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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCCC1
Full Name:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Alias:
3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing; 3-methylcrotonyl-CoA:carbon dioxide ligase alpha; 3-methylcrotonyl-CoA;carbon dioxide ligase alpha; EC 6.4.1.4; MCCA; MCCase alpha; MCC-B; Methylcrotonoyl-CoA carboxylase alpha, mitochondrial; Methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Type:
EC 6.4.1.4; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Ligase
Mass (Da):
80473
Number AA:
725
UniProt ID:
Q96RQ3
International Prot ID:
IPI00024580
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0009374
GO:0004485
PhosphoSite+
KinaseNET
Biological Process:
GO:0006768
GO:0006552
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
A
A
S
A
V
S
V
L
L
V
Site 2
S8
M
A
A
A
S
A
V
S
V
L
L
V
A
A
E
Site 3
S24
N
R
W
H
R
L
P
S
L
L
L
P
P
R
T
Site 4
T31
S
L
L
L
P
P
R
T
W
V
W
R
Q
R
T
Site 5
Y41
W
R
Q
R
T
M
K
Y
T
T
A
T
G
R
N
Site 6
T42
R
Q
R
T
M
K
Y
T
T
A
T
G
R
N
I
Site 7
T50
T
A
T
G
R
N
I
T
K
V
L
I
A
N
R
Site 8
S86
Y
S
E
A
D
R
N
S
M
H
V
D
M
A
D
Site 9
Y96
V
D
M
A
D
E
A
Y
S
I
G
P
A
P
S
Site 10
S97
D
M
A
D
E
A
Y
S
I
G
P
A
P
S
Q
Site 11
S103
Y
S
I
G
P
A
P
S
Q
Q
S
Y
L
S
M
Site 12
S106
G
P
A
P
S
Q
Q
S
Y
L
S
M
E
K
I
Site 13
Y107
P
A
P
S
Q
Q
S
Y
L
S
M
E
K
I
I
Site 14
S109
P
S
Q
Q
S
Y
L
S
M
E
K
I
I
Q
V
Site 15
S164
I
R
D
M
G
I
K
S
T
S
K
S
I
M
A
Site 16
Y181
G
V
P
V
V
E
G
Y
H
G
E
D
Q
S
D
Site 17
Y200
E
H
A
R
R
I
G
Y
P
V
M
I
K
A
V
Site 18
S220
K
G
M
R
I
V
R
S
E
Q
E
F
Q
E
Q
Site 19
S230
E
F
Q
E
Q
L
E
S
A
R
R
E
A
K
K
Site 20
S238
A
R
R
E
A
K
K
S
F
N
D
D
A
M
L
Site 21
T252
L
I
E
K
F
V
D
T
P
R
H
V
E
V
Q
Site 22
Y270
D
H
H
G
N
A
V
Y
L
F
E
R
D
C
S
Site 23
S277
Y
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
Site 24
S296
A
P
A
P
G
I
K
S
E
V
R
K
K
L
G
Site 25
T347
L
Q
V
E
H
P
V
T
E
M
I
T
G
T
D
Site 26
S371
A
G
E
K
I
P
L
S
Q
E
E
I
T
L
Q
Site 27
Y387
H
A
F
E
A
R
I
Y
A
E
D
P
S
N
N
Site 28
S392
R
I
Y
A
E
D
P
S
N
N
F
M
P
V
A
Site 29
S406
A
G
P
L
V
H
L
S
T
P
R
A
D
P
S
Site 30
T407
G
P
L
V
H
L
S
T
P
R
A
D
P
S
T
Site 31
S413
S
T
P
R
A
D
P
S
T
R
I
E
T
G
V
Site 32
T414
T
P
R
A
D
P
S
T
R
I
E
T
G
V
R
Site 33
T418
D
P
S
T
R
I
E
T
G
V
R
Q
G
D
E
Site 34
T449
A
D
R
Q
A
A
L
T
K
L
R
Y
S
L
R
Site 35
S454
A
L
T
K
L
R
Y
S
L
R
Q
Y
N
I
V
Site 36
Y458
L
R
Y
S
L
R
Q
Y
N
I
V
G
L
H
T
Site 37
T523
I
L
K
E
K
A
M
T
D
T
F
T
L
Q
A
Site 38
T525
K
E
K
A
M
T
D
T
F
T
L
Q
A
H
D
Site 39
T527
K
A
M
T
D
T
F
T
L
Q
A
H
D
Q
F
Site 40
S535
L
Q
A
H
D
Q
F
S
P
F
S
S
S
S
G
Site 41
S538
H
D
Q
F
S
P
F
S
S
S
S
G
R
R
L
Site 42
S539
D
Q
F
S
P
F
S
S
S
S
G
R
R
L
N
Site 43
S540
Q
F
S
P
F
S
S
S
S
G
R
R
L
N
I
Site 44
S541
F
S
P
F
S
S
S
S
G
R
R
L
N
I
S
Site 45
S548
S
G
R
R
L
N
I
S
Y
T
R
N
M
T
L
Site 46
Y549
G
R
R
L
N
I
S
Y
T
R
N
M
T
L
K
Site 47
T550
R
R
L
N
I
S
Y
T
R
N
M
T
L
K
D
Site 48
T554
I
S
Y
T
R
N
M
T
L
K
D
G
K
N
N
Site 49
Y568
N
V
A
I
A
V
T
Y
N
H
D
G
S
Y
S
Site 50
Y574
T
Y
N
H
D
G
S
Y
S
M
Q
I
E
D
K
Site 51
T582
S
M
Q
I
E
D
K
T
F
Q
V
L
G
N
L
Site 52
S591
Q
V
L
G
N
L
Y
S
E
G
D
C
T
Y
L
Site 53
T596
L
Y
S
E
G
D
C
T
Y
L
K
C
S
V
N
Site 54
Y597
Y
S
E
G
D
C
T
Y
L
K
C
S
V
N
G
Site 55
S601
D
C
T
Y
L
K
C
S
V
N
G
V
A
S
K
Site 56
S622
E
N
T
I
Y
L
F
S
K
E
G
S
I
E
I
Site 57
Y636
I
D
I
P
V
P
K
Y
L
S
S
V
S
S
Q
Site 58
S638
I
P
V
P
K
Y
L
S
S
V
S
S
Q
E
T
Site 59
S639
P
V
P
K
Y
L
S
S
V
S
S
Q
E
T
Q
Site 60
S642
K
Y
L
S
S
V
S
S
Q
E
T
Q
G
G
P
Site 61
T645
S
S
V
S
S
Q
E
T
Q
G
G
P
L
A
P
Site 62
S688
K
M
E
H
T
I
K
S
P
K
D
G
T
V
K
Site 63
T693
I
K
S
P
K
D
G
T
V
K
K
V
F
Y
R
Site 64
T709
G
A
Q
A
N
R
H
T
P
L
V
E
F
E
E
Site 65
S719
V
E
F
E
E
E
E
S
D
K
R
E
S
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation