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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMC6L1
Full Name:
Structural maintenance of chromosomes protein 6
Alias:
FLJ22116; SMC6; Structural maintenance of chromosomes 6; Structural maintenance of chromosomes 6-like 1 (yeast)
Type:
DNA repair
Mass (Da):
126326
Number AA:
1091
UniProt ID:
Q96SB8
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
K
E
E
N
F
S
S
P
K
N
A
K
R
P
Site 2
T100
L
G
G
R
A
V
A
T
N
R
G
S
S
L
K
Site 3
S104
A
V
A
T
N
R
G
S
S
L
K
G
F
V
K
Site 4
S105
V
A
T
N
R
G
S
S
L
K
G
F
V
K
D
Site 5
S116
F
V
K
D
G
Q
N
S
A
D
I
S
I
T
L
Site 6
S120
G
Q
N
S
A
D
I
S
I
T
L
R
N
R
G
Site 7
T122
N
S
A
D
I
S
I
T
L
R
N
R
G
D
D
Site 8
S134
G
D
D
A
F
K
A
S
V
Y
G
N
S
I
L
Site 9
S147
I
L
I
Q
Q
H
I
S
I
D
G
S
R
S
Y
Site 10
S151
Q
H
I
S
I
D
G
S
R
S
Y
K
L
K
S
Site 11
S153
I
S
I
D
G
S
R
S
Y
K
L
K
S
A
T
Site 12
Y154
S
I
D
G
S
R
S
Y
K
L
K
S
A
T
G
Site 13
S158
S
R
S
Y
K
L
K
S
A
T
G
S
V
V
S
Site 14
S162
K
L
K
S
A
T
G
S
V
V
S
T
R
K
E
Site 15
S165
S
A
T
G
S
V
V
S
T
R
K
E
E
L
I
Site 16
T166
A
T
G
S
V
V
S
T
R
K
E
E
L
I
A
Site 17
S187
I
Q
V
D
N
P
V
S
V
L
T
Q
E
M
S
Site 18
T190
D
N
P
V
S
V
L
T
Q
E
M
S
K
Q
F
Site 19
S194
S
V
L
T
Q
E
M
S
K
Q
F
L
Q
S
K
Site 20
Y207
S
K
N
E
G
D
K
Y
K
F
F
M
K
A
T
Site 21
Y223
L
E
Q
M
K
E
D
Y
S
Y
I
M
E
T
K
Site 22
Y225
Q
M
K
E
D
Y
S
Y
I
M
E
T
K
E
R
Site 23
T245
H
Q
G
E
E
R
L
T
E
L
K
R
Q
C
V
Site 24
S260
E
K
E
E
R
F
Q
S
I
A
G
L
S
T
M
Site 25
S265
F
Q
S
I
A
G
L
S
T
M
K
T
N
L
E
Site 26
T269
A
G
L
S
T
M
K
T
N
L
E
S
L
K
H
Site 27
Y360
V
V
A
K
K
R
A
Y
N
E
A
E
V
L
Y
Site 28
Y367
Y
N
E
A
E
V
L
Y
N
R
S
L
N
E
Y
Site 29
Y374
Y
N
R
S
L
N
E
Y
K
A
L
K
K
D
D
Site 30
S394
R
I
E
E
L
K
K
S
T
D
Q
S
L
E
P
Site 31
S398
L
K
K
S
T
D
Q
S
L
E
P
E
R
L
E
Site 32
S411
L
E
R
Q
K
K
I
S
W
L
K
E
R
V
K
Site 33
S426
A
F
Q
N
Q
E
N
S
V
N
Q
E
I
E
Q
Site 34
S472
Q
L
K
E
L
K
D
S
K
T
D
R
L
K
R
Site 35
T474
K
E
L
K
D
S
K
T
D
R
L
K
R
F
G
Site 36
Y495
L
E
A
I
D
D
A
Y
R
Q
G
H
F
T
Y
Site 37
T501
A
Y
R
Q
G
H
F
T
Y
K
P
V
G
P
L
Site 38
Y502
Y
R
Q
G
H
F
T
Y
K
P
V
G
P
L
G
Site 39
Y534
L
K
G
L
L
Q
A
Y
C
C
H
N
H
A
D
Site 40
Y553
Q
A
L
M
K
R
F
Y
L
P
G
T
S
R
P
Site 41
T557
K
R
F
Y
L
P
G
T
S
R
P
P
I
I
V
Site 42
S558
R
F
Y
L
P
G
T
S
R
P
P
I
I
V
S
Site 43
S565
S
R
P
P
I
I
V
S
E
F
R
N
E
I
Y
Site 44
Y572
S
E
F
R
N
E
I
Y
D
V
R
H
R
A
A
Site 45
Y580
D
V
R
H
R
A
A
Y
H
P
D
F
P
T
V
Site 46
S626
V
A
R
A
V
M
Q
S
Q
K
P
P
K
N
C
Site 47
Y649
D
Q
V
F
A
G
R
Y
Y
S
S
E
N
T
R
Site 48
Y650
Q
V
F
A
G
R
Y
Y
S
S
E
N
T
R
P
Site 49
S651
V
F
A
G
R
Y
Y
S
S
E
N
T
R
P
K
Site 50
T655
R
Y
Y
S
S
E
N
T
R
P
K
F
L
S
R
Site 51
S661
N
T
R
P
K
F
L
S
R
D
V
D
S
E
I
Site 52
S666
F
L
S
R
D
V
D
S
E
I
S
D
L
E
N
Site 53
S669
R
D
V
D
S
E
I
S
D
L
E
N
E
V
E
Site 54
S690
L
N
L
Q
Q
H
L
S
A
L
E
K
D
I
K
Site 55
Y710
L
K
R
C
Q
L
H
Y
K
E
L
K
M
K
I
Site 56
S722
M
K
I
R
K
N
I
S
E
I
R
E
L
E
N
Site 57
S735
E
N
I
E
E
H
Q
S
V
D
I
A
T
L
E
Site 58
S771
E
N
M
E
H
L
K
S
L
K
I
E
A
E
N
Site 59
Y780
K
I
E
A
E
N
K
Y
D
A
I
K
F
K
I
Site 60
S806
D
E
L
N
L
A
D
S
E
V
D
N
Q
K
R
Site 61
Y818
Q
K
R
G
K
R
H
Y
E
E
K
Q
K
E
H
Site 62
T828
K
Q
K
E
H
L
D
T
L
N
K
K
K
R
E
Site 63
S848
K
E
L
E
E
K
M
S
Q
A
R
Q
I
C
P
Site 64
S863
E
R
I
E
V
E
K
S
A
S
I
L
D
K
E
Site 65
S865
I
E
V
E
K
S
A
S
I
L
D
K
E
I
N
Site 66
Y895
R
E
E
I
M
R
Q
Y
Q
E
A
R
E
T
Y
Site 67
T901
Q
Y
Q
E
A
R
E
T
Y
L
D
L
D
S
K
Site 68
Y902
Y
Q
E
A
R
E
T
Y
L
D
L
D
S
K
V
Site 69
S907
E
T
Y
L
D
L
D
S
K
V
R
T
L
K
K
Site 70
T911
D
L
D
S
K
V
R
T
L
K
K
F
I
K
L
Site 71
T938
Q
Q
F
R
R
C
L
T
L
R
C
K
L
Y
F
Site 72
S950
L
Y
F
D
N
L
L
S
Q
R
A
Y
C
G
K
Site 73
Y954
N
L
L
S
Q
R
A
Y
C
G
K
M
N
F
D
Site 74
T966
N
F
D
H
K
N
E
T
L
S
I
S
V
Q
P
Site 75
S968
D
H
K
N
E
T
L
S
I
S
V
Q
P
G
E
Site 76
S970
K
N
E
T
L
S
I
S
V
Q
P
G
E
G
N
Site 77
S988
F
N
D
M
R
A
L
S
G
G
E
R
S
F
S
Site 78
S1009
S
L
W
S
I
A
E
S
P
F
R
C
L
D
E
Site 79
Y1020
C
L
D
E
F
D
V
Y
M
D
M
V
N
R
R
Site 80
S1054
L
L
T
P
Q
S
M
S
S
L
P
S
S
K
L
Site 81
S1055
L
T
P
Q
S
M
S
S
L
P
S
S
K
L
I
Site 82
S1059
S
M
S
S
L
P
S
S
K
L
I
R
I
L
R
Site 83
S1068
L
I
R
I
L
R
M
S
D
P
E
R
G
Q
T
Site 84
T1075
S
D
P
E
R
G
Q
T
T
L
P
F
R
P
V
Site 85
T1083
T
L
P
F
R
P
V
T
Q
E
E
D
D
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation