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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHF12
Full Name:
PHD finger protein 12
Alias:
PHD factor 1; PHD finger protein 12: PHD factor 1: PHD finger protein 12: PHD factor 1: PHD finger protein 12: PHD factor 1
Type:
Mass (Da):
109698
Number AA:
1004
UniProt ID:
Q96QT6
International Prot ID:
IPI00292750
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0017053
GO:0017053
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0016564
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045892
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
M
E
T
K
T
I
V
Y
D
L
D
T
S
G
G
Site 2
T16
T
I
V
Y
D
L
D
T
S
G
G
L
M
E
Q
Site 3
T33
A
L
L
A
P
P
K
T
D
E
A
E
K
R
S
Site 4
S50
P
E
K
E
P
R
R
S
G
R
A
T
N
H
D
Site 5
T54
P
R
R
S
G
R
A
T
N
H
D
S
C
D
S
Site 6
S58
G
R
A
T
N
H
D
S
C
D
S
C
K
E
G
Site 7
S61
T
N
H
D
S
C
D
S
C
K
E
G
G
D
L
Site 8
S88
Q
C
C
N
P
P
L
S
E
E
M
L
P
P
G
Site 9
S125
V
N
G
L
V
D
K
S
G
K
R
T
T
S
P
Site 10
T129
V
D
K
S
G
K
R
T
T
S
P
S
S
D
T
Site 11
T130
D
K
S
G
K
R
T
T
S
P
S
S
D
T
D
Site 12
S131
K
S
G
K
R
T
T
S
P
S
S
D
T
D
L
Site 13
S133
G
K
R
T
T
S
P
S
S
D
T
D
L
L
D
Site 14
S134
K
R
T
T
S
P
S
S
D
T
D
L
L
D
R
Site 15
T136
T
T
S
P
S
S
D
T
D
L
L
D
R
S
A
Site 16
S142
D
T
D
L
L
D
R
S
A
S
K
T
E
L
K
Site 17
S144
D
L
L
D
R
S
A
S
K
T
E
L
K
A
I
Site 18
T146
L
D
R
S
A
S
K
T
E
L
K
A
I
A
H
Site 19
S162
R
I
L
E
R
R
A
S
R
P
G
T
P
T
S
Site 20
T166
R
R
A
S
R
P
G
T
P
T
S
S
A
S
T
Site 21
T168
A
S
R
P
G
T
P
T
S
S
A
S
T
E
T
Site 22
S169
S
R
P
G
T
P
T
S
S
A
S
T
E
T
P
Site 23
S170
R
P
G
T
P
T
S
S
A
S
T
E
T
P
T
Site 24
S172
G
T
P
T
S
S
A
S
T
E
T
P
T
S
E
Site 25
T173
T
P
T
S
S
A
S
T
E
T
P
T
S
E
Q
Site 26
T175
T
S
S
A
S
T
E
T
P
T
S
E
Q
N
D
Site 27
S178
A
S
T
E
T
P
T
S
E
Q
N
D
V
D
E
Site 28
Y201
P
V
A
A
E
P
D
Y
V
Q
P
Q
L
R
R
Site 29
T223
A
A
M
E
R
N
P
T
Q
F
Q
L
P
N
E
Site 30
T234
L
P
N
E
L
T
C
T
T
A
L
P
G
S
S
Site 31
T235
P
N
E
L
T
C
T
T
A
L
P
G
S
S
K
Site 32
S240
C
T
T
A
L
P
G
S
S
K
R
R
R
K
E
Site 33
S241
T
T
A
L
P
G
S
S
K
R
R
R
K
E
E
Site 34
T249
K
R
R
R
K
E
E
T
T
G
K
N
V
K
K
Site 35
T250
R
R
R
K
E
E
T
T
G
K
N
V
K
K
T
Site 36
T257
T
G
K
N
V
K
K
T
Q
H
E
L
D
H
N
Site 37
T306
D
C
L
E
P
P
L
T
A
M
P
L
G
R
W
Site 38
T344
V
F
D
R
F
Q
D
T
V
S
Q
H
V
V
K
Site 39
S346
D
R
F
Q
D
T
V
S
Q
H
V
V
K
V
D
Site 40
S371
P
N
R
R
V
L
Q
S
V
K
R
R
S
L
K
Site 41
S376
L
Q
S
V
K
R
R
S
L
K
V
P
D
A
I
Site 42
S385
K
V
P
D
A
I
K
S
Q
Y
Q
F
P
P
P
Site 43
Y387
P
D
A
I
K
S
Q
Y
Q
F
P
P
P
L
I
Site 44
S413
C
N
G
I
P
E
E
S
Q
M
H
L
L
N
S
Site 45
T425
L
N
S
E
H
L
A
T
Q
A
E
Q
Q
E
W
Site 46
S448
C
S
I
L
K
H
L
S
A
K
Q
M
P
S
H
Site 47
S454
L
S
A
K
Q
M
P
S
H
W
D
S
E
Q
T
Site 48
S458
Q
M
P
S
H
W
D
S
E
Q
T
E
K
A
D
Site 49
S479
T
D
S
S
V
T
T
S
L
Q
T
A
D
K
T
Site 50
T486
S
L
Q
T
A
D
K
T
P
T
P
S
H
Y
P
Site 51
T488
Q
T
A
D
K
T
P
T
P
S
H
Y
P
L
S
Site 52
S490
A
D
K
T
P
T
P
S
H
Y
P
L
S
C
P
Site 53
Y492
K
T
P
T
P
S
H
Y
P
L
S
C
P
S
G
Site 54
S495
T
P
S
H
Y
P
L
S
C
P
S
G
I
S
T
Site 55
S498
H
Y
P
L
S
C
P
S
G
I
S
T
Q
N
S
Site 56
S501
L
S
C
P
S
G
I
S
T
Q
N
S
L
S
C
Site 57
T502
S
C
P
S
G
I
S
T
Q
N
S
L
S
C
S
Site 58
S505
S
G
I
S
T
Q
N
S
L
S
C
S
P
P
H
Site 59
S507
I
S
T
Q
N
S
L
S
C
S
P
P
H
Q
S
Site 60
S509
T
Q
N
S
L
S
C
S
P
P
H
Q
S
P
A
Site 61
S514
S
C
S
P
P
H
Q
S
P
A
L
E
D
I
G
Site 62
T532
C
A
E
K
S
K
K
T
P
C
G
T
A
N
G
Site 63
Y553
K
A
N
G
P
H
L
Y
S
S
P
T
D
S
T
Site 64
S555
N
G
P
H
L
Y
S
S
P
T
D
S
T
D
P
Site 65
T557
P
H
L
Y
S
S
P
T
D
S
T
D
P
R
R
Site 66
S559
L
Y
S
S
P
T
D
S
T
D
P
R
R
L
P
Site 67
T560
Y
S
S
P
T
D
S
T
D
P
R
R
L
P
G
Site 68
T570
R
R
L
P
G
A
N
T
P
L
P
G
L
S
H
Site 69
S576
N
T
P
L
P
G
L
S
H
R
Q
G
W
P
R
Site 70
T586
Q
G
W
P
R
P
L
T
P
P
A
A
G
G
L
Site 71
S611
T
E
N
A
T
G
P
S
S
C
P
Q
R
S
L
Site 72
S612
E
N
A
T
G
P
S
S
C
P
Q
R
S
L
V
Site 73
S617
P
S
S
C
P
Q
R
S
L
V
P
V
P
S
L
Site 74
S630
S
L
P
P
S
I
P
S
S
C
A
S
I
E
N
Site 75
S631
L
P
P
S
I
P
S
S
C
A
S
I
E
N
T
Site 76
S634
S
I
P
S
S
C
A
S
I
E
N
T
S
T
L
Site 77
T638
S
C
A
S
I
E
N
T
S
T
L
Q
R
K
T
Site 78
T640
A
S
I
E
N
T
S
T
L
Q
R
K
T
V
Q
Site 79
T645
T
S
T
L
Q
R
K
T
V
Q
S
Q
I
G
P
Site 80
S648
L
Q
R
K
T
V
Q
S
Q
I
G
P
P
L
T
Site 81
T655
S
Q
I
G
P
P
L
T
D
S
R
P
L
G
S
Site 82
S657
I
G
P
P
L
T
D
S
R
P
L
G
S
P
P
Site 83
S662
T
D
S
R
P
L
G
S
P
P
N
A
T
R
V
Site 84
T671
P
N
A
T
R
V
L
T
P
P
Q
A
A
G
D
Site 85
S690
T
T
A
N
Q
R
F
S
S
P
A
P
S
S
D
Site 86
S691
T
A
N
Q
R
F
S
S
P
A
P
S
S
D
G
Site 87
S695
R
F
S
S
P
A
P
S
S
D
G
K
V
S
P
Site 88
S696
F
S
S
P
A
P
S
S
D
G
K
V
S
P
G
Site 89
S701
P
S
S
D
G
K
V
S
P
G
T
L
S
I
G
Site 90
T712
L
S
I
G
S
A
L
T
V
P
S
F
P
A
N
Site 91
S715
G
S
A
L
T
V
P
S
F
P
A
N
S
T
A
Site 92
S764
R
I
H
Q
L
F
P
S
R
V
Q
P
S
P
G
Site 93
S769
F
P
S
R
V
Q
P
S
P
G
S
V
G
T
H
Site 94
S772
R
V
Q
P
S
P
G
S
V
G
T
H
Q
L
A
Site 95
Y816
N
M
C
Y
R
T
L
Y
I
G
T
G
A
D
M
Site 96
Y845
G
K
H
A
C
I
F
Y
D
E
N
T
K
H
Y
Site 97
Y857
K
H
Y
E
L
L
N
Y
S
E
H
G
T
T
V
Site 98
T862
L
N
Y
S
E
H
G
T
T
V
D
N
V
L
Y
Site 99
T863
N
Y
S
E
H
G
T
T
V
D
N
V
L
Y
S
Site 100
Y869
T
T
V
D
N
V
L
Y
S
C
D
F
S
E
K
Site 101
S870
T
V
D
N
V
L
Y
S
C
D
F
S
E
K
T
Site 102
S874
V
L
Y
S
C
D
F
S
E
K
T
P
P
T
P
Site 103
T877
S
C
D
F
S
E
K
T
P
P
T
P
P
S
S
Site 104
T880
F
S
E
K
T
P
P
T
P
P
S
S
I
V
A
Site 105
S883
K
T
P
P
T
P
P
S
S
I
V
A
K
V
Q
Site 106
S884
T
P
P
T
P
P
S
S
I
V
A
K
V
Q
S
Site 107
S891
S
I
V
A
K
V
Q
S
V
I
R
R
R
R
H
Site 108
S914
E
E
A
A
M
M
S
S
Q
A
Q
G
P
Q
R
Site 109
S929
R
P
C
N
C
K
A
S
S
S
S
L
I
G
G
Site 110
S930
P
C
N
C
K
A
S
S
S
S
L
I
G
G
S
Site 111
S931
C
N
C
K
A
S
S
S
S
L
I
G
G
S
G
Site 112
S932
N
C
K
A
S
S
S
S
L
I
G
G
S
G
A
Site 113
S937
S
S
S
L
I
G
G
S
G
A
G
W
E
G
T
Site 114
S977
K
Q
P
K
G
D
A
S
L
L
Q
D
G
V
L
Site 115
S989
G
V
L
A
E
K
L
S
L
K
P
H
Q
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation