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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AlphaK3
Full Name:
Alpha-protein kinase 1
Alias:
ALPK1; EC 2.7.11.-; LAK; Lymphocyte alpha-kinase
Type:
Protein-serine kinase, Atypical group, Alpha family
Mass (Da):
138890
Number AA:
1244
UniProt ID:
Q96QP1
International Prot ID:
IPI00304706
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Site 2
S34
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
Site 3
S45
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
Site 4
T49
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
Site 5
Y68
F
V
P
E
K
W
Q
Y
K
Q
A
V
G
P
E
Site 6
T78
A
V
G
P
E
D
K
T
N
L
K
D
V
I
G
Site 7
S158
Q
A
R
I
S
V
N
S
G
K
L
L
K
A
E
Site 8
S170
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
Site 9
Y183
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
Site 10
S187
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
Site 11
S236
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
Site 12
Y254
V
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Site 13
S266
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
H
Site 14
S277
E
F
D
H
H
L
L
S
A
A
E
A
C
K
L
Site 15
S309
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
Site 16
Y310
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
Site 17
S311
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
Site 18
S312
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
Site 19
S313
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
Site 20
T338
A
F
E
I
G
L
L
T
K
R
D
D
E
P
V
Site 21
T346
K
R
D
D
E
P
V
T
G
K
Q
E
L
H
S
Site 22
S353
T
G
K
Q
E
L
H
S
F
V
K
A
A
F
G
Site 23
T363
K
A
A
F
G
L
T
T
V
H
R
R
L
H
G
Site 24
T374
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
Site 25
S379
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
Site 26
Y390
K
E
A
M
G
K
L
Y
N
F
S
T
S
S
R
Site 27
S393
M
G
K
L
Y
N
F
S
T
S
S
R
S
Q
D
Site 28
T394
G
K
L
Y
N
F
S
T
S
S
R
S
Q
D
R
Site 29
S395
K
L
Y
N
F
S
T
S
S
R
S
Q
D
R
E
Site 30
S398
N
F
S
T
S
S
R
S
Q
D
R
E
A
L
S
Site 31
S405
S
Q
D
R
E
A
L
S
Q
E
V
M
S
V
I
Site 32
S423
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
Site 33
S431
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
Site 34
Y432
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
Site 35
S436
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
Site 36
T458
D
F
Q
K
I
L
D
T
Y
S
Q
H
H
T
S
Site 37
Y459
F
Q
K
I
L
D
T
Y
S
Q
H
H
T
S
V
Site 38
T464
D
T
Y
S
Q
H
H
T
S
V
C
E
V
F
E
Site 39
S465
T
Y
S
Q
H
H
T
S
V
C
E
V
F
E
S
Site 40
T486
N
E
Q
K
D
A
K
T
G
V
C
I
T
A
L
Site 41
T502
T
E
I
K
N
I
D
T
V
S
T
T
Q
E
K
Site 42
S504
I
K
N
I
D
T
V
S
T
T
Q
E
K
P
H
Site 43
T516
K
P
H
C
Q
R
D
T
G
I
S
S
S
L
M
Site 44
S519
C
Q
R
D
T
G
I
S
S
S
L
M
G
K
N
Site 45
S521
R
D
T
G
I
S
S
S
L
M
G
K
N
V
Q
Site 46
T540
R
G
G
R
R
N
W
T
H
S
D
A
F
R
V
Site 47
S542
G
R
R
N
W
T
H
S
D
A
F
R
V
S
L
Site 48
S548
H
S
D
A
F
R
V
S
L
D
Q
D
V
E
T
Site 49
T555
S
L
D
Q
D
V
E
T
E
T
E
P
S
D
Y
Site 50
S560
V
E
T
E
T
E
P
S
D
Y
S
N
D
E
G
Site 51
Y562
T
E
T
E
P
S
D
Y
S
N
D
E
G
A
V
Site 52
S563
E
T
E
P
S
D
Y
S
N
D
E
G
A
V
F
Site 53
S573
E
G
A
V
F
N
K
S
L
S
G
S
Q
T
S
Site 54
S575
A
V
F
N
K
S
L
S
G
S
Q
T
S
S
A
Site 55
S577
F
N
K
S
L
S
G
S
Q
T
S
S
A
W
S
Site 56
T579
K
S
L
S
G
S
Q
T
S
S
A
W
S
N
L
Site 57
S580
S
L
S
G
S
Q
T
S
S
A
W
S
N
L
S
Site 58
S581
L
S
G
S
Q
T
S
S
A
W
S
N
L
S
G
Site 59
S584
S
Q
T
S
S
A
W
S
N
L
S
G
F
S
S
Site 60
S587
S
S
A
W
S
N
L
S
G
F
S
S
S
A
S
Site 61
S590
W
S
N
L
S
G
F
S
S
S
A
S
W
E
E
Site 62
S591
S
N
L
S
G
F
S
S
S
A
S
W
E
E
V
Site 63
S592
N
L
S
G
F
S
S
S
A
S
W
E
E
V
N
Site 64
S594
S
G
F
S
S
S
A
S
W
E
E
V
N
Y
H
Site 65
Y600
A
S
W
E
E
V
N
Y
H
V
D
D
R
S
A
Site 66
S606
N
Y
H
V
D
D
R
S
A
R
K
E
P
G
K
Site 67
T619
G
K
E
H
L
V
D
T
Q
C
S
T
A
L
S
Site 68
S626
T
Q
C
S
T
A
L
S
E
E
L
E
N
D
R
Site 69
S640
R
E
G
R
A
M
H
S
L
H
S
Q
L
H
D
Site 70
S643
R
A
M
H
S
L
H
S
Q
L
H
D
L
S
L
Site 71
S649
H
S
Q
L
H
D
L
S
L
Q
E
P
N
N
D
Site 72
S661
N
N
D
N
L
E
P
S
Q
N
Q
P
Q
Q
Q
Site 73
T672
P
Q
Q
Q
M
P
L
T
P
F
S
P
H
N
T
Site 74
S675
Q
M
P
L
T
P
F
S
P
H
N
T
P
G
I
Site 75
T679
T
P
F
S
P
H
N
T
P
G
I
F
L
A
P
Site 76
T709
R
N
M
G
P
R
N
T
S
A
H
S
R
P
S
Site 77
S710
N
M
G
P
R
N
T
S
A
H
S
R
P
S
Y
Site 78
S713
P
R
N
T
S
A
H
S
R
P
S
Y
R
S
A
Site 79
S716
T
S
A
H
S
R
P
S
Y
R
S
A
S
W
S
Site 80
Y717
S
A
H
S
R
P
S
Y
R
S
A
S
W
S
S
Site 81
S719
H
S
R
P
S
Y
R
S
A
S
W
S
S
D
S
Site 82
S721
R
P
S
Y
R
S
A
S
W
S
S
D
S
G
R
Site 83
S723
S
Y
R
S
A
S
W
S
S
D
S
G
R
P
K
Site 84
S724
Y
R
S
A
S
W
S
S
D
S
G
R
P
K
N
Site 85
S726
S
A
S
W
S
S
D
S
G
R
P
K
N
I
G
Site 86
S737
K
N
I
G
T
H
P
S
V
Q
K
E
E
A
F
Site 87
T753
I
I
V
E
F
P
E
T
N
C
D
V
K
D
R
Site 88
S770
K
E
Q
G
E
E
I
S
E
R
G
A
G
P
T
Site 89
T777
S
E
R
G
A
G
P
T
F
K
A
S
P
S
W
Site 90
S781
A
G
P
T
F
K
A
S
P
S
W
V
D
P
E
Site 91
S783
P
T
F
K
A
S
P
S
W
V
D
P
E
G
E
Site 92
S794
P
E
G
E
T
A
E
S
T
E
D
A
P
L
D
Site 93
T822
M
L
P
C
S
S
F
T
P
N
W
P
V
Q
N
Site 94
S832
W
P
V
Q
N
P
D
S
R
K
S
G
G
P
V
Site 95
S835
Q
N
P
D
S
R
K
S
G
G
P
V
A
E
Q
Site 96
S849
Q
G
I
D
P
D
A
S
T
V
D
E
E
G
Q
Site 97
T850
G
I
D
P
D
A
S
T
V
D
E
E
G
Q
L
Site 98
S860
E
E
G
Q
L
L
D
S
T
D
V
P
C
T
N
Site 99
T861
E
G
Q
L
L
D
S
T
D
V
P
C
T
N
G
Site 100
T866
D
S
T
D
V
P
C
T
N
G
H
G
S
H
R
Site 101
T887
P
P
G
Q
R
A
E
T
P
N
S
S
V
S
G
Site 102
S890
Q
R
A
E
T
P
N
S
S
V
S
G
N
I
L
Site 103
S891
R
A
E
T
P
N
S
S
V
S
G
N
I
L
F
Site 104
S893
E
T
P
N
S
S
V
S
G
N
I
L
F
P
V
Site 105
T906
P
V
L
S
E
D
C
T
T
T
E
E
G
N
Q
Site 106
T907
V
L
S
E
D
C
T
T
T
E
E
G
N
Q
P
Site 107
S921
P
G
N
M
L
N
C
S
Q
N
S
S
S
S
S
Site 108
S924
M
L
N
C
S
Q
N
S
S
S
S
S
V
W
W
Site 109
S925
L
N
C
S
Q
N
S
S
S
S
S
V
W
W
L
Site 110
S926
N
C
S
Q
N
S
S
S
S
S
V
W
W
L
K
Site 111
S927
C
S
Q
N
S
S
S
S
S
V
W
W
L
K
S
Site 112
S928
S
Q
N
S
S
S
S
S
V
W
W
L
K
S
P
Site 113
S934
S
S
V
W
W
L
K
S
P
A
F
S
S
G
S
Site 114
S938
W
L
K
S
P
A
F
S
S
G
S
S
E
G
D
Site 115
S939
L
K
S
P
A
F
S
S
G
S
S
E
G
D
S
Site 116
S941
S
P
A
F
S
S
G
S
S
E
G
D
S
P
W
Site 117
S942
P
A
F
S
S
G
S
S
E
G
D
S
P
W
S
Site 118
S946
S
G
S
S
E
G
D
S
P
W
S
Y
L
N
S
Site 119
S949
S
E
G
D
S
P
W
S
Y
L
N
S
S
G
S
Site 120
Y950
E
G
D
S
P
W
S
Y
L
N
S
S
G
S
S
Site 121
S953
S
P
W
S
Y
L
N
S
S
G
S
S
W
V
S
Site 122
S954
P
W
S
Y
L
N
S
S
G
S
S
W
V
S
L
Site 123
S956
S
Y
L
N
S
S
G
S
S
W
V
S
L
P
G
Site 124
S957
Y
L
N
S
S
G
S
S
W
V
S
L
P
G
K
Site 125
S960
S
S
G
S
S
W
V
S
L
P
G
K
M
R
K
Site 126
S1005
N
T
G
V
F
K
P
S
Q
L
H
R
A
H
S
Site 127
S1012
S
Q
L
H
R
A
H
S
A
L
L
L
K
Y
S
Site 128
Y1018
H
S
A
L
L
L
K
Y
S
K
K
S
E
L
W
Site 129
S1019
S
A
L
L
L
K
Y
S
K
K
S
E
L
W
T
Site 130
T1026
S
K
K
S
E
L
W
T
A
Q
E
T
I
V
Y
Site 131
Y1037
T
I
V
Y
L
G
D
Y
L
T
V
K
K
K
G
Site 132
T1039
V
Y
L
G
D
Y
L
T
V
K
K
K
G
R
Q
Site 133
Y1064
Q
E
E
I
L
G
R
Y
V
G
K
D
Y
K
E
Site 134
Y1069
G
R
Y
V
G
K
D
Y
K
E
Q
K
G
L
W
Site 135
T1087
T
D
V
E
R
Q
M
T
A
Q
H
Y
V
T
E
Site 136
Y1091
R
Q
M
T
A
Q
H
Y
V
T
E
F
N
K
R
Site 137
Y1100
T
E
F
N
K
R
L
Y
E
Q
N
I
P
T
Q
Site 138
S1142
L
G
E
F
V
K
L
S
N
N
T
K
V
V
K
Site 139
Y1152
T
K
V
V
K
T
E
Y
K
A
T
E
Y
G
L
Site 140
T1155
V
K
T
E
Y
K
A
T
E
Y
G
L
A
Y
G
Site 141
Y1157
T
E
Y
K
A
T
E
Y
G
L
A
Y
G
H
F
Site 142
Y1161
A
T
E
Y
G
L
A
Y
G
H
F
S
Y
E
F
Site 143
S1165
G
L
A
Y
G
H
F
S
Y
E
F
S
N
H
R
Site 144
Y1191
G
N
G
K
G
L
I
Y
L
T
D
P
Q
I
H
Site 145
Y1216
F
G
K
R
G
I
F
Y
F
F
N
N
Q
H
V
Site 146
S1233
N
E
I
C
H
R
L
S
L
T
R
P
S
M
E
Site 147
S1238
R
L
S
L
T
R
P
S
M
E
K
P
C
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation