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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IFT140
Full Name:
Intraflagellar transport protein 140 homolog
Alias:
WD and tetratricopeptide repeats protein 2
Type:
Mass (Da):
165193
Number AA:
1462
UniProt ID:
Q96RY7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
A
P
D
A
A
G
S
P
S
F
I
S
W
H
Site 2
S19
P
D
A
A
G
S
P
S
F
I
S
W
H
P
V
Site 3
S22
A
G
S
P
S
F
I
S
W
H
P
V
H
P
F
Site 4
S42
I
S
T
T
S
T
G
S
V
D
I
Y
L
E
Q
Site 5
Y46
S
T
G
S
V
D
I
Y
L
E
Q
G
E
C
V
Site 6
T56
Q
G
E
C
V
P
D
T
H
V
E
R
P
F
R
Site 7
S66
E
R
P
F
R
V
A
S
L
C
W
H
P
T
R
Site 8
T86
G
W
E
T
G
E
V
T
V
F
N
K
Q
D
K
Site 9
T101
E
Q
H
T
M
P
L
T
H
T
A
D
I
T
V
Site 10
T107
L
T
H
T
A
D
I
T
V
L
R
W
S
P
S
Site 11
T141
Q
R
G
R
V
Q
G
T
P
L
L
K
H
E
Y
Site 12
Y148
T
P
L
L
K
H
E
Y
G
K
H
L
T
H
C
Site 13
S189
D
M
F
N
W
K
K
S
S
S
G
S
L
L
K
Site 14
S190
M
F
N
W
K
K
S
S
S
G
S
L
L
K
M
Site 15
S191
F
N
W
K
K
S
S
S
G
S
L
L
K
M
G
Site 16
S193
W
K
K
S
S
S
G
S
L
L
K
M
G
S
H
Site 17
S199
G
S
L
L
K
M
G
S
H
E
G
L
L
F
F
Site 18
S208
E
G
L
L
F
F
V
S
L
M
D
G
T
V
H
Site 19
T213
F
V
S
L
M
D
G
T
V
H
Y
V
D
E
K
Site 20
Y216
L
M
D
G
T
V
H
Y
V
D
E
K
G
K
T
Site 21
T223
Y
V
D
E
K
G
K
T
T
Q
V
V
S
A
D
Site 22
S228
G
K
T
T
Q
V
V
S
A
D
S
T
I
Q
M
Site 23
Y238
S
T
I
Q
M
L
F
Y
M
E
K
R
E
A
L
Site 24
S255
V
T
E
N
L
R
L
S
L
Y
T
V
P
P
E
Site 25
Y257
E
N
L
R
L
S
L
Y
T
V
P
P
E
G
K
Site 26
T258
N
L
R
L
S
L
Y
T
V
P
P
E
G
K
A
Site 27
T277
K
V
K
L
S
G
K
T
G
R
R
A
D
I
A
Site 28
S314
R
G
E
N
Y
I
L
S
P
D
E
K
F
G
F
Site 29
S360
K
V
P
D
F
L
G
S
P
G
A
E
G
K
D
Site 30
T373
K
D
R
W
A
L
Q
T
P
T
E
L
Q
G
N
Site 31
T382
T
E
L
Q
G
N
I
T
Q
I
Q
W
G
S
R
Site 32
S405
V
I
S
V
A
I
L
S
E
R
A
M
S
S
H
Site 33
S410
I
L
S
E
R
A
M
S
S
H
F
H
Q
Q
V
Site 34
Y495
A
M
H
E
E
N
V
Y
T
V
E
S
N
R
V
Site 35
T496
M
H
E
E
N
V
Y
T
V
E
S
N
R
V
Q
Site 36
S499
E
N
V
Y
T
V
E
S
N
R
V
Q
V
R
T
Site 37
T506
S
N
R
V
Q
V
R
T
W
Q
G
T
V
K
Q
Site 38
S545
T
D
L
A
H
F
K
S
F
D
L
S
R
R
E
Site 39
S549
H
F
K
S
F
D
L
S
R
R
E
A
K
A
H
Site 40
S558
R
E
A
K
A
H
C
S
C
R
S
L
A
E
L
Site 41
S561
K
A
H
C
S
C
R
S
L
A
E
L
V
P
G
Site 42
T583
R
C
S
S
S
G
S
T
I
S
I
L
P
S
K
Site 43
S585
S
S
S
G
S
T
I
S
I
L
P
S
K
A
D
Site 44
S589
S
T
I
S
I
L
P
S
K
A
D
N
S
P
D
Site 45
S594
L
P
S
K
A
D
N
S
P
D
S
K
I
C
F
Site 46
S597
K
A
D
N
S
P
D
S
K
I
C
F
Y
D
V
Site 47
Y602
P
D
S
K
I
C
F
Y
D
V
E
M
D
T
V
Site 48
T610
D
V
E
M
D
T
V
T
V
F
D
F
K
T
G
Site 49
T616
V
T
V
F
D
F
K
T
G
Q
I
D
R
R
E
Site 50
T624
G
Q
I
D
R
R
E
T
L
S
F
N
E
Q
E
Site 51
S626
I
D
R
R
E
T
L
S
F
N
E
Q
E
T
N
Site 52
S635
N
E
Q
E
T
N
K
S
H
L
F
V
D
E
G
Site 53
Y646
V
D
E
G
L
K
N
Y
V
P
V
N
H
F
W
Site 54
T669
V
C
E
A
V
Q
E
T
P
R
S
Q
P
Q
S
Site 55
S672
A
V
Q
E
T
P
R
S
Q
P
Q
S
A
N
G
Site 56
S676
T
P
R
S
Q
P
Q
S
A
N
G
Q
P
Q
D
Site 57
S710
H
G
F
L
L
H
E
S
F
P
R
P
A
T
S
Site 58
T716
E
S
F
P
R
P
A
T
S
H
S
L
L
G
M
Site 59
S717
S
F
P
R
P
A
T
S
H
S
L
L
G
M
E
Site 60
S719
P
R
P
A
T
S
H
S
L
L
G
M
E
V
P
Site 61
Y727
L
L
G
M
E
V
P
Y
Y
Y
F
T
R
K
P
Site 62
Y728
L
G
M
E
V
P
Y
Y
Y
F
T
R
K
P
E
Site 63
Y729
G
M
E
V
P
Y
Y
Y
F
T
R
K
P
E
E
Site 64
T731
E
V
P
Y
Y
Y
F
T
R
K
P
E
E
A
D
Site 65
S755
H
H
I
P
Q
M
V
S
R
R
P
L
R
D
F
Site 66
S794
D
M
D
E
A
F
K
S
I
K
L
I
K
S
E
Site 67
S800
K
S
I
K
L
I
K
S
E
A
V
W
E
N
M
Site 68
T814
M
A
R
M
C
V
K
T
Q
R
L
D
V
A
K
Site 69
Y866
L
E
D
A
E
Q
L
Y
R
K
C
K
R
H
D
Site 70
Y879
H
D
L
L
N
K
F
Y
Q
A
A
G
R
W
Q
Site 71
T903
D
R
V
H
L
R
S
T
Y
H
R
Y
A
G
H
Site 72
Y904
R
V
H
L
R
S
T
Y
H
R
Y
A
G
H
L
Site 73
S914
Y
A
G
H
L
E
A
S
A
D
C
S
R
A
L
Site 74
S918
L
E
A
S
A
D
C
S
R
A
L
S
Y
Y
E
Site 75
S922
A
D
C
S
R
A
L
S
Y
Y
E
K
S
D
T
Site 76
Y923
D
C
S
R
A
L
S
Y
Y
E
K
S
D
T
H
Site 77
Y924
C
S
R
A
L
S
Y
Y
E
K
S
D
T
H
R
Site 78
S927
A
L
S
Y
Y
E
K
S
D
T
H
R
F
E
V
Site 79
T929
S
Y
Y
E
K
S
D
T
H
R
F
E
V
P
R
Site 80
S939
F
E
V
P
R
M
L
S
E
D
L
P
S
L
E
Site 81
S944
M
L
S
E
D
L
P
S
L
E
L
Y
V
N
K
Site 82
Y948
D
L
P
S
L
E
L
Y
V
N
K
M
K
D
K
Site 83
Y978
M
D
A
A
L
H
Y
Y
E
L
A
R
D
H
F
Site 84
S1013
E
T
G
N
L
A
A
S
Y
H
L
A
R
Q
Y
Site 85
Y1014
T
G
N
L
A
A
S
Y
H
L
A
R
Q
Y
E
Site 86
Y1020
S
Y
H
L
A
R
Q
Y
E
S
Q
E
E
V
G
Site 87
Y1033
V
G
Q
A
V
H
F
Y
T
R
A
Q
A
F
K
Site 88
Y1073
D
M
I
E
A
A
R
Y
Y
E
E
K
G
V
Q
Site 89
Y1074
M
I
E
A
A
R
Y
Y
E
E
K
G
V
Q
M
Site 90
Y1088
M
D
R
A
V
M
L
Y
H
K
A
G
H
F
S
Site 91
T1120
I
A
E
D
L
D
E
T
S
D
P
A
L
L
A
Site 92
S1121
A
E
D
L
D
E
T
S
D
P
A
L
L
A
R
Site 93
S1137
S
D
F
F
I
E
H
S
Q
Y
E
R
A
V
E
Site 94
Y1139
F
F
I
E
H
S
Q
Y
E
R
A
V
E
L
L
Site 95
S1165
L
C
L
G
Q
N
M
S
I
T
E
E
M
A
E
Site 96
S1181
M
T
V
A
K
D
S
S
D
L
P
E
E
S
R
Site 97
S1187
S
S
D
L
P
E
E
S
R
R
E
L
L
E
Q
Site 98
Y1212
Y
H
L
A
T
K
K
Y
T
Q
A
G
N
K
L
Site 99
S1228
A
M
R
A
L
L
K
S
G
D
T
E
K
I
T
Site 100
T1235
S
G
D
T
E
K
I
T
F
F
A
S
V
S
R
Site 101
S1239
E
K
I
T
F
F
A
S
V
S
R
Q
K
E
I
Site 102
Y1247
V
S
R
Q
K
E
I
Y
I
M
A
A
N
Y
L
Site 103
Y1297
A
Q
V
E
I
D
E
Y
Q
N
Y
D
K
A
H
Site 104
Y1300
E
I
D
E
Y
Q
N
Y
D
K
A
H
G
A
L
Site 105
Y1311
H
G
A
L
T
E
A
Y
K
C
L
A
K
A
K
Site 106
S1321
L
A
K
A
K
A
K
S
P
L
D
Q
E
T
R
Site 107
S1334
T
R
L
A
Q
L
Q
S
R
M
A
L
V
K
R
Site 108
T1348
R
F
I
Q
A
R
R
T
Y
T
E
D
P
K
E
Site 109
Y1349
F
I
Q
A
R
R
T
Y
T
E
D
P
K
E
S
Site 110
T1350
I
Q
A
R
R
T
Y
T
E
D
P
K
E
S
I
Site 111
S1371
L
E
E
P
D
L
D
S
T
I
R
I
G
D
V
Site 112
T1372
E
E
P
D
L
D
S
T
I
R
I
G
D
V
Y
Site 113
Y1386
Y
G
F
L
V
E
H
Y
V
R
K
E
E
Y
Q
Site 114
T1394
V
R
K
E
E
Y
Q
T
A
Y
R
F
L
E
E
Site 115
S1412
R
L
P
L
A
N
M
S
Y
Y
V
S
P
Q
A
Site 116
Y1414
P
L
A
N
M
S
Y
Y
V
S
P
Q
A
V
D
Site 117
T1434
L
G
L
P
L
P
R
T
V
P
E
Q
V
R
H
Site 118
S1443
P
E
Q
V
R
H
N
S
M
E
D
A
R
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation