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Updated November 2019
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Protein Info
Short Name:
ERBB2IP
Full Name:
Protein LAP2
Alias:
Densin-180-like protein; Erbb2 interacting protein; Erbb2-interacting protein; ERBIN; LAP2
Type:
Adapter/scaffold protein
Mass (Da):
158298
Number AA:
1412
UniProt ID:
Q96RT1
International Prot ID:
IPI00438286
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005604
GO:0005737
GO:0030056
Uniprot
OncoNet
Molecular Function:
GO:0005176
GO:0005178
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0045175
GO:0007155
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein LAP2 Y1104 phosphosite-specific antibody AB-PN513#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN513#Protein LAP2 (E1101-Y1107, human) pY1104 phosphopeptide - Powder PE-04AER99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AER99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
C
L
R
G
E
E
E
T
V
T
T
L
D
Y
S
Site 2
T25
R
G
E
E
E
T
V
T
T
L
D
Y
S
H
C
Site 3
T26
G
E
E
E
T
V
T
T
L
D
Y
S
H
C
S
Site 4
Y29
E
T
V
T
T
L
D
Y
S
H
C
S
L
E
Q
Site 5
S33
T
L
D
Y
S
H
C
S
L
E
Q
V
P
K
E
Site 6
T43
Q
V
P
K
E
I
F
T
F
E
K
T
L
E
E
Site 7
T47
E
I
F
T
F
E
K
T
L
E
E
L
Y
L
D
Site 8
Y52
E
K
T
L
E
E
L
Y
L
D
A
N
Q
I
E
Site 9
S70
K
Q
L
F
N
C
Q
S
L
H
K
L
S
L
P
Site 10
T83
L
P
D
N
D
L
T
T
L
P
A
S
I
A
N
Site 11
S100
N
L
R
E
L
D
V
S
K
N
G
I
Q
E
F
Site 12
S128
E
A
S
V
N
P
I
S
K
L
P
D
G
F
S
Site 13
S135
S
K
L
P
D
G
F
S
Q
L
L
N
L
T
Q
Site 14
T179
Q
L
K
M
L
P
K
T
M
N
R
L
T
Q
L
Site 15
T184
P
K
T
M
N
R
L
T
Q
L
E
R
L
D
L
Site 16
S193
L
E
R
L
D
L
G
S
N
E
F
T
E
V
P
Site 17
T197
D
L
G
S
N
E
F
T
E
V
P
E
V
L
E
Site 18
T220
W
M
D
A
N
R
L
T
F
I
P
G
F
I
G
Site 19
T233
I
G
S
L
K
Q
L
T
Y
L
D
V
S
K
N
Site 20
Y234
G
S
L
K
Q
L
T
Y
L
D
V
S
K
N
N
Site 21
S238
Q
L
T
Y
L
D
V
S
K
N
N
I
E
M
V
Site 22
S250
E
M
V
E
E
G
I
S
T
C
E
N
L
Q
D
Site 23
T251
M
V
E
E
G
I
S
T
C
E
N
L
Q
D
L
Site 24
S261
N
L
Q
D
L
L
L
S
S
N
S
L
Q
Q
L
Site 25
S262
L
Q
D
L
L
L
S
S
N
S
L
Q
Q
L
P
Site 26
S264
D
L
L
L
S
S
N
S
L
Q
Q
L
P
E
T
Site 27
T271
S
L
Q
Q
L
P
E
T
I
G
S
L
K
N
I
Site 28
S274
Q
L
P
E
T
I
G
S
L
K
N
I
T
T
L
Site 29
Y290
I
D
E
N
Q
L
M
Y
L
P
D
S
I
G
G
Site 30
S307
S
V
E
E
L
D
C
S
F
N
E
V
E
A
L
Site 31
S316
N
E
V
E
A
L
P
S
S
I
G
Q
L
T
N
Site 32
T322
P
S
S
I
G
Q
L
T
N
L
R
T
F
A
A
Site 33
T326
G
Q
L
T
N
L
R
T
F
A
A
D
H
N
Y
Site 34
Y333
T
F
A
A
D
H
N
Y
L
Q
Q
L
P
P
E
Site 35
S376
K
L
K
V
I
N
L
S
D
N
R
L
K
N
L
Site 36
S386
R
L
K
N
L
P
F
S
F
T
K
L
Q
Q
L
Site 37
S399
Q
L
T
A
M
W
L
S
D
N
Q
S
K
P
L
Site 38
S403
M
W
L
S
D
N
Q
S
K
P
L
I
P
L
Q
Site 39
S415
P
L
Q
K
E
T
D
S
E
T
Q
K
M
V
L
Site 40
T417
Q
K
E
T
D
S
E
T
Q
K
M
V
L
T
N
Site 41
Y425
Q
K
M
V
L
T
N
Y
M
F
P
Q
Q
P
R
Site 42
T433
M
F
P
Q
Q
P
R
T
E
D
V
M
F
I
S
Site 43
S440
T
E
D
V
M
F
I
S
D
N
E
S
F
N
P
Site 44
S444
M
F
I
S
D
N
E
S
F
N
P
S
L
W
E
Site 45
S448
D
N
E
S
F
N
P
S
L
W
E
E
Q
R
K
Site 46
Y483
R
E
G
N
L
K
R
Y
P
T
P
Y
P
D
E
Site 47
T485
G
N
L
K
R
Y
P
T
P
Y
P
D
E
L
K
Site 48
Y487
L
K
R
Y
P
T
P
Y
P
D
E
L
K
N
M
Site 49
T497
E
L
K
N
M
V
K
T
V
Q
T
I
V
H
R
Site 50
T510
H
R
L
K
D
E
E
T
N
E
D
S
G
R
D
Site 51
S514
D
E
E
T
N
E
D
S
G
R
D
L
K
P
H
Site 52
T535
N
K
D
V
G
V
K
T
S
E
S
T
T
T
V
Site 53
S536
K
D
V
G
V
K
T
S
E
S
T
T
T
V
K
Site 54
S538
V
G
V
K
T
S
E
S
T
T
T
V
K
S
K
Site 55
T540
V
K
T
S
E
S
T
T
T
V
K
S
K
V
D
Site 56
T541
K
T
S
E
S
T
T
T
V
K
S
K
V
D
E
Site 57
S544
E
S
T
T
T
V
K
S
K
V
D
E
R
E
K
Site 58
Y552
K
V
D
E
R
E
K
Y
M
I
G
N
S
V
Q
Site 59
S557
E
K
Y
M
I
G
N
S
V
Q
K
I
S
E
P
Site 60
S562
G
N
S
V
Q
K
I
S
E
P
E
A
E
I
S
Site 61
S569
S
E
P
E
A
E
I
S
P
G
S
L
P
V
T
Site 62
S572
E
A
E
I
S
P
G
S
L
P
V
T
A
N
M
Site 63
T576
S
P
G
S
L
P
V
T
A
N
M
K
A
S
E
Site 64
S598
H
D
D
V
F
E
E
S
E
E
L
S
S
D
E
Site 65
S602
F
E
E
S
E
E
L
S
S
D
E
E
M
K
M
Site 66
S603
E
E
S
E
E
L
S
S
D
E
E
M
K
M
A
Site 67
S630
Q
P
K
V
V
A
L
S
N
N
K
K
D
D
T
Site 68
T637
S
N
N
K
K
D
D
T
K
E
T
D
S
L
S
Site 69
S642
D
D
T
K
E
T
D
S
L
S
D
E
V
T
H
Site 70
S644
T
K
E
T
D
S
L
S
D
E
V
T
H
N
S
Site 71
T648
D
S
L
S
D
E
V
T
H
N
S
N
Q
N
N
Site 72
S656
H
N
S
N
Q
N
N
S
N
C
S
S
P
S
R
Site 73
S659
N
Q
N
N
S
N
C
S
S
P
S
R
M
S
D
Site 74
S660
Q
N
N
S
N
C
S
S
P
S
R
M
S
D
S
Site 75
S662
N
S
N
C
S
S
P
S
R
M
S
D
S
V
S
Site 76
S665
C
S
S
P
S
R
M
S
D
S
V
S
L
N
T
Site 77
S667
S
P
S
R
M
S
D
S
V
S
L
N
T
D
S
Site 78
S669
S
R
M
S
D
S
V
S
L
N
T
D
S
S
Q
Site 79
S674
S
V
S
L
N
T
D
S
S
Q
D
T
S
L
C
Site 80
S675
V
S
L
N
T
D
S
S
Q
D
T
S
L
C
S
Site 81
T678
N
T
D
S
S
Q
D
T
S
L
C
S
P
V
K
Site 82
S679
T
D
S
S
Q
D
T
S
L
C
S
P
V
K
Q
Site 83
S682
S
Q
D
T
S
L
C
S
P
V
K
Q
T
H
I
Site 84
S693
Q
T
H
I
D
I
N
S
K
I
R
Q
E
D
E
Site 85
S704
Q
E
D
E
N
F
N
S
L
L
Q
N
G
D
I
Site 86
S714
Q
N
G
D
I
L
N
S
S
T
E
E
K
F
K
Site 87
S715
N
G
D
I
L
N
S
S
T
E
E
K
F
K
A
Site 88
T716
G
D
I
L
N
S
S
T
E
E
K
F
K
A
H
Site 89
Y733
K
D
F
N
L
P
E
Y
D
L
N
V
E
E
R
Site 90
T751
I
E
K
S
V
D
S
T
A
T
A
D
D
T
H
Site 91
T757
S
T
A
T
A
D
D
T
H
K
L
D
H
I
N
Site 92
T775
N
K
L
I
T
N
D
T
F
Q
P
E
I
M
E
Site 93
T786
E
I
M
E
R
S
K
T
Q
D
I
V
L
G
T
Site 94
S797
V
L
G
T
S
F
L
S
I
N
S
K
E
E
T
Site 95
S800
T
S
F
L
S
I
N
S
K
E
E
T
E
H
L
Site 96
T804
S
I
N
S
K
E
E
T
E
H
L
E
N
G
N
Site 97
Y813
H
L
E
N
G
N
K
Y
P
N
L
E
S
V
N
Site 98
S826
V
N
K
V
N
G
H
S
E
E
T
S
Q
S
P
Site 99
S830
N
G
H
S
E
E
T
S
Q
S
P
N
R
T
E
Site 100
S832
H
S
E
E
T
S
Q
S
P
N
R
T
E
P
H
Site 101
T836
T
S
Q
S
P
N
R
T
E
P
H
D
S
D
C
Site 102
S841
N
R
T
E
P
H
D
S
D
C
S
V
D
L
G
Site 103
S844
E
P
H
D
S
D
C
S
V
D
L
G
I
S
K
Site 104
S850
C
S
V
D
L
G
I
S
K
S
T
E
D
L
S
Site 105
S852
V
D
L
G
I
S
K
S
T
E
D
L
S
P
Q
Site 106
T853
D
L
G
I
S
K
S
T
E
D
L
S
P
Q
K
Site 107
S857
S
K
S
T
E
D
L
S
P
Q
K
S
G
P
V
Site 108
S861
E
D
L
S
P
Q
K
S
G
P
V
G
S
V
V
Site 109
S866
Q
K
S
G
P
V
G
S
V
V
K
S
H
S
I
Site 110
S870
P
V
G
S
V
V
K
S
H
S
I
T
N
M
E
Site 111
S872
G
S
V
V
K
S
H
S
I
T
N
M
E
I
G
Site 112
Y884
E
I
G
G
L
K
I
Y
D
I
L
S
D
N
G
Site 113
S888
L
K
I
Y
D
I
L
S
D
N
G
P
Q
Q
P
Site 114
T897
N
G
P
Q
Q
P
S
T
T
V
K
I
T
S
A
Site 115
S913
D
G
K
N
I
V
R
S
K
S
A
T
L
L
Y
Site 116
S915
K
N
I
V
R
S
K
S
A
T
L
L
Y
D
Q
Site 117
T917
I
V
R
S
K
S
A
T
L
L
Y
D
Q
P
L
Site 118
Y920
S
K
S
A
T
L
L
Y
D
Q
P
L
Q
V
F
Site 119
T928
D
Q
P
L
Q
V
F
T
G
S
S
S
S
S
D
Site 120
S930
P
L
Q
V
F
T
G
S
S
S
S
S
D
L
I
Site 121
S931
L
Q
V
F
T
G
S
S
S
S
S
D
L
I
S
Site 122
S932
Q
V
F
T
G
S
S
S
S
S
D
L
I
S
G
Site 123
S933
V
F
T
G
S
S
S
S
S
D
L
I
S
G
T
Site 124
S934
F
T
G
S
S
S
S
S
D
L
I
S
G
T
K
Site 125
S938
S
S
S
S
D
L
I
S
G
T
K
A
I
F
K
Site 126
S948
K
A
I
F
K
F
D
S
N
H
N
P
E
E
P
Site 127
T962
P
N
I
I
R
G
P
T
S
G
P
Q
S
A
P
Site 128
S963
N
I
I
R
G
P
T
S
G
P
Q
S
A
P
Q
Site 129
S967
G
P
T
S
G
P
Q
S
A
P
Q
I
Y
G
P
Site 130
Y972
P
Q
S
A
P
Q
I
Y
G
P
P
Q
Y
N
I
Site 131
Y977
Q
I
Y
G
P
P
Q
Y
N
I
Q
Y
S
S
S
Site 132
Y981
P
P
Q
Y
N
I
Q
Y
S
S
S
A
A
V
K
Site 133
S982
P
Q
Y
N
I
Q
Y
S
S
S
A
A
V
K
D
Site 134
S983
Q
Y
N
I
Q
Y
S
S
S
A
A
V
K
D
T
Site 135
S984
Y
N
I
Q
Y
S
S
S
A
A
V
K
D
T
L
Site 136
T990
S
S
A
A
V
K
D
T
L
W
H
S
K
Q
N
Site 137
S994
V
K
D
T
L
W
H
S
K
Q
N
P
Q
I
D
Site 138
S1004
N
P
Q
I
D
H
A
S
F
P
P
Q
L
L
P
Site 139
S1013
P
P
Q
L
L
P
R
S
E
S
T
E
N
Q
S
Site 140
S1015
Q
L
L
P
R
S
E
S
T
E
N
Q
S
Y
A
Site 141
S1020
S
E
S
T
E
N
Q
S
Y
A
K
H
S
A
N
Site 142
Y1021
E
S
T
E
N
Q
S
Y
A
K
H
S
A
N
M
Site 143
Y1042
N
V
R
A
N
T
A
Y
H
L
H
Q
R
L
G
Site 144
S1060
H
G
E
M
W
A
I
S
P
N
D
R
L
I
P
Site 145
S1072
L
I
P
A
V
T
R
S
T
I
Q
R
Q
S
S
Site 146
T1073
I
P
A
V
T
R
S
T
I
Q
R
Q
S
S
V
Site 147
S1078
R
S
T
I
Q
R
Q
S
S
V
S
S
T
A
S
Site 148
S1079
S
T
I
Q
R
Q
S
S
V
S
S
T
A
S
V
Site 149
S1081
I
Q
R
Q
S
S
V
S
S
T
A
S
V
N
L
Site 150
S1082
Q
R
Q
S
S
V
S
S
T
A
S
V
N
L
G
Site 151
T1083
R
Q
S
S
V
S
S
T
A
S
V
N
L
G
D
Site 152
S1085
S
S
V
S
S
T
A
S
V
N
L
G
D
P
G
Site 153
S1093
V
N
L
G
D
P
G
S
T
R
R
A
Q
I
P
Site 154
T1094
N
L
G
D
P
G
S
T
R
R
A
Q
I
P
E
Site 155
Y1104
A
Q
I
P
E
G
D
Y
L
S
Y
R
E
F
H
Protein LAP2 Y1104 phosphosite-specific antibody AB-PN513#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN513#Protein LAP2 (E1101-Y1107, human) pY1104 phosphopeptide - Powder PE-04AER99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AER99
Site 156
S1106
I
P
E
G
D
Y
L
S
Y
R
E
F
H
S
A
Site 157
Y1107
P
E
G
D
Y
L
S
Y
R
E
F
H
S
A
G
Site 158
T1116
E
F
H
S
A
G
R
T
P
P
M
M
P
G
S
Site 159
S1123
T
P
P
M
M
P
G
S
Q
R
P
L
S
A
R
Site 160
S1128
P
G
S
Q
R
P
L
S
A
R
T
Y
S
I
D
Site 161
Y1132
R
P
L
S
A
R
T
Y
S
I
D
G
P
N
A
Site 162
S1133
P
L
S
A
R
T
Y
S
I
D
G
P
N
A
S
Site 163
S1140
S
I
D
G
P
N
A
S
R
P
Q
S
A
R
P
Site 164
S1144
P
N
A
S
R
P
Q
S
A
R
P
S
I
N
E
Site 165
S1148
R
P
Q
S
A
R
P
S
I
N
E
I
P
E
R
Site 166
T1156
I
N
E
I
P
E
R
T
M
S
V
S
D
F
N
Site 167
S1158
E
I
P
E
R
T
M
S
V
S
D
F
N
Y
S
Site 168
S1160
P
E
R
T
M
S
V
S
D
F
N
Y
S
R
T
Site 169
Y1164
M
S
V
S
D
F
N
Y
S
R
T
S
P
S
K
Site 170
S1165
S
V
S
D
F
N
Y
S
R
T
S
P
S
K
R
Site 171
T1167
S
D
F
N
Y
S
R
T
S
P
S
K
R
P
N
Site 172
S1168
D
F
N
Y
S
R
T
S
P
S
K
R
P
N
A
Site 173
S1170
N
Y
S
R
T
S
P
S
K
R
P
N
A
R
V
Site 174
S1179
R
P
N
A
R
V
G
S
E
H
S
L
L
D
P
Site 175
S1182
A
R
V
G
S
E
H
S
L
L
D
P
P
G
K
Site 176
S1190
L
L
D
P
P
G
K
S
K
V
P
R
D
W
R
Site 177
T1216
L
E
K
K
H
P
Q
T
S
S
S
G
D
P
C
Site 178
S1217
E
K
K
H
P
Q
T
S
S
S
G
D
P
C
Q
Site 179
S1218
K
K
H
P
Q
T
S
S
S
G
D
P
C
Q
D
Site 180
S1219
K
H
P
Q
T
S
S
S
G
D
P
C
Q
D
G
Site 181
Y1235
F
I
S
G
Q
Q
N
Y
S
S
A
T
L
S
H
Site 182
S1236
I
S
G
Q
Q
N
Y
S
S
A
T
L
S
H
K
Site 183
S1237
S
G
Q
Q
N
Y
S
S
A
T
L
S
H
K
D
Site 184
S1241
N
Y
S
S
A
T
L
S
H
K
D
V
P
P
D
Site 185
S1249
H
K
D
V
P
P
D
S
L
M
K
M
P
L
S
Site 186
S1256
S
L
M
K
M
P
L
S
N
G
Q
M
G
Q
P
Site 187
Y1270
P
L
R
P
Q
A
N
Y
S
Q
I
H
H
P
P
Site 188
S1271
L
R
P
Q
A
N
Y
S
Q
I
H
H
P
P
Q
Site 189
S1280
I
H
H
P
P
Q
A
S
V
A
R
H
P
S
R
Site 190
S1286
A
S
V
A
R
H
P
S
R
E
Q
L
I
D
Y
Site 191
Y1293
S
R
E
Q
L
I
D
Y
L
M
L
K
V
A
H
Site 192
Y1304
K
V
A
H
Q
P
P
Y
T
Q
P
H
C
S
P
Site 193
T1305
V
A
H
Q
P
P
Y
T
Q
P
H
C
S
P
R
Site 194
S1310
P
Y
T
Q
P
H
C
S
P
R
Q
G
H
E
L
Site 195
S1335
K
D
P
E
L
G
F
S
I
S
G
G
V
G
G
Site 196
S1337
P
E
L
G
F
S
I
S
G
G
V
G
G
R
G
Site 197
S1366
V
Q
P
E
G
P
A
S
K
L
L
Q
P
G
D
Site 198
Y1381
K
I
I
Q
A
N
G
Y
S
F
I
N
I
E
H
Site 199
S1382
I
I
Q
A
N
G
Y
S
F
I
N
I
E
H
G
Site 200
S1393
I
E
H
G
Q
A
V
S
L
L
K
T
F
Q
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation