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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SRPK1
Full Name:
Serine/threonine-protein kinase SRPK1
Alias:
EC 2.7.11.1; SFRS protein kinase 1; SFRSK1; SRPK1a protein kinase
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
CMGC
group; SRPK family
Mass (Da):
74325
Number AA:
655
UniProt ID:
Q96SB4
International Prot ID:
IPI00290439
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0030154
GO:0007059
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/arginine-rich protein-specific kinase 1; SRPK1a protein kinase S222 phosphosite-specific antibody AB-PK819#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK819#SRPKSubtide - SRPK1 protein kinase substrate peptide - Powder PE-01BJL95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BJL95#Serine/arginine-rich protein-specific kinase 1 / SRPK1a protein kinase (I219-D225, human) pS222 phosphopeptide - Powder PE-04APR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APR99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
K
D
K
A
Q
R
K
S
E
T
Q
H
R
G
S
Site 2
T28
K
A
Q
R
K
S
E
T
Q
H
R
G
S
A
P
Site 3
S33
S
E
T
Q
H
R
G
S
A
P
H
S
E
S
D
Site 4
S37
H
R
G
S
A
P
H
S
E
S
D
L
P
E
Q
Site 5
S39
G
S
A
P
H
S
E
S
D
L
P
E
Q
E
E
Site 6
S51
Q
E
E
E
I
L
G
S
D
D
D
E
Q
E
D
Site 7
Y62
E
Q
E
D
P
N
D
Y
C
K
G
G
Y
H
L
Site 8
Y80
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
Site 9
S113
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
Site 10
Y117
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
Site 11
S130
D
E
I
R
L
L
K
S
V
R
N
S
D
P
N
Site 12
S134
L
L
K
S
V
R
N
S
D
P
N
D
P
N
R
Site 13
Y181
K
W
I
I
K
S
N
Y
Q
G
L
P
L
P
C
Site 14
Y202
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
R
I
Site 15
S222
Q
E
E
E
I
L
G
S
D
D
D
E
Q
E
D
Serine/arginine-rich protein-specific kinase 1; SRPK1a protein kinase S222 phosphosite-specific antibody AB-PK819#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK819#Serine/arginine-rich protein-specific kinase 1 / SRPK1a protein kinase (I219-D225, human) pS222 phosphopeptide - Powder PE-04APR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APR99
Site 16
Y227
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
E
Site 17
T236
R
R
L
A
A
E
A
T
E
W
Q
R
S
G
A
Site 18
S241
E
A
T
E
W
Q
R
S
G
A
P
P
P
S
G
Site 19
S247
R
S
G
A
P
P
P
S
G
S
A
V
S
T
A
Site 20
S249
G
A
P
P
P
S
G
S
A
V
S
T
A
P
Q
Site 21
S252
P
P
S
G
S
A
V
S
T
A
P
Q
P
K
P
Site 22
T253
P
S
G
S
A
V
S
T
A
P
Q
P
K
P
A
Site 23
S264
P
K
P
A
D
K
M
S
K
N
K
K
K
K
L
Site 24
S309
R
P
N
K
Q
E
E
S
E
S
P
V
E
R
P
Site 25
S311
N
K
Q
E
E
S
E
S
P
V
E
R
P
L
K
Site 26
T326
E
N
P
P
N
K
M
T
Q
E
K
L
E
E
S
Site 27
T335
E
K
L
E
E
S
S
T
I
G
Q
D
Q
T
L
Site 28
T341
S
T
I
G
Q
D
Q
T
L
M
E
R
D
T
E
Site 29
T347
Q
T
L
M
E
R
D
T
E
G
G
A
A
E
I
Site 30
Y365
G
V
I
E
V
I
N
Y
T
Q
N
S
N
N
E
Site 31
T373
T
Q
N
S
N
N
E
T
L
R
H
K
E
D
L
Site 32
S395
V
Q
N
L
N
Q
E
S
S
F
L
S
S
Q
N
Site 33
S396
Q
N
L
N
Q
E
S
S
F
L
S
S
Q
N
G
Site 34
S399
N
Q
E
S
S
F
L
S
S
Q
N
G
D
S
S
Site 35
S400
Q
E
S
S
F
L
S
S
Q
N
G
D
S
S
T
Site 36
S405
L
S
S
Q
N
G
D
S
S
T
S
Q
E
T
D
Site 37
S406
S
S
Q
N
G
D
S
S
T
S
Q
E
T
D
S
Site 38
T407
S
Q
N
G
D
S
S
T
S
Q
E
T
D
S
C
Site 39
S408
Q
N
G
D
S
S
T
S
Q
E
T
D
S
C
T
Site 40
S413
S
T
S
Q
E
T
D
S
C
T
P
I
T
S
E
Site 41
T415
S
Q
E
T
D
S
C
T
P
I
T
S
E
V
S
Site 42
T418
T
D
S
C
T
P
I
T
S
E
V
S
D
T
M
Site 43
S419
D
S
C
T
P
I
T
S
E
V
S
D
T
M
V
Site 44
T424
I
T
S
E
V
S
D
T
M
V
C
Q
S
S
S
Site 45
S431
T
M
V
C
Q
S
S
S
T
V
G
Q
S
F
S
Site 46
T432
M
V
C
Q
S
S
S
T
V
G
Q
S
F
S
E
Site 47
S436
S
S
S
T
V
G
Q
S
F
S
E
Q
H
I
S
Site 48
S438
S
T
V
G
Q
S
F
S
E
Q
H
I
S
Q
L
Site 49
S443
S
F
S
E
Q
H
I
S
Q
L
Q
E
S
I
R
Site 50
S448
H
I
S
Q
L
Q
E
S
I
R
A
E
I
P
C
Site 51
S473
P
L
D
N
K
G
K
S
T
A
G
N
F
L
V
Site 52
T514
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
Site 53
Y517
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
Site 54
S519
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
Site 55
T530
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
Site 56
Y549
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
Site 57
S555
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
Site 58
Y559
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
Site 59
S587
L
I
V
A
G
K
Y
S
K
E
F
F
T
K
K
Site 60
T601
K
G
D
L
K
H
I
T
K
L
K
P
W
G
L
Site 61
S619
L
V
E
K
Y
E
W
S
Q
E
E
A
A
G
F
Site 62
T643
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation