PhosphoNET

           
Protein Info 
   
Short Name:  CaMKK2
Full Name:  Calcium/calmodulin-dependent protein kinase kinase 2
Alias:  Calcium/calmodulin-dependent protein kinase; Calcium/calmodulin-dependent protein kinase kinase 2, beta; CaM-kinase kinase beta; CAMKK; CaMKK beta; CAMKKB; EC 2.7.11.17; KIAA0787; KKCC2; MGC15254
Type:  Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; Other group; CAMKK family; Meta subfamily
Mass (Da):  64732
Number AA:  588
UniProt ID:  Q96RR4
International Prot ID:  IPI00290239
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005509  GO:0005516 PhosphoSite+ KinaseNET
Biological Process:  GO:0000165  GO:0019722  GO:0045941 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MSSCVSSQPSSNR
Site 2S7_MSSCVSSQPSSNRA
Site 3S10SCVSSQPSSNRAAPQ
Site 4S11CVSSQPSSNRAAPQD
Site 5S25DELGGRGSSSSESQK
Site 6S26ELGGRGSSSSESQKP
Site 7S27LGGRGSSSSESQKPC
Site 8S28GGRGSSSSESQKPCE
Site 9S30RGSSSSESQKPCEAL
Site 10S85GQEVPLDSSGSQARP
Site 11S86QEVPLDSSGSQARPH
Site 12S88VPLDSSGSQARPHLS
Site 13S95SQARPHLSGRKLSLQ
Site 14S100HLSGRKLSLQERSQG
Site 15S105KLSLQERSQGGLAAG
Site 16S114GGLAAGGSLDMNGRC
Site 17S125NGRCICPSLPYSPVS
Site 18Y128CICPSLPYSPVSSPQ
Site 19S129ICPSLPYSPVSSPQS
Site 20S132SLPYSPVSSPQSSPR
Site 21S133LPYSPVSSPQSSPRL
Site 22S136SPVSSPQSSPRLPRR
Site 23S137PVSSPQSSPRLPRRP
Site 24T145PRLPRRPTVESHHVS
Site 25S148PRRPTVESHHVSITG
Site 26Y176DEIGKGSYGVVKLAY
Site 27Y183YGVVKLAYNENDNTY
Site 28Y190YNENDNTYYAMKVLS
Site 29Y191NENDNTYYAMKVLSK
Site 30T216RRPPPRGTRPAPGGC
Site 31Y234RGPIEQVYQEIAILK
Site 32Y264DPNEDHLYMVFELVN
Site 33T280GPVMEVPTLKPLSED
Site 34S285VPTLKPLSEDQARFY
Site 35Y292SEDQARFYFQDLIKG
Site 36Y305KGIEYLHYQKIIHRD
Site 37S316IHRDIKPSNLLVGED
Site 38S334KIADFGVSNEFKGSD
Site 39S340VSNEFKGSDALLSNT
Site 40S345KGSDALLSNTVGTPA
Site 41S358PAFMAPESLSETRKI
Site 42S360FMAPESLSETRKIFS
Site 43T362APESLSETRKIFSGK
Site 44S367SETRKIFSGKALDVW
Site 45S400ERIMCLHSKIKSQAL
Site 46S404CLHSKIKSQALEFPD
Site 47S433MLDKNPESRIVVPEI
Site 48S456HGAEPLPSEDENCTL
Site 49S474TEEEVENSVKHIPSL
Site 50T483KHIPSLATVILVKTM
Site 51S495KTMIRKRSFGNPFEG
Site 52S503FGNPFEGSRREERSL
Site 53S509GSRREERSLSAPGNL
Site 54S511RREERSLSAPGNLLT
Site 55T518SAPGNLLTKKPTREC
Site 56S527KPTRECESLSELKEA
Site 57S529TRECESLSELKEARQ
Site 58S553APRGGGGSALVRGSP
Site 59S564RGSPCVESCWAPAPG
Site 60S572CWAPAPGSPARMHPL
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


Click here to download a PPT of the image above

2019 Kinexus Bioinformatics Corporation