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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PASK
Full Name:
PAS domain-containing serine/threonine-protein kinase
Alias:
EC 2.7.11.1; KIAA0135; PASKIN; PAS-kinase
Type:
Protein-serine kinase, CAMK group, CAMKL family, PASK subfamily
Mass (Da):
142929
Number AA:
1323
UniProt ID:
Q96RG2
International Prot ID:
IPI00398824
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0006355
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
ZIPtide KinSub - DAPK3 (ZIPK) protein kinase substrate peptide - Powder PE-01ANB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ANB95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
E
D
Q
R
C
L
S
Q
S
L
P
L
P
V
Site 2
S19
D
Q
R
C
L
S
Q
S
L
P
L
P
V
S
A
Site 3
S25
Q
S
L
P
L
P
V
S
A
E
G
P
A
A
Q
Site 4
T34
E
G
P
A
A
Q
T
T
A
E
P
S
R
S
F
Site 5
S38
A
Q
T
T
A
E
P
S
R
S
F
S
S
A
H
Site 6
S40
T
T
A
E
P
S
R
S
F
S
S
A
H
R
H
Site 7
S42
A
E
P
S
R
S
F
S
S
A
H
R
H
L
S
Site 8
S43
E
P
S
R
S
F
S
S
A
H
R
H
L
S
R
Site 9
S49
S
S
A
H
R
H
L
S
R
R
N
G
L
S
R
Site 10
S55
L
S
R
R
N
G
L
S
R
L
C
Q
S
R
T
Site 11
S60
G
L
S
R
L
C
Q
S
R
T
A
L
S
E
D
Site 12
T62
S
R
L
C
Q
S
R
T
A
L
S
E
D
R
W
Site 13
S65
C
Q
S
R
T
A
L
S
E
D
R
W
S
S
Y
Site 14
S70
A
L
S
E
D
R
W
S
S
Y
C
L
S
S
L
Site 15
S71
L
S
E
D
R
W
S
S
Y
C
L
S
S
L
A
Site 16
Y72
S
E
D
R
W
S
S
Y
C
L
S
S
L
A
A
Site 17
S75
R
W
S
S
Y
C
L
S
S
L
A
A
Q
N
I
Site 18
S99
A
P
E
H
T
D
P
S
E
P
R
G
S
V
S
Site 19
S104
D
P
S
E
P
R
G
S
V
S
C
C
S
L
L
Site 20
S106
S
E
P
R
G
S
V
S
C
C
S
L
L
R
G
Site 21
S109
R
G
S
V
S
C
C
S
L
L
R
G
L
S
S
Site 22
S116
S
L
L
R
G
L
S
S
G
W
S
S
P
L
L
Site 23
S119
R
G
L
S
S
G
W
S
S
P
L
L
P
A
P
Site 24
S159
C
G
L
L
G
Y
S
S
Q
D
L
I
G
Q
K
Site 25
S176
Q
F
F
L
R
S
D
S
D
V
V
E
A
L
S
Site 26
S183
S
D
V
V
E
A
L
S
E
E
H
M
E
A
D
Site 27
S205
G
T
V
V
D
I
I
S
R
S
G
E
K
I
P
Site 28
S214
S
G
E
K
I
P
V
S
V
W
M
K
R
M
R
Site 29
S239
L
E
P
V
E
R
V
S
T
W
V
A
F
Q
S
Site 30
T240
E
P
V
E
R
V
S
T
W
V
A
F
Q
S
D
Site 31
S246
S
T
W
V
A
F
Q
S
D
G
T
V
T
S
C
Site 32
S252
Q
S
D
G
T
V
T
S
C
D
S
L
F
A
H
Site 33
S265
A
H
L
H
G
Y
V
S
G
E
D
V
A
G
Q
Site 34
S286
P
S
V
Q
L
P
P
S
G
Q
H
I
P
K
N
Site 35
S299
K
N
L
K
I
Q
R
S
V
G
R
A
R
D
G
Site 36
T307
V
G
R
A
R
D
G
T
T
F
P
L
S
L
K
Site 37
T308
G
R
A
R
D
G
T
T
F
P
L
S
L
K
L
Site 38
S312
D
G
T
T
F
P
L
S
L
K
L
K
S
Q
P
Site 39
S317
P
L
S
L
K
L
K
S
Q
P
S
S
E
E
A
Site 40
S320
L
K
L
K
S
Q
P
S
S
E
E
A
T
T
G
Site 41
S321
K
L
K
S
Q
P
S
S
E
E
A
T
T
G
E
Site 42
T326
P
S
S
E
E
A
T
T
G
E
A
A
P
V
S
Site 43
S333
T
G
E
A
A
P
V
S
G
Y
R
A
S
V
W
Site 44
Y396
Y
S
Y
M
D
L
A
Y
N
S
S
L
Q
L
P
Site 45
S398
Y
M
D
L
A
Y
N
S
S
L
Q
L
P
D
L
Site 46
S415
C
L
D
V
G
N
E
S
G
C
G
E
R
T
L
Site 47
T421
E
S
G
C
G
E
R
T
L
D
P
W
Q
G
Q
Site 48
S460
E
I
R
K
L
M
E
S
Q
D
I
F
T
G
T
Site 49
S496
V
D
N
V
P
E
G
S
L
P
V
H
G
E
Q
Site 50
S524
E
E
P
V
A
I
E
S
P
G
Q
D
L
L
G
Site 51
S533
G
Q
D
L
L
G
E
S
R
S
E
P
V
D
V
Site 52
S535
D
L
L
G
E
S
R
S
E
P
V
D
V
K
P
Site 53
S545
V
D
V
K
P
F
A
S
C
E
D
S
E
A
P
Site 54
S549
P
F
A
S
C
E
D
S
E
A
P
V
P
A
E
Site 55
S582
R
M
G
V
S
G
P
S
G
S
D
L
W
A
G
Site 56
S629
R
S
Q
D
L
A
P
S
P
S
G
M
A
G
L
Site 57
S631
Q
D
L
A
P
S
P
S
G
M
A
G
L
S
F
Site 58
T640
M
A
G
L
S
F
G
T
P
T
L
D
E
P
W
Site 59
T642
G
L
S
F
G
T
P
T
L
D
E
P
W
L
G
Site 60
T659
N
D
R
E
E
L
Q
T
C
L
I
K
E
Q
L
Site 61
T691
P
T
E
C
Q
A
V
T
A
P
V
S
S
C
D
Site 62
S695
Q
A
V
T
A
P
V
S
S
C
D
L
G
G
R
Site 63
T709
R
D
L
C
G
G
C
T
G
S
S
S
A
C
Y
Site 64
S738
A
Q
E
V
D
V
N
S
F
S
W
N
L
K
E
Site 65
S749
N
L
K
E
L
F
F
S
D
Q
T
D
Q
T
S
Site 66
T752
E
L
F
F
S
D
Q
T
D
Q
T
S
S
N
C
Site 67
T755
F
S
D
Q
T
D
Q
T
S
S
N
C
S
C
A
Site 68
S756
S
D
Q
T
D
Q
T
S
S
N
C
S
C
A
T
Site 69
S757
D
Q
T
D
Q
T
S
S
N
C
S
C
A
T
S
Site 70
S760
D
Q
T
S
S
N
C
S
C
A
T
S
E
L
R
Site 71
S764
S
N
C
S
C
A
T
S
E
L
R
E
T
P
S
Site 72
T769
A
T
S
E
L
R
E
T
P
S
S
L
A
V
G
Site 73
S771
S
E
L
R
E
T
P
S
S
L
A
V
G
S
D
Site 74
S772
E
L
R
E
T
P
S
S
L
A
V
G
S
D
P
Site 75
S777
P
S
S
L
A
V
G
S
D
P
D
V
G
S
L
Site 76
S783
G
S
D
P
D
V
G
S
L
Q
E
Q
G
S
C
Site 77
S789
G
S
L
Q
E
Q
G
S
C
V
L
D
D
R
E
Site 78
S816
Q
G
R
R
F
R
E
S
C
V
G
H
D
P
T
Site 79
S839
S
S
E
H
Y
A
A
S
D
R
E
S
P
G
H
Site 80
S843
Y
A
A
S
D
R
E
S
P
G
H
V
P
S
T
Site 81
S849
E
S
P
G
H
V
P
S
T
L
D
A
G
P
E
Site 82
T850
S
P
G
H
V
P
S
T
L
D
A
G
P
E
D
Site 83
T874
L
N
V
Q
V
T
S
T
P
V
I
V
M
R
G
Site 84
S895
E
I
Q
E
G
A
Y
S
G
S
C
Y
H
R
D
Site 85
S897
Q
E
G
A
Y
S
G
S
C
Y
H
R
D
G
L
Site 86
Y899
G
A
Y
S
G
S
C
Y
H
R
D
G
L
R
L
Site 87
S907
H
R
D
G
L
R
L
S
I
Q
F
E
V
R
R
Site 88
S935
L
V
K
D
L
L
H
S
Q
R
D
S
A
A
R
Site 89
S939
L
L
H
S
Q
R
D
S
A
A
R
T
R
L
F
Site 90
T943
Q
R
D
S
A
A
R
T
R
L
F
L
A
S
L
Site 91
S949
R
T
R
L
F
L
A
S
L
P
G
S
T
H
S
Site 92
T954
L
A
S
L
P
G
S
T
H
S
T
A
A
E
L
Site 93
S956
S
L
P
G
S
T
H
S
T
A
A
E
L
T
G
Site 94
T957
L
P
G
S
T
H
S
T
A
A
E
L
T
G
P
Site 95
S996
A
A
C
E
G
E
Y
S
Q
K
Y
S
T
M
S
Site 96
Y999
E
G
E
Y
S
Q
K
Y
S
T
M
S
P
L
G
Site 97
S1000
G
E
Y
S
Q
K
Y
S
T
M
S
P
L
G
S
Site 98
T1001
E
Y
S
Q
K
Y
S
T
M
S
P
L
G
S
G
Site 99
S1003
S
Q
K
Y
S
T
M
S
P
L
G
S
G
A
F
Site 100
T1161
E
R
G
K
L
F
Y
T
F
C
G
T
I
E
Y
Site 101
T1165
L
F
Y
T
F
C
G
T
I
E
Y
C
A
P
E
Site 102
Y1179
E
V
L
M
G
N
P
Y
R
G
P
E
L
E
M
Site 103
T1209
P
F
C
E
L
E
E
T
V
E
A
A
I
H
P
Site 104
T1240
Q
P
V
P
E
R
R
T
T
L
E
K
L
V
T
Site 105
T1241
P
V
P
E
R
R
T
T
L
E
K
L
V
T
D
Site 106
T1247
T
T
L
E
K
L
V
T
D
P
W
V
T
Q
P
Site 107
Y1260
Q
P
V
N
L
A
D
Y
T
W
E
E
V
F
R
Site 108
T1261
P
V
N
L
A
D
Y
T
W
E
E
V
F
R
V
Site 109
S1273
F
R
V
N
K
P
E
S
G
V
L
S
A
A
S
Site 110
S1277
K
P
E
S
G
V
L
S
A
A
S
L
E
M
G
Site 111
S1280
S
G
V
L
S
A
A
S
L
E
M
G
N
R
S
Site 112
S1287
S
L
E
M
G
N
R
S
L
S
D
V
A
Q
A
Site 113
S1289
E
M
G
N
R
S
L
S
D
V
A
Q
A
Q
E
Site 114
T1322
P
G
D
P
R
L
L
T
S
_
_
_
_
_
_
Site 115
S1323
G
D
P
R
L
L
T
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation