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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATAD5
Full Name:
ATPase family AAA domain-containing protein 5
Alias:
Chromosome fragility-associated gene 1 protein
Type:
Mass (Da):
207529
Number AA:
1844
UniProt ID:
Q96QE3
International Prot ID:
IPI00102575
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006950
GO:0006974
GO:0009719
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
K
R
K
K
D
D
D
T
S
T
C
K
T
I
T
Site 2
S34
R
K
K
D
D
D
T
S
T
C
K
T
I
T
K
Site 3
T35
K
K
D
D
D
T
S
T
C
K
T
I
T
K
Y
Site 4
T38
D
D
T
S
T
C
K
T
I
T
K
Y
L
S
P
Site 5
T40
T
S
T
C
K
T
I
T
K
Y
L
S
P
L
G
Site 6
Y42
T
C
K
T
I
T
K
Y
L
S
P
L
G
K
T
Site 7
S44
K
T
I
T
K
Y
L
S
P
L
G
K
T
R
D
Site 8
Y65
K
P
S
N
I
L
D
Y
F
R
K
T
S
P
T
Site 9
T69
I
L
D
Y
F
R
K
T
S
P
T
N
E
K
T
Site 10
S70
L
D
Y
F
R
K
T
S
P
T
N
E
K
T
Q
Site 11
T72
Y
F
R
K
T
S
P
T
N
E
K
T
Q
L
G
Site 12
T76
T
S
P
T
N
E
K
T
Q
L
G
K
E
C
K
Site 13
S86
G
K
E
C
K
I
K
S
P
E
S
V
P
V
D
Site 14
S89
C
K
I
K
S
P
E
S
V
P
V
D
S
N
K
Site 15
S94
P
E
S
V
P
V
D
S
N
K
D
C
T
T
P
Site 16
T99
V
D
S
N
K
D
C
T
T
P
L
E
M
F
S
Site 17
T100
D
S
N
K
D
C
T
T
P
L
E
M
F
S
N
Site 18
S137
N
E
A
P
I
E
I
S
S
D
D
S
K
E
D
Site 19
S138
E
A
P
I
E
I
S
S
D
D
S
K
E
D
Y
Site 20
S141
I
E
I
S
S
D
D
S
K
E
D
Y
S
L
N
Site 21
Y145
S
D
D
S
K
E
D
Y
S
L
N
N
D
F
V
Site 22
S146
D
D
S
K
E
D
Y
S
L
N
N
D
F
V
E
Site 23
S154
L
N
N
D
F
V
E
S
S
T
S
V
L
R
Y
Site 24
S157
D
F
V
E
S
S
T
S
V
L
R
Y
K
K
Q
Site 25
Y161
S
S
T
S
V
L
R
Y
K
K
Q
V
E
V
L
Site 26
S177
E
N
I
Q
D
T
K
S
Q
P
N
T
M
T
S
Site 27
T181
D
T
K
S
Q
P
N
T
M
T
S
L
Q
N
S
Site 28
S184
S
Q
P
N
T
M
T
S
L
Q
N
S
K
K
V
Site 29
S188
T
M
T
S
L
Q
N
S
K
K
V
N
P
K
Q
Site 30
S217
C
R
D
V
V
D
L
S
E
S
L
P
L
A
E
Site 31
S219
D
V
V
D
L
S
E
S
L
P
L
A
E
E
L
Site 32
S244
K
Q
M
E
N
T
T
S
H
A
N
S
R
D
N
Site 33
S248
N
T
T
S
H
A
N
S
R
D
N
V
T
E
A
Site 34
T253
A
N
S
R
D
N
V
T
E
A
A
Q
L
N
D
Site 35
S266
N
D
S
I
I
T
V
S
Y
E
E
F
L
K
S
Site 36
Y267
D
S
I
I
T
V
S
Y
E
E
F
L
K
S
H
Site 37
S273
S
Y
E
E
F
L
K
S
H
K
E
N
K
V
E
Site 38
S285
K
V
E
E
I
P
D
S
T
M
S
I
C
V
P
Site 39
S288
E
I
P
D
S
T
M
S
I
C
V
P
S
E
T
Site 40
S302
T
V
D
E
I
V
K
S
G
Y
I
S
E
S
E
Site 41
Y304
D
E
I
V
K
S
G
Y
I
S
E
S
E
N
S
Site 42
S306
I
V
K
S
G
Y
I
S
E
S
E
N
S
E
I
Site 43
S308
K
S
G
Y
I
S
E
S
E
N
S
E
I
S
Q
Site 44
S311
Y
I
S
E
S
E
N
S
E
I
S
Q
Q
V
R
Site 45
S314
E
S
E
N
S
E
I
S
Q
Q
V
R
F
K
T
Site 46
S354
K
Q
F
E
M
E
N
S
L
S
D
P
E
N
E
Site 47
S356
F
E
M
E
N
S
L
S
D
P
E
N
E
Q
T
Site 48
T363
S
D
P
E
N
E
Q
T
V
Q
K
R
K
S
N
Site 49
S369
Q
T
V
Q
K
R
K
S
N
V
V
I
Q
E
E
Site 50
S388
A
V
L
E
A
G
S
S
E
A
V
K
P
K
C
Site 51
S412
K
A
F
R
Q
P
A
S
D
A
L
K
N
G
V
Site 52
S422
L
K
N
G
V
K
K
S
S
D
K
Q
K
D
L
Site 53
Y435
D
L
N
E
K
C
L
Y
E
V
G
R
D
D
N
Site 54
S443
E
V
G
R
D
D
N
S
K
K
I
M
E
N
S
Site 55
S450
S
K
K
I
M
E
N
S
G
I
Q
M
V
S
K
Site 56
T465
N
G
N
L
Q
L
H
T
D
K
G
S
F
L
K
Site 57
S469
Q
L
H
T
D
K
G
S
F
L
K
E
K
N
K
Site 58
T485
L
K
K
K
N
K
K
T
L
D
T
G
A
I
P
Site 59
Y514
F
F
L
K
E
K
Q
Y
Q
N
R
M
S
L
R
Site 60
S519
K
Q
Y
Q
N
R
M
S
L
R
Q
R
K
T
E
Site 61
T525
M
S
L
R
Q
R
K
T
E
F
F
K
S
S
T
Site 62
S530
R
K
T
E
F
F
K
S
S
T
L
F
N
N
E
Site 63
S538
S
T
L
F
N
N
E
S
L
V
Y
E
D
I
A
Site 64
Y541
F
N
N
E
S
L
V
Y
E
D
I
A
N
D
D
Site 65
S554
D
D
L
L
K
V
S
S
L
C
N
N
N
K
L
Site 66
S562
L
C
N
N
N
K
L
S
R
K
T
S
I
P
V
Site 67
T565
N
N
K
L
S
R
K
T
S
I
P
V
K
D
I
Site 68
S566
N
K
L
S
R
K
T
S
I
P
V
K
D
I
K
Site 69
T575
P
V
K
D
I
K
L
T
Q
S
K
A
E
S
E
Site 70
S577
K
D
I
K
L
T
Q
S
K
A
E
S
E
A
S
Site 71
S581
L
T
Q
S
K
A
E
S
E
A
S
L
L
N
V
Site 72
S584
S
K
A
E
S
E
A
S
L
L
N
V
S
T
P
Site 73
S589
E
A
S
L
L
N
V
S
T
P
K
S
T
R
R
Site 74
T590
A
S
L
L
N
V
S
T
P
K
S
T
R
R
S
Site 75
S593
L
N
V
S
T
P
K
S
T
R
R
S
G
R
I
Site 76
S597
T
P
K
S
T
R
R
S
G
R
I
S
S
T
P
Site 77
S601
T
R
R
S
G
R
I
S
S
T
P
T
T
E
T
Site 78
S602
R
R
S
G
R
I
S
S
T
P
T
T
E
T
I
Site 79
T603
R
S
G
R
I
S
S
T
P
T
T
E
T
I
R
Site 80
T605
G
R
I
S
S
T
P
T
T
E
T
I
R
G
I
Site 81
T606
R
I
S
S
T
P
T
T
E
T
I
R
G
I
D
Site 82
T608
S
S
T
P
T
T
E
T
I
R
G
I
D
S
D
Site 83
S614
E
T
I
R
G
I
D
S
D
D
V
Q
D
N
S
Site 84
S621
S
D
D
V
Q
D
N
S
Q
L
K
A
S
T
Q
Site 85
T627
N
S
Q
L
K
A
S
T
Q
K
A
A
N
L
S
Site 86
S634
T
Q
K
A
A
N
L
S
E
K
H
S
L
Y
T
Site 87
S638
A
N
L
S
E
K
H
S
L
Y
T
A
E
L
I
Site 88
S651
L
I
T
V
P
F
D
S
E
S
P
I
R
M
K
Site 89
S653
T
V
P
F
D
S
E
S
P
I
R
M
K
F
T
Site 90
T660
S
P
I
R
M
K
F
T
R
I
S
T
P
K
K
Site 91
S663
R
M
K
F
T
R
I
S
T
P
K
K
S
K
K
Site 92
T664
M
K
F
T
R
I
S
T
P
K
K
S
K
K
K
Site 93
S668
R
I
S
T
P
K
K
S
K
K
K
S
N
K
R
Site 94
S672
P
K
K
S
K
K
K
S
N
K
R
S
E
K
S
Site 95
S676
K
K
K
S
N
K
R
S
E
K
S
E
A
T
D
Site 96
S679
S
N
K
R
S
E
K
S
E
A
T
D
G
G
F
Site 97
S688
A
T
D
G
G
F
T
S
Q
I
R
K
A
S
N
Site 98
S694
T
S
Q
I
R
K
A
S
N
T
S
K
N
I
S
Site 99
T696
Q
I
R
K
A
S
N
T
S
K
N
I
S
K
A
Site 100
S697
I
R
K
A
S
N
T
S
K
N
I
S
K
A
K
Site 101
S701
S
N
T
S
K
N
I
S
K
A
K
Q
L
I
E
Site 102
S718
K
A
L
H
I
S
R
S
K
V
T
E
E
I
A
Site 103
S731
I
A
I
P
L
R
R
S
S
R
H
Q
T
L
P
Site 104
S732
A
I
P
L
R
R
S
S
R
H
Q
T
L
P
E
Site 105
T736
R
R
S
S
R
H
Q
T
L
P
E
R
K
K
L
Site 106
S749
K
L
S
E
T
E
D
S
V
I
I
I
D
S
S
Site 107
S756
S
V
I
I
I
D
S
S
P
T
A
L
K
H
P
Site 108
S784
L
G
K
K
L
N
T
S
T
K
N
V
P
G
K
Site 109
S812
K
A
A
D
P
V
P
S
F
D
E
S
S
Q
D
Site 110
S816
P
V
P
S
F
D
E
S
S
Q
D
T
S
E
K
Site 111
S817
V
P
S
F
D
E
S
S
Q
D
T
S
E
K
S
Site 112
T820
F
D
E
S
S
Q
D
T
S
E
K
S
Q
D
C
Site 113
S821
D
E
S
S
Q
D
T
S
E
K
S
Q
D
C
D
Site 114
S824
S
Q
D
T
S
E
K
S
Q
D
C
D
V
Q
C
Site 115
S840
A
K
R
D
F
L
M
S
G
L
P
D
L
L
K
Site 116
T894
P
P
S
C
P
L
L
T
K
F
K
E
L
N
T
Site 117
T918
I
A
L
G
E
F
S
T
L
N
S
K
L
K
S
Site 118
S921
G
E
F
S
T
L
N
S
K
L
K
S
G
N
S
Site 119
S925
T
L
N
S
K
L
K
S
G
N
S
A
A
V
F
Site 120
S928
S
K
L
K
S
G
N
S
A
A
V
F
M
R
T
Site 121
S954
L
L
E
E
I
R
W
S
N
P
E
F
S
L
K
Site 122
S959
R
W
S
N
P
E
F
S
L
K
K
Y
F
P
L
Site 123
Y963
P
E
F
S
L
K
K
Y
F
P
L
L
L
K
K
Site 124
S979
I
E
H
Q
V
L
S
S
E
C
H
S
K
Q
E
Site 125
S983
V
L
S
S
E
C
H
S
K
Q
E
L
E
A
D
Site 126
S992
Q
E
L
E
A
D
V
S
H
K
E
T
K
R
K
Site 127
T996
A
D
V
S
H
K
E
T
K
R
K
L
V
E
A
Site 128
S1006
K
L
V
E
A
E
N
S
K
S
K
R
K
K
P
Site 129
S1008
V
E
A
E
N
S
K
S
K
R
K
K
P
N
E
Site 130
Y1016
K
R
K
K
P
N
E
Y
S
K
N
L
E
K
T
Site 131
S1017
R
K
K
P
N
E
Y
S
K
N
L
E
K
T
N
Site 132
T1023
Y
S
K
N
L
E
K
T
N
R
K
S
E
E
L
Site 133
S1027
L
E
K
T
N
R
K
S
E
E
L
S
K
R
N
Site 134
S1031
N
R
K
S
E
E
L
S
K
R
N
N
S
S
G
Site 135
S1036
E
L
S
K
R
N
N
S
S
G
I
K
L
D
S
Site 136
S1037
L
S
K
R
N
N
S
S
G
I
K
L
D
S
S
Site 137
S1043
S
S
G
I
K
L
D
S
S
K
D
S
G
T
E
Site 138
S1044
S
G
I
K
L
D
S
S
K
D
S
G
T
E
D
Site 139
S1047
K
L
D
S
S
K
D
S
G
T
E
D
M
L
W
Site 140
Y1058
D
M
L
W
T
E
K
Y
Q
P
Q
T
A
S
E
Site 141
S1107
D
E
K
H
E
D
F
S
G
G
I
D
F
K
G
Site 142
S1115
G
G
I
D
F
K
G
S
S
D
D
E
E
E
S
Site 143
S1116
G
I
D
F
K
G
S
S
D
D
E
E
E
S
R
Site 144
S1122
S
S
D
D
E
E
E
S
R
L
C
N
T
V
L
Site 145
T1127
E
E
S
R
L
C
N
T
V
L
I
T
G
P
T
Site 146
S1159
K
I
F
E
V
N
A
S
S
Q
R
S
G
R
Q
Site 147
S1160
I
F
E
V
N
A
S
S
Q
R
S
G
R
Q
I
Site 148
S1163
V
N
A
S
S
Q
R
S
G
R
Q
I
L
S
Q
Site 149
S1169
R
S
G
R
Q
I
L
S
Q
L
K
E
A
T
Q
Site 150
Y1196
K
P
C
F
F
N
S
Y
Y
I
G
K
S
P
S
Site 151
Y1197
P
C
F
F
N
S
Y
Y
I
G
K
S
P
S
K
Site 152
S1201
N
S
Y
Y
I
G
K
S
P
S
K
I
S
S
P
Site 153
S1203
Y
Y
I
G
K
S
P
S
K
I
S
S
P
K
K
Site 154
S1206
G
K
S
P
K
K
I
S
S
P
K
K
V
V
T
Site 155
S1207
K
S
P
S
K
I
S
S
P
K
K
V
V
T
S
Site 156
T1213
S
S
P
K
K
V
V
T
S
P
R
K
V
P
P
Site 157
S1214
S
P
K
K
V
V
T
S
P
R
K
V
P
P
P
Site 158
S1222
P
R
K
V
P
P
P
S
P
K
S
S
G
P
K
Site 159
S1225
V
P
P
P
S
P
K
S
S
G
P
K
R
A
L
Site 160
S1226
P
P
P
S
P
K
S
S
G
P
K
R
A
L
P
Site 161
T1236
K
R
A
L
P
P
K
T
L
A
N
Y
F
K
V
Site 162
Y1240
P
P
K
T
L
A
N
Y
F
K
V
S
P
K
P
Site 163
S1244
L
A
N
Y
F
K
V
S
P
K
P
K
N
N
E
Site 164
S1266
N
N
K
G
I
K
N
S
F
E
Q
K
Q
I
T
Site 165
T1273
S
F
E
Q
K
Q
I
T
Q
T
K
S
T
N
A
Site 166
S1277
K
Q
I
T
Q
T
K
S
T
N
A
T
N
S
N
Site 167
T1281
Q
T
K
S
T
N
A
T
N
S
N
V
K
D
V
Site 168
S1300
P
S
R
K
N
A
T
S
L
I
L
F
E
E
V
Site 169
T1335
T
K
R
P
V
I
L
T
T
S
D
P
T
F
S
Site 170
T1336
K
R
P
V
I
L
T
T
S
D
P
T
F
S
L
Site 171
T1377
C
L
T
E
N
F
R
T
D
V
K
D
F
V
T
Site 172
Y1399
D
I
R
K
S
I
L
Y
L
Q
F
W
I
R
S
Site 173
T1417
V
L
E
E
R
P
L
T
L
Y
R
G
N
S
R
Site 174
Y1419
E
E
R
P
L
T
L
Y
R
G
N
S
R
N
V
Site 175
S1423
L
T
L
Y
R
G
N
S
R
N
V
Q
L
V
C
Site 176
Y1440
H
G
L
D
N
K
I
Y
P
K
N
T
K
K
K
Site 177
S1470
F
G
L
K
N
I
F
S
P
S
E
D
L
F
S
Site 178
S1477
S
P
S
E
D
L
F
S
F
L
K
H
K
I
T
Site 179
T1525
P
V
D
T
I
P
E
T
K
N
F
C
G
P
S
Site 180
S1532
T
K
N
F
C
G
P
S
V
T
V
D
A
S
A
Site 181
S1538
P
S
V
T
V
D
A
S
A
A
T
K
S
M
N
Site 182
S1552
N
C
L
A
R
K
H
S
E
R
E
Q
P
L
K
Site 183
S1561
R
E
Q
P
L
K
K
S
Q
K
K
K
Q
K
K
Site 184
T1569
Q
K
K
K
Q
K
K
T
L
V
I
L
D
D
S
Site 185
T1581
D
D
S
D
L
F
D
T
D
L
D
F
P
D
Q
Site 186
S1589
D
L
D
F
P
D
Q
S
I
S
L
S
S
V
S
Site 187
S1591
D
F
P
D
Q
S
I
S
L
S
S
V
S
S
S
Site 188
S1593
P
D
Q
S
I
S
L
S
S
V
S
S
S
S
N
Site 189
S1594
D
Q
S
I
S
L
S
S
V
S
S
S
S
N
A
Site 190
S1596
S
I
S
L
S
S
V
S
S
S
S
N
A
E
E
Site 191
S1597
I
S
L
S
S
V
S
S
S
S
N
A
E
E
S
Site 192
S1598
S
L
S
S
V
S
S
S
S
N
A
E
E
S
K
Site 193
S1599
L
S
S
V
S
S
S
S
N
A
E
E
S
K
T
Site 194
S1604
S
S
S
N
A
E
E
S
K
T
G
D
E
E
S
Site 195
T1606
S
N
A
E
E
S
K
T
G
D
E
E
S
K
A
Site 196
S1611
S
K
T
G
D
E
E
S
K
A
R
D
K
G
N
Site 197
T1622
D
K
G
N
N
P
E
T
K
K
S
I
P
C
P
Site 198
S1625
N
N
P
E
T
K
K
S
I
P
C
P
P
K
T
Site 199
T1632
S
I
P
C
P
P
K
T
T
A
G
K
K
C
S
Site 200
T1664
S
F
L
D
A
L
L
T
D
V
R
E
Q
N
K
Site 201
Y1672
D
V
R
E
Q
N
K
Y
G
R
N
D
F
S
W
Site 202
T1680
G
R
N
D
F
S
W
T
N
G
K
V
T
S
G
Site 203
S1693
S
G
L
C
D
E
F
S
L
E
S
N
D
G
W
Site 204
S1696
C
D
E
F
S
L
E
S
N
D
G
W
T
S
Q
Site 205
T1701
L
E
S
N
D
G
W
T
S
Q
S
S
G
E
L
Site 206
S1702
E
S
N
D
G
W
T
S
Q
S
S
G
E
L
K
Site 207
T1718
A
A
E
A
L
S
F
T
K
C
S
S
A
I
S
Site 208
S1725
T
K
C
S
S
A
I
S
K
A
L
E
T
L
N
Site 209
S1733
K
A
L
E
T
L
N
S
C
K
K
L
G
R
D
Site 210
T1742
K
K
L
G
R
D
P
T
N
D
L
T
F
Y
V
Site 211
T1746
R
D
P
T
N
D
L
T
F
Y
V
S
Q
K
R
Site 212
Y1748
P
T
N
D
L
T
F
Y
V
S
Q
K
R
N
N
Site 213
Y1757
S
Q
K
R
N
N
V
Y
F
S
Q
S
A
A
N
Site 214
S1759
K
R
N
N
V
Y
F
S
Q
S
A
A
N
L
D
Site 215
S1773
D
N
A
W
K
R
I
S
V
I
K
S
V
F
S
Site 216
S1777
K
R
I
S
V
I
K
S
V
F
S
S
R
S
L
Site 217
S1783
K
S
V
F
S
S
R
S
L
L
Y
V
G
N
R
Site 218
Y1786
F
S
S
R
S
L
L
Y
V
G
N
R
Q
A
S
Site 219
S1793
Y
V
G
N
R
Q
A
S
I
I
E
Y
L
P
T
Site 220
Y1797
R
Q
A
S
I
I
E
Y
L
P
T
L
R
N
I
Site 221
T1807
T
L
R
N
I
C
K
T
E
K
L
K
E
Q
G
Site 222
S1816
K
L
K
E
Q
G
K
S
K
R
R
F
L
H
Y
Site 223
Y1823
S
K
R
R
F
L
H
Y
F
E
G
I
H
L
D
Site 224
T1838
I
P
K
E
T
V
N
T
L
A
A
D
F
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation