KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CDK5RAP2
Full Name:
CDK5 regulatory subunit-associated protein 2
Alias:
C48; C5P2_HUMAN; CDK5 activator-binding protein C48; Centrosome-associated protein 215; CEP215; CK5P2; FLJ10867; KIAA1633
Type:
Protein kinase regulator, activator
Mass (Da):
215024
Number AA:
1893
UniProt ID:
Q96SN8
International Prot ID:
IPI00329038
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0008017
GO:0042808
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0007420
GO:0045664
GO:0045595
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
G
C
S
G
L
V
P
S
V
P
D
D
L
D
G
Site 2
S48
N
G
V
L
P
N
V
S
E
E
T
V
S
P
T
Site 3
T51
L
P
N
V
S
E
E
T
V
S
P
T
R
A
R
Site 4
S53
N
V
S
E
E
T
V
S
P
T
R
A
R
N
M
Site 5
T68
K
D
F
E
N
Q
I
T
E
L
K
K
E
N
F
Site 6
Y82
F
N
L
K
L
R
I
Y
F
L
E
E
R
M
Q
Site 7
Y100
H
G
P
T
E
H
I
Y
K
T
N
I
E
L
K
Site 8
S112
E
L
K
V
E
V
E
S
L
K
R
E
L
Q
E
Site 9
S133
K
A
S
K
A
V
E
S
L
A
E
A
G
G
S
Site 10
S140
S
L
A
E
A
G
G
S
E
I
Q
R
V
K
E
Site 11
T161
Q
Q
V
E
D
L
L
T
K
R
I
L
L
L
E
Site 12
S197
A
L
R
L
R
L
E
S
K
L
S
E
M
K
K
Site 13
S200
L
R
L
E
S
K
L
S
E
M
K
K
M
H
E
Site 14
S229
L
I
E
E
L
K
L
S
L
K
S
K
E
A
L
Site 15
S245
Q
C
L
K
E
E
K
S
Q
M
A
C
P
D
E
Site 16
S256
C
P
D
E
N
V
S
S
G
E
L
R
G
L
C
Site 17
T274
R
E
E
K
E
R
E
T
E
A
A
Q
M
E
H
Site 18
S287
E
H
Q
K
E
R
N
S
F
E
E
R
I
Q
A
Site 19
S313
I
A
T
E
K
K
N
S
L
K
R
D
K
A
I
Site 20
T324
D
K
A
I
Q
G
L
T
M
A
L
K
S
K
E
Site 21
S329
G
L
T
M
A
L
K
S
K
E
K
K
V
E
E
Site 22
S339
K
K
V
E
E
L
N
S
E
I
E
K
L
S
A
Site 23
T360
E
A
L
Q
K
A
Q
T
Q
E
F
Q
G
S
E
Site 24
S366
Q
T
Q
E
F
Q
G
S
E
D
Y
E
T
A
L
Site 25
Y369
E
F
Q
G
S
E
D
Y
E
T
A
L
S
G
K
Site 26
T371
Q
G
S
E
D
Y
E
T
A
L
S
G
K
E
A
Site 27
S374
E
D
Y
E
T
A
L
S
G
K
E
A
L
S
A
Site 28
S380
L
S
G
K
E
A
L
S
A
A
L
R
S
Q
N
Site 29
S385
A
L
S
A
A
L
R
S
Q
N
L
T
K
S
T
Site 30
T389
A
L
R
S
Q
N
L
T
K
S
T
E
N
H
R
Site 31
S391
R
S
Q
N
L
T
K
S
T
E
N
H
R
L
R
Site 32
T392
S
Q
N
L
T
K
S
T
E
N
H
R
L
R
R
Site 33
S400
E
N
H
R
L
R
R
S
I
K
K
I
T
Q
E
Site 34
T405
R
R
S
I
K
K
I
T
Q
E
L
S
D
L
Q
Site 35
S409
K
K
I
T
Q
E
L
S
D
L
Q
Q
E
R
E
Site 36
S430
E
E
A
H
R
E
K
S
K
G
D
C
T
I
R
Site 37
T435
E
K
S
K
G
D
C
T
I
R
D
L
R
N
E
Site 38
S463
A
M
E
N
R
Y
K
S
L
L
S
E
S
N
K
Site 39
S466
N
R
Y
K
S
L
L
S
E
S
N
K
K
L
H
Site 40
T486
I
K
H
L
T
E
S
T
N
Q
K
D
V
L
L
Site 41
T525
L
R
S
E
G
L
I
T
E
K
C
S
S
Q
Q
Site 42
S530
L
I
T
E
K
C
S
S
Q
Q
P
P
G
S
K
Site 43
S536
S
S
Q
Q
P
P
G
S
K
T
I
F
S
K
E
Site 44
T538
Q
Q
P
P
G
S
K
T
I
F
S
K
E
K
K
Site 45
S541
P
G
S
K
T
I
F
S
K
E
K
K
Q
S
S
Site 46
S547
F
S
K
E
K
K
Q
S
S
D
Y
E
E
L
I
Site 47
S548
S
K
E
K
K
Q
S
S
D
Y
E
E
L
I
Q
Site 48
Y550
E
K
K
Q
S
S
D
Y
E
E
L
I
Q
V
L
Site 49
Y564
L
K
K
E
Q
D
I
Y
T
H
L
V
K
S
L
Site 50
T565
K
K
E
Q
D
I
Y
T
H
L
V
K
S
L
Q
Site 51
S570
I
Y
T
H
L
V
K
S
L
Q
E
S
D
S
I
Site 52
S574
L
V
K
S
L
Q
E
S
D
S
I
N
N
L
Q
Site 53
S576
K
S
L
Q
E
S
D
S
I
N
N
L
Q
A
E
Site 54
T607
S
Y
Q
N
L
R
K
T
L
E
E
Q
I
S
E
Site 55
S613
K
T
L
E
E
Q
I
S
E
I
R
R
R
E
E
Site 56
S622
I
R
R
R
E
E
E
S
F
S
L
Y
S
D
Q
Site 57
S624
R
R
E
E
E
S
F
S
L
Y
S
D
Q
T
S
Site 58
Y626
E
E
E
S
F
S
L
Y
S
D
Q
T
S
Y
L
Site 59
S627
E
E
S
F
S
L
Y
S
D
Q
T
S
Y
L
S
Site 60
S631
S
L
Y
S
D
Q
T
S
Y
L
S
I
C
L
E
Site 61
Y632
L
Y
S
D
Q
T
S
Y
L
S
I
C
L
E
E
Site 62
S649
R
F
Q
V
E
H
F
S
Q
E
E
L
K
K
K
Site 63
S658
E
E
L
K
K
K
V
S
D
L
I
Q
L
V
K
Site 64
Y668
I
Q
L
V
K
E
L
Y
T
D
N
Q
H
L
K
Site 65
S697
G
F
P
D
R
L
A
S
T
E
Q
T
E
L
L
Site 66
T698
F
P
D
R
L
A
S
T
E
Q
T
E
L
L
A
Site 67
T701
R
L
A
S
T
E
Q
T
E
L
L
A
S
K
E
Site 68
S706
E
Q
T
E
L
L
A
S
K
E
D
E
D
T
I
Site 69
T712
A
S
K
E
D
E
D
T
I
K
I
G
E
D
D
Site 70
S725
D
D
E
I
N
F
L
S
D
Q
H
L
Q
Q
S
Site 71
S732
S
D
Q
H
L
Q
Q
S
N
E
I
M
K
D
L
Site 72
S740
N
E
I
M
K
D
L
S
K
G
G
C
K
N
G
Site 73
Y748
K
G
G
C
K
N
G
Y
L
R
H
T
E
S
K
Site 74
T752
K
N
G
Y
L
R
H
T
E
S
K
I
S
D
C
Site 75
S754
G
Y
L
R
H
T
E
S
K
I
S
D
C
D
G
Site 76
S757
R
H
T
E
S
K
I
S
D
C
D
G
A
H
A
Site 77
S815
F
L
T
E
Q
E
V
S
G
E
H
L
D
G
K
Site 78
T826
L
D
G
K
T
E
K
T
P
K
Q
K
G
E
L
Site 79
T839
E
L
V
H
F
V
Q
T
N
S
F
S
K
P
H
Site 80
S841
V
H
F
V
Q
T
N
S
F
S
K
P
H
D
E
Site 81
S852
P
H
D
E
L
K
L
S
C
E
A
Q
L
V
K
Site 82
S872
K
V
G
L
K
D
A
S
V
Q
T
V
A
T
E
Site 83
S904
K
P
I
N
T
A
L
S
A
E
H
R
P
E
N
Site 84
S936
T
N
R
E
A
K
K
S
R
L
P
I
L
I
K
Site 85
S945
L
P
I
L
I
K
P
S
R
S
L
G
N
M
Y
Site 86
S947
I
L
I
K
P
S
R
S
L
G
N
M
Y
R
L
Site 87
Y952
S
R
S
L
G
N
M
Y
R
L
P
A
T
Q
E
Site 88
T957
N
M
Y
R
L
P
A
T
Q
E
V
V
T
Q
L
Site 89
T980
G
E
L
K
E
F
K
T
C
N
K
Q
L
H
Q
Site 90
T1001
A
V
M
E
G
R
P
T
P
D
K
T
L
L
N
Site 91
T1005
G
R
P
T
P
D
K
T
L
L
N
A
Q
P
P
Site 92
Y1017
Q
P
P
V
G
A
A
Y
Q
D
S
P
G
E
Q
Site 93
S1020
V
G
A
A
Y
Q
D
S
P
G
E
Q
K
G
I
Site 94
T1029
G
E
Q
K
G
I
K
T
T
S
S
V
W
R
D
Site 95
S1032
K
G
I
K
T
T
S
S
V
W
R
D
K
E
M
Site 96
S1041
W
R
D
K
E
M
D
S
D
Q
Q
R
S
Y
E
Site 97
Y1047
D
S
D
Q
Q
R
S
Y
E
I
D
S
E
I
C
Site 98
S1061
C
P
P
D
D
L
A
S
L
P
S
C
K
E
N
Site 99
S1064
D
D
L
A
S
L
P
S
C
K
E
N
P
E
D
Site 100
S1074
E
N
P
E
D
V
L
S
P
T
S
V
A
T
Y
Site 101
S1077
E
D
V
L
S
P
T
S
V
A
T
Y
L
S
S
Site 102
T1080
L
S
P
T
S
V
A
T
Y
L
S
S
K
S
Q
Site 103
Y1081
S
P
T
S
V
A
T
Y
L
S
S
K
S
Q
P
Site 104
S1083
T
S
V
A
T
Y
L
S
S
K
S
Q
P
S
A
Site 105
S1084
S
V
A
T
Y
L
S
S
K
S
Q
P
S
A
K
Site 106
S1086
A
T
Y
L
S
S
K
S
Q
P
S
A
K
V
S
Site 107
S1089
L
S
S
K
S
Q
P
S
A
K
V
S
V
M
G
Site 108
S1093
S
Q
P
S
A
K
V
S
V
M
G
T
D
Q
S
Site 109
T1097
A
K
V
S
V
M
G
T
D
Q
S
E
S
I
N
Site 110
S1100
S
V
M
G
T
D
Q
S
E
S
I
N
T
S
N
Site 111
S1106
Q
S
E
S
I
N
T
S
N
E
T
E
Y
L
K
Site 112
Y1111
N
T
S
N
E
T
E
Y
L
K
Q
K
I
H
D
Site 113
Y1126
L
E
T
E
L
E
G
Y
Q
N
F
I
F
Q
L
Site 114
S1158
E
G
A
Q
D
G
L
S
K
P
K
N
G
S
D
Site 115
S1164
L
S
K
P
K
N
G
S
D
G
E
E
M
T
F
Site 116
T1170
G
S
D
G
E
E
M
T
F
S
S
L
H
Q
V
Site 117
S1172
D
G
E
E
M
T
F
S
S
L
H
Q
V
R
Y
Site 118
S1173
G
E
E
M
T
F
S
S
L
H
Q
V
R
Y
V
Site 119
Y1179
S
S
L
H
Q
V
R
Y
V
K
H
V
K
I
L
Site 120
S1196
L
A
P
E
M
I
D
S
R
V
L
E
N
L
K
Site 121
Y1211
Q
Q
L
E
E
Q
E
Y
K
L
Q
K
E
Q
N
Site 122
S1238
Q
N
K
F
R
D
L
S
P
P
R
Y
D
S
L
Site 123
Y1242
R
D
L
S
P
P
R
Y
D
S
L
V
Q
S
Q
Site 124
S1244
L
S
P
P
R
Y
D
S
L
V
Q
S
Q
A
R
Site 125
S1248
R
Y
D
S
L
V
Q
S
Q
A
R
E
L
S
L
Site 126
S1254
Q
S
Q
A
R
E
L
S
L
Q
R
Q
Q
I
K
Site 127
T1276
I
S
R
Q
H
M
N
T
M
I
K
A
F
E
E
Site 128
Y1292
L
Q
A
S
D
V
D
Y
C
V
A
E
G
F
Q
Site 129
S1321
K
L
F
L
N
G
K
S
V
G
V
E
M
N
T
Site 130
T1342
R
I
E
E
D
N
L
T
Y
Q
H
L
L
P
E
Site 131
Y1343
I
E
E
D
N
L
T
Y
Q
H
L
L
P
E
S
Site 132
S1350
Y
Q
H
L
L
P
E
S
P
E
P
S
A
S
H
Site 133
S1354
L
P
E
S
P
E
P
S
A
S
H
A
L
S
D
Site 134
S1356
E
S
P
E
P
S
A
S
H
A
L
S
D
Y
E
Site 135
S1360
P
S
A
S
H
A
L
S
D
Y
E
T
S
E
K
Site 136
Y1362
A
S
H
A
L
S
D
Y
E
T
S
E
K
S
F
Site 137
T1364
H
A
L
S
D
Y
E
T
S
E
K
S
F
F
S
Site 138
S1365
A
L
S
D
Y
E
T
S
E
K
S
F
F
S
R
Site 139
S1368
D
Y
E
T
S
E
K
S
F
F
S
R
D
Q
K
Site 140
T1380
D
Q
K
Q
D
N
E
T
E
K
T
S
V
M
V
Site 141
T1383
Q
D
N
E
T
E
K
T
S
V
M
V
N
S
F
Site 142
T1404
E
H
I
Q
E
I
R
T
L
R
K
R
L
E
E
Site 143
T1415
R
L
E
E
S
I
K
T
N
E
K
L
R
K
Q
Site 144
S1428
K
Q
L
E
R
Q
G
S
E
F
V
Q
G
S
T
Site 145
S1436
E
F
V
Q
G
S
T
S
I
F
A
S
G
S
E
Site 146
S1440
G
S
T
S
I
F
A
S
G
S
E
L
H
S
S
Site 147
S1442
T
S
I
F
A
S
G
S
E
L
H
S
S
L
T
Site 148
S1446
A
S
G
S
E
L
H
S
S
L
T
S
E
I
H
Site 149
S1447
S
G
S
E
L
H
S
S
L
T
S
E
I
H
F
Site 150
T1449
S
E
L
H
S
S
L
T
S
E
I
H
F
L
R
Site 151
S1450
E
L
H
S
S
L
T
S
E
I
H
F
L
R
K
Site 152
S1483
E
N
D
K
L
R
E
S
L
S
R
K
T
V
S
Site 153
S1485
D
K
L
R
E
S
L
S
R
K
T
V
S
L
E
Site 154
T1488
R
E
S
L
S
R
K
T
V
S
L
E
H
L
Q
Site 155
S1490
S
L
S
R
K
T
V
S
L
E
H
L
Q
R
E
Site 156
Y1498
L
E
H
L
Q
R
E
Y
A
S
V
K
E
E
N
Site 157
S1500
H
L
Q
R
E
Y
A
S
V
K
E
E
N
E
R
Site 158
S1513
E
R
L
Q
K
E
G
S
E
K
E
R
H
N
Q
Site 159
S1529
L
I
Q
E
V
R
C
S
G
Q
E
L
S
R
V
Site 160
S1534
R
C
S
G
Q
E
L
S
R
V
Q
E
E
V
K
Site 161
S1548
K
L
R
Q
Q
L
L
S
Q
N
D
K
L
L
Q
Site 162
S1556
Q
N
D
K
L
L
Q
S
L
R
V
E
L
K
A
Site 163
Y1564
L
R
V
E
L
K
A
Y
E
K
L
D
E
E
H
Site 164
S1578
H
R
R
L
R
E
A
S
G
E
G
W
K
G
Q
Site 165
S1608
L
R
L
Q
L
E
R
S
I
E
T
S
S
T
L
Site 166
S1612
L
E
R
S
I
E
T
S
S
T
L
Q
S
R
L
Site 167
S1613
E
R
S
I
E
T
S
S
T
L
Q
S
R
L
K
Site 168
T1614
R
S
I
E
T
S
S
T
L
Q
S
R
L
K
E
Site 169
S1617
E
T
S
S
T
L
Q
S
R
L
K
E
Q
L
A
Site 170
Y1659
D
K
H
D
G
D
K
Y
P
M
E
S
D
N
S
Site 171
S1663
G
D
K
Y
P
M
E
S
D
N
S
F
D
L
F
Site 172
S1666
Y
P
M
E
S
D
N
S
F
D
L
F
D
S
S
Site 173
S1673
S
F
D
L
F
D
S
S
Q
A
V
T
P
K
S
Site 174
T1677
F
D
S
S
Q
A
V
T
P
K
S
V
S
E
T
Site 175
S1680
S
Q
A
V
T
P
K
S
V
S
E
T
P
P
L
Site 176
S1682
A
V
T
P
K
S
V
S
E
T
P
P
L
S
G
Site 177
T1684
T
P
K
S
V
S
E
T
P
P
L
S
G
N
D
Site 178
S1688
V
S
E
T
P
P
L
S
G
N
D
T
D
S
L
Site 179
T1692
P
P
L
S
G
N
D
T
D
S
L
S
C
D
S
Site 180
S1694
L
S
G
N
D
T
D
S
L
S
C
D
S
G
S
Site 181
S1696
G
N
D
T
D
S
L
S
C
D
S
G
S
S
A
Site 182
S1699
T
D
S
L
S
C
D
S
G
S
S
A
T
S
T
Site 183
S1701
S
L
S
C
D
S
G
S
S
A
T
S
T
P
C
Site 184
S1702
L
S
C
D
S
G
S
S
A
T
S
T
P
C
V
Site 185
S1705
D
S
G
S
S
A
T
S
T
P
C
V
S
R
L
Site 186
S1710
A
T
S
T
P
C
V
S
R
L
V
T
G
H
H
Site 187
S1742
E
A
L
L
K
Q
I
S
Q
G
Q
R
L
L
A
Site 188
T1755
L
A
E
M
D
I
Q
T
Q
E
A
P
S
S
T
Site 189
S1761
Q
T
Q
E
A
P
S
S
T
S
Q
E
L
G
T
Site 190
T1768
S
T
S
Q
E
L
G
T
K
G
P
H
P
A
P
Site 191
S1777
G
P
H
P
A
P
L
S
K
F
V
S
S
V
S
Site 192
T1785
K
F
V
S
S
V
S
T
A
K
L
T
L
E
E
Site 193
T1789
S
V
S
T
A
K
L
T
L
E
E
A
Y
R
R
Site 194
S1804
L
K
L
L
W
R
V
S
L
P
E
D
G
Q
C
Site 195
S1849
T
M
K
L
L
Q
L
S
K
R
Q
E
K
V
I
Site 196
T1885
P
G
G
A
H
P
G
T
C
S
P
S
R
P
G
Site 197
S1887
G
A
H
P
G
T
C
S
P
S
R
P
G
S
_
Site 198
S1889
H
P
G
T
C
S
P
S
R
P
G
S
_
_
_
Site 199
S1893
C
S
P
S
R
P
G
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation