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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TESK2
Full Name:
Dual specificity testis-specific protein kinase 2
Alias:
Testicular protein kinase 2
Type:
Mass (Da):
63639
Number AA:
571
UniProt ID:
Q96S53
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
D
R
S
K
R
N
S
I
A
G
F
P
P
R
Site 2
S33
G
G
G
E
G
N
V
S
Q
V
G
R
V
W
P
Site 3
S41
Q
V
G
R
V
W
P
S
S
Y
R
A
L
I
S
Site 4
S48
S
S
Y
R
A
L
I
S
A
F
S
R
L
T
R
Site 5
S51
R
A
L
I
S
A
F
S
R
L
T
R
L
D
D
Site 6
T60
L
T
R
L
D
D
F
T
C
E
K
I
G
S
G
Site 7
S70
K
I
G
S
G
F
F
S
E
V
F
K
V
R
H
Site 8
S80
F
K
V
R
H
R
A
S
G
Q
V
M
A
L
K
Site 9
S93
L
K
M
N
T
L
S
S
N
R
A
N
M
L
K
Site 10
S109
V
Q
L
M
N
R
L
S
H
P
N
I
L
R
F
Site 11
T130
Q
G
Q
L
H
A
L
T
E
Y
I
N
S
G
N
Site 12
Y132
Q
L
H
A
L
T
E
Y
I
N
S
G
N
L
E
Site 13
S144
N
L
E
Q
L
L
D
S
N
L
H
L
P
W
T
Site 14
T151
S
N
L
H
L
P
W
T
V
R
V
K
L
A
Y
Site 15
T178
G
I
F
H
R
D
L
T
S
K
N
C
L
I
K
Site 16
Y191
I
K
R
D
E
N
G
Y
S
A
V
V
A
D
F
Site 17
S192
K
R
D
E
N
G
Y
S
A
V
V
A
D
F
G
Site 18
Y233
E
V
L
R
D
E
P
Y
N
E
K
A
D
V
F
Site 19
Y259
R
I
Q
A
D
P
D
Y
L
P
R
T
E
N
F
Site 20
T263
D
P
D
Y
L
P
R
T
E
N
F
G
L
D
Y
Site 21
Y270
T
E
N
F
G
L
D
Y
D
A
F
Q
H
M
V
Site 22
S301
M
D
P
K
L
R
P
S
F
V
E
I
G
K
T
Site 23
T308
S
F
V
E
I
G
K
T
L
E
E
I
L
S
R
Site 24
S314
K
T
L
E
E
I
L
S
R
L
Q
E
E
E
Q
Site 25
T330
R
D
R
K
L
Q
P
T
A
R
G
L
L
E
K
Site 26
S345
A
P
G
V
K
R
L
S
S
L
D
D
K
I
P
Site 27
S346
P
G
V
K
R
L
S
S
L
D
D
K
I
P
H
Site 28
S355
D
D
K
I
P
H
K
S
P
C
P
R
R
T
I
Site 29
T361
K
S
P
C
P
R
R
T
I
W
L
S
R
S
Q
Site 30
S365
P
R
R
T
I
W
L
S
R
S
Q
S
D
I
F
Site 31
S367
R
T
I
W
L
S
R
S
Q
S
D
I
F
S
R
Site 32
S369
I
W
L
S
R
S
Q
S
D
I
F
S
R
K
P
Site 33
S373
R
S
Q
S
D
I
F
S
R
K
P
P
R
T
V
Site 34
T379
F
S
R
K
P
P
R
T
V
S
V
L
D
P
Y
Site 35
S381
R
K
P
P
R
T
V
S
V
L
D
P
Y
Y
R
Site 36
Y386
T
V
S
V
L
D
P
Y
Y
R
P
R
D
G
A
Site 37
Y387
V
S
V
L
D
P
Y
Y
R
P
R
D
G
A
A
Site 38
T396
P
R
D
G
A
A
R
T
P
K
V
N
P
F
S
Site 39
S403
T
P
K
V
N
P
F
S
A
R
Q
D
L
M
G
Site 40
S456
P
P
I
R
R
W
R
S
L
P
G
S
P
E
F
Site 41
S460
R
W
R
S
L
P
G
S
P
E
F
L
H
Q
E
Site 42
S477
P
F
V
G
R
E
E
S
L
S
D
G
P
P
P
Site 43
S479
V
G
R
E
E
S
L
S
D
G
P
P
P
R
L
Site 44
S487
D
G
P
P
P
R
L
S
S
L
K
Y
R
V
K
Site 45
S488
G
P
P
P
R
L
S
S
L
K
Y
R
V
K
E
Site 46
Y491
P
R
L
S
S
L
K
Y
R
V
K
E
I
P
P
Site 47
S516
A
H
E
A
M
D
C
S
I
L
Q
E
E
N
G
Site 48
S526
Q
E
E
N
G
F
G
S
R
P
Q
G
T
S
P
Site 49
S532
G
S
R
P
Q
G
T
S
P
C
P
A
G
A
S
Site 50
S539
S
P
C
P
A
G
A
S
E
E
M
E
V
E
E
Site 51
T552
E
E
R
P
A
G
S
T
P
A
T
F
S
T
S
Site 52
T555
P
A
G
S
T
P
A
T
F
S
T
S
G
I
G
Site 53
S557
G
S
T
P
A
T
F
S
T
S
G
I
G
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation