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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPK
Full Name:
TP53-regulating kinase
Alias:
BUD32; C20ORF64; DJ101A2.2; EC 2.7.11.1; Kinase PRPK; Nori-2; Nori-2p; P53-related protein kinase; Prpk; TP53 regulating kinase; TP53RK
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; Bud32 family
Mass (Da):
28160
Number AA:
253
UniProt ID:
Q96S44
International Prot ID:
IPI00290305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0002039
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
A
A
R
A
T
T
P
A
D
G
E
E
Site 2
T8
M
A
A
A
R
A
T
T
P
A
D
G
E
E
P
Site 3
S29
L
A
A
A
R
E
R
S
S
R
F
L
S
G
L
Site 4
S30
A
A
A
R
E
R
S
S
R
F
L
S
G
L
E
Site 5
S34
E
R
S
S
R
F
L
S
G
L
E
L
V
K
Q
Site 6
Y67
K
H
R
F
P
K
G
Y
R
H
P
A
L
E
A
Site 7
T81
A
R
L
G
R
R
R
T
V
Q
E
A
R
A
L
Site 8
Y112
D
Y
A
S
N
C
L
Y
M
E
E
I
E
G
S
Site 9
S119
Y
M
E
E
I
E
G
S
V
T
V
R
D
Y
I
Site 10
T121
E
E
I
E
G
S
V
T
V
R
D
Y
I
Q
S
Site 11
Y125
G
S
V
T
V
R
D
Y
I
Q
S
T
M
E
T
Site 12
S128
T
V
R
D
Y
I
Q
S
T
M
E
T
E
K
T
Site 13
T129
V
R
D
Y
I
Q
S
T
M
E
T
E
K
T
P
Site 14
T132
Y
I
Q
S
T
M
E
T
E
K
T
P
Q
G
L
Site 15
T135
S
T
M
E
T
E
K
T
P
Q
G
L
S
N
L
Site 16
S140
E
K
T
P
Q
G
L
S
N
L
A
K
T
I
G
Site 17
S190
D
F
G
L
S
F
I
S
A
L
P
E
D
K
G
Site 18
Y201
E
D
K
G
V
D
L
Y
V
L
E
K
A
F
L
Site 19
S209
V
L
E
K
A
F
L
S
T
H
P
N
T
E
T
Site 20
T214
F
L
S
T
H
P
N
T
E
T
V
F
E
A
F
Site 21
T216
S
T
H
P
N
T
E
T
V
F
E
A
F
L
K
Site 22
S224
V
F
E
A
F
L
K
S
Y
S
T
S
S
K
K
Site 23
S226
E
A
F
L
K
S
Y
S
T
S
S
K
K
A
R
Site 24
S228
F
L
K
S
Y
S
T
S
S
K
K
A
R
P
V
Site 25
S229
L
K
S
Y
S
T
S
S
K
K
A
R
P
V
L
Site 26
S250
R
L
R
G
R
K
R
S
M
V
G
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation