
M
S
S
R
L
Site 131
S870
L
K
R
R
N
S
S
S
S
M
S
S
R
L
S
Site 132
S871
K
R
R
N
S
S
S
S
M
S
S
R
L
S
I
Site 133
S873
R
N
S
S
S
S
M
S
S
R
L
S
I
Y
D
Site 134
S874
N
S
S
S
S
M
S
S
R
L
S
I
Y
D
N
Site 135
S877
S
S
M
S
S
R
L
S
I
Y
D
N
V
P
G
Site 136
Y879
M
S
S
R
L
S
I
Y
D
N
V
P
G
S
I
Site 137
S885
I
Y
D
N
V
P
G
S
I
L
Y
S
S
S
G
Site 138
S891
G
S
I
L
Y
S
S
S
G
D
L
A
D
L
E
Site 139
Y911
P
E
L
D
D
I
L
Y
H
V
K
G
M
Q
R
Site 140
S928
N
Q
W
S
E
K
F
S
D
E
G
D
S
D
S
Site 141
S933
K
F
S
D
E
G
D
S
D
S
A
L
D
S
V
Site 142
S935
S
D
E
G
D
S
D
S
A
L
D
S
V
S
P
Site 143
S939
D
S
D
S
A
L
D
S
V
S
P
C
P
S
S
Site 144
S941
D
S
A
L
D
S
V
S
P
C
P
S
S
P
K
Site 145
S945
D
S
V
S
P
C
P
S
S
P
K
Q
I
H
L
Site 146
S946
S
V
S
P
C
P
S
S
P
K
Q
I
H
L
D
Site 147
T960
D
V
D
N
D
R
T
T
P
S
D
L
D
S
T
Site 148
S962
D
N
D
R
T
T
P
S
D
L
D
S
T
G
N
Site 149
S966
T
T
P
S
D
L
D
S
T
G
N
S
L
N
E
Site 150
S970
D
L
D
S
T
G
N
S
L
N
E
P
E
E
P
Site 151
S986
E
I
P
E
R
R
D
S
G
V
G
A
S
L
T
Site 152
S991
R
D
S
G
V
G
A
S
L
T
R
S
N
R
H
Site 153
T993
S
G
V
G
A
S
L
T
R
S
N
R
H
R
L
Site 154
S995
V
G
A
S
L
T
R
S
N
R
H
R
L
R
W
Site 155
S1004
R
H
R
L
R
W
H
S
F
Q
S
S
H
R
P
Site 156
S1007
L
R
W
H
S
F
Q
S
S
H
R
P
S
L
N
Site 157
S1008
R
W
H
S
F
Q
S
S
H
R
P
S
L
N
S
Site 158
S1012
F
Q
S
S
H
R
P
S
L
N
S
V
S
L
Q
Site 159
S1015
S
H
R
P
S
L
N
S
V
S
L
Q
I
N
C
Site 160
S1017
R
P
S
L
N
S
V
S
L
Q
I
N
C
Q
S
Site 161
Y1046
L
T
A
L
L
E
K
Y
T
P
S
N
K
H
G
Site 162
T1047
T
A
L
L
E
K
Y
T
P
S
N
K
H
G
F
Site 163
S1055
P
S
N
K
H
G
F
S
W
A
V
P
K
F
M
Site 164
Y1070
K
R
I
K
V
P
D
Y
K
D
R
S
V
F
G
Site 165
S1074
V
P
D
Y
K
D
R
S
V
F
G
V
P
L
T
Site 166
S1094
T
G
Q
P
L
P
Q
S
I
Q
Q
A
M
R
Y
Site 167
Y1101
S
I
Q
Q
A
M
R
Y
L
R
N
H
C
L
D
Site 168
S1116
Q
V
G
L
F
R
K
S
G
V
K
S
R
I
Q
Site 169
S1120
F
R
K
S
G
V
K
S
R
I
Q
A
L
R
Q
Site 170
Y1138
G
A
I
D
C
V
N
Y
E
G
Q
S
A
Y
D
Site 171
Y1153
V
A
D
M
L
K
Q
Y
F
R
D
L
P
E
P
Site 172
T1163
D
L
P
E
P
L
M
T
N
K
L
S
E
T
F
Site 173
T1169
M
T
N
K
L
S
E
T
F
L
Q
I
Y
Q
Y
Site 174
Y1174
S
E
T
F
L
Q
I
Y
Q
Y
V
P
K
D
Q
Site 175
Y1176
T
F
L
Q
I
Y
Q
Y
V
P
K
D
Q
R
L
Site 176
T1203
E
N
R
E
V
L
Q
T
L
L
Y
F
L
S
D
Site 177
S1209
Q
T
L
L
Y
F
L
S
D
V
T
A
A
V
K
Site 178
T1221
A
V
K
E
N
Q
M
T
P
T
N
L
A
V
C
Site 179
T1238
P
S
L
F
H
L
N
T
L
K
R
E
N
S
S
Site 180
S1244
N
T
L
K
R
E
N
S
S
P
R
V
M
Q
R
Site 181
S1245
T
L
K
R
E
N
S
S
P
R
V
M
Q
R
K
Site 182
S1254
R
V
M
Q
R
K
Q
S
L
G
K
P
D
Q
K
Site 183
S1296
E
M
S
R
C
R
N
S
Y
T
E
Q
E
L
K
Site 184
Y1297
M
S
R
C
R
N
S
Y
T
E
Q
E
L
K
P
Site 185
T1306
E
Q
E
L
K
P
L
T
L
E
A
L
G
H
L
Site 186
S1318
G
H
L
G
N
D
D
S
A
D
Y
Q
H
F
L
Site 187
Y1321
G
N
D
D
S
A
D
Y
Q
H
F
L
Q
D
C
Site 188
S1345
E
K
F
K
G
W
V
S
Y
S
T
S
E
Q
A
Site 189
S1347
F
K
G
W
V
S
Y
S
T
S
E
Q
A
E
L
Site 190
S1349
G
W
V
S
Y
S
T
S
E
Q
A
E
L
S
Y
Site 191
S1355
T
S
E
Q
A
E
L
S
Y
K
K
V
S
E
G
Site 192
Y1356
S
E
Q
A
E
L
S
Y
K
K
V
S
E
G
P
Site 193
S1407
K
V
I
E
I
L
D
S
Q
T
E
I
Y
Q
Y
Site 194
Y1412
L
D
S
Q
T
E
I
Y
Q
Y
V
Q
N
S
M
Site 195
Y1414
S
Q
T
E
I
Y
Q
Y
V
Q
N
S
M
A
P
Site 196
Y1427
A
P
H
P
A
R
D
Y
V
V
L
R
T
W
R
Site 197
T1432
R
D
Y
V
V
L
R
T
W
R
T
N
L
P
K
Site 198
T1435
V
V
L
R
T
W
R
T
N
L
P
K
G
A
C
Site 199
Y1482
P
G
K
S
K
L
T
Y
M
C
R
V
D
L
R
Site 200
Y1496
R
G
H
M
P
E
W
Y
T
K
S
F
G
H
L
Site 201
S1514
E
V
V
K
I
R
D
S
F
S
N
Q
N
T
E
Site 202
S1516
V
K
I
R
D
S
F
S
N
Q
N
T
E
T
K
Site 203
T1520
D
S
F
S
N
Q
N
T
E
T
K
D
T
K
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation