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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPM7
Full Name:
Transient receptor potential cation channel subfamily M member 7
Alias:
EC 2.7.11.1; Long transient receptor potential channel 7; LTRPC7
Type:
Channel, cation; Protein kinase, atypical; EC 2.7.11.1;
ATYPICAL
group; Alpha family; ChaK subfamily
Mass (Da):
212697
Number AA:
1865
UniProt ID:
Q96QT4
International Prot ID:
IPI00290032
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005262
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Transient receptor potential cation channel subfamily M member 7 pan-specific antibody AB-NK305-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK305-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
Q
K
S
W
I
E
S
T
L
T
K
R
E
C
Site 2
T12
S
W
I
E
S
T
L
T
K
R
E
C
V
Y
I
Site 3
Y18
L
T
K
R
E
C
V
Y
I
I
P
S
S
K
D
Site 4
S57
Q
H
A
C
F
T
A
S
L
A
M
K
Y
S
D
Site 5
Y62
T
A
S
L
A
M
K
Y
S
D
V
K
L
G
D
Site 6
S63
A
S
L
A
M
K
Y
S
D
V
K
L
G
D
H
Site 7
S87
V
E
K
H
T
E
Q
S
P
T
D
A
Y
G
V
Site 8
T89
K
H
T
E
Q
S
P
T
D
A
Y
G
V
I
N
Site 9
Y92
E
Q
S
P
T
D
A
Y
G
V
I
N
F
Q
G
Site 10
S103
N
F
Q
G
G
S
H
S
Y
R
A
K
Y
V
R
Site 11
Y108
S
H
S
Y
R
A
K
Y
V
R
L
S
Y
D
T
Site 12
S112
R
A
K
Y
V
R
L
S
Y
D
T
K
P
E
V
Site 13
Y113
A
K
Y
V
R
L
S
Y
D
T
K
P
E
V
I
Site 14
T115
Y
V
R
L
S
Y
D
T
K
P
E
V
I
L
Q
Site 15
S138
E
L
P
K
L
V
I
S
V
H
G
G
M
Q
K
Site 16
S193
D
A
L
K
E
H
A
S
R
S
S
R
K
I
C
Site 17
S195
L
K
E
H
A
S
R
S
S
R
K
I
C
T
I
Site 18
S196
K
E
H
A
S
R
S
S
R
K
I
C
T
I
G
Site 19
T201
R
S
S
R
K
I
C
T
I
G
I
A
P
W
G
Site 20
S233
Q
T
L
L
N
P
L
S
K
L
N
V
L
N
N
Site 21
T269
L
R
R
E
L
E
K
T
I
N
Q
Q
R
I
H
Site 22
S348
A
A
E
P
D
I
I
S
T
I
K
K
T
F
N
Site 23
T353
I
I
S
T
I
K
K
T
F
N
F
G
Q
N
E
Site 24
T367
E
A
L
H
L
F
Q
T
L
M
E
C
M
K
R
Site 25
T379
M
K
R
K
E
L
I
T
V
F
H
I
G
S
D
Site 26
Y478
I
P
R
L
E
E
L
Y
N
T
K
Q
G
P
T
Site 27
T480
R
L
E
E
L
Y
N
T
K
Q
G
P
T
N
P
Site 28
T523
I
E
Y
L
M
G
G
T
Y
R
C
T
Y
T
R
Site 29
Y524
E
Y
L
M
G
G
T
Y
R
C
T
Y
T
R
K
Site 30
Y528
G
G
T
Y
R
C
T
Y
T
R
K
R
F
R
L
Site 31
T529
G
T
Y
R
C
T
Y
T
R
K
R
F
R
L
I
Site 32
Y537
R
K
R
F
R
L
I
Y
N
S
L
G
G
N
N
Site 33
S539
R
F
R
L
I
Y
N
S
L
G
G
N
N
R
R
Site 34
S547
L
G
G
N
N
R
R
S
G
R
N
T
S
S
S
Site 35
T551
N
R
R
S
G
R
N
T
S
S
S
T
P
Q
L
Site 36
S552
R
R
S
G
R
N
T
S
S
S
T
P
Q
L
R
Site 37
S553
R
S
G
R
N
T
S
S
S
T
P
Q
L
R
K
Site 38
S554
S
G
R
N
T
S
S
S
T
P
Q
L
R
K
S
Site 39
T555
G
R
N
T
S
S
S
T
P
Q
L
R
K
S
H
Site 40
S561
S
T
P
Q
L
R
K
S
H
E
S
F
G
N
R
Site 41
S564
Q
L
R
K
S
H
E
S
F
G
N
R
A
D
K
Site 42
T583
R
H
N
H
F
I
K
T
A
Q
P
Y
R
P
K
Site 43
T593
P
Y
R
P
K
I
D
T
V
M
E
E
G
K
K
Site 44
T615
V
D
I
D
D
P
E
T
K
R
F
P
Y
P
L
Site 45
Y620
P
E
T
K
R
F
P
Y
P
L
N
E
L
L
I
Site 46
S669
M
A
Y
E
A
K
Q
S
D
L
V
D
D
T
S
Site 47
T675
Q
S
D
L
V
D
D
T
S
E
E
L
K
Q
Y
Site 48
S676
S
D
L
V
D
D
T
S
E
E
L
K
Q
Y
S
Site 49
Y682
T
S
E
E
L
K
Q
Y
S
N
D
F
G
Q
L
Site 50
S697
A
V
E
L
L
E
Q
S
F
R
Q
D
E
T
M
Site 51
T703
Q
S
F
R
Q
D
E
T
M
A
M
K
L
L
T
Site 52
S719
E
L
K
N
W
S
N
S
T
C
L
K
L
A
V
Site 53
S757
R
L
N
M
R
K
N
S
W
Y
K
V
I
L
S
Site 54
Y759
N
M
R
K
N
S
W
Y
K
V
I
L
S
I
L
Site 55
S783
Y
K
T
K
A
E
M
S
H
I
P
Q
S
Q
D
Site 56
T795
S
Q
D
A
H
Q
M
T
M
D
D
S
E
N
N
Site 57
S823
K
E
V
R
I
L
D
S
N
E
G
K
N
E
M
Site 58
T842
K
S
K
K
L
P
I
T
R
K
F
Y
A
F
Y
Site 59
Y849
T
R
K
F
Y
A
F
Y
H
A
P
I
V
K
F
Site 60
S907
K
V
R
E
I
F
M
S
E
A
G
K
V
N
Q
Site 61
Y1023
V
P
R
K
A
I
L
Y
P
H
E
A
P
S
W
Site 62
Y1122
R
Y
H
F
I
M
A
Y
H
E
K
P
V
L
P
Site 63
T1154
K
R
R
K
K
D
K
T
S
D
G
P
K
L
F
Site 64
S1155
R
R
K
K
D
K
T
S
D
G
P
K
L
F
L
Site 65
T1163
D
G
P
K
L
F
L
T
E
E
D
Q
K
K
L
Site 66
Y1181
E
E
Q
C
V
E
M
Y
F
N
E
K
D
D
K
Site 67
S1191
E
K
D
D
K
F
H
S
G
S
E
E
R
I
R
Site 68
S1193
D
D
K
F
H
S
G
S
E
E
R
I
R
V
T
Site 69
T1200
S
E
E
R
I
R
V
T
F
E
R
V
E
Q
M
Site 70
Y1220
E
V
G
D
R
V
N
Y
I
K
R
S
L
Q
S
Site 71
S1224
R
V
N
Y
I
K
R
S
L
Q
S
L
D
S
Q
Site 72
S1227
Y
I
K
R
S
L
Q
S
L
D
S
Q
I
G
H
Site 73
S1230
R
S
L
Q
S
L
D
S
Q
I
G
H
L
Q
D
Site 74
T1248
L
T
V
D
T
L
K
T
L
T
A
Q
K
A
S
Site 75
S1255
T
L
T
A
Q
K
A
S
E
A
S
K
V
H
N
Site 76
S1258
A
Q
K
A
S
E
A
S
K
V
H
N
E
I
T
Site 77
T1265
S
K
V
H
N
E
I
T
R
E
L
S
I
S
K
Site 78
S1269
N
E
I
T
R
E
L
S
I
S
K
H
L
A
Q
Site 79
S1271
I
T
R
E
L
S
I
S
K
H
L
A
Q
N
L
Site 80
S1287
D
D
G
P
V
R
P
S
V
W
K
K
H
G
V
Site 81
T1297
K
K
H
G
V
V
N
T
L
S
S
S
L
P
Q
Site 82
S1299
H
G
V
V
N
T
L
S
S
S
L
P
Q
G
D
Site 83
S1301
V
V
N
T
L
S
S
S
L
P
Q
G
D
L
E
Site 84
S1351
N
F
P
E
A
G
S
S
S
G
A
L
F
P
S
Site 85
S1358
S
S
G
A
L
F
P
S
A
V
S
P
P
E
L
Site 86
S1361
A
L
F
P
S
A
V
S
P
P
E
L
R
Q
R
Site 87
S1386
N
K
N
Q
K
L
G
S
S
S
T
S
I
P
H
Site 88
S1387
K
N
Q
K
L
G
S
S
S
T
S
I
P
H
L
Site 89
S1388
N
Q
K
L
G
S
S
S
T
S
I
P
H
L
S
Site 90
T1389
Q
K
L
G
S
S
S
T
S
I
P
H
L
S
S
Site 91
S1390
K
L
G
S
S
S
T
S
I
P
H
L
S
S
P
Site 92
S1395
S
T
S
I
P
H
L
S
S
P
P
T
K
F
F
Site 93
S1396
T
S
I
P
H
L
S
S
P
P
T
K
F
F
V
Site 94
T1399
P
H
L
S
S
P
P
T
K
F
F
V
S
T
P
Site 95
S1404
P
P
T
K
F
F
V
S
T
P
S
Q
P
S
C
Site 96
T1405
P
T
K
F
F
V
S
T
P
S
Q
P
S
C
K
Site 97
S1407
K
F
F
V
S
T
P
S
Q
P
S
C
K
S
H
Site 98
S1410
V
S
T
P
S
Q
P
S
C
K
S
H
L
E
T
Site 99
S1413
P
S
Q
P
S
C
K
S
H
L
E
T
G
T
K
Site 100
T1417
S
C
K
S
H
L
E
T
G
T
K
D
Q
E
T
Site 101
T1419
K
S
H
L
E
T
G
T
K
D
Q
E
T
V
C
Site 102
T1424
T
G
T
K
D
Q
E
T
V
C
S
K
A
T
E
Site 103
S1427
K
D
Q
E
T
V
C
S
K
A
T
E
G
D
N
Site 104
T1435
K
A
T
E
G
D
N
T
E
F
G
A
F
V
G
Site 105
S1446
A
F
V
G
H
R
D
S
M
D
L
Q
R
F
K
Site 106
T1455
D
L
Q
R
F
K
E
T
S
N
K
I
K
I
L
Site 107
S1456
L
Q
R
F
K
E
T
S
N
K
I
K
I
L
S
Site 108
S1463
S
N
K
I
K
I
L
S
N
N
N
T
S
E
N
Site 109
T1467
K
I
L
S
N
N
N
T
S
E
N
T
L
K
R
Site 110
S1468
I
L
S
N
N
N
T
S
E
N
T
L
K
R
V
Site 111
T1471
N
N
N
T
S
E
N
T
L
K
R
V
S
S
L
Site 112
S1476
E
N
T
L
K
R
V
S
S
L
A
G
F
T
D
Site 113
S1477
N
T
L
K
R
V
S
S
L
A
G
F
T
D
C
Site 114
T1482
V
S
S
L
A
G
F
T
D
C
H
R
T
S
I
Site 115
T1487
G
F
T
D
C
H
R
T
S
I
P
V
H
S
K
Site 116
S1493
R
T
S
I
P
V
H
S
K
Q
A
E
K
I
S
Site 117
S1500
S
K
Q
A
E
K
I
S
R
R
P
S
T
E
D
Site 118
S1504
E
K
I
S
R
R
P
S
T
E
D
T
H
E
V
Site 119
T1505
K
I
S
R
R
P
S
T
E
D
T
H
E
V
D
Site 120
T1508
R
R
P
S
T
E
D
T
H
E
V
D
S
K
A
Site 121
S1513
E
D
T
H
E
V
D
S
K
A
A
L
I
P
D
Site 122
S1527
D
W
L
Q
D
R
P
S
N
R
E
M
P
S
E
Site 123
S1533
P
S
N
R
E
M
P
S
E
E
G
T
L
N
G
Site 124
T1537
E
M
P
S
E
E
G
T
L
N
G
L
T
S
P
Site 125
T1542
E
G
T
L
N
G
L
T
S
P
F
K
P
A
M
Site 126
S1543
G
T
L
N
G
L
T
S
P
F
K
P
A
M
D
Site 127
T1551
P
F
K
P
A
M
D
T
N
Y
Y
Y
S
A
V
Site 128
Y1553
K
P
A
M
D
T
N
Y
Y
Y
S
A
V
E
R
Site 129
Y1554
P
A
M
D
T
N
Y
Y
Y
S
A
V
E
R
N
Site 130
Y1555
A
M
D
T
N
Y
Y
Y
S
A
V
E
R
N
N
Site 131
S1567
R
N
N
L
M
R
L
S
Q
S
I
P
F
T
P
Site 132
S1569
N
L
M
R
L
S
Q
S
I
P
F
T
P
V
P
Site 133
T1573
L
S
Q
S
I
P
F
T
P
V
P
P
R
G
E
Site 134
T1583
P
P
R
G
E
P
V
T
V
Y
R
L
E
E
S
Site 135
Y1585
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
Site 136
S1591
V
Y
R
L
E
E
S
S
P
N
I
L
N
N
S
Site 137
S1598
S
P
N
I
L
N
N
S
M
S
S
W
S
Q
L
Site 138
S1600
N
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
Site 139
S1603
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
Site 140
S1615
C
A
K
I
E
F
L
S
K
E
E
M
G
G
G
Site 141
S1641
S
E
H
D
I
L
K
S
G
H
L
Y
I
I
K
Site 142
T1657
F
L
P
E
V
V
N
T
W
S
S
I
Y
K
E
Site 143
S1660
E
V
V
N
T
W
S
S
I
Y
K
E
D
T
V
Site 144
T1666
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
Site 145
T1685
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
Site 146
S1695
F
N
Q
M
K
P
K
S
I
P
Y
S
P
R
F
Site 147
S1699
K
P
K
S
I
P
Y
S
P
R
F
L
E
V
F
Site 148
T1724
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
Site 149
Y1730
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
Site 150
T1741
N
G
D
E
I
I
P
T
N
T
L
E
E
I
M
Site 151
Y1756
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
Site 152
Y1758
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
Site 153
T1776
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
A
Site 154
S1779
G
E
N
L
T
D
P
S
V
I
K
A
E
E
K
Site 155
Y1829
P
D
L
K
R
N
D
Y
T
P
D
K
I
I
F
Site 156
T1830
D
L
K
R
N
D
Y
T
P
D
K
I
I
F
P
Site 157
S1842
I
F
P
Q
D
E
P
S
D
L
N
L
Q
P
G
Site 158
S1851
L
N
L
Q
P
G
N
S
T
K
E
S
E
S
T
Site 159
S1855
P
G
N
S
T
K
E
S
E
S
T
N
S
V
R
Site 160
S1857
N
S
T
K
E
S
E
S
T
N
S
V
R
L
M
Site 161
T1858
S
T
K
E
S
E
S
T
N
S
V
R
L
M
L
Site 162
S1860
K
E
S
E
S
T
N
S
V
R
L
M
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation